stok-ex101_212.htm

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED

This License and Collaboration Agreement (this “Agreement”) is entered into as of January 9, 202 2 (the “Effective Date”), by and between Stoke Therapeutics, Inc., a Delaware corporation having offices at 45 Wiggins Avenue, Bedford, MA 01730 (“Stoke”), and Acadia Pharmaceuticals Inc. a Delaware corporation having offices at 12830 El Camino Real, Suite 400 San Diego, CA 92130 (“Acadia”). Stoke and Acadia are referred to in this Agreement individually as a “Party” and collectively as the “Parties.”

WHEREAS, Stoke has developed a proprietary technology platform, TANGO, for identifying antisense oligonucleotides and other compounds for use in treating severe genetic diseases;

WHEREAS , Acadia is a pharmaceutical company engaged in the research, development and commercialization of novel biopharmaceutical products;

WHEREAS, the Parties desire to collaborate to identify one or more Products (as defined herein) for modulating the genes SYNGAP1, MECP2 and [***] for further Development and Commercialization worldwide, in each case as set forth herein;

WHEREAS, in connection with the foregoing, Stoke is willing to grant to Acadia, and Acadia is willing to accept, licenses under certain of Stoke’s patents and other intellectual property rights with respect to the Products, all on the terms and conditions herein.

NOW, THEREFORE, in consideration of the promises and mutual covenants herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows:

Whenever used in this Agreement, the capitalized terms defined in this Article 1 and elsewhere in this Agreement, and any cognates or correlatives thereof, whether used in the singular or plural, shall have the specified meanings.

1.1“Acadia Collaboration Know-How” means any and all Collaboration Know-How generated, developed, conceived or reduced to practice solely by on behalf of Acadia, its Affiliates or Sublicensees in the course of performing activities under this Agreement.

1.2“Acadia Housemarks” means (a) the corporate logo of Acadia, (b) the trademark “Acadia”, (c) any other Trademark, trade name, or service mark (whether registered or unregistered) containing the word “Acadia”, (d) any other corporate logo or Trademark of Acadia used by Acadia to identify Acadia or any of its Affiliates, and (e) all intellectual property rights and goodwill associated with any and all of the foregoing in clauses (a) through (e).

1.3“Acadia SYNGAP1 Know-How ” means, with respect to a SYNGAP1 Co-Co Product, any and all Know-How Controlled by Acadia (or any of its Affiliates) during the Term that is necessary or reasonably useful for the Development, Manufacture or Commercialization such SYNGAP1 Co-Co Product and that is (a) Acadia Collaboration Know-How, (b) Acadia’s and its Affiliates’ interests in any Joint Collaboration Know-How, or (c) other Know-How Controlled by Acadia that (i) Acadia discloses to Stoke and that the Parties mutually agree to use, and is actually used, in the Development of such SYNGAP1 Co-Co Product under the applicable SYNGAP1 Co-Development Plan, or (ii) is actually used by Acadia in the course of performing its responsibilities under this Agreement (including the applicable SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan) (the Know-How in this clause (c), may include Know-How existing on the Effective Date or during the Term, as applicable, the “Other Acadia Contributed Know-How ”), but in each case excluding any Acquiring Person Intellectual Property.

1.4“Acadia SYNGAP1 Patents ” means, with respect to a SYNGAP1 Co-Co Product, any and all Patent Rights Controlled by Acadia (or any of its Affiliates) during the Term that Cover, or are otherwise necessary or reasonably useful for the Development, Manufacture or Commercialization of, such SYNGAP1 Co-Co Product and that are (a) Collaboration Patents, or (b) other Patent Rights Controlled by Acadia or its Affiliates that claim Other Acadia Contributed Know-How, but in each case excluding any Acquiring Person Intellectual Property.

1.5“Acadia SYNGAP1 Technology” means, with respect to a SYNGAP1 Co-Co Product, the Acadia SYNGAP1 Know-How and the Acadia SYNGAP1 Patents.

1.6“Acquiring Person” means a Third Party (the “Acquiror”) that acquires a Party through a Change of Control, together with any Affiliates of such Acquiror existing immediately prior to the consummation of the Change of Control. For clarity, an “Acquiring Person” of a Party shall exclude the Party and all of its Affiliates existing immediately prior to the consummation of the Change of Control.

1.7 “Act” means, as applicable, the United States Federal Food, Drug and Cosmetic Act, 21 U.S.C. § 301 et seq., as such may be amended from time to time.

1.8 “Affiliate” means any entity directly or indirectly controlled by, controlling, or under common control with, a Party to this Agreement, regardless of whether such entity is or becomes an Affiliate on or after the Effective Date, but only for so long as such control exists. For purposes of this definition, “control ” (including, with correlative meanings, “controlled by”, “controlling” and “under common control with”) means (a) possession, direct or indirect, of the power to direct or cause direction of the management or policies of an entity (whether through ownership of securities or other ownership interests, by contract or otherwise), or (b) beneficial ownership of fifty percent (50%) or more (or the maximum ownership interest permitted by Applicable Laws giving control) of the voting securities or other ownership or general partnership interest (whether directly or indirectly) or other comparable equity interests in an entity.

1.9 “Antisense Oligonucleotide” or “ASO” means an RNA construct (modified or unmodified), including the sequence of such construct and the chemistry of natural and non-natural nucleic acids contained in such construct and the other chemical elements contained in such construct.

1.10“Antitrust Filings ” means any required filing or application under any antitrust, competition or other similar Applicable Laws that are designed or intended to prohibit, restrict or regulate actions having the purpose or effect of monopolization or restraint of trade or lessening competition through merger or acquisition, including the HSR Act and similar Applicable Laws of any jurisdiction.

1.11 “Applicable Laws ” means the applicable provisions of any and all federal, national, supranational, regional, state and local laws, treaties, statutes, rules, regulations, guidelines or requirements, administrative codes, guidance, ordinances, judgments, decrees, directives, injunctions, orders, or permits of or from any court, arbitrator, Regulatory Authority, Governmental Authority, data protection authority, taxing authority, national securities exchange or exchange listing organization having jurisdiction over or related to the relevant subject item that may be in effect from time to time during the Term.

1.12 “Approved Labeling ” means, with respect to a SYNGAP1 Co-Co Product: (a) the Regulatory Authority-approved full prescribing information for such SYNGAP1 Co-Co Product; and (b) the Regulatory Authority-approved labels and other written, printed, or graphic materials on any container, wrapper, or any package insert that is used with or for such SYNGAP1 Co-Co Product.

1.13 “Business Day” means a day other than a Saturday, Sunday or any other day on which banking institutions in Boston, Massachusetts or San Diego, California are authorized or required by Applicable Laws to remain closed.

1.14 “Calendar Quarter ” means the respective periods of three (3) consecutive calendar months ending on March 31, June 30, September 30, and December 31; provided, however, that the first Calendar Quarter of the Term shall begin on the Effective Date and end on the last day of the then-current Calendar Quarter and the last Calendar Quarter of the Term shall begin on the first day of such Calendar Quarter and end on the last day of the Term.

1.15 “Calendar Year ” means each successive period of twelve (12) months commencing on January 1 and ending on December 31; provided, however, that the first Calendar Year of the Term shall begin on the Effective Date and end on December 31 of the then-current Calendar Year and the last Calendar Year of the Term shall begin on the first day of such Calendar Year and end on the last day of the Term.

1.16 “Change of Control” with respect to a Party, shall be deemed to have occurred if any of the following occurs after the Effective Date:

(i)any Third Party “person ” or “group” (as such terms are defined below) (i) is or becomes, through one or a series of transactions, the “beneficial owner” (as defined below), directly or indirectly, of the then-outstanding shares of common stock of such Party (or any direct or indirect parent entity or ultimate parent entity of such Party) representing fifty percent (50%) or more of the total then-outstanding common stock (or foreign equivalent thereof) (the “Outstanding Common Stock”), (ii) is or becomes, through one or a series of transactions, the “beneficial owner”, directly or indirectly, of shares of securities, capital stock or other interests (including partnership interests) of such Party (or any direct or indirect parent entity or ultimate parent entity of such Party) then-outstanding and normally entitled (without regard to the occurrence of any contingency) to vote in the election of the directors, managers or similar supervisory positions (“Outstanding Voting Stock”) of such Party (or any direct or indirect parent entity or ultimate parent entity of such Party) representing fifty percent

(50%) or more of the total voting power of all Outstanding Voting Stock of such Party (or any direct or indirect parent entity or ultimate parent entity of such Party) or (iii) has the power, directly or indirectly, to elect a majority of the members of the Party’s (or any direct or indirect parent entities or ultimate parent entities of such Party) board of directors (or similar governing body); or

(ii)such Party (or any direct or indirect parent entity or ultimate parent entity of such Party) enters into a merger, consolidation or similar transaction with a Person (whether or not such Party (or any direct or indirect parent entity or ultimate parent entity of such Party) is the surviving entity) (a “Business Combination”), in each case, unless, following such Business Combination, (i) the individuals and entities who were the beneficial owners, respectively, of the Outstanding Common Stock and Outstanding Voting Stock of such Party (and the ultimate parent entity thereof) immediately prior to such Business Combination beneficially own, directly or indirectly, fifty percent (50%) or more of, respectively, (1) the then-outstanding shares of common stock (or foreign equivalent thereof) and (2) the combined voting power of the then-outstanding voting securities entitled to vote generally in the election of directors, of the corporation or other entity resulting from such Business Combination (and the ultimate parent entity thereof) and (ii) fifty percent (50%) or more of the members of the board of directors (or similar governing body) of the corporation or other entity resulting from such Business Combination (and ultimate parent entity thereof, as applicable) were members of the board of directors (or similar governing body) of such Party (or ultimate parent entity of such Party, as applicable) at the time of the execution of the initial agreement, or became members of the board of directors of such corporation or other entity by virtue of the action of the board of directors (or similar governing body) of such Party (or ultimate parent entity), providing for such Business Combination; or

(iii)any direct or indirect acquisition or issuance, whether in a single transaction or a series of related transactions, whether by one or more persons or by a group, and whether through any merger, reorganization, consolidation, tender offer, self-tender, exchange offer, stock acquisition, asset acquisition, binding share exchange, business combination , recapitalization, liquidation, dissolution, joint venture or otherwise, of the assets or businesses of such Party or any of its subsidiaries (including securities of subsidiaries) equal to at least a majority of the consolidated assets of such Party of any of its subsidiaries or at least a majority of the net revenues or net income of such Party or any of its subsidiaries (for the 12-month period ending on the last day of such Party’s most recently completed fiscal quarter).

For the purpose of this definition of Change of Control, (x) “person ” and “group” have the meanings given such terms under Sections 13(d) and 14(d) of the United States Securities Exchange Act of 1934 and the term “group” includes any group acting for the purpose of acquiring, holding or disposing of securities within the meaning of Rule 13d-5(b)(1) under the aforesaid Act;

(y) a “beneficial owner” shall be determined in accordance with Rule 13d-3 under the aforesaid Act, except that a Person shall be deemed to have beneficial ownership of all shares that any such Person has the right to acquire, whether such right which may be exercised immediately or only after the passage of time; and (z) the terms “beneficially owned” and “beneficially own” shall have meanings correlative to that of “beneficial owner.”

1.17 “Clinical Trial” means any clinical study involving the administration of a product to a human subject.

1.19“Collaboration Know-How” means any and all Know-How, whether patentable or not, that is generated, developed, conceived or reduced to practice by or on behalf of a Party, its Affiliates or Sublicensees in the course of performing activities or exercising rights under this under this Agreement.

1.20“Collaboration Patents ” means any and all Patent Rights that claim any Collaboration Know-How.

1.21“Collaboration Technology” means, collectively, the Collaboration Know-How and the Collaboration Patents.

