X0306 4 2020-04-25 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001779092 Duraibabu Prathyusha C/O SANGAMO THERAPEUTICS, INC. 7000 MARINA BLVD BRISBANE CA 94005 0 1 0 0 VP Principal Acct. Officer Common Stock 2020-04-25 4 F 0 647 8.32 D 26603 D Represents shares underlying the portion of the restricted stock unit grant that vested on April 25, 2020 surrendered by the Reporting Person to the Issuer for tax withholding, using the Issuer's closing stock price on April 24, 2020 of $8.32/share, pursuant to the terms of the Issuer's 2018 Equity Incentive Plan. Includes: 1,270 shares resulting from the April 25, 2020 vesting of Reporting Person's April 25, 2019 restricted stock unit ("RSU") grant; 3,833 shares subject to such RSU grant that will vest in two remaining annual installments on April 25, 2021 and 2022, resulting in such RSU grant being vested in full on the third (3rd) anniversary of the grant date; 16,500 shares of common stock issuable upon settlement of RSUs granted to the Reporting Person on February 25, 2020; and 3,000 shares of common stock issuable upon settlement of RSUs granted to the Reporting Person on March 25, 2020. All such RSUs vest with respect to 1/3rd of the shares in each respective RSU grant in three equal annual installments over the three-year period measured from the date of grant, subject to the Reporting Person's continued service with the Issuer through such dates. /s/ Matthew Colvin, Attorney-in-Fact for Prathyusha Duraibabu 2020-04-28