X0306 4 2015-05-05 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001202278 ANDO DALE G C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 0 1 0 0 VP, Therapeutic Dev. & CMO Common Stock 2015-05-05 4 M 0 15000 3.45 A 110376 D Common Stock 2015-05-05 4 S 0 15000 12.2865 D 95376 D Employee Stock Option (Right to Buy) 3.45 2015-05-05 4 M 0 15000 0 A 2018-12-09 Common Stock 15000 65798 D The sales reported in this Form 4 were effected pursuant to the Rule 10b5-1 trading plan adopted by the Reporting Person on June 23, 2014. Includes 11,666, 15,333 and 25,000 shares subject to RSUs granted on December 6, 2012, December 12, 2013 and December 11, 2014 respectively, which will be issued as such units vest in accordance with their terms. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.14 to $12.73, inclusive. The Reporting Person undertakes to provide to Sangamo BioSciences, Inc., any security holder of Sangamo BioSciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. All shares underlying this option are vested and immediately exercisable. /s/ Florence Tam, attorney-in-fact 2015-05-05