1.22“Commercialization Costs” means, with respect to the Commercialization of a given SYNGAP1 Co-Co Product in the Territory in a given period, the following Internal Costs and External Costs incurred during such period with respect to such SYNGAP1 Co-Co Product in such period, but solely to the extent (a) incurred by a Party (or its Affiliate) as a cost or expense in accordance with U.S. GAAP, (b) directly attributable or reasonably allocable to such SYNGAP1 Co-Co Product, and (c) within the scope of the activities set forth in the applicable SYNGAP1 Co-Commercialization Plan and in accordance with the applicable SYNGAP1 Co-Commercialization Budget (plus any Permitted Commercialization Overage):

(a)costs related to (i) managed care market and marketing, (ii) marketing (including telemarketing), promotion, detailing, advertising, and promotional materials, and (iii) activities related to obtaining reimbursement from payers and costs of sales and marketing data; and (iv) samples;

(b)costs incurred in connection with preparation of the applicable SYNGAP1 Co-Commercialization Plan, including market research, including collection of data regarding competitors, and selection of each SYNGAP1 Co-Co Product Mark;

(c)the Manufacturing Cost for the SYNGAP1 Co-Co Product for use in Commercialization activities;

(d)such costs and expenses associated with MAAs and Regulatory Approval for the SYNGAP1 Co-Co Product in any country in the Territory and the maintenance thereof, including fees and local costs and expenses for pharmacovigilance activities and other regulatory activities;

(e)costs incurred in connection with preparation and approval of SYNGAP1 Co-Co Product Materials to be used by the Parties for the Commercialization of the SYNGAP1 Co-Co Product in the Territory;

(f)costs that are attributable to the distribution of the SYNGAP1 Co-Co Product, including storage and distribution activities, packaging, and labeling of the SYNGAP1 Co-Co Product (to the extent not included in Manufacturing Costs), customer services, collection of data about sales to hospitals and other end users, order entry, billing, credit, and credit and collection services and other such activities;

(g)costs incurred in connection with preparation of training materials and carrying out of the training activities for the Field Force that shall Commercialize the SYNGAP1 Co-Co Product in the Territory;

(i)operation and maintenance of the Field Force in the Territory, sales bulletins and other communications, sales meetings, call reporting and other monitoring/tracking costs, development and copying of training, motivational and communications materials to the extent relating to the SYNGAP1 Co-Co Product in the Territory, and other services ancillary to the foregoing (to the extent not otherwise falling within Medical Affairs);

(j)reimbursement assistance services or other patient service or distribution related costs, call center set up, maintenance and operation for personnel used in connection therewith;

(k)establishing and conducting one or more training facilities for potential users of the SYNGAP1 Co-Co Product, including trainer costs, facility costs, supplies, and user costs;

(l)patient assistance program costs associated with programs designed to facilitate patient education and access, including engagements with patient advocacy groups (including sponsorships and grants to patient and disease advocacy organizations), patient support programs , co-pay assistance, and patient assistance programs , and any field-based team dedicated to patient access related activities for a SYNGAP1 Co-Co Product;

(m)such costs and expenses associated with the conduct of Medical Affairs activities conducted in connection with the SYNGAP1 Co-Co Product;

(n)costs of any lobbying activities related to the SYNGAP1 Co-Co Product in the Territory;

(o)the cost of product liability insurance for the SYNGAP1 Co-Co Product in the Territory; and

(p)any other categories of expenses incurred in the performance of activities under the SYNGAP1 Co-Commercialization Plan in accordance with the SYNGAP1 Co-Commercialization Budget for a SYNGAP1 Co-Co Product.

Notwithstanding any provision to the contrary set forth in this Agreement, no Development Milestone Payment or Sales Milestone Payment hereunder shall be considered a Development Cost, Commercialization Cost or Other Expense, and no expense included as a Commercialization Cost shall be included as a Development Cost or Other Expense. Commercialization Costs specifically exclude any costs or expenses of a Party or its Affiliates to the extent caused by such Party or its Affiliate’s breach of this Agreement.

1.23 “Commercialize” means, with respect to a product, any and all activities directed to the offering for sale and sale of such product, including: (a) activities directed to storing, marketing, promoting, detailing, distributing, importing, exporting, selling and offering to sell (including receiving, accepting, and filling orders); (b) handling all returns; (c) controlling invoicing, order processing, and collection of accounts receivable for the sales; (d) booking and recording sales in its books of account, (e) distributing and managing inventory; (f) determining jurisdictions in which MAAs for such product will be made, preparing and submitting such MAAs, and interacting with Regulatory Authorities regarding any of the foregoing (including with respect to labeling); (g) seeking Pricing and Reimbursement Approvals (as applicable), (h) conduct of any Clinical Trials of the product after the receipt of Regulatory Approval for such product for any indication, including conduct of any Phase IV Clinical Trials and coordination of investigator initiated studies Initiated after such initial Regulatory Approval; and (i) Medical Affairs, but excluding in each case (a)-(i) activities to the extent solely directed to Manufacturing or Development. Commercialization shall also include activities related to additional forms, formulations, or indications for a product after receipt of Regulatory Approval of such product . “Commercialization ,” “Commercializing,” and “Commercialized” will be construed accordingly.

1.26 “Control ” or “Controlled” means, subject to Section 2.6(b), Section 2.6(c) and Section 17.1(b), with respect to any material, Know-How, Patent Rights or other intellectual property rights, the legal authority or right (whether by ownership, license or otherwise, other than pursuant to this Agreement ) of a Party or its Affiliates to grant the other Party the access, licenses or sublicenses, of the scope set forth herein, under such material, Know-How, Patent Rights or other intellectual property rights, without violating the terms of any agreement or other arrangement with any Third Party existing at the time such Party would be required hereunder to grant the other Party such access or license or sublicense.

1.27 “Cover” means, as to a product and a Patent Right, that, in the absence of a license granted under, or ownership of, such Patent Right, the making, using, selling, offering for sale or importation of such product would infringe such Patent Right or, as to a pending claim included in such Patent Right, the making, using, selling, offering for sale or importation of such product would infringe such Patent Right if such pending claim were to issue in an issued Patent Right without modification.

1.28 “Develop ” means, with respect to a product, any and all internal and external activities directed to (a) research and development of such product, including non-clinical testing,

toxicology, CMC, non-clinical activities and pre-clinical studies, (b) Clinical Trials for such product (other than those expressly included within Commercialization), and (c) preparation, submission, review, and development of data or information for the purpose of submission to a Regulatory Authority to obtain authorization to conduct Clinical Trials included within the foregoing clause (b). “Development ,” “Developing ,” and “Developed” will be construed accordingly.

1.29“Development Costs” means, with respect to the Development of a given SYNGAP1 Co-Co Product in the Territory in a given period, the following Internal Costs and External Costs incurred during such period with respect to such SYNGAP1 Co-Co Product in such period, but solely to the extent (a) incurred by a Party (or its Affiliate) as a cost or expense in accordance with U.S. GAAP, (b) directly attributable or reasonably allocable to such SYNGAP1 Co-Co Product, and (c) within the scope of the activities set forth in the applicable SYNGAP1 Co-Development Plan and in accordance with the applicable SYNGAP1 Co-Development Budget (plus any Permitted Development Overage):

(a)such costs and expenses that are directly attributable or reasonably allocable to Development activities for achieving MAA approval for the SYNGAP1 Co-Co Product in the Territory (and any costs associated with maintaining Regulatory Approval will be considered a “Commercialization Cost” for the purposes of this Agreement);

(b)such costs and expenses that are directly attributable or reasonably allocable to CMC Development activities for the SYNGAP1 Co-Co Product in the Territory;

(c)such costs and expenses incurred in connection with the conduct of any Clinical Trials for the SYNGAP1 Co-Co Product (including the cost of comparator agents used in such Clinical Trial (if any) and advertising costs for recruitment of patients, costs for branding, public relations, and communications plan, including publications and educational programs);

(d)the Manufacturing Cost for the SYNGAP1 Co-Co Product for use in Development activities, including technology transfer costs, the costs for placebo and any Third Party product and validation and registration lots of such SYNGAP1 Co-Co Product;

(e)costs for conducting advisory board meetings or other consultant programs, the purpose of which is to obtain advice and feedback related to the Development of the SYNGAP1 Co-Co Product; and

(f)such costs and expenses for non-clinical activities for the SYNGAP1 Co-Co Product, including, for example, in vivo or in vitro toxicology experiments and corresponding statistical analyses under the applicable SYNGAP1 Research Plan.

Notwithstanding any provision to the contrary set forth in this Agreement, no expense included as a Development Cost shall be included as a Commercialization Cost or Other Expense. For clarity, any Clinical Trials included in “Commercialization Costs” (e.g. post-marketing and Phase IV Clinical Trials) are excluded from “Development Costs.” Development Costs specifically exclude any costs or expenses of a Party or its Affiliates to the extent caused by such Party or its Affiliate’s breach of this Agreement.

1.30“Development Milestone Event ” mean a development milestone event set forth in Section 9.2(a), Section 9.3(a) or Section 9.4(a).

1.31“Development Milestone Payment ” means a development milestone payment set forth in Section 9.2(a), Section 9.3(a) or Section 9.4(a).

1.32 “Development Plan ” means any or all of the MECP2 Development Plan or [***] Development Plan, as the context requires.

1.33“Development Program ” means any or all of the MECP2 Development Program or [***] Development Program, as the context requires.

1.34“Directed Against ” means, with respect to an ASO or other compound, and with respect to a particular target , that such ASO or other compound is engineered or selected to modulate such target for therapeutic benefit.

1.35 “Distributor” means any Third Party that purchases Product from a Party, its Affiliates or Sublicensees for resale in the Territory and such Third Party takes title to such Product; provided, however, that such Third Party does not pay royalties or commissions to such Party or any of its Affiliates or Sublicensees with respect to its resale of such Product. For clarity, a “Distributor” shall not be considered a sublicensee for purposes of this Agreement (even if licenses are granted to such Distributor for purposes of conducting its activities).

1.36 “Dollar” means the U.S. dollar, and “$” shall be interpreted accordingly.

1.37“EMA” means the European Medicines Agency or any successor entity thereto.

1.38“European Union” or “E.U.” means (i) the United Kingdom, and (ii) the organization of member states of the European Union, as it may be constituted from time to time during the Term.

1.39“Executive Officer” means, respectively, Acadia’s Chief Executive Officer (or the officer or employee of Acadia then serving in a substantially equivalent capacity) and Stoke’s Chief Executive Officer (or the officer or employee of Stoke then serving in a substantially equivalent capacity).

1.40 “Exploit ” means, with respect to a Product, to make, use, offer to sell, sell, import, export, practice, research, develop , manufacture commercialize or otherwise exploit (including Develop, Manufacture, perform Medical Affairs activities and Commercialize), and have others do the same.

1.41“External Costs” mean costs and expenses paid to Third Parties (or payable to Third Parties and accrued in accordance with U.S. GAAP) by a Party or its Affiliate and incurred in the performance of the relevant activity under this Agreement, including the cost of materials (including taxes and duties thereon) and services, but excluding any (a) capital expenditures and financing costs, and (b) any items included under the FTE Rate. For clarity, with respect to any Clinical Trial, External Costs include all payments made to Third Parties providing services in connection with the conduct of such study, including study sites (including start-up fees and patient

visit fees), laboratory services providers and contract research organizations, and any related logistics cost (such as shipping, insurance and storage costs of clinical supply).

1.42“FDA” means the United States Food and Drug Administration or any successor entity thereto.

1.44“Field Force ” means, for a given SYNGAP1 Co-Co Product and a given country, the full set of sales representatives, field managers, district managers, regional managers, national sales managers, regional trainers, medical science trainers and the training department and other personnel allocated by the Parties for the Promotion of such SYNGAP1 Co-Co Product in such country.

1.45 “First Commercial Sale” means, with respect to a Product, the first sale of such Product by a Party, its Affiliate or Sublicensee to a Third Party for distribution, use or consumption in any country in the Territory after Regulatory Approval has been obtained for such Product in such country, excluding, however, any sale or other distribution for use in a Clinical Trial.

1.46“FTE ” means a qualified full-time person , or more than one person working the equivalent of a full-time person , performing activities under a Research Plan, SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan (including any Medical Affairs plan thereunder). Overtime, and work on weekends, holidays and the like will not be counted with any multiplier (e.g., time-and-a-half or double time) toward the number of hours that are used to calculate the FTE contribution. The portion of an FTE billable by a Party for one (1) employee during a given accounting period will be determined by (a) dividing the number of hours worked directly by such employee on the work to be conducted under this Agreement during such accounting period by the number of FTE hours applicable for such accounting period based on [***] working hours per Calendar Year, or (b) to the extent applicable to a Party and its tracking methodologies, the appropriate allocation by a Party of a given individual to activities performed hereunder (e.g., 85% of a given individual’s total hours). FTE efforts will include the work of the JSC, membership oversight activities, and alliance management, but will exclude executive management, general corporate, legal, or administrative personnel. FTEs will be pro-rated on a daily basis if necessary.

