X0306 4 2015-03-16 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001234386 LANPHIER EDWARD O II C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 1 1 0 0 President & CEO Common Stock 2015-03-16 4 M 0 25000 6.82 A 260000 D Common Stock 2015-03-16 4 S 0 25000 17.2922 D 235000 D Common Stock 2015-03-17 4 G 0 3500 0 D 1185521 I By Trust Employee Stock Option (Right to Buy) 6.82 2015-03-16 4 M 0 25000 0 D 2016-12-12 Common Stock 25000 125000 D Includes 60,000, 50,000 shares and 125,000 subject to RSUs granted on December 6, 2012, December 12, 2013 and December 11, 2014, respectively, that will be issued as such units vest in accordance with their terms. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 20, 2014. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.04 to $17.48, inclusive. The Reporting Person undertakes to provide to Sangamo BioSciences, Inc., any security holder of Sangamo BioSciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. These shares are held in the Edward O. Lanphier II and Cameron M. Lanphier Trust U/T/A August 30, 2002, Edward O. Lanphier II and Cameron M. Lanphier, Trustees. All shares underlying these options are vested and exercisable immediately. /s/ Florence Tam, attorney-in-fact 2015-03-18