X0306 4 2015-05-01 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001343543 Gregory Philip D C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 0 1 0 0 SVP of Research & CSO Common Stock 2015-05-01 4 M 0 3000 3.45 A 119410 D Common Stock 2015-05-01 4 M 0 5000 5.35 A 124410 D Common Stock 2015-05-01 4 M 0 7000 5.70 A 131410 D Common Stock 2015-05-01 4 S 0 15000 12.6247 D 116410 D Employee Stock Option (Right to Buy) 3.45 2015-05-01 4 M 0 3000 0.00 A 2018-12-09 Common Stock 3000 19500 D Employee Stock Option (Right to Buy) 5.35 2015-05-01 4 M 0 5000 0.00 A 2019-12-06 Common Stock 5000 25000 D Employee Stock Option (Right to Buy) 5.70 2015-05-01 4 M 0 7000 0.00 A 2020-12-07 Common Stock 7000 31172 D Includes 13,333, 23,333 and 37,500 shares subject to RSUs granted on December 6, 2012, December 12, 2013 and December 11, 2014 respectively, which will be issued as such units vest in accordance with their terms. The sales reported in this Form 4 were effected pursuant to the Rule 10b5-1 trading plan adopted by the Reporting Person on February 19, 2014. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.40 to $12.92, inclusive. The Reporting Person undertakes to provide to Sangamo BioSciences, Inc., any security holder of Sangamo BioSciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. All shares underlying this option are vested and immediately exercisable. /s/ Florence Tam, attorney-in-fact 2015-05-05