1.47“FTE Rate” means [***] per FTE per Calendar Year, and which rate, beginning in the Calendar Year 2023, is subject to annual adjustment in each Calendar Year during the Term as agreed by the JSC based on the percentage increase or decrease in the Consumer Price Index for All Urban Consumers (CPI-U) published by the U.S. Bureau of Labor Statistics as of December 31 of each Calendar Year, over the level of such Consumer Price Index as of December 31 of the prior Calendar Year, with the first such increase to be effective on January 1, 2023. Notwithstanding the foregoing, for any Calendar Year during the Term that is less than a full year, the above referenced rate shall be proportionately reduced to reflect such portion of such full Calendar Year. For avoidance of doubt, the FTE Rate is hereby deemed to include all direct and indirect internal costs associated with a given FTE for purposes of allocating costs under this Agreement, including all wages and salaries, employee benefits, bonus, taxes, travel and entertainment, costs associated with facilities usage (including conducting internal experiments,

studies or analyses), administrative support and access to and use of equipment, consumables, materials, and laboratory supplies (to the extent not included as a separate cost in the applicable Research Plan, SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan), costs directly allocable to FTEs, such as costs for property and liability insurance, rent, utilities, HR and IT support, repairs, office supplies, internet and telephone, and no such other direct or indirect costs shall be included in the determination of cost allocation hereunder. The FTE Rate will in no case include general and administrative personnel costs (other than those set forth herein), such as costs of general company management, or financial, legal or business development personnel costs. For clarity, the FTE Rate will not include manufacturing plant overhead that is included in the definition of Manufacturing Costs.

1.48“Generic Drug or Biosimilar Product ” means, with respect to a Product, and on a Product-by-Product and country-by-country basis, any product (including a “generic product ,” “generic drug,” “biogeneric,” “follow-on biologic,” “follow-on biological product ,” “follow-on protein product ,” “similar biological medicinal product ,” or “biosimilar product ”) approved by way of an abbreviated regulatory mechanism by the relevant Regulatory Authority in a country in reference to such Product, that in each case: (a) is sold in the same country (or is commercially available in the same country via import from another country) as such Product by any Third Party that is not a Sublicensee of the applicable Party or any of its Affiliates and that did not purchase such product in a chain of distribution that included any of the applicable Party or any of its Affiliates or its Sublicensees; and (b) meets the applicable equivalency determination by the applicable Regulatory Authority in such country (including, as applicable, a determination that the product is “comparable,” “interchangeable,” “bioequivalent,” “biosimilar” or other term of similar meaning, with respect to the Product), in each case, as is necessary to permit substitution of such product for the Product under Applicable Laws in such country, including, with respect to the U.S., a Product with an approved Abbreviated New Drug Application under Section 505(j) of the Act (21 U.S.C. 355(j)) or a Product licensed as a “biosimilar” or “interchangeable” biological product under Section 351(k) of the PHSA (42 U.S.C. 262(k)), or, outside the United States, in accordance with European Directive 2001/83/EC on the Community Code for medicinal products (Article 10(4) and Section 4, Part II of Annex I ) and European Regulation EEC/2309/93 establishing the Community procedures for the authorization and evaluation of medicinal products, each as amended, and together with all associated guidance, and any counterparts thereof or equivalent process inside or outside of the United States or EU to the foregoing.

1.49“GLP Tox Study” means, with respect to a Molecule, Clinical Candidate or a Product, an in vivo toxicology study that is conducted pursuant to a Research Plan in compliance with Good Laboratory Practices.

1.50“Good Clinical Practices ” or “GCP ” means the applicable then-current standards for clinical activities for pharmaceuticals or biologicals, as set forth in the Act and any regulations or guidance documents promulgated thereunder, as amended from time to time, together with, with respect to work performed in a country other than the United States, any similar standards of good clinical practice as are required by any Regulatory Authority in such country, to the extent such standards are not less stringent than applicable U.S. standards or ICH Guidelines, including ICH E6.

1.51“Good Laboratory Practices” or “GLP” means the applicable then-current standards for laboratory activities for pharmaceuticals or biologicals, as set forth in the Act and any regulations or guidance documents promulgated thereunder, as amended from time to time, together with, with respect to work performed in a country other than the United States, any similar standards of good laboratory practice as are required by any Regulatory Authority in such country.

1.52“Good Manufacturing Practices” or “GMP” means the applicable then-current standards for conducting Manufacturing activities for pharmaceuticals or biologicals (or active pharmaceutical ingredients) as are required by any applicable Regulatory Authority in the Territory, to the extent such standards are not less stringent than applicable U.S. standards as provided in, but not limited to, 21 C.F.R. Parts 210 and 211, or ICH Guidelines, including ICH Q7.

1.53“Governmental Authority” means any federal, state, national, state, provincial, or local government, or political subdivision thereof, or any multinational organization or any authority, agency or commission entitled to exercise any administrative, executive, judicial, legislative, police, regulatory or taxing authority or power, or any court or tribunal (or any department, bureau or division thereof, or any governmental arbitrator or arbitral body).

1.55“Hatch-Waxman Act” means rights conferred in the U.S. under the Drug Price Competition and Patent Term Restoration Act, 21 U.S.C. §355, as amended (or any successor statute or regulation).

1.56“IND ” means an investigational new drug application filed with the FDA or any similar application filed with a Regulatory Authority in a country other than the U.S. required to commence Clinical Trials of a pharmaceutical product.

1.57 “Initiation ” means, with respect to a Clinical Trial, the administration of the first dose of the product being studied to the first human subject in such Clinical Trial.

1.58 “Internal Costs ” means, for any period, the product obtained by multiplying (i) the actual total FTEs (or portion thereof) devoted to the performance of the relevant activities as specifically set fort h in the applicable Research Plan, SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan, in each case, during such period, by (ii) the applicable FTE Rate.

1.59“Joint Collaboration Know-How” means any and all Collaboration Know-How that is generated, developed, conceived or reduced to practice jointly by or on behalf of both (i) Acadia, its Affiliates or Sublicensees, and (ii) Stoke, its Affiliates or Sublicensees.

1.60“Joint Collaboration Patents ” means any and all Patent Rights that claim Joint Collaboration Know-How, but do not claim Acadia Collaboration Know-How or Stoke Collaboration Know-How.

1.61“Know-How ” means any proprietary scientific or technical information, inventions, discoveries, results and data of any type whatsoever, in any tangible or intangible form,

including inventions, discoveries, databases, safety information, practices, methods, instructions, techniques, processes, drawings, documentation, specifications, formulations, formulae, knowledge, know-how, trade secrets, materials, skill, experience, test data and other information and technology applicable to formulations, compositions or products or to their manufacture , development , registration, use, marketing or sale or to methods of assaying or testing them, including pharmacological, pharmaceutical, medicinal chemistry, biological, chemical, biochemical, toxicological and clinical test data, physical and analytical, safety, quality control data, manufacturing , and stability data, materials, studies and procedures, and manufacturing process and development information, results and data.

1.62 “Licensed Product” means any MECP2 Licensed Product, [***] Licensed Product or SYNGAP1 Opt-Out Product, or all of the foregoing, as the context requires.

1.63“Licensed Product Patents” means, with respect to a Molecule or Clinical Candidate (or any modification or derivative of such Molecule or Clinical Candidate), the Stoke MECP2 Patents, Stoke [***] Patents, Stoke SYNGAP1 Patents or Joint Collaboration Patents, as applicable, that have at least one claim that claims the composition of a Molecule or Clinical Candidate or any use thereof, or any modification or derivative of such Molecule or Clinical Candidate, or any formulation, method of use or method of manufacture of such Molecule or Clinical Candidate or any modification or derivative of such Molecule or Clinical Candidate.

1.66 “Manufacture ” means, with respect to a product , any and all manufacturing-related activities that support the Development and Commercialization, including seeking and obtaining of Regulatory Approval, as applicable, of such product , including manufacturing process development and scale-up, validation, qualification and audit of clinical and commercial manufacturing facilities, bulk production and fill/finish work, stability testing, characterization, related quality assurance technical support activities and CMC activities, and including the synthesis, manufacturing, processing, formulating, packaging, labeling, holding, quality control testing and release of such product . “Manufacturing ” and “Manufactured” will be construed accordingly.

1.68 “Marketing Authorization Application” or “MAA” means (a) any New Drug Application (as defined in the Act), any Biologics License Application (as defined in the PHSA) and applicable regulations promulgated thereunder by the FDA filed with the FDA to gain approval to market a pharmaceutical product in the U.S., (b) a marketing authorization application filed with (i) the EMA under the centralized EMA filing procedure to gain approval to market a biopharmaceutical in the E.U., or (ii) a Regulatory Authority in any E.U. country if the centralized EMA filing procedure is not used to gain approval to market a biopharmaceutical in the E.U., or (c) any other equivalent or related Regulatory Material filed in support of approval to market a biopharmaceutical in any country outside of the U.S. or E.U., and, in each case ((a) through (c)),

including any amendments thereto, and supplemental applications, but excluding applications for Pricing and Reimbursement Approval.

1.69“Material Communications” means written, telephonic, or in person communications from or with any Regulatory Authority (including any meeting minutes from any meetings with any Regulatory Authority) concerning any of the following: key product quality attributes (e.g., purity), safety findings (e.g., serious adverse events, emerging safety signals), clinical or non-clinical findings affecting patient safety, lack of efficacy, receipt or denial of Regulatory Approval, the design of Clinical Trials, or the need for additional non clinical studies or pre-clinical studies (e.g., additional toxicology or carcinogenicity studies).

1.70“MECP2 Licensed Product” means (a) a product containing or comprising, as an active ingredient (i) a Molecule arising out of the MECP2 Research Program, including any such Molecule that is a Clinical Candidate, (ii) a Molecule Directed Against MECP2 that is owned or Controlled by Stoke as of the Effective Date or (iii) any modification or derivative of a Molecule identified in clause (i) or (ii), which Molecule is Directed Against MECP2 , and (b) any and all forms, presentations, delivery systems, dosages, and formulations of a product described in (a).

1.71“Medical Affairs” means, with respect to a product , any and all activities for conducting medical affairs for such product , including field medical (medical scientific liaisons and payor liaisons), medical information and health economics outcomes research , development and execution of strategic and tactical medical product plans, generation of clinical and health economic outcomes data via post hoc analyses and real world evidence studies; development of economic models, production of value dossiers, key opinion leader strategy development and communications, generation and execution of responses to medical information requests, publication of scientific findings, presentations at medical scientific congresses and virtual medical engagements; medical education, symposia, congresses, advisory boards (to the extent related to Medical Affairs or clinical guidance), conducting health economics and outcomes research, conducting medical science liaison activities, activities performed in connection with patient registries, and other medical programs and communications, including continuing education grants, and research grants (including conducting investigator-initiated studies), to the extent related to medical scientific affairs and not to other activities that involve the promotion , marketing, sale, or other Commercialization of such product .

1.72 “Net Sales” means, with respect to any Product, the gross amounts invoiced by (i) a Party or its Affiliate and (ii) with respect to any such Product that is a Licensed Product, any Sublicensee thereof (any such entity of (i) and (ii), a “Selling Party”) to Third Party customers for sales of such Product in the Territory, less the following deductions actually incurred, allowed, paid, accrued or specifically allocated in its financial statements for such Product, all in accordance with U.S. GAAP, consistently applied, for:

Such amounts shall be determined from the books and records of such Party or its Sublicensee maintained in accordance with U.S. GAAP or, in the case of Sublicensees, such similar accounting principles, consistently applied. Net Sales shall not be imputed to transfers of Products for use in clinical trials , non-clinical Development activities or other Development activities with respect to Products, as applicable, by or on behalf of the Parties, for bona fide charitable purposes or for compassionate use, patient program or for Product samples, in each case if no monetary consideration exceeding the cost of goods for such Product is received for such transfers.

In the event that a Licensed Product is sold as part of a Combination Product (where “Combination Product ” means any single-priced product(s) which comprises the Licensed Product and one or more Other Active Ingredients (“Other Product(s)”)), the Net Sales of such Licensed Product, for the purposes of determining royalty payments, shall be determined by [***].

