X0306 4 2014-08-08 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001547959 Ramasastry Saira C/O SANGAMO BIOSCIENCES INC., POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 1 0 0 0 Common Stock 2014-08-08 4 M 0 10000 5.03 A 10000 D Common Stock 2014-08-08 4 S 0 10000 14.00 D 0 D Employee Stock Option (Right to Buy) 5.03 2014-08-08 4 M 0 10000 0.00 D 2022-06-20 Common Stock 10000 24450 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 14, 2014, as amended. Each option is immediately exercisable for all option shares, but shares purchased under the option are subject to certain repurchase rights by the Issuer upon the cessation of the Reporting Person's service on the Board of Directors of the Issuer. The shares subject to each option vest in monthly installments upon completion of each month of Board service over a three year period. /s/ Florence Tam, attorney-in-fact 2014-08-12