X0306 4 2015-03-10 0 0001001233 SANGAMO BIOSCIENCES INC SGMO 0001302390 Wolff Henry Ward C/O SANGAMO BIOSCIENCES INC. POINT RICHMOND TECH CNTR, 501 CANAL BLVD RICHMOND CA 94804 0 1 0 0 Exec VP & CFO Common Stock 2015-03-10 4 M 0 10000 3.45 A 216849 D Common Stock 2015-03-10 4 S 0 10000 16.6836 D 206849 D Common Stock 2015-03-10 4 S 0 2000 16.6826 D 204849 D Employee Stock Option (Right to Buy) 3.45 2015-03-10 4 M 0 10000 0 A 2018-12-09 Common Stock 10000 152000 D Includes 15,000, 23,333 and 37,500 shares subject to RSUs granted on December 6, 2012, December 12, 2013 and December 11, 2014 respectively that will be issued as such units vest in accordance with their terms. All sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2014, as amended. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.38 to $16.88, inclusive. The Reporting Person undertakes to provide to Sangamo BioSciences, Inc., any security holder of Sangamo BioSciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.45 to $16.89, inclusive. The Reporting Person undertakes to provide to Sangamo BioSciences, Inc., any security holder of Sangamo BioSciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. All shares underlying these options are vested and exercisable immediately. /s/ Florence Tam, attorney-in-fact 2015-03-12