X0306 4 2019-02-25 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001765497 Woolfson Adrian C/O SANGAMO THERAPEAUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 0 1 0 0 EVP, Research and Development Stock Option (Right-to-Buy) 9.03 2019-02-25 4 A 0 250000 0.00 A 2029-02-24 Common Stock 250000 250000 D One-quarter (1/4) of the option shares vest and become exercisable upon completion of one (1) year of service by the Reporting Person measured from the February 25, 2019 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Matthew Colvin, Attorney-in-Fact for Adrian Woolfson 2019-02-27