Bicycle Therapeutics plc

Blocks A & B, Portway Building

Granta Park Great Abington, Cambridge CB21 6GS

United Kingdom

August 12, 2025

Via Edgar

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Jessica Dickerson

RE:	Bicycle Therapeutics plc
	Registration Statement on Form S-3
	File No. 333-289423
	Acceleration Request
		Requested Date:	August 14, 2025
		Requested Time:	4:00 p.m. Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Exchange Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-289423) (the “Registration Statement”) to become effective at 4:00 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm that event with Jaime L. Chase of Cooley LLP, counsel to the registrant, at (202) 728-7096.

[Signature page follows]

Sincerely,
Bicycle Therapeutics plc
By:	/s/ Alethia Young
	Alethia Young
	Chief Financial Officer
cc:	Kevin Lee, Chief Executive Officer, Bicycle Therapeutics plc
	Laura A. Berezin, Cooley LLP
	Jaime L. Chase, Cooley LLP