X0306 4 2019-01-24 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001675687 Macrae Sandy 501 CANAL BLVD. RICHMOND CA 94804 1 1 0 0 President and CEO Common Stock 2018-01-24 4 F 0 3974 11.10 D 27526 D Represents shares underlying the portion of the restricted stock unit grant that vested on January 24, 2019 surrendered by the Reporting Person to the Issuer for tax withholding, using the Issuer's closing stock price on January 24, 2019 of $11.10/share, pursuant to the terms of the Issuer's 2013 Stock Incentive Plan. Includes 6,526 shares resulting from the January 24, 2019 vesting of Reporting Person's January 24, 2018 restricted stock unit grant and 21,000 shares subject to such restricted stock unit grant that will vest in two (2) additional equal annual installments on each anniversary of the grant date, such that they will be vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such date. Denise Winn, Attorney-in-Fact for Sandy Macrae 2019-01-28