X0306 4 2016-11-30 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001691265 Conner Edward R. C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR. 501 CANAL BLVD RICHMOND CA 94804 0 1 0 0 Senior VP & CMO Employee Stock Option (Right to Buy) 3.20 2016-11-30 4 A 0 200000 0 A 2026-11-29 Common Stock 200000 200000 D One-quarter (1/4) of the option shares will vest and become exercisable upon completion of one (1) year of service by the Reporting Person measured from the grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Florence Tam, Attorney-in-Fact 2016-12-02