X0306 4 2019-02-25 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001755198 Boissel Stephane C/O SANGAMO THERAPEUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 0 1 0 0 EVP, Corporate Strategy Common Stock 2019-02-25 4 A 0 17500 0.00 A 17500 D Stock Option (Right-to-Buy) 9.03 2019-02-25 4 A 0 105000 0.00 A 2029-02-24 Common Stock 105000 105000 D Represents 17,500 shares subject to restricted stock units granted on February 25, 2019 that will vest in three (3) equal annual installments on each anniversary of the grant date, such that they will be vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such date. One-quarter (1/4) of the option shares vest and become exercisable upon completion of one (1) year of service by the Reporting Person measured from the February 25, 2019 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Matthew Colvin, Attorney-in-Fact for Stephane Boissel 2019-02-27