X0306 4/A 2017-11-30 2017-12-04 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001691262 Herberts Curt A. III C/O SANGAMO THERAPEUTICS, INC. POINT RICHMOND TECH CTR, 501 CANAL BLVD. RICHMOND CA 94804 0 1 0 0 Sr.VP & Chief Business Officer Common Stock 2017-11-30 4 M 0 13433 9.41 A 31266 D Common Stock 2017-11-30 4 S 0 13433 16.00 D 17833 D Common Stock 2017-12-01 4 M 0 781 9.41 A 18614 D Common Stock 2017-12-01 4 M 0 416 8.87 A 19030 D Common Stock 2017-12-01 4 S 0 3197 16.70 D 15833 D Stock Option (Right to Buy) 9.41 2017-11-30 4 M 0 13433 0.00 D 2025-12-07 Common Stock 13433 20313 D Stock Option (Right to Buy) 9.41 2017-12-01 4 M 0 781 0.00 D 2025-12-07 Common Stock 781 19532 D Stock Option (Right to Buy) 8.87 2017-12-01 4 M 0 416 0.00 D 2025-07-26 Common Stock 416 4168 D Includes 2,000 shares acquired by the Reporting Person on October 31, 2017 under the Issuer's Employee Stock Purchase Plan. All sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 22, 2017. The shares were sold at prices ranging from $16.25 to $17.175 The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. One-quarter (1/4) of the option shares vested and became exercisable upon completion of one (1) year of service by the Reporting Person measured from the December 8, 2015 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. One-quarter (1/4) of the option shares vested and became exercisable upon completion of one (1) year of service by the Reporting Person measured from the July 27, 2015 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. This Form 4 Amendment is being filed solely to correct the original filing which inadvertently did not include a power of attorney as an exhibit. /s/ Denise Winn, Attorney-in-Fact 2017-12-04