X0306 4 2018-01-24 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001675687 Macrae Sandy C/O SANGAMO THERAPEUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 1 1 0 0 President, CEO and Director Common Stock 2018-01-24 4 A 0 31500 0.00 A 31500 D Stock Option (Right to Buy) 20.05 2018-01-24 4 A 0 189000 0.00 A 2028-01-23 Common Stock 189000 189000 D Represents 31,500 shares subject to restricted stock units granted on January 24, 2018 that will vest in three (3) equal annual installments on each anniversary of the grant date, such that they will be vested in full on the third (3rd) anniversary of the grant date, subject to the Reporting Person's continued service with the Issuer through such date. One-quarter (1/4) of the option shares vest and became exercisable upon completion of one (1) year of service by the Reporting Person measured from the January 24, 2018 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Denise Winn, Attorney-in-Fact 2018-01-31