X0306 4 2018-01-08 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001691265 Conner Edward R. C/O SANGAMO THERAPEUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 0 1 0 0 Sr. VP & Chief Medical Officer Common Stock 2018-01-08 4 M 0 5000 3.20 A 7000 D Common Stock 2018-01-08 4 S 0 5000 17.109 D 2000 D Stock Option (Right to Buy) 3.20 2018-01-08 4 M 0 5000 0.00 D 2026-11-30 Common Stock 5000 190000 D Includes 2,000 shares acquired by the Reporting Person on October 31, 2017 under the Issuer's Employee Stock Purchase Plan. All sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 16, 2017. The price reported is a weighted average price. The shares were sold at prices ranging from $16.90 to $17.40 The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. One-quarter (1/4) of the option shares vested and became exercisable upon completion of one (1) year of service by the Reporting Person measured from the grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Denise Winn, Attorney-in-Fact 2018-01-10