EX-99.1 2 cai_ex99-1.htm EX-99.1 Document


Exhibit 99.1
Caris Life Sciences Reports Third Quarter 2025 Financial Results and Increases 2025 Revenue Guidance
Revenue growth of 113% driven by strong performance in molecular profiling services
Raises 2025 revenue guidance to $720 to $730 million, representing year-over-year growth of 75-77%
IRVING, Texas, November 05, 2025— Caris Life Sciences, Inc. (Nasdaq: CAI), a leading, patient centric, next-generation AI TechBio company, today reported financial results for the quarter ended September 30, 2025.
Third Quarter 2025 Financial Highlights
•Reported total revenue of $216.8 million, an increase of 113.4% over the corresponding prior year period.
•Completed 50,763 clinical therapy selection cases, an increase of 18.2% over the corresponding prior year period.
•Reported gross margin of 68.0%, a 2,432 bps improvement over the corresponding prior year period.
•Achieved net income of $24.3 million.
•Reported positive Adjusted EBITDA of $51.2 million.
•Reported positive net cash flow from operating activities of $62.4 million, and positive free cash flow of $55.3 million.
•Raised full-year 2025 revenue guidance to an updated range of $720 to $730 million, representing growth of 75% to 77% year-over-year.
“We delivered another record quarter for revenue and clinical volume, achieving positive net income and demonstrating the operating strength of our comprehensive, patient-first approach,” said David D. Halbert, Founder, Chairman and CEO of Caris Life Sciences. “These results reflect the core strength of our business and our continued progress toward delivering the next generation of personalized solutions through our exciting pipeline in MRD and early detection.”
Recent Operating Highlights
•Surpassed 959,000 total profiles and 660,000 total matched profiles through September 30, 2025.
◦More than 577,000 Whole Exome and 628,000 Whole Transcriptome profiles through September 30, 2025.
•Published study validating optimal sequencing in informing therapy choices for breast cancer subgroups:
◦Comparison of trastuzumab deruxtecan and sacituzumab govitecan in HER2-negative metastatic breast cancer: a large real-world data analysis.
•Published a study validating the analytical and clinical performance of MI Cancer Seek
◦Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay.


Third Quarter 2025 Summary Financial Results
(amounts in thousands, except case volume, average selling price (“ASP”) and per share data)
Q3 2025
Q3 2024
% Change Y/Y
Total revenue
$216,833 $101,620 113.4 %
Molecular profiling services
207,587 93,803 121.3 %
Pharma research & developmental services
9,246 7,817 18.3 %
Total clinical case volume
50,76342,95618.2 %
MI Profile for therapy selection volume
43,22638,40912.5 %
Caris Assure for therapy selection volume
7,5374,54765.8 %
Total clinical ASP
$4,089 $2,184 87.2 %
MI Profile for therapy selection ASP
4,273 2,241 90.7 %
Caris Assure for therapy selection ASP
3,034 1,697 78.8 %
Total gross margin68.0 %43.7 %24.3 %
Total operating expenses
$114,863 $105,254 9.1 %
Total income (loss) from operations$32,642 $(60,842)153.7 %
Net income (loss)$24,325 $(67,729)135.9 %
Net income (loss) per share attributable to common shareholders, basic
$0.09 $(2.59)103.5 %
Net income (loss) per share attributable to common shareholders, diluted
$0.08 $(2.59)103.1 %
Net cash provided by (used in) operating activities$62,425 $(69,427)189.9 %
Non-GAAP measures(1)
Adjusted EBITDA$51,167 $(45,587)212.2 %
Free cash flow
$55,330 $(71,255)177.7 %


Consolidated balance sheet data
September 30, 2025December 31, 2024
Change
Cash, cash equivalents, restricted cash and marketable securities
$759,254 $70,229 $689,025 
Total outstanding debt, net of debt discounts$376,460 $379,528 $(3,068)
________________________________
(1) See “Non-GAAP Measures” below.
Third Quarter 2025 Financial Results
Total revenue was $216.8 million for the three months ended September 30, 2025, compared to $101.6 million for the three months ended September 30, 2024, an increase of $115.2 million, or 113.4%.
The increase in total revenue was driven primarily by an 121.3% growth in molecular profiling services revenue, which was $207.6 million for the three months ended September 30, 2025, compared to $93.8 million for the three months ended September 30, 2024. The increase in molecular profiling services revenue was primarily driven by an increase in total clinical case volume and ASP improvements across therapy selection solutions.


