X0306 4 2017-02-28 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001697802 Yi Kathy 501 CANAL BLVD POINT RICHMOND TECH CENTER RICHMOND CA 94804 0 1 0 0 Senior VP & CFO Employee Stock Option (Right to Buy) 4.55 2017-02-28 4 A 0 200000 0 A 2027-02-27 Common Stock 200000 200000 D The stock option vests and becomes exercisable for 25% of the shares upon the Reporting Person's completion of one year of service measured from February 27, 2017, and the balance of the shares will vest and become exercisable in 36 equal monthly installments upon her completion of each additional month of service thereafter. /s/ Kathy Yi 2017-02-28