X0306 4 2020-03-16 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001389147 DILLY STEPHEN GEORGE C/O SANGAMO THERAPEAUTICS, INC. 7000 MARINA BLVD. BRISBANE CA 94005 1 0 0 0 Common Stock 2020-03-16 4 M 0 15000 5.42 A 20000 D Common Stock 2020-03-16 4 S 0 15000 6.0174 D 5000 D Stock Option (Right-to-Buy) 5.42 2020-03-16 4 M 0 15000 0.00 D 2020-03-30 Common Stock 15000 35000 D Includes 2,500 shares of common stock subject to restricted stock units ("RSUs") granted on June 10, 2019. The RSUs will fully vest on the earlier of (x) June 10, 2020 (the first anniversary of the date of grant) or (y) the day prior to Issuer's 2020 annual stockholders meeting, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such dates. The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 15, 2019. The price reported is a weighted average price. The shares were sold at prices ranging from $6.00 to $6.20 The Reporting Person will provide upon request to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. The option was immediately exercisable for all option shares, but shares purchased under the option were subject to certain repurchase rights by the Issuer upon the cessation of the Reporting Person's service on the Board of Directors of the Issuer. The shares subject to each option vested in monthly installments upon completion of each month of Board service over a three year period measured from the date of grant. /s/ Matthew Colvin, Attorney-in-Fact for Stephen G. Dilly 2020-03-18