Gross profit, calculated as total revenue less cost of services, for the three months ended September 30, 2025 and 2024, was $147.5 million and $44.4 million, respectively, representing a gross margin of 68.0% and 43.7%, respectively.
Operating expenses were $114.9 million for the three months ended September 30, 2025, compared to $105.3 million for the three months ended September 30, 2024, an increase of $9.6 million, or 9.1%. The increase was primarily driven by increased stock-based compensation expense and headcount-related costs.
Net income was $24.3 million for the three months ended September 30, 2025, as compared to a net loss of $(67.7) million for the three months ended September 30, 2024. Net income per share attributable to common shareholders, basic and diluted was $0.09 and $0.08 per share, respectively, for the three months ended September 30, 2025, as compared to a net loss per share attributable to common shareholders, basic and diluted of $(2.59) and $(2.59), respectively, for the three months ended September 30, 2024.
Net cash provided by operating activities was $62.4 million for the three months ended September 30, 2025, as compared to net cash used in operating activities of $69.4 million for the three months ended September 30, 2024, a 189.9% improvement. The improvement was driven by improved reimbursement from molecular profiling services.
2025 Financial Outlook and Guidance
Caris Life Sciences expects full year 2025 revenue to be in the range of $720.0 million to $730.0 million, representing growth of 75% to 77% compared to full year 2024. Clinical therapy selection volume is expected to be in the growth range of 21% to 22% compared to full year 2024.
Conference Call Information
Event:
Caris Third Quarter 2025 Financial Results Conference Call
Date:Wednesday, November 5, 2025
Time:3:30 p.m. CT (4:30 p.m. ET)
Webcast Link:
https://edge.media-server.com/mmc/p/uwjxydsa
Accompanying materials will be posted on our investor relations website at https://investor.carislifesciences.com prior to the conference call. A replay of the conference call will be available on our investor relations website shortly after the conclusion of the call.
About Caris Life Sciences
Caris Life Sciences® (Caris) is a leading, patient-centric, next-generation AI TechBio company and precision medicine pioneer that is actively developing and commercializing innovative solutions to transform healthcare. Through comprehensive molecular profiling (Whole Exome and Whole Transcriptome Sequencing) and the application of advanced AI and machine learning algorithms at scale, Caris has created the large-scale, multimodal clinico-genomic database and computing capability needed to analyze and further unravel the molecular complexity of disease. This convergence of next-generation sequencing, AI and machine learning technologies, and high-performance computing provides a differentiated platform to develop the latest generation of advanced precision medicine diagnostic solutions for early detection, diagnosis, monitoring, therapy selection and drug development.
Caris was founded with a vision to realize the potential of precision medicine in order to improve the human condition. Headquartered in Irving, Texas Caris has offices in Phoenix, New York, Cambridge


