X0306 4 2020-01-24 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001675687 Macrae Sandy C/O SANGAMO THERAPEAUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 1 1 0 0 President and CEO Common Stock 2020-01-24 4 F 0 4283 7.50 D 86493 D Represents shares underlying the portion of the restricted stock unit grant that vested on January 24, 2020 surrendered by the Reporting Person to the Issuer for tax withholding, using the Issuer's closing stock price on January 24, 2020 of $7.50/share, pursuant to the terms of the Issuer's 2013 Stock Incentive Plan. Includes 6,217 shares resulting from the January 24, 2020 vesting of Reporting Person's January 24, 2018 restricted stock unit grant and 10,500 shares subject to such restricted stock unit grant that will vest on January 24, 2021 resulting in such restricted stock unit grant being vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such date. Additionally, this amount includes 63,250 shares subject to restricted stock units granted on February 25, 2019 that will vest in three (3) equal annual installments on each anniversary of the grant date, such that they will be vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such dates. Denise Winn, Attorney-in-Fact for Sandy Macrae 2020-01-28