Calculation of Filing Fee Tables

F-1

XORTX Therapeutics Inc.

Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable

		Security Type	Security Class Title	Fee Calculation or Carry Forward Rule	Amount Registered	Proposed Maximum Offering Price Per Unit	Maximum Aggregate Offering Price	Fee Rate	Amount of Registration Fee	Carry Forward Form Type	Carry Forward File Number	Carry Forward Initial Effective Date	Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward
Newly Registered Securities
Fees to be Paid	1	Equity	Common Shares, no par value per share	457(o)			$ 4,000,000.00	0.0001531	$ 612.40
Fees to be Paid	2	Other	Pre-funded Warrants to purchase common shares	Other				0.0001531	$ 0.00
Fees to be Paid	3	Other	Common Warrants to purchase common shares	Other				0.0001531	$ 0.00
Fees to be Paid	4	Equity	Common shares underlying the Common Warrants	457(o)			$ 4,000,000.00	0.0001531	$ 612.40
Fees to be Paid	5	Other	Placement Agent Warrants to purchase common shares	Other				0.0001531	$ 0.00
Fees to be Paid	6	Equity	Common shares underlying the Placement Agent Warrants	457(o)			$ 220,000.00	0.0001531	$ 33.68
Fees to be Paid	7	Equity	Common shares underlying the Pre-funded Warrants	Other				0.0001531	$ 0.00
Fees Previously Paid
Carry Forward Securities
Carry Forward Securities
			Total Offering Amounts:				$ 8,220,000.00		$ 1,258.48
			Total Fees Previously Paid:						$ 0.00
			Total Fee Offsets:						$ 0.00
			Net Fee Due:						$ 1,258.48

Offering Note

1	Estimated solely for the purpose of calculating the amount of the registration fee in pursuant to Rule 457(o) under the Securities Act of 1933, as amended (the "Securities Act"). Pursuant to Rule 416 under the Securities Act, this registration statement shall also cover any additional shares of the registrant's securities that become issuable by reason of any share splits, share dividends or similar transactions.
2	The proposed maximum aggregate offering price of the common shares will be reduced on a dollar-for-dollar basis based on the offering price of any pre-funded warrants issued in the offering, and the proposed maximum aggregate offering price of the pre-funded warrants to be issued in the offering will be reduced on a dollar-for-dollar basis based on the offering price of any common shares issued in the offering. Accordingly, the proposed maximum aggregate offering price of the common shares and pre-funded warrants (including the common shares issuable upon exercise of the pre-funded warrants), if any, is $4,000,000.
3	No separate registration fee is payable pursuant to Rule 457(g) under the Securities Act.
4	See Offering Note 1.
5	No separate registration fee is payable pursuant to Rule 457(g) under the Securities Act. Represents warrants issuable to the placement agent, or its designees, to purchase a number of common shares equal to 5.0% of the aggregate number of common shares and pre-funded warrants being offered in this offering, at an exercise price equal to 110% of the combined public offering price per common share and accompanying warrants.
6	See Offering Note1.
7	See Offering Note 2.

Table 2: Fee Offset Claims and Sources ☑Not Applicable

		Registrant or Filer Name	Form or Filing Type	File Number	Initial Filing Date	Filing Date	Fee Offset Claimed	Security Type Associated with Fee Offset Claimed	Security Title Associated with Fee Offset Claimed	Unsold Securities Associated with Fee Offset Claimed	Unsold Aggregate Offering Amount Associated with Fee Offset Claimed	Fee Paid with Fee Offset Source
Rules 457(b) and 0-11(a)(2)
Fee Offset Claims	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Fee Offset Sources	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Rule 457(p)
Fee Offset Claims	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Fee Offset Sources	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

Table 3: Combined Prospectuses ☑Not Applicable

	Security Type	Security Class Title	Amount of Securities Previously Registered	Maximum Aggregate Offering Price of Securities Previously Registered	Form Type	File Number	Initial Effective Date
N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A