X0306 4 2015-12-11 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001234386 LANPHIER EDWARD O II C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 1 1 0 0 President & CEO Common Stock 2015-12-11 4 F 0 21741 8.68 D 306951 D Common Stock 2015-12-12 4 F 0 13045 8.68 D 293906 D Common Stock 1172521 I By Trust Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units. Includes 25,000 and 83,333 shares subject to restricted stock units granted on December 12, 2013 and December 11, 2014, respectively that will be issued as such units vest in accordance with their terms. These shares are held in the Edward O. Lanphier II and Cameron M. Lanphier Trust U/T/A August 30, 2002, Edward O. Lanphier II and Cameron M. Lanphier, Trustees. /s/ Florence Tam, attorney-in-fact 2015-12-15