X0202 4 2007-10-15 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001234386 LANPHIER EDWARD O II C/O SANGAMO BIOSCIENCES, INC. STE: 100A POINT RICHMOND TECH CNTR, 501 CANAL BL RICHMOND CA 94804 1 1 0 0 Pres & Chief Ex Officer Common Stock 2007-10-15 4 S 0 33 15.89 D 1719459 I By Trust Common Stock 2007-10-15 4 S 0 4867 15.90 D 1714592 I By Trust Common Stock 2007-10-15 4 S 0 100 15.92 D 1714492 I By Trust Common Stock 2007-10-15 4 S 0 700 16.10 D 1713792 I By Trust Common Stock 2007-10-15 4 S 0 1100 16.11 D 1712692 I By Trust Common Stock 2007-10-15 4 S 0 200 16.12 D 1712492 I By Trust Common Stock 2007-10-15 4 S 0 3000 16.13 D 1709492 I By Trust Common Stock 2007-10-15 4 S 0 7600 16.20 D 1701892 I By Trust Common Stock 2007-10-15 4 S 0 2400 16.25 D 1699492 I By Trust Common Stock 2007-10-15 4 S 0 3000 16.30 D 1696492 I By Trust Common Stock 2007-10-15 4 S 0 400 16.32 D 1696092 I By Trust Common Stock 2007-10-15 4 S 0 1600 16.33 D 1694492 I By Trust Common Stock 200000 D Common Stock 100000 I By Trust for Son Common Stock 100000 I By Trust for Daughter Common Stock 100000 I By Trust for Daughter Common Stock 100000 I By Trust for Daughter The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 28, 2006. These shares are held in the Edward O. Lanphier II and Cameron M. Lanphier Trust U/T/A August 30, 2002, Edward O. Lanphier II and Cameron M. Lanphier, Trustees. Reporting Person disclaims beneficial ownership of the shares held by each of his children and this report shall not be deemed to be an admission that Mr. Lanphier is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. /s/ Edward O. Lanphier, II 2007-10-16