X0306 4 2016-12-12 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001691262 Herberts Curt A. III C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR. 501 CANAL BLVD RICHMOND CA 94804 0 1 0 0 Senior VP & CBO Common Stock 2016-12-12 4 F 0 4852 3.05 D 33300 D Represents shares withheld to satisfy the Reporting Person's tax withholding obligation upon the vesting and issuance of RSUs. Includes 3,333 and 12,500 shares subject to RSUs granted on December 11, 2014 and December 8, 2015 respectively, that will be issued as such units vest in accordance with their terms. /s/ Florence Tam, Attorney-in-Fact 2016-12-14