X0306 4 2019-05-15 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001697802 Yi Kathy C/O SANGAMO THERAPEUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 0 1 0 0 EVP & Chief Financial Officer Common Stock 2019-05-15 4 M 0 5000 4.55 A 30512 D Common Stock 2019-05-15 4 S 0 5000 10.00 D 25512 D Stock Option (Right to Buy) 4.55 2019-05-15 4 M 0 5000 0.00 D 2027-02-27 Common Stock 5000 125000 D The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 14, 2017. Includes 4,833 shares subject to restricted stock units granted on January 24, 2018 that will vest in two (2) remaining equal annual installments on each anniversary of the grant date, such that they will be vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such dates. Additionally, this amount includes 19,250 shares subject to restricted stock units granted on February 25, 2019 that will vest in three (3) equal annual installments on each anniversary of the grant date, such that they will be vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such dates. One-quarter (1/4) of the option shares vested and became exercisable upon completion of one (1) year of service by the Reporting Person measured from February 27, 2017, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Denise Winn, Attorney-in-Fact for Kathy Yi 2019-05-17