In the event that the weighted average sale price of the Licensed Product can be determined but the weighted average sale price of the Other Product(s) cannot be determined, Net Sales for purposes of determining royalty payments shall be calculated by [***].

In the event that the weighted average sale price of the Other Product(s) can be determined but the weighted average sale price of the Licensed Product cannot be determined, Net Sales for purposes of determining royalty payments shall be calculated by [***].

In the event that the weighted average sale price of both the Licensed Product and the Other Product(s) in the Combination Product cannot be determined, the Parties shall enter into good faith negotiations to determine the appropriate value to be allocated to the Licensed Product and the Other Product(s).

The weighted average sale price for a Licensed Product, Other Product, or Combination Product shall be calculated [***] and such price shall be used during all applicable royalty reporting periods for [***]. When determining the weighted average sale price of a Licensed Product, Other Product or Combination Product, the weighted average sale price shall be calculated by [***]. In the initial [***], a forecasted weighted average sale price shall be used for the Licensed Product, Other Products or Combination Product. Any over or under payment in the initial year due to a difference between forecasted and actual weighted average sale prices shall be paid or credited in the first royalty payment of the following [***].

Adjuvants and excipients shall not be deemed to be “active compound(s) or ingredients” except where such adjuvant or excipient is recognized by the FDA as an active ingredient in accordance with 21 C.F.R. § 210.3(b)(7).

For avoidance of doubt, for purposes of determining the Net Sales of any SYNGAP1 Co-Co Product that includes an Other Active Ingredient, no adjustment will be made to the Net Sales

based on the weighted average sale price of the SYNGAP1 Co-Co Product or the Other Active Ingredient, and the determination of costs and revenues from any such SYNGAP1 Co-Co Product will be determined in accordance with Section 9.6.

1.73“NMPA ” means the National Medical Licensed Products Administration in China, and local counterparts thereto, or any successor entity thereto.

1.74“[***] Licensed Product” means (a) a product containing or comprising, as an active ingredient (i) a Molecule arising out of the [***] Research Program, including any such Molecule that is a Clinical Candidate, (ii) a Molecule Directed Against [***] that is owned or Controlled by Stoke as of the Effective Date or (iii) any modification or derivative of a Molecule identified in clause (i) or (ii), which Molecule is Directed Against [***], and (b) any and all forms, presentations, delivery systems, dosages, and formulations of a product described in (a).

1.75“Opt-Out Party ” means (i) Stoke after it exercised its Development Opt-Out Right pursuant to Section 8.1(a) or (ii) Stoke after it exercised its Commercialization Opt-Out Right pursuant to Section 8.2(a), as the case may be.

1.76“Other Active Ingredient ” means a clinically active material(s), other than a Molecule (or modification or derivative thereof that is Directed Against the applicable Target), that provides pharmacological activity in a biopharmaceutical or pharmaceutical product, excluding formulation components such as coatings, stabilizers, excipients or solvents, adjuvants or delivery technologies.

1.77“Other Expenses ” means, with respect to the Exploitation of a SYNGAP1 Co-Co Product in the Territory in a given period, the following items, but solely to the extent (a) incurred by a Party (or its Affiliate) as a cost or expense in accordance with U.S. GAAP, and (b) directly attributable or reasonably allocable to the Exploitation of such SYNGAP1 Co-Co Product:

(a)Losses arising from any Third Party Claim relating to the Exploitation of such SYNGAP1 Co-Co Product in the Territory, including fees and disbursements to counsel, incurred by either Party in connection with the defense of any such Third Party Claim brought in the Territory that are expressly permitted to be applied as Other Expenses pursuant to Section 13.2;

(b)Third Party Co-Co In-License Payments under Third Party Co-Co In-License Agreements;

(c)Internal Costs and External Costs incurred in connection with the performance of regulatory activities for the Territory to the extent not included in Development Costs or Commercialization Costs;

(d)Internal Costs and External Costs of conducting a recall of a SYNGAP1 Co-Co Product in the Territory

(h)External Costs incurred in connection with the negotiation of an agreement with a Third Party licensee or sublicensee under Section 2.2(b)(i)(B)(including legal costs and attorneys’ fees).

No expense included as an Other Expense shall also be included as a Commercialization Cost, or Development Cost. Other Expenses specifically exclude any costs or expenses of a Party or its Affiliates to the extent caused by such Party or its Affiliate’s breach of this Agreement.

1.78“Packaging and Labeling ” means, with respect to a SYNGAP1 Co-Co Product, primary, secondary, or tertiary packaging and labeling of such SYNGAP1 Co-Co Product (in its commercial packaging presentation) for sale or use in the Territory, consistent with respect to the applicable SYNGAP1 Co-Commercialization Plan, including the Approved Labeling and insertion of materials such as patient inserts, patient medication guides, and professional inserts and any other written, printed, or graphic materials accompanying such SYNGAP1 Co-Co Product and any brand security or anti-counterfeiting measures included in the packaging elements for such SYNGAP1 Co-Co Product considered to be part of the finished packaged SYNGAP1 Co-Co Product, and all testing and release thereof.

1.79“Patent Rights ” means: (a) pending patent applications, issued patents, utility models and designs; (b) reissues, substitutions, confirmations, registrations, validations, re-examinations, additions, continuations, continued prosecution applications, continuations-in-part, or divisions of or to any of the foregoing; and (c) extensions, renewals or restorations of any of the foregoing by existing or future extension, renewal or restoration mechanisms, including supplementary protection certificates or the equivalent thereof.

1.80 “Person” means an individual, corporation, partnership, limited liability company, limited partnership, trust, business trust, association, joint stock company, joint venture, syndicate, sole proprietorship, unincorporated organization, Governmental Authority or any other form of entity not specifically listed herein.

1.81“Pharmacovigilance Costs ” means, with respect to a SYNGAP1 Co-Co Product, those Internal Costs and External Costs, in each case, directly attributable or reasonably allocable to the performance of any activities related to pharmacovigilance for such SYNGAP1 Co-Co Product, including establishing, updating, and maintaining a global safety database for such SYNGAP1 Co-Co Product and the performance of any other activities under the Pharmacovigilance Agreement.

1.82“Phase I/II Clinical Trial ” means, with respect to a product, a Clinical Trial that provides for the first introduction of such product into patients in a target patient population with the primary purpose of determining safety, metabolism and pharmacokinetic properties and clinical pharmacology of such product, in a manner that is consistent with U.S. 21 C.F.R. 312.21(a) or corresponding foreign regulations, and that is also prospectively designed to generate sufficient data (if successful) to support the commencement of a Phase III Clinical Trial for, or to file for accelerated approval of, such product.

1.83“Phase III Clinical Trial ” means, with respect to a product , a Clinical Trial performed to gain evidence with statistical significance of the efficacy of such product in a target population and to obtain expanded evidence of safety for such product that is needed to evaluate the overall benefit-risk relationship of such product, to form the basis for approval of an MAA by a Regulatory Authority and to provide an adequate basis for physician labeling, as described in 21 C.F.R. 312.21(c), as amended from time to time, or the corresponding regulation in jurisdictions other than the United States.

1.84“Phase IV Clinical Trial” means a post-registrational Clinical Trial conducted in any country or countries and required as a condition to, or for the maintenance of, any Regulatory Approval for a Product in the Territory.

1.85“PHSA” means the United States Public Health Service Act, as may be amended, or any subsequent or superseding law, statute or regulation.

1.86“PMDA” means the Japanese Pharmaceuticals and Medical Devices Agency or any successor entity thereto.

1.87“Pricing and Reimbursement Approval ” means, with respect to any country or jurisdiction in which one or more Governmental Authorities determine or approve the pricing at which a product will be charged to, or reimbursed by, public or private payors, the approval, agreement , determination or decision by such applicable Governmental Authority(ies) establishing the pricing and reimbursement status for such product for any such payor or group of payors (including all activities related to tenders and contracts).

1.88 “Pricing Matters” means, with respect to a SYNGAP1 Co-Co Product, all issues and decisions regarding price, price terms and other contract terms with respect to such SYNGAP1 Co-Co Product sales in the Territory, including discounts, rebates, other price concessions and service fees to payors and purchasers and includes all financial issues and financial decisions with respect to contracting with managed care entities, hospitals, pharmacies, group purchasing organizations, pharmacy benefit managers, and government, and specifically includes issues and decisions about the offer of discounts or rebates for formulary placement for such SYNGAP1 Co-Co Product.

1.89 “Product” means any or all MECP2 Licensed Products, [***] Licensed Products, SYNGAP1 Co-Co Products or SYNGAP1 Opt-Out Products, as the context requires.

1.90 “Program ” means each Research Program corresponding to a Target, and references to a Program hereunder refer to such Program both during the applicable Research Term and thereafter for the Term (including the applicable Target and related Products).

1.91 “Promotion ” means, with respect to a given SYNGAP1 Co-Co Product, any activities aimed at encouraging the use of such SYNGAP1 Co-Co Products in a country, including marketing, promoting, conducting calls and details, contract administration, key account management and advertising (including educating, speaking programs and promotional symposia).

1.92“Prosecute and Maintain” means activities directed to (a) preparing, filing and prosecuting applications (of all types) for any Patent Rights, or (b) managing or settling any patent

office or regulatory agency interference, re-issue, reexamination, supplemental examination, inter partes or post-grant review proceedings, revocation, nullification, or cancellation proceeding relating to the foregoing (but excluding, for clarity, defense of challenges to the applicable Patent Rights as a counterclaim in an infringement proceeding).

1.93“Regulatory Approval” means, collectively, any and all approvals (including supplements, amendments, pre- and post-approvals, Pricing and Reimbursement Approvals), licenses, registrations, permits, notifications, and authorizations (including marketing and labeling authorizations) or waivers of any Regulatory Authority that are necessary for the testing, research, development , registration, manufacture (including formulation), use, storage, import, export, transport, promotion , marketing, distribution, offer for sale, sale or other commercialization of a pharmaceutical product (including any Product) in any country or jurisdiction.

1.94“Regulatory Authority” means any Governmental Authority, including the FDA, EMA, NMPA, PMDA or any health regulatory authority in any country or jurisdiction that is a counterpart to the foregoing agencies, in each case, that holds responsibility for the Development , Manufacture, distribution, importation, exportation and Commercialization of, and the granting of Regulatory Approval for, a pharmaceutical product in such country or jurisdiction.

1.95“Regulatory Exclusivity ” means, with respect to a Product in any country in the Territory, a period of data or marketing exclusivity (other than Patent Rights exclusivity) granted or afforded by applicable Law or by a Regulatory Authority in such country that prevents the approval or marketing of any Generic Drug or Biosimilar Product of such Product in such country, including reference product exclusivity under Section 351(k)(7)(C) of the PHSA and pediatric exclusivity under Section 351(m) of the same and any foreign equivalents.

1.96“Regulatory Filing” means any documentation comprising or relating to or supporting any submission or application with any Regulatory Authority with respect to a Product or its use or potential use in humans, including any documents submitted to any Regulatory Authority and all supporting data, including INDs, Regulatory Approval applications, and all correspondence with any Regulatory Authority with respect to any Product (including minutes of any meetings, telephone conferences or discussions with any Regulatory Authority).

1.97“Regulatory Materials ” means all Regulatory Filings, regulatory registrations, applications, authorizations, approvals (including approvals of MAAs, supplements and amendments, pre- and post-approvals, Pricing and Reimbursement Approvals and labeling approvals, and INDs) and other submissions made to or with any Regulatory Authority, including drug master files, for Development (including the conduct of Clinical Trials), Manufacture or Commercialization of a pharmaceutical product in a country or regulatory jurisdiction, together with all related correspondence to or from any Regulatory Authority and all documents referenced in the complete regulatory chronology for each MAA, including any US Certificate of Pharmaceutical Product.

1.98“Research Budget ” means any or all of the MECP2 Research Budget , [***] Research Budget or SYNGAP1 Research Budget, as the context requires.

1.99“Research Costs” means, with respect to a given Research Plan in a given period, the Internal Costs and External Costs (a) incurred by Stoke (or its Affiliate) during such period as a cost or expense in accordance with U.S. GAAP, (b) directly attributable or reasonably allocable to the applicable Target, and (c) within the scope of the activities set forth in the applicable Research Plan and in accordance with the applicable Research Budget (plus any Permitted Research Overage).