(MA), Tokyo, Japan and Basel, Switzerland. Caris or its distributor partners provide services in the U.S. and other international markets.
We intend to use the investor page of our website, https://investor.carislifesciences.com, as a distribution channel of material information about the Company and for complying with our disclosure obligations under Regulation FD. The information we post on our investor webpage may be deemed material. Accordingly, investors should subscribe to our investor alerts, in addition to following our press releases, SEC filings, public conference calls and webcasts.
Forward-Looking Statements
This press release contains forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. All statements other than statements of historical facts contained in this press release are forward-looking statements, including statements regarding our business, solutions, plans, objectives, goals, industry trends, financial outlook and guidance. In some cases forward-looking statements can be identified by words such as “may,” “will,” “should,” “would,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “potential,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or similar expressions.
You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in these forward-looking statements are reasonable based on information currently available to us, we cannot guarantee that the future results, discoveries, levels of activity, performance or events and circumstances reflected in forward-looking statements will be achieved or occur. Forward-looking statements involve known and unknown risks and uncertainties, some of which are beyond our control. Risks and uncertainties that could cause our actual results to differ materially from those indicated or implied by the forward-looking statements in this press release include, among other things: developments in the precision medicine industry; our future financial performance, results of operations or other operational results or metrics; development, analytical and clinical validation, timing and performance of future solutions by us and our competitors; commercial market acceptance for our solutions, including acceptance of preventive as well as diagnostic testing paradigms, and our ability to meet resulting demand; the rapidly evolving competitive environment in which we operate; third-party payer reimbursement and coverage decisions related to our solutions; risks related to data management, storage, and processing capabilities and our ability to integrate and deploy artificial intelligence and advanced data analytics technologies; our ability to protect and enhance our intellectual property; regulatory requirements, decisions or approvals (including the timing and conditions thereof) related to our solutions; reliance on third-party suppliers; our compliance with laws and regulations; the outcome of government investigations and litigation; risks related to our indebtedness; and our ability to hire and retain key personnel as well as risks, uncertainties, and other factors described in the section titled “Risk Factors” and elsewhere in our Quarterly Report on Form 10-Q filed on or about November 5, 2025, and in our other filings we make with the SEC from time to time. We undertake no obligation to update any forward-looking statements to reflect changes in events, circumstances or our beliefs after the date of this press release, except as required by law.
Non-GAAP Measures
We use Adjusted EBITDA and free cash flow, financial measures not calculated in accordance with generally accepted accounting principles in the United States (“GAAP”), to supplement our condensed consolidated financial statements, which are presented in accordance with GAAP. We believe the non-GAAP financial measures we use, are useful in evaluating our performance and liquidity. Our non-GAAP financial measures have limitations as analytical tools, however, and you should not consider them in isolation or as substitutes for analysis of our results as reported under


GAAP. Other companies, including other companies in our industry, may not use these measures or may calculate these measures differently than as presented herein, limiting their usefulness as comparative measures.
We define Adjusted EBITDA as net loss, adjusted to exclude interest income, interest expense, changes in fair value of financial instruments, other expense, net, the provision for (benefit from) income taxes, depreciation and amortization, and stock-based compensation expense. We use Adjusted EBITDA in conjunction with GAAP measures as part of our overall assessment of our performance, including the preparation of our annual operating budget and quarterly forecasts, to evaluate the effectiveness of our business strategies, and to communicate with our board of directors concerning our financial performance. We believe Adjusted EBITDA provides useful information to investors and others in understanding and evaluating our operating results in the same manner as our management team and board of directors. Adjusted EBITDA provides a useful measure for period-to-period comparisons of our business, as it removes the effect of certain non-cash expenses and certain variable charges.
We define free cash flow as net cash used in operating activities less purchases of property and equipment. We believe free cash flow is a useful measure of liquidity that provides an additional basis for assessing our ability to generate cash. A reconciliation of the non-GAAP financial measures used in this press release to the respective comparable GAAP financial measures, can be found below.
Caris Life Sciences Media:
Corporate Communications
CorpComm@CarisLS.com
214.294.5606
Investor Relations:
InvestorRelations@CarisLS.com
917.689.3511


Caris Life Sciences, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(unaudited)
(amounts in thousands, except share and per share data)Three Months Ended September 30,Nine Months Ended September 30,
2025202420252024
Revenue:
Molecular profiling services$207,587 $93,803 $484,593 $254,692 
Pharma research and development services9,246 7,817 34,554 27,653 
Total revenue216,833 101,620 519,147 282,345 
Costs and operating expenses:
Cost of Services - Molecular profiling services66,980 54,810 193,195 167,134 
Cost of Services - Pharma research and development services2,347 2,398 7,698 7,130 
Selling and marketing expense41,267 36,758 123,355 115,077 
General and administrative expense51,973 40,852 168,458 126,273 
Research and development expense21,624 27,644 69,739 86,807 
Total costs and operating expenses184,191 162,462 562,445 502,421 
Income (Loss) from operations32,642 (60,842)(43,298)(220,076)
Other expense, net:
Interest income7,360 1,744 9,482 6,152 
Interest expense(13,507)(13,799)(45,497)(36,763)
Changes in fair value of financial instruments(2,081)5,131 (52,285)6,067 
Other income (expense), net(89)37 (18,447)(323)
Total other expense, net(8,317)(6,887)(106,747)(24,867)
Income (Loss) before income taxes and provision for income taxes24,325 (67,729)(150,045)(244,943)
Provision for income taxes— — — — 
Net income (loss)24,325 (67,729)(150,045)(244,943)
Other comprehensive income, net of tax:
Unrealized gain on available-for-sale securities— — — 7 
Foreign currency translation adjustments79 (120)538 (20)
Comprehensive income (loss)24,404 (67,849)(149,507)(244,956)
Net income (loss) attributable to common shareholders:
Net income (loss)24,325 (67,729)(150,045)(244,943)
Deemed dividend from Series D redeemable convertible preferred stock— — (384,436)— 
Adjustments of redeemable convertible preferred stock to redemption value— (24,661)(85,433)(71,368)
Net income (loss) attributable to common shareholders$24,325 $(92,390)$(619,914)$(316,311)
Net income (loss) per share attributable to common shareholders:
Basic$0.09 $(2.59)$(4.83)$(8.92)
Diluted$0.08 $(2.59)$(4.83)$(8.92)
Weighted-average shares used in computing net income (loss) per share attributable to common shareholders:
Basic282,099,07335,643,589128,447,67335,442,927
Diluted297,211,83835,643,589128,447,67335,442,927


