X0306 4 2020-02-25 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001561733 LOEB GARY C/O SANGAMO THERAPEUTICS, INC. 7000 MARINA BLVD BRISBANE CA 94005 0 1 0 0 EVP, General Counsel & Sec. Common Stock 2020-02-25 4 A 0 500000 0.00 A 50000 D Stock Option (Right-to-Buy) 6.80 2020-02-25 4 A 1 100000 0.00 A 2030-02-24 Common Stock 100000 100000 D Represents 50,000 shares subject to restricted stock units granted on February 25, 2020 that will vest in three (3) equal annual installments on each anniversary of the grant date, such that they will be vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such dates. One-quarter (1/4) of the option shares vest and become exercisable upon completion of one (1) year of service by the Reporting Person measured from the February 25, 2020 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Matthew Colvin, Attorney-in-Fact for Gary Loeb 2020-02-26