1.100 “Research Plan ” means any or all of the MECP2 Research Plan , [***] Research Plan or SYNGAP1 Research Plan, as the context requires.

1.101 “Research Program ” means any or all of the MECP2 Research Program , [***] Research Program or SYNGAP1 Research Program, as the context requires.

1.102“Research Term” means, with respect to a Research Program, the period of time beginning on the Effective Date and ending [***], as may be extended pursuant to Section 4.3.

1.103“Sales Milestone Event” mean a sales milestone event set forth in Section 9.2(b), Section 9.3(b) or Section 9.4(b).

1.104“Sales Milestone Payment” means a sales milestone payment set forth in Section 9.2(b), Section 9.3(b) or Section 9.4(b).

1.105“Segregate ” means, with respect to an Acquiring Person COC Program or Acquired COC Program , to segregate the research, development and commercialization activities relating to such Acquiring Person COC Program or Acquired COC Program , from research, development and commercialization activities with respect to the Product under this Agreement, including (i) ensuring that: (a) no personnel involved in performing the research, development or commercialization , as applicable, of such Acquiring Person COC Program or Acquired COC Program are involved in the research, development or commercialization of, or otherwise have access to non-public plans or non-public information relating to the research, development or commercialization of, the Product or any other Confidential Information of either Party or any Collaboration Know-How; and (b) no personnel involved in performing the research, development or commercialization of the Product are involved in the research, development or commercialization of, or otherwise have access to non-public plans or information relating to, the research, development or commercialization of such Acquiring Person COC Program or Acquired COC Program, provided that in either case ((a) or (b)), applicable personnel within a Party’s (or its Affiliates’) financial functions may review financial information with respect to the Acquiring Person COC Program or Acquired COC Program as necessary to comply with its financial oversight and reporting obligations, (ii) establishing reasonable firewall protections and safeguards (that are reasonably acceptable to the other Party) designed to ensure that research, development or commercialization , as applicable, of such Acquiring Person COC Program or Acquired COC Program is segregated from the research, development or commercialization of the Product and (iii) ensuring that the research, development or commercialization , as applicable, of such Acquiring Person COC Program or Acquired COC Program does not delay or otherwise inhibit the conduct of the research, development or commercialization , as applicable, of the Product hereunder.

1.106“Stoke Collaboration Know-How ” means any and all Collaboration Know-How generated, developed, conceived or reduced to practice solely by or on behalf of Stoke, its Affiliates or Sublicensees in the course of performing activities under this Agreement.

1.107“Stoke Existing In-License” means all license agreement(s) between Stoke or its Affiliate and a Third Party pursuant to which Stoke or its Affiliate Controls any of the Stoke MECP2 Technology, Stoke [***] Technology or Stoke SYNGAP1 Technology as of the Effective Date. Schedule 1.107 includes all Stoke Existing In-Licenses.

1.108“Stoke Housemarks” means (a) the corporate logo of Stoke, (b) the trademark “Stoke”, (c) any other Trademark, trade name, or service mark (whether registered or unregistered) containing the word “Stoke”, (d) any other corporate logo or Trademark of Stoke used by Stoke to identify Stoke or any of its Affiliates, and (e) all intellectual property rights and goodwill associated with any and all of the foregoing in clauses (a) through (e).

1.109“Stoke MECP2 Know-How ” means any and all Know-How Controlled by Stoke (or any of its Affiliates) as of the Effective Date or during the Term that is necessary or reasonably useful for the Development, Manufacture or Commercialization of MECP2 Licensed Products, including (a) any such Know-How that is Stoke Collaboration Know-How, (b) Stoke’s and its Affiliates’ interests in any Joint Collaboration Know-How, and (c) other Know-How Controlled by Stoke that (i) Stoke discloses to Acadia and that the Parties mutually agree to use, and is actually used, in the Development of such MECP2 Licensed Products under the MECP2 Research Plan or MECP2 Development Plan, or (ii) is actually used by Stoke in the course of performing its responsibilities under this Agreement (including under the MECP2 Research Plan or MECP2 Development Plan) but in each case excluding any Acquiring Person Intellectual Property.

1.110“Stoke MECP2 Patents ” means any and all Patent Rights Controlled by Stoke (or any of its Affiliates) as of the Effective Date or during the Term, that Cover, or are otherwise necessary or reasonably useful for the Development, Manufacture or Commercialization of, the MECP2 Licensed Products, including Stoke’s and its Affiliates’ interests in any such Patent Rights that are Joint Collaboration Patents, but excluding any Acquiring Person Intellectual Property . All Stoke MECP2 Patents as of the Effective Date are set forth on Schedule 1.110.

1.111“Stoke MECP2 Technology ” means the Stoke MECP2 Know-How and the Stoke MECP2 Patents.

1.112“Stoke [***] Know-How ” means any and all Know-How Controlled by Stoke (or any of its Affiliates) as of the Effective Date or during the Term that is necessary or reasonably useful for the Development, Manufacture or Commercialization of [***] Licensed Products, including (a) any such Know-How that is Stoke Collaboration Know-How, (b) Stoke’s and its Affiliates’ interests in any Joint Collaboration Know-How and (c) other Know-How Controlled by Stoke that (i) Stoke discloses to Acadia and that the Parties mutually agree to use, and is actually used, in the Development of such [***] Licensed Products under the [***] Research Plan or [***] Development Plan, or (ii) is actually used by Stoke in the course of performing its responsibilities under this Agreement (including under the [***] Research Plan or [***] Development Plan) but in each case excluding any Acquiring Person Intellectual Property.

1.113“Stoke [***] Patents ” means any and all Patent Rights Controlled by Stoke (or any of its Affiliates) as of the Effective Date or during the Term, that Cover, or are otherwise necessary or reasonably useful for the Development, Manufacture or Commercialization of, the [***] Licensed Products, including Stoke’s and its Affiliates’ interests in any such Patent Rights that are Joint Collaboration Patents, but excluding any Acquiring Person Intellectual Property. All Stoke [***] Patents as of the Effective Date are set forth on Schedule 1.113.

1.114“Stoke [***] Technology” means the Stoke [***] Know-How and the Stoke [***] Patents.

1.115“Stoke SYNGAP1 Know-How ” means, with respect to a SYNGAP1 Co-Co Product, any and all Know-How Controlled by Stoke (or any of its Affiliates) as of the Effective Date or during the Term that is necessary or reasonably useful for the Development, Manufacture or Commercialization such SYNGAP1 Co-Co Product and that is (a) Stoke Collaboration Know-How, (b) Stoke’s and its Affiliates’ interests in any Joint Collaboration Know-How, or (c) other Know-How Controlled by Stoke that (i) Stoke discloses to Acadia and that the Parties mutually agree to use, and is actually used, in the Development of such SYNGAP1 Co-Co Product under the SYNGAP1 Research Plan or applicable SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan, or (ii) is actually used by Stoke in the course of performing its responsibilities under this Agreement (including under the SYNGAP1 Research Plan or applicable SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan) (the Know-How in this clause (c), “Other Stoke Contributed Know-How ”), but in each case excluding any Acquiring Person Intellectual Property.

1.116“Stoke SYNGAP1 Patents ” means, with respect to a SYNGAP1 Co-Co Product, any and all Patent Rights Controlled by Stoke (or any of its Affiliates) as of the Effective Date or during the Term that Cover, or are otherwise necessary or reasonably useful for the Development, Manufacture or Commercialization of, such SYNGAP1 Co-Co Product and that are (a) Collaboration Patents, or (b) other Patent Rights Controlled by Stoke or its Affiliates that claim Other Stoke Contributed Know-How, but in each case excluding any Acquiring Person Intellectual Property. All Stoke SYNGAP1 Patents as of the Effective Date are set forth on Schedule 1.116.

1.117“Stoke SYNGAP1 Technology ” means the Stoke SYNGAP1 Know-How and the Stoke SYNGAP1 Patents.

1.118 “Sublicensee ” means a Third Party that is granted a license or sublicense to research, develop , make, have made, use, keep, import, export, offer for sale, sell, or otherwise Exploit a Product in the Field in the Territory (including any option to any of the foregoing), beyond the mere right to purchase such Product from a Party and its Affiliates, and excludes each Party’s Affiliates or Third Party subcontractors that act solely for such Party or its Affiliates in the supply chain or that perform discrete services (as opposed to being granted broad rights or responsibilities) on behalf of such Party or its Affiliates.

1.119“Sublicensee Revenue ” means all amounts (including upfront payments , license fees, milestone payments and royalties) received by a Party or any of its Affiliates from any licensee or sublicensee in consideration for the grant by such Party or any of its Affiliates of a license or sublicense of any of the rights granted under this Agreement with respect to a SYNGAP1

Co-Co Product in the Territory, in all cases, in accordance with Section 2.2(b)(i). Sublicensee Revenue in the form of non-cash consideration shall be valued at fair market value at the time of receipt by the relevant Party. To the extent that a payment not explicitly tied to the SYNGAP1 Co-Co Product is made under a sublicense agreement that grants rights both to the SYNGAP1 Co-Co Product and one or more other products (e.g., an upfront payment ), then the portion of such payment that shall be considered Sublicensee Revenue hereunder shall be determined by the Parties in good faith and shall reasonably reflect the fair value of the contribution of the SYNGAP1 Co-Co Product in comparison to the other products under such agreement , and in the event that the Parties are unable to agree, the dispute shall be resolved pursuant to Section 17.4.

1.120 “SYNGAP1 Co-Co Product” means (a) a product containing or comprising, as an active ingredient (i) a Molecule arising out of the SYNGAP1 Research Program, including any such Molecule that is a Clinical Candidate, (ii) a Molecule Directed Against SYNGAP1 that is owned or Controlled by Stoke as of the Effective Date or (iii) any modification or derivative of a Molecule identified in clause (i) or (ii), which Molecule is Directed Against SYNGAP1 , and (b) any and all forms, presentations, delivery systems, dosages, and formulations of a product described in (a).

1.121“SYNGAP1 Co-Co Product Marks ” means, with respect to a SYNGAP1 Co-Co Product, any Trademark (whether registered or unregistered) for use on, with, or to refer to such SYNGAP1 Co-Co Product or used with patient support or other information or services or SYNGAP1 Co-Co Product Materials associated with such SYNGAP1 Co-Co Product in the Territory during the Term, including related internet domain names.

1.122“SYNGAP1 Co-Co Product Materials” means, with respect to a SYNGAP1 Co-Co Product, any and all promotional materials, training materials, medical education materials, Packaging and Labeling, and all other literature or other information related to such SYNGAP1 Co-Co Product for use in the Territory.

1.123“SYNGAP1 Co-Co Product Net Revenues” means, with respect to a given SYNGAP1 Co-Co Product in a given period, the sum of all Net Sales of such SYNGAP1 Co-Co Product generated during such period and Sublicensee Revenue received in connection with such SYNGAP1 Co-Co Product during such period.

1.124“SYNGAP1 Opt-Out Product ” means any SYNGAP1 Co-Co Product for which (i) the Development Opt-Out Party has exercised its Development Opt-Out Right or (ii) Stoke has exercised its Commercialization Opt-Out Right pursuant to Article 8.

1.125“SYNGAP1 Product Patents” means, with respect to a SYNGAP1 Co-Co Product that contains or comprises a Molecule or Clinical Candidate (or any modification or derivative of such Molecule or Clinical Candidate), the Stoke SYNGAP1 Patents, Acadia SYNGAP1 Patents or Joint Collaboration Patents, as applicable, that have at least one claim that claims the composition of a Molecule or Clinical Candidate or any use thereof, or any modification or derivative of such Molecule or Clinical Candidate, or any formulation, method of use or method of manufacture of such Molecule or Clinical Candidate or any modification or derivative of such Molecule or Clinical Candidate.

1.126 “Target” means any or all of MECP2, [***] and SYNGAP1, as the context requires.

1.128“Third Party” means any Person other than a Party or an Affiliate of a Party.