Caris Life Sciences, Inc.
Condensed Consolidated Balance Sheets
(unaudited)
(amounts in thousands, except share data)As of September 30,As of December 31,
20252024
Assets
Current assets:
Cash, cash equivalents, and restricted cash$754,739 $65,442 
Short-term marketable securities2,272 2,201 
Accounts receivable26,697 88,244 
Supplies49,303 39,572 
Prepaid expenses and other current assets21,234 20,270 
Total current assets854,245 215,729 
Property and equipment, net63,997 67,817 
Goodwill19,344 19,344 
Other assets46,985 40,844 
Total assets$984,571 $343,734 
Liabilities, Redeemable Convertible Preferred Stock, and Shareholders' Equity (Deficit)
Current liabilities:
Accounts payable$28,999 $27,791 
Accrued expenses and other current liabilities56,867 77,542 
Current portion of indebtedness164 60,090 
Total current liabilities86,030 165,423 
Long-term indebtedness, net of debt discounts376,296 319,438 
Warrant liabilities— 91,642 
Other long-term liabilities43,881 44,418 
Total liabilities506,207 620,921 
Commitments and contingencies
Redeemable convertible preferred stock:
Series A preferred stock, par value $0.001: no and 490,000,000 shares authorized as of September 30, 2025 and December 31, 2024; no and 485,795,293 shares issued and outstanding as of September 30, 2025 and December 31, 2024; and $296,335 aggregate liquidation preference as of December 31, 2024
— 709,261 
Series B preferred stock, par value $0.001: no and 30,000,000 shares authorized as of September 30, 2025 and December 31, 2024; no and 29,629,630 shares issued and outstanding as of September 30, 2025 and December 31, 2024; and $16,000 aggregate liquidation preference as of December 31, 2024
— 42,963 
Series C preferred stock, par value $0.001: no and 142,000,000 shares authorized as of September 30, 2025 and December 31, 2024; no and 116,200,835 shares issued and outstanding as of September 30, 2025 and December 31, 2024; and $408,715 aggregate liquidation preference as of December 31, 2024
— 408,715 
Series D preferred stock, par value $0.001: no and 102,600,000 shares authorized as of September 30, 2025 and December 31, 2024; no and 102,516,283 shares issued and outstanding as of September 30, 2025 and December 31, 2024; and $1,060,712 aggregate liquidation preference as of December 31, 2024
— 1,060,712 
Redeemable convertible preferred stock— 2,221,651 
Shareholders' equity (deficit):
Preferred stock, $0.001 par value per share; 100,000,000 and no shares authorized as of September 30, 2025 and December 31, 2024, respectively; no shares issued and outstanding as of September 30, 2025 and December 31, 2024
— — 
Common stock $0.001 par value; 2,800,000,000 and 1,150,000,000 shares authorized as of September 30, 2025 and December 31, 2024, respectively; 283,723,897 and 36,686,819 shares issued as of September 30, 2025 and December 31, 2024, respectively; 282,103,259 and 36,504,319 shares outstanding as of September 30, 2025 and December 31, 2024, respectively; shares issued and outstanding include 23,446 and 662,000 unvested shares subject to repurchase as of September 30, 2025 and December 31, 2024, respectively
283 38 
Treasury stock at cost, 1,620,638 and 182,500 shares of common stock as of September 30, 2025 and December 31, 2024, respectively
(16,917)(330)
Additional paid-in capital3,124,943 — 
Related party promissory note receivable— (26,456)
Accumulated deficit(2,630,693)(2,472,300)
Accumulated other comprehensive income748 210 
Total shareholders' equity (deficit)478,364 (2,498,838)
Total liabilities, redeemable convertible preferred stock, and shareholders' equity (deficit)$984,571 $343,734 


