X0306 4 2015-06-22 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001376797 Cleveland Paul B C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 1 0 0 0 Stock Option (Right to Buy) 11.44 2015-06-22 4 A 0 10000 0 A 2025-06-21 Common Stock 10000 10000 D Each option is immediately exercisable for all option shares, but shares purchased under the option are subject to certain repurchase rights by the Issuer upon the cessation of the Reporting Person's service on the Board of Directors of the Issuer. The shares subject to each option vest in monthly installments upon completion of each month of Board service over a one year period. /s/ Florence Tam, Attorney-in-Fact 2015-06-24