1.129“Third Party Co-Co In-License Agreement” means, subject to the provisions of Section 2.6 , a license or other similar agreement between a Party (or its Affiliate) and a Third Party pursuant to which such Party (or its Affiliates) obtains a license or similar right in any (a) Know-How necessary or reasonably useful for the Development, Manufacture or Commercialization of a SYNGAP1 Co-Co Product under this Agreement; or (b) Patent Right that claims or covers a SYNGAP1 Co-Co Product or the Development, Manufacture or Commercialization of SYNGAP1 Co-Co Product.

1.130“Third Party Co-Co In-License Payments” means, with respect to a SYNGAP1 Co-Co Product, any upfront payment , milestone payment, royalty or any other similar payment paid to any Third Party by a Party (or its Affiliates) during the Term under any Third Party Co-Co In-License Agreement, which payments are directly attributable to or reasonably allocable to (a) the Development (including Manufacture for purposes of Development) or (b) the Commercialization (including Manufacture for purposes of Commercialization), of such SYNGAP1 Co-Co Product for the Territory in accordance with this Agreement; provided that, for clarity, “Third Party Co-Co In-License Payments” shall exclude any amounts payable by Stoke (or its Affiliates) to a Third Party under the Stoke Existing In-License. Notwithstanding the foregoing, if the applicable Third Party Co-Co In-License Agreement giving rise to Third Party Co-Co In-License Payments includes or applies to any (i) products other than the SYNGAP1 Co-Co Product, or (ii) intellectual property other than intellectual property covering or claiming the SYNGAP1 Co-Co Product, then, in each case ((i) and (ii)), the Parties shall mutually agree upon a fair and reasonable allocation of the applicable payments to the SYNGAP1 Co-Co Product in the Territory for purposes of including in Third Party Co-Co In-License Payments, and in the event that the Parties are unable to agree, the dispute shall be resolved pursuant to Section 17.4.

1.131“Third Party In-License Agreements” means, subject to the provisions of Section 2.6 , a license or other similar agreement between a Party (or its Affiliate) and a Third Party pursuant to which such Party (or its Affiliates) obtains a license or similar right in any (a) Know-How necessary or reasonably useful for the Development, Manufacture or Commercialization of a Licensed Product under this Agreement; or (b) Patent Right that claims or covers a Licensed Product or the Development, Manufacture or Commercialization of a Licensed Product; provided, however, that the Stoke Existing In-License is hereby deemed not to be Third Party In-License Agreements for any purposes under this Agreement.

1.132“Third Party In-License Payments ” means, with respect to a Licensed Product, any upfront payment , milestone payment, royalty or any other similar payment paid to any Third Party by a Party (or its Affiliates) during the Term under any Third Party In-License Agreement, which payments are directly attributable to or reasonably allocable to (a) the Development (including Manufacture for purposes of Development) or (b) the Commercialization (including Manufacture for purposes of Commercialization), of such Licensed Product for the Territory in

accordance with this Agreement; provided that, for clarity, “Third Party In-License Payments” shall exclude any amounts payable by Stoke (or its Affiliates) to a Third Party under the Stoke Existing In-License. If a Third Party In-License Agreement giving rise to Third Party In-License Payments includes or applies to any (i) products other than a Licensed Product, or (ii) intellectual property other than intellectual property covering or claiming a Licensed Product, then, in each case ((i) and (ii)), the Parties shall mutually agree upon a fair and reasonable allocation of such payments to the Licensed Product in the Territory, and in the event that the Parties are unable to agree, the dispute shall be resolved pursuant to Section 17.4.

1.133 “Trademark ” means any trademark, trade name, service mark, service name, product name, brand, domain name, trade dress, logo, slogan, or other indicia of origin or ownership, and (a) all registrations, applications for registrations, and other intellectual property rights associated with any of the foregoing, and (b) the goodwill associated with each of the foregoing.

1.134“United States ” or “U.S.” means the United States of America and its territories and possessions.

1.135 “U.S. GAAP” means generally accepted accounting principles as practiced in the United States, as generally and consistently applied throughout each Party’s organization.

1.136“Valid Claim ” means: (a) a claim of an issued and unexpired Patent Rights within the Stoke MECP2 Patents, Stoke [***] Patents, Stoke SYNGAP1 Patents or Collaboration Patents that has not been abandoned, cancelled or held permanently revoked, unenforceable or invalid by a decision of a court or other governmental agency of competent jurisdiction unappealed within the time allowed for appeal, or that has not been admitted to be invalid or unenforceable through reissue or disclaimer or otherwise; or (b) a claim of a pending patent application within the Stoke MECP2 Patents, Stoke [***] Patents, Stoke SYNGAP1 Patents or Collaboration Patents, which patent application was filed and is being prosecuted in good faith and has not been cancelled, withdrawn from consideration, abandoned or finally disallowed without the possibility of appeal or refiling of the application and that has not been pending for more than [***] from the earliest date from which the patent application claims priority. Notwithstanding the foregoing, if, such a pending patent application issues after the expiration of the [***] mentioned above, each claim of the applicable issued patent shall, subject to clause (a) above, be deemed to be a Valid Claim with effect from the date of issue.

1.137Additional Definitions. The following table identifies the location of definitions set forth in various Sections of this Agreement:


Assumed Commercialization Activities	7.3
Assumed Development Activities	6.8
Audited Party	9.8
Auditing Party	9.8
BBA	16.3
Claim	13.1(a)
Clinical Candidate	4.6(e)
Clinical Candidate Notice	4.6(e)
CMO	6.3
Commercialization Activities Cure Period	7.3
Commercialization Cost Report	9.6(b)(ii)
Commercialization Opt-Out	8.2(a)
Commercialization Opt-Out Date	8.2(a)
Commercialization Opt-Out Notice	8.2(a)
Commercialization Opt-Out Right	8.2(a)
Commercialization Opt-Out Transition Activities	8.2(b)
Commercialization Opt-Out Transition Plan	8.2(b)
Commercialization Strategy	7.1(d)(i)
Committee	3.6
Confidential Information	10.1
Confidentiality Agreement	17.12
Continuing Party	15.10(a)
Cost Reconciliation Report	9.6(b)(iii)
Cost Reports	9.6(b)(ii)
Critical Success Factors	4.1
Deadlocked Matter	3.7(a)
Development Activities Cure Period	6.8
Development Cost Report	9.6(b)(ii)
Development Opt-Out	8.1(a)
Development Opt-Out Date	8.1(a)
Development Opt-Out Notice	8.1(a)
Development Opt-Out Party	8.1(a)
Development Opt-Out Right	8.1(a)
Development Opt-Out Transition Activities	8.1(b)
Development Opt-Out Transition Plan	8.1(b)
Development Opt-Out Window	8.1(a)
Development Records	5.2(e)
Dispute	17.4(a)
Divestiture	2.5(b)(ii)
Effective Date	Preamble
Excess Commercialization Overage	7.2(b)
Excess Development Overage	6.4(b)
Excess Research Overage	4.4(c)
Excluded Claim	17.4(b)


H-W Notice Letter	14.5
ICC	17.4(a)
ICC Arbitration Rules	17.4(a)
Indemnitee	13.1(c)
Indemnitor	13.1(c)
Infringement	14.4(a)
Interim Commercialization Cost Report	9.6(b)(i)
Interim Cost Reports	9.6(b)(i)
Interim Development Cost Report	9.6(b)(i)
Interim Revenue Report	9.6(b)(iv)
JAMS	17.4(c)
JCC	3.2
JDC	3.2
JSC	3.2
Lead Commercialization Party	7.1(d)(i)
Lead Development Party	6.1(a)
Lead Regulatory Party	6.9(a)
Licensor Party	2.6(a)
Losses	13.1(a)
MECP2 Development Plan	5.2(a)
MECP2 Development Program	5.2(a)
MECP2 Research Budget	4.1
MECP2 Research Plan	4.1
MECP2 Research Program	4.1
MECP2 Royalty Term	9.2(c)(ii)
MECP2 Technology Transfer	5.1(a)
MECP2 Third Party License(s)	9.2(c)(iii)(C)
Molecule	4.6(e)
[***] Development Plan	5.2(a)
[***] Research Budget	4.1
[***] Research Plan	4.1
[***] Technology Transfer	5.1(b)
[***] Third Party License(s)	9.3(c)(iii)(C)
Party	Preamble
Parties	Preamble
Patent Term Extensions	14.7
Payee	9.9(b)
Paying Party	9.9(b)
Permitted Commercialization Overage	7.2(b)
Permitted Development Overage	6.4(b)
Permitted Research Overage	4.4(c)
Pharmacovigilance Agreement	6.10
Pricing Guidelines	7.4
Promotional Working Group	3.5(b)(v)
Public Official	12.3(g)(iv)


Publishing Notice	11.1(b)(ii)
Publishing Party	11.1(b)(ii)
Regulatory Strategy	6.9(a)
Research Plan Records	4.6(a)
Results	4.6(c)
Revenue Reconciliation Report	9.6(b)(vi)
Revenue Report	9.6(b)(v)
Securities Regulator	11.2(b)
Shared Patent Enforcement Costs	14.4(c)(iii)
Stoke	Preamble
Stoke Indemnitee	13.1(b)
Stoke Patents	14.3(a)
SYNGAP1 Co-Co Clinical Supply Agreement	6.3
SYNGAP1 Co-Co Commercial Supply Agreement	7.7
SYNGAP1 Co-Co Technology Transfer Plan	7.7
SYNGAP1 Co-Commercialization Budget	7.1(a)
SYNGAP1 Co-Commercialization Plan	7.1(a)
SYNGAP1 Co-Development Plan	6.1(a)
SYNGAP1 Commercialization Technology Transfer	8.2(c)
SYNGAP1 Development Technology Transfer	8.1(c)
SYNGAP1 Opt-Out Product	8.1(b)
SYNGAP1 Research Budget	4.1
SYNGAP1 Research Plan	4.1
SYNGAP1 Research Program	4.1
SYNGAP1 Royalty Term	9.5(b)
SYNGAP1 Terminated Product	15.10(a)
SYNGAP1 Third Party License(s)	9.5(c)(iii)
Tax Partnership	16.1
Term	15.1
Terminated Party	15.10(a)
Terminated Product	15.8(a)
Termination Notice Period	15.5
Trademark Costs	7.9(d)
Upfront Payment	9.1
Working Group	3.6

(a)MECP2 Exclusive License Grant to Acadia. Subject to the terms and conditions of this Agreement, Stoke (on behalf of itself and its Affiliates) hereby grants to Acadia an exclusive (even as to Stoke and its Affiliates, subject to the remainder of this Section 2.1(a)), non-transferable (except as set forth in Section 17.1(a)), sublicensable (as set forth in Section 2.2 ) license under the Stoke MECP2 Technology to Develop, make, have made, use, sell, offer for sale, import, Commercialize (for avoidance of doubt, including, Medical Affairs activities) and otherwise Exploit MECP2 Licensed Products in the Field in the Territory. Stoke retains the right (on behalf of itself and its Affiliates) to practice the Stoke MECP2 Technology in order to conduct its responsibilities under the MECP2 Research Plan.

(b)[***] Exclusive License Grant to Acadia. Subject to the terms and conditions of this Agreement, Stoke (on behalf of itself and its Affiliates) hereby grants to Acadia an exclusive (even as to Stoke and its Affiliates, subject to the remainder of this Section 2.1(b)), non-transferable (except as set forth in Section 17.1(a)), sublicensable (as set forth in Section 2.2) license under the Stoke [***] Technology to Develop, make, have made, use, sell, offer for sale, import, Commercialize (for avoidance of doubt, including Medical Affairs activities), and otherwise Exploit [***] Licensed Products in the Field in the Territory. Stoke retains the right (on behalf of itself and its Affiliates) to practice the Stoke [***] Technology in order to conduct its responsibilities under the [***] Research Plan.

(i)Exclusive License Grant to Acadia. Subject to the terms and conditions of this Agreement, on a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, Stoke (on behalf of itself and its Affiliates) hereby grants to Acadia a co- exclusive (with Stoke and its Affiliates), non-transferable (except as set forth in Section 17.1(a)), sublicensable (as set forth in Section 2.2), license under the Stoke SYNGAP1 Technology to Develop, make, have made, use, sell, offer for sale, import, Commercialize (for avoidance of doubt, including Medical Affairs activities) and otherwise Exploit such SYNGAP1 Co-Co Product in the Field in the Territory. Stoke retains the right (on behalf of itself and its Affiliates) to practice the SYNGAP1 Technology to exercise its rights and perform its obligations hereunder and as set forth in Section 2.3.