Caris Life Sciences, Inc.
Condensed Consolidated Statement of Cash Flows
(unaudited)
(amounts in thousands)Nine Months Ended September 30,
20252024
Cash flows from operating activities
Net loss$(150,045)$(244,943)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization18,324 39,847 
Stock-based compensation expense56,639 13,666 
Non-cash operating lease expense4,323 4,224 
Amortization of debt discounts12,163 5,148 
Changes in fair value of financial instruments52,284 (6,068)
Loss on debt extinguishment17,930 — 
Other788 3,947 
Changes in operating assets and liabilities:
Accounts receivable61,232 (15,009)
Supplies(11,144)4,211 
Prepaid expenses and other current assets(4,805)(2,176)
Other assets(326)(158)
Accounts payable(1,196)5,054 
Accrued expenses and other liabilities(17,792)(14,021)
Net cash provided by (used in) operating activities38,375 (206,278)
Cash flows from investing activities
Maturities of marketable securities— 61,376 
Purchases of property and equipment(11,170)(6,154)
Net cash provided by (used in) investing activities(11,170)55,222 
Cash flows from financing activities
Payments made on finance lease obligations(67)(136)
Proceeds from exercise of stock options3,775 1,258 
Payment of taxes withheld from net settlement of exercised options and vested RSUs(18,218)— 
Payment of deferred offering costs(7,710)(1,034)
Proceeds from the 2023 term loan, net of issuance costs— 199,978 
Purchase of treasury stock(22)— 
Issuance of Series E Preferred Stock, net of issuance costs87,637 — 
Issuance of Series F Preferred Stock, net of issuance costs33,601 — 
Issuance of the 2025 Convertible Notes, net of issuance costs27,865 — 
Issuance of the 2025 Warrants10,270 — 
Payments of 2023 term loan amendment fee(4,000)— 
Proceeds from initial public offering, net of underwriting discounts and commissions528,459 — 
Net cash provided by financing activities661,590 200,066 
Effect of exchange rate changes on cash, cash equivalents, and restricted cash159 (3)
Net increase in cash, cash equivalents, and restricted cash688,954 49,007 
Cash, cash equivalents, and restricted cash at beginning of period68,028 60,007 
Cash, cash equivalents, and restricted cash at end of period$756,982 $109,014 


Reconciliation of GAAP Net Loss to Adjusted EBITDA
(unaudited)
(amounts in thousands)Three Months Ended September 30,Nine Months Ended September 30,
2025202420252024
Net income (loss)$24,325 $(67,729)$(150,045)$(244,943)
Interest income(7,360)(1,744)(9,482)(6,152)
Interest expense13,507 13,799 45,497 36,763 
Changes in fair value of financial instruments2,081 (5,131)52,285 (6,067)
Other income (expense), net89 (37)18,447 323 
Provision for income taxes— — — — 
Depreciation and amortization expense4,870 10,532 18,324 39,847 
Stock-based compensation expense13,655 4,723 56,639 13,666 
Adjusted EBITDA$51,167 $(45,587)$31,665 $(166,564)

Reconciliation of Net Cash Used in Operating Activities to Free Cash Flow
(unaudited)
(amounts in thousands)
Three Months Ended September 30,Nine Months Ended September 30,
2025202420252024
Net cash provided by (used in) operating activities$62,425 $(69,427)$38,375 $(206,278)
Less: purchases of property and equipment(7,095)(1,828)(11,170)(6,154)
Free cash flow$55,330 $(71,255)$27,205 $(212,432)