X0306 4 2017-01-26 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001675687 Macrae Sandy C/O SANGAMO THERAPEUTICS, INC. POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 0 1 0 0 President and CEO Employee Stock Option (Right to Buy) 3.50 2017-01-26 4 A 0 360000 0 A 2027-01-25 Common Stock 360000 360000 D The stock option vests and becomes exercisable for 25% of the shares upon the Reporting Person's completion of one year of service measured from the grant date, and the balance of the shares will vest and become exercisable in 36 successive equal monthly installments upon his completion of each additional month of service thereafter. /s/ Florence Tam, Attorney-in-Fact 2017-01-30