S-3 S-3 EX-FILING FEES 0001814114 Orchestra BioMed Holdings, Inc. N/A N/A 0001814114 2025-10-30 2025-10-30 0001814114 1 2025-10-30 2025-10-30 0001814114 2 2025-10-30 2025-10-30 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-3

Orchestra BioMed Holdings, Inc.

Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial Effective Date

Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward

Newly Registered Securities
Fees to be Paid 1 Equity Common Stock, par value $0.0001 per share Other 6,027,890 $ 3.85 $ 23,207,376.50 0.0001381 $ 3,204.94
Fees to be Paid 2 Equity Common Stock, par value $0.0001 per share, issuable upon exercise of warrants Other 2,000,000 $ 3.85 $ 7,700,000.00 0.0001381 $ 1,063.37
Fees Previously Paid
Carry Forward Securities
Carry Forward Securities

Total Offering Amounts:

$ 30,907,376.50

$ 4,268.31

Total Fees Previously Paid:

$ 0.00

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 4,268.31

Offering Note

1

(1) The "Amount Registered" consists of a maximum of 6,027,890 shares of the Registrant's common stock(the "Common Stock") to be sold by the selling stockholders. Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of Common Stock in connection with any stock dividend, stock split, recapitalization or other similar transactions. The "Proposed Maximum Offering Price" is estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) of the Securities Act, and is calculated based on $3.85 per share, the average of the high and low prices of the Common Stock, as reported on the Nasdaq Global Market on October 28, 2025, which is a date within five business days prior to the date of filing the Registration Statement.

2

(2) The "Amount Registered" consists of a maximum of 2,000,000 shares of the Registrant's Common Stock issuable to the selling stockholders upon exercise of warrants. Pursuant to Rule 416(a) of the Securities Act, this Registration Statement shall also cover any additional shares of Common Stock in connection with any stock dividend, stock split, recapitalization or other similar transactions. The "Proposed Maximum Offering Price" is estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) of the Securities Act, and is calculated based on $3.85 per share, the average of the high and low prices of the Common Stock, as reported on the Nasdaq Global Market on October 28, 2025, which is a date within five business days prior to the date of filing the Registration Statement.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rules 457(b) and 0-11(a)(2)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Rule 457(p)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Table 3: Combined Prospectuses ☑Not Applicable

Security Type

Security Class Title

Amount of Securities Previously Registered

Maximum Aggregate Offering Price of Securities Previously Registered

Form Type

File Number

Initial Effective Date

N/A N/A N/A N/A N/A N/A N/A N/A