The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 29,604 1,224,825 SH   DFND 1,2,3,4 1,224,825 0 0
AKAZOO SA SHS L0164E108 1,695 321,600 SH   DFND 1,2,3,4 321,600 0 0
ALLY FINL INC COM 02005N100 21,821 714,040 SH   DFND 1,2,3,4 714,040 0 0
ALPHABET INC CAP STK CL A 02079K305 32,317 24,128 SH   DFND 1,2,3,4 24,128 0 0
ARQULE INC COM 04269E107 1,996 100,000 SH Call DFND 1,2,3,4 100,000 0 0
ATHENEX INC COM 04685N103 2,291 150,000 SH Call DFND 1,2,3,4 150,000 0 0
ATHENEX INC COM 04685N103 17,561 1,150,000 SH   DFND 1,2,3,4 1,150,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 885 43,669 SH   DFND 1,2,3,4 43,669 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 2,026 100,000 SH Call DFND 1,2,3,4 100,000 0 0
BEYOND AIR INC COM 08862L103 2,811 537,471 SH   DFND 1,2,3,4 537,471 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16 300 SH Call DFND 1,2,3,4 300 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 68,470 1,257,720 SH   DFND 1,2,3,4 1,257,720 0 0
CARA THERAPEUTICS INC COM 140755109 7,597 471,575 SH   DFND 1,2,3,4 471,575 0 0
CENTENNIAL RESOURCE DEV INC CL A 15136A102 11,781 2,550,000 SH   DFND 1,2,3,4 2,550,000 0 0
CONSTELLIUM SE CL A SHS F21107101 27,844 2,077,925 SH   DFND 1,2,3,4 2,077,925 0 0
CROCS INC COM 227046109 18,147 433,213 SH   DFND 1,2,3,4 433,213 0 0
CROWN HOLDINGS INC COM 228368106 35,364 487,507 SH   DFND 1,2,3,4 487,507 0 0
DISNEY WALT CO COM DISNEY 254687106 417 2,884 SH   DFND 1,2,3,4 2,884 0 0
ELDORADO RESORTS INC COM 28470R102 31,633 530,401 SH   DFND 1,2,3,4 530,401 0 0
EXICURE INC COM 30205M101 1,001 350,000 SH   DFND 1,2,3,4 350,000 0 0
FACEBOOK INC CL A 30303M102 1,270 6,190 SH   DFND 1,2,3,4 6,190 0 0
FASTENAL CO COM 311900104 9,977 270,000 SH   DFND 1,2,3,4 270,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 20,367 983,924 SH   DFND 1,2,3,4 983,924 0 0
GARDNER DENVER HLDGS INC COM 36555P107 7,996 218,000 SH   DFND 1,2,3,4 218,000 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 1,517 733,050 SH   DFND 1,2,3,4 733,050 0 0
GREAT ELM CAP GROUP INC COM NEW 39036P209 4,232 1,267,030 SH   DFND 1,2,3,4 1,267,030 0 0
GS ACQUISITION HLDGS CORP COM CL A 36255F102 14,865 1,347,647 SH   DFND 1,2,3,4 1,347,647 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 7,057 1,198,212 SH   DFND 1,2,3,4 1,198,212 0 0
HUYA INC ADS REP SHS A 44852D108 4,119 229,484 SH   DFND 1,2,3,4 229,484 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 2,768 100,000 SH Put DFND 1,2,3,4 100,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 1,230 3,000,000 PRN   DFND 1,2,3,4 3,000,000 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 3,001 156,791 SH   DFND 1,2,3,4 156,791 0 0
MASCO CORP COM 574599106 463 9,648 SH   DFND 1,2,3,4 9,648 0 0
MEDICINES CO COM 584688105 12,741 150,000 SH Put DFND 1,2,3,4 150,000 0 0
MICROSOFT CORP COM 594918104 21,947 139,167 SH   DFND 1,2,3,4 139,167 0 0
MOLECULAR TEMPLATES INC COM 608550109 9,727 695,500 SH   DFND 1,2,3,4 695,500 0 0
MOMO INC ADR 60879B107 11,361 339,149 SH   DFND 1,2,3,4 339,149 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 12,384 553,577 SH   DFND 1,2,3,4 553,577 0 0
PRETIUM RES INC COM 74139C102 3,850 345,889 SH   DFND 1,2,3,4 345,889 0 0
PTC THERAPEUTICS INC COM 69366J200 9,784 203,711 SH   DFND 1,2,3,4 203,711 0 0
PURPLE INNOVATION INC COM 74640Y106 2,777 318,791 SH   DFND 1,2,3,4 318,791 0 0
RAPID7 INC COM 753422104 17,488 312,168 SH   DFND 1,2,3,4 312,168 0 0
REGENERON PHARMACEUTICALS COM 75886F107 714 1,901 SH   DFND 1,2,3,4 1,901 0 0
SALESFORCE COM INC COM 79466L302 9,383 57,691 SH   DFND 1,2,3,4 57,691 0 0
SCYNEXIS INC COM 811292101 2,088 2,294,444 SH   DFND 1,2,3,4 2,294,444 0 0
SELECT SECTOR SPDR TR COMMUNICATION 81369Y852 12,067 225,000 SH Put DFND 1,2,3,4 225,000 0 0
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308 617 9,800 SH   DFND 1,2,3,4 9,800 0 0
SESEN BIO INC COM 817763105 1,919 1,845,616 SH   DFND 1,2,3,4 1,845,616 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 9,799 571,382 SH   DFND 1,2,3,4 571,382 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 64,372 200,000 SH Put DFND 1,2,3,4 200,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 33,289 350,000 SH Put DFND 1,2,3,4 350,000 0 0
TRILOGY METALS INC NEW COM 89621C105 4,081 1,569,446 SH   DFND 1,2,3,4 1,569,446 0 0
UNION PACIFIC CORP COM 907818108 10,487 58,008 SH   DFND 1,2,3,4 58,008 0 0
VEEVA SYS INC CL A COM 922475108 4,220 30,000 SH   DFND 1,2,3,4 30,000 0 0
WILLSCOT CORP COM 971375126 14,625 790,952 SH   DFND 1,2,3,4 790,952 0 0