(ii)Exclusive License Grant to Stoke. Subject to the terms and conditions of this Agreement, on a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, Acadia (on behalf of itself and its Affiliates) hereby grants to Stoke a co-exclusive (with Acadia and its Affiliates), non-transferable (except as set forth in Section 17.1(a)), sublicensable (as set forth in Section 2.2), license under the Acadia SYNGAP1 Technology to Develop, make, have made, use, sell, offer for sale, import, Commercialize (for avoidance of doubt, including Medical Affairs activities) and otherwise Exploit such SYNGAP1 Co-Co Product in the Field in the Territory. Acadia retains the right (on behalf of itself and its Affiliates) to practice the

SYNGAP1 Technology to exercise its rights and perform its obligations hereunder and as set forth in Section 2.3.

(i)Sublicensing Rights. Subject to the terms and conditions of this Agreement, Acadia shall have the right to grant sublicenses of the rights granted to it under Section 2.1(a) and Section 2.1(b) through multiple tiers, without Stoke’s prior consent, on a Target-by-Target basis to (x) its Affiliates, provided that such sublicense shall automatically terminate if such sublicensee ceases to be an Affiliate of Acadia, and (y) Third Parties, provided that in the case of (y), Acadia shall not sublicense any of its rights under Section 2.1(a) or Section 2.1(b) until the conclusion of the Research Term without Stoke’s prior written consent, which shall not be unreasonably withheld, conditioned or delayed. Each sublicense granted by Acadia pursuant to this Section 2.2(a) shall be pursuant to a written agreement that (A) is consistent with the terms of this Agreement, (B) includes obligations of confidentiality and non-use applicable to the Confidential Information of the other Party that are at least as stringent as those set forth in Article 10 and (C) includes terms that are consistent with the intellectual property provisions set forth in this Agreement. Acadia shall promptly provide Stoke with a copy of each such final executed sublicense, which sublicense may be redacted to protect confidential information of the Sublicensee or to redact information related to any product other than a Product (but shall be sufficient, after such redactions, for Stoke to determine the scope of the licenses and sublicenses granted to such Sublicensee with respect to any Product). If any such sublicense is not in English, Acadia will provide Stoke with a translation thereof into English. No sublicensing by Acadia, its Affiliate or Sublicensee in accordance with this Section 2.2(a)(i) shall relieve Acadia of its obligations under this Agreement or any liability hereunder.

(ii)Subcontracting Rights. Acadia (and its Affiliates and Sublicensees) may engage a Third Party subcontractors in connection with the performance of its obligations or exercise of its rights under any Development Program or with respect to the Manufacture or Commercialization of any Licensed Product. No subcontracting by Acadia, its Affiliate or Sublicensee in accordance with this Section 2.2(a)(ii) shall relieve Acadia of its obligations under this Agreement or any liability hereunder. Each agreement with any Third Party subcontractor engaged in accordance with this Section 2.2(a)(ii) must (A) be consistent with the terms of this Agreement, (B) include obligations of confidentiality and non-use applicable to the Confidential Information of the other Party that are at least as stringent as those set forth in Article 10 and (C) include terms that are consistent with the intellectual property provisions set forth in this Agreement.

(A)Sublicensing Rights. Notwithstanding anything to the contrary in this Agreement, except as permitted under this Section 2.2(b), neither Party shall grant a sublicense of the rights granted to such Party under Section 2.1(c) unless approved by the JSC.

If either Party wishes to grant a license or sublicense (as applicable) to a Third Party to Develop, Manufacture, or Commercialize any SYNGAP1 Co-Co Product in the Territory, then such Party shall notify the JSC, and the JSC shall review such proposal and determine whether to consent to the extension of rights to such licensee or sublicensee. Following any such written consent, the proposing Party shall have the right to lead discussions with potential Sublicensees, negotiate terms , and execute a written agreement with such Sublicensee, provided that such Party shall provide the final form of any such agreement to the JSC for the JSC’s approval prior to execution thereof. In addition, the Parties shall coordinate through the JSC with respect to the performance of any such Sublicensees, as applicable, to ensure the efficient Development, Manufacture, and Commercialization of the SYNGAP1 Co-Co Products throughout the Territory.

(B)Costs and Income from Sublicensing Activities in the Territory. The External Costs incurred in connection with the negotiation of an agreement with an actual or prospective Third Party Sublicensee (including legal costs and attorneys’ fees) for the Territory in accordance with Section 2.2(b)(i) shall be shared equally by the Parties as Other Expenses. Any Sublicensee Revenue received from such Third Party Sublicensee shall be shared by the Parties in accordance with Section 9.6(a).

(C)Sublicense Agreements. Each sublicense to a Third Party granted by a Party pursuant to this Section 2.2(b)(i) shall (1) be subject and subordinate to this Agreement, (2) be consistent with the terms of this Agreement, (3) include obligations of confidentiality and non-use applicable to the Confidential Information of the other Party that are at least as stringent as those set forth in Article 10, and (4) include terms that are consistent with the intellectual property provisions set forth in this Agreement, unless, in each case, the Parties agree otherwise.

(D)Responsibility for Sublicensees. Notwithstanding any sublicense, the Party that grants rights to a Sublicensee pursuant to this Section 2.2(b)(i) shall remain primarily liable to the other Party for the performance of all of its obligations under, and such Party’s compliance with all provisions of, this Agreement. Each Party agrees that it shall be fully responsible and liable for any breach of the terms of this Agreement by any of its Sublicensees to the same extent as if such Party itself has committed any such breach, and shall provide notice thereof to the other Party via the JSC, JDC or JCC, as appropriate and such Committee shall discuss ways to mitigate the effects and damage, if any, arising from such breach.

(A)Subcontracting Rights. Either Party may engage a Third Party subcontractor in connection with the performance of its obligations or exercise of its rights under any SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan in the Territory; provided that (1) any subcontractor engaged to perform Development (including Medical Affairs) activities with respect to a SYNGAP1 Co-Co Product must be set forth in the SYNGAP1 Co-Development Plan for such SYNGAP1 Co-Co Product, and (2) any subcontractor engaged to perform Commercialization activities with respect to a SYNGAP1 Co-Co Product in or for the Territory must be set forth in the SYNGAP1 Co-Commercialization Plan for such SYNGAP1 Co-Co Product.

(B)Subcontracting Requirements. No subcontracting by either Party in accordance with Section 2.2(b)(ii)(A) shall relieve the subcontracting Party of its obligations under this Agreement or any liability hereunder. Each agreement with any Third Party subcontractor engaged in accordance with Section 2.2(b)(ii)(A) must (1) be consistent with the terms of this Agreement, (2) include obligations of confidentiality and non-use applicable to the Confidential Information of the other Party that are at least as stringent as those set forth in Article 10 and (3) include terms that are consistent with the intellectual property provisions set forth in this Agreement. Upon the other Party’s request, the subcontracting Party shall provide the other Party with a copy of any executed agreement with a Third Party subcontractor performing Development, Manufacturing, Commercialization, or Medical Affairs activities under this Agreement in the Territory (which copy may be redacted to remove provisions that are not necessary to monitor compliance with this Section 2.2(b)(ii)(B)). Each Party shall remain directly responsible for any uncured material breach of this Agreement by a subcontractor, and for any damage to the other Party caused thereby, and shall provide notice thereof to the other Party via the JSC , JDC or JCC, as appropriate and such Committee shall discuss ways to mitigate the effects and damage, if any, arising from such breach.

2.3Retained Rights. In addition to any other rights retained by Stoke hereunder with respect to the Stoke MECP2 Technology, Stoke [***] Technology and Stoke SYNGAP1 Technology , and subject to the terms and conditions set forth herein, including Section 2.5 , Stoke retains the exclusive right to practice, license and otherwise exploit the Stoke MECP2 Technology, Stoke [***] Technology and Stoke SYNGAP1 Technology in the Territory outside the scope of the licenses granted under Section 2.1 , including with respect to products other than the Products. In addition to any other rights retained by Acadia hereunder with respect to the Acadia SYNGAP1 Technology , and subject to the terms and conditions set forth herein, including Section 2.5 , Acadia retains the exclusive right to practice, license and otherwise exploit the Acadia SYNGAP1 Technology in the Territory outside the scope of the licenses granted under Section 2.1(c)(ii), including with respect to products other than the SYNGAP1 Co-Co Products. For clarity, the licenses granted to Acadia under Section 2.1 do not extend to Other Active Ingredients that may be covered by Stoke MECP2 Technology, Stoke [***] Technology or Stoke SYNGAP1 Technology.

2.4No Implied Licenses; Negative Covenants. Except as expressly set forth herein, neither Party shall acquire any right, license or other interest, by implication or otherwise, under any Know-How, Trademarks, Patent Rights or other intellectual property of the other Party, pursuant to this Agreement. Acadia shall not, and shall not permit any of its Affiliates, Sublicensees or subcontractors to, practice or otherwise exploit any Stoke MECP2 Technology, Stoke [***] Technology and Stoke SYNGAP1 Technology in the Territory outside the scope of the licenses granted under Section 2.1. Stoke shall not, and shall not permit any of its Affiliates, Sublicensees or subcontractors to, practice or otherwise exploit any Acadia SYNGAP1 Technology outside the scope of the license granted in Section 2.1(c)(ii).

(i)MECP2 and [***]. With respect to the MECP2 Target and the [***] Target, during the period beginning on the Effective Date and ending upon the earlier of (x) (A) with respect to [***], and (B) with respect to [***] and (y) termination of this Agreement with respect to such Target, [***] will not, and will ensure that its Affiliates and Sublicensees do not, either (1) alone or with a Third Party, research, Develop, perform Medical Affairs activities, Commercialize or otherwise Exploit any Competing Product anywhere in the Territory or (2) grant any rights to any Third Party (including through granting a license, option or other right) to research, Develop, perform Medical Affairs activities, Commercialize or otherwise Exploit any Competing Product anywhere in the Territory.

(ii)SYNGAP1 . With respect to the SYNGAP1 Target, during the period beginning on the Effective Date and ending upon the earlier of (x) [***] and (y) termination of this Agreement with respect to such Target, each Party will not, and will ensure that its Affiliates and Sublicensees do not, either (1) alone or with a Third Party, research, Develop, perform Medical Affairs activities, Commercialize or otherwise Exploit any Competing Product anywhere in the Territory or (2) grant any rights to any Third Party (including through granting a license, option or other right) to research, Develop, perform Medical Affairs activities, Commercialize or otherwise Exploit any Competing Product anywhere in the Territory.

(i)If [***], or one of its Affiliates or Sublicensees, undergoes a Change of Control and, on the date of the closing of such Change of Control, the Acquiring Person has a product or program that, upon the closing of such Change of Control, would be in violation of Section 2.5(a) with respect to a Competing Product (“Acquiring Person COC Program”), then [***] will not be in breach of Section 2.5(a), as a result of such Change of Control or the continuation of such Acquiring Person COC Program by such Acquiring Person thereafter, provided that the Acquiring Person promptly Segregates the Acquiring Person COC Program.

(ii)If [***], or one of its Affiliates or Sublicensees, acquires a Third Party (or business or assets of a Third Party) (by merger, purchase of assets, stock acquisition or otherwise), and on the date of the closing of such transaction, such Third Party has a product or program that, upon the closing of such transaction, would be in violation of Section 2.5(a) with respect to a Competing Product (“Acquired COC Program”), then [***] will not be in breach of Section 2.5(a), as a result of such transaction or the continuation of such Acquired COC Program by [***], or its Affiliate or Sublicensee, as applicable, thereafter for a period of up to [***] following the closing of such transaction, provided that [***] (A) Divests such Acquired COC Program within [***] following the closing of such transaction and (B) prior to such Divestiture, promptly Segregates such Acquired COC Program. For the purpose of this Section 2.5(b)(ii), “Divestiture” means (1) the divestiture of the Acquired COC Program through (x) an outright sale or assignment of all material rights in such Acquired COC Program to a Third Party or (y) an exclusive out-license of all Exploitation rights with respect to such Acquired COC Program, with no further material role, influence or authority, directly or indirectly, with respect to such Acquired

COC Program, or (2) the complete cessation of all Exploitation activities with respect to such Acquired COC Program. For clarity, customary technology transfer and coordination of patent and regulatory matters and the right to receive royalties, milestones or other payments in connection with clause (1) above, shall be permitted for any such Divestiture. When used as a verb, “Divest” and “Divested” means to cause a Divestiture.

(a)Generally. The licenses granted under Sections 2.1(a), 2.1(b) and 2.1(c) may include certain rights licensed by a Third Party to the license-granting party (or its Affiliate) (the “Licensor Party”), including, with respect to Section 2.1(c), under Third Party In-License Agreements. Any sublicense of Third Party intellectual property rights granted by the Licensor Party pursuant to Sections 2.1(a), 2.1(b) and 2.1(c) to the other Party shall be subject to the terms and conditions of the Third Party In-License Agreement applicable to sublicensees under which such sublicense is granted, subject to Sections 2.6(b) and 2.6(c). As of the Effective Date, the Stoke Existing In-License is the only such in-license agreements.

(b)MECP2 and [***] Research Programs. Stoke shall bear all costs and expenses, including all milestone payments and royalties that become due and payable under any Stoke Existing In-License. If, during the applicable Research Term for the MECP2 Research Program or [***] Research Program , the Parties desire to include Third Party Know-How or Patent Rights in a Research Plan, and such use would require the practice of rights subject to a Third Party In-License Agreement , then prior to using such Third Party Know-How or Patent Rights in the performance of the relevant Research Plan, the Parties shall mutually agree upon the allocation of any amounts that would become owing to such Third Party as a result of Stoke’s use of such Third Party’s Know-How or Patent Rights in the performance of the Research Plan or Acadia’s practice of the sublicensed rights under such Third Party’s Know-How or Patent Rights in the Development, Manufacture, or Commercialization of any Licensed Product under this Agreement.

(i)New Third Party Co-Co In-License Agreements After Effective Date. During the Term, without the approval of the JSC, neither Party nor any of its Affiliates may enter into any Third Party Co-Co In-License Agreement with respect to any intellectual property rights that will be used for the research, Development, Commercialization or Manufacture of a SYNGAP1 Co-Co Product hereunder. For the avoidance of doubt, any license or other similar agreement between a Party (or its Affiliate) and a Third Party pursuant to which such Party (or its Affiliates) obtains a license or similar right in any Know-How or Patent Right that was entered into in violation of the provisions of this Section 2.6(c) shall not be a “Third Party Co-Co In-License Agreement” for purposes of this Agreement, unless the other Party approves in writing the inclusion of such license or other similar agreement as a “Third Party Co-Co In-License Agreement”, in such other Party’s discretion.

(ii)Third Party Co-Co In-License Agreements as of the Effective Date. As of the Effective Date, the Stoke Existing In-License is the only Third Party Co-Co In-License Agreement. No amounts paid or payable by either Party under any other license or other similar agreement between a Party (or its Affiliate) and a Third Party, in existence as of the

Effective Date, pursuant to which such Party (or its Affiliates) has obtained a license or similar right in any Know-How or Patent Right shall be deemed to be a “Third Party Payment” for purposes of this Agreement, unless the other Party approves in writing the inclusion of such license or other similar agreement as a “Third Party Co-Co In-License Agreement”, in such other Party’s discretion, in which case (a) such license or similar agreement shall thereafter be a “Third Party Co-Co In-License Agreement” hereunder and (b) the applicable payments pursuant to such Third Party Co-Co In-License Agreement made thereafter shall be included hereunder as “Third Party Co-Co In-License Payments” (to the extent such payments otherwise fall within the definition of “Third Party Co-Co In-License Payments”).

3.1Alliance Manager. Within [***] following the Effective Date, each Party shall appoint an individual to act as the Alliance Manager for such Party (each, an “Alliance Manager ”). Each Alliance Manager shall thereafter be permitted to attend meetings of the JSC or any of its subcommittees as a nonvoting observer. The Alliance Managers shall be the primary point of contact for the Parties regarding the activities contemplated under this Agreement and shall help facilitate all such activities hereunder.

3.2Joint Steering Committee. Within [***] after the Effective Date, the Parties shall establish a joint steering committee (the “JSC”) composed of up to three (3) senior representatives from each Party that shall oversee and manage the collaboration between the Parties. The JSC may, from time to time, establish subcommittees as it deems necessary to further the purposes of this Agreement; provided that the Parties shall in any event establish a joint development subcommittee (“JDC”) in accordance with Section 3.4 and a joint commercialization subcommittee (“JCC”) in accordance with Section 3.5. The JSC may change its size from time to time on mutual agreement of the Parties; provided, that the JSC shall consist at all times of an equal number of representatives of each Party. Each Party may replace any of its JSC representatives with a qualified employee of such Party at any time upon written notice to the other Party. The JSC may invite non-members to participate in the discussions and meetings of the JSC; provided, that such participants shall have no voting authority at the JSC and shall be bound by the confidentiality obligations no less stringent than those provided in this Agreement. The JSC shall have two (2) co-chairpersons, one from each Party. The role of the co-chairpersons shall be to convene and preside at meetings of such JSC. The Alliance Managers shall work with the co-chairpersons to prepare and circulate agendas and to ensure the preparation of minutes. The co-chairpersons shall have no additional powers or rights beyond those held by the other JSC representatives.

(a)Specific responsibilities of the JSC. The JSC shall have the following responsibilities:

(i)review, discuss and approve updates or amendments to each Research Plan and each Research Budget;

(iii)for each Research Program, review and discuss the Molecules arising from such Research Program, and determine whether to approve any such Molecules as Clinical Candidates for further Development and Commercialization hereunder;

(iv)review, discuss and approve each Development Plan and Development budget, and review, discuss and approve any updates or amendments thereto;

(vi)oversee, review, discuss and approve each SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget, and review, discuss and approve any updates or amendments thereto;

(vii)review the overall strategy regarding Regulatory Approval of each SYNGAP1 Co-Co Product in the Territory;

(viii)for each SYNGAP1 Co-Commercialization Plan and SYNGAP1 Co-Commercialization Budget, review, discuss and approve any updates or amendments thereto and oversee the Commercialization of SYNGAP1 Co-Co Products in the Territory;

(ix)r eview and approve any Excess Research Overage , Excess Development Overage , or Excess Commercialization Overage;

(x)resolve all matters that are in dispute as escalated to the JSC by the JDC or JCC that cannot be resolved by such committee; and

(xi)perform such other functions as expressly set forth in this Agreement or as otherwise agreed by the Parties in writing.

3.3Meetings. The JSC and each of its subcommittees shall each meet at least [***] during the Research Term, and more often as may be necessary. The JSC and each of its subcommittees may conduct such meetings by telephone, videoconference, internet meeting or in person, as determined by their members for each meeting. Each Party may call special meetings of the JSC or any of its subcommittees with at least [***] prior written notice, or a shorter time period in exigent circumstances, to resolve particular matters requested by such Party that are within the purview of the JSC or the subcommittee, as applicable. Each Party may invite a reasonable number of participants, in addition to its representatives, to attend JSC and subcommittee meetings in a nonvoting capacity; provided that if either Party intends to have any Third Party (including any consultant) attend such a meeting, such Party shall provide prior written notice to the other Party. Such Party shall ensure that such Third Party is bound by confidentiality and non-use obligations consistent with the terms of this Agreement. Each Party is responsible for its own expenses incurred in connection with participating in and attending all such meetings. Each Party’s Alliance Manager or his/her designee shall keep minutes of each JSC and subcommittee meeting that records in writing all decisions made, action items assigned or completed and other appropriate matters. Each Party’s Alliance Manager shall help consolidate and then send meeting minutes to all members of the JSC or the subcommittee, as applicable, promptly after a meeting for review. Each member shall have [***] from receipt in which to comment on and to approve the minutes (such approval not to be unreasonably withheld,

conditioned or delayed). If a member, within such time period, does not notify either Party’s Alliance Manager that s/he does not approve of the minutes, the minutes shall be deemed to have been approved by such member.

(a)General. Within [***] after the Effective Date, the Parties shall establish the JDC to coordinate the Development activities (including the related regulatory activities) of the Parties related to the Development of Products in accordance with this Agreement. Each Party shall appoint three (3) representatives to the JDC, with each representative having knowledge and expertise in the development of compounds and products similar to the potential Clinical Candidates and Products and having sufficient seniority within the applicable Party to make decisions arising within the scope of the JDC’s responsibilities. The JDC may change its size from time to time on mutual agreement of the Parties; provided, that the JDC shall consist at all times of an equal number of representatives of each Party. Each Party may replace any of its JDC representatives with a qualified employee of such Party at any time upon written notice to the other Party. The JDC may invite non-members to participate in the discussions and meetings of the JDC; provided, that such participants shall have no voting authority at the JDC and shall be bound by the confidentiality obligations no less stringent than those provided in this Agreement. The JDC shall have two (2) co-chairpersons, one from each Party. The role of the co-chairpersons shall be to convene and preside at meetings of such JDC. The Alliance Managers shall work with the co-chairpersons to prepare and circulate agendas and to ensure the preparation of minutes. The co-chairpersons shall have no additional powers or rights beyond those held by the other JDC representatives.

(b)Specific Responsibilities of the JDC. The JDC shall have the following responsibilities:

(i)prepare and submit to the JSC for approval each Development Plan and Development Budget, and any updates or amendments thereto;

(ii)oversee the conduct of each Development Plan, and receive and discuss reports from Acadia pursuant to Section 5.2(e);

(iii)oversee the conduct of each SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget;

(iv)for each SYNGAP1 Co-Development Plan , design, implement and review the overall strategy for Development and the design of all Clinical Trials conducted under the SYNGAP1 Co-Development Plan;

(v)for each SYNGAP1 Co-Co Product, oversee the conduct of all Clinical Trials under the applicable SYNGAP1 Co-Development Plan, including the carrying out of such activities as are required to comply with applicable regulatory requirements with respect thereto, including preparation and submission of Regulatory Materials for all such Clinical Trials prior to the first Regulatory Approval for such SYNGAP1 Co-Co Product;

(vi)facilitate the flow of information between the Parties with respect to the Development of a SYNGAP1 Co-Co Product, including any Manufacturing updates related to clinical supply;

(vii)review and approve Third Party subcontractors with respect to any work to be conducted by such subcontractor under a SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan; and

(viii)perform such other functions as expressly set forth in this Agreement or as the JSC may request from time to time.

(a)General. No later than [***] prior to the anticipated first MAA filing for the first SYNGAP1 Co-Co Product in the Territory, the Parties shall establish the JCC to oversee and manage the Commercialization with respect to the SYNGAP1 Co-Co Products. Each Party shall appoint three (3) representatives to the JCC, with each representative having knowledge and expertise in the development of compounds and products similar to the potential Clinical Candidates and Products and having sufficient seniority within the applicable Party to make decisions arising within the scope of the JCC’s responsibilities. The JCC may change its size from time to time on mutual agreement of the Parties; provided, that the JCC shall consist at all times of an equal number of representatives of each Party. Each Party may replace any of its JCC representatives with a qualified employee of such Party at any time upon written notice to the other Party. The JCC may invite non-members to participate in the discussions and meetings of the JCC; provided, that such participants shall have no voting authority at the JCC and shall be bound by the confidentiality obligations no less stringent than those provided in this Agreement. The JCC shall have two (2) co-chairpersons, one from each Party. The role of the co-chairpersons shall be to convene and preside at meetings of such JCC. The Alliance Managers shall work with the co-chairpersons to prepare and circulate agendas and to ensure the preparation of minutes. The co-chairpersons shall have no additional powers or rights beyond those held by the other JCC representatives.

(b)Specific Responsibilities of the JCC. The JCC shall have the following responsibilities:

(i)for each SYNGAP1 Co-Co Product, review and oversee the overall strategy for Regulatory Approval of such SYNGAP1 Co-Co Product in the Territory, and review and oversee the carrying out of such activities as are required to comply with applicable regulatory requirements with respect to Clinical Trials conducted after the first Regulatory Approval for such SYNGAP1 Co-Co Product, including preparation and submission of Regulatory Materials with respect thereto;

(ii)prepare and submit to the JSC for review and approval each SYNGAP1 Co-Commercialization Plan or SYNGAP1 Co-Commercialization Budget, and any updates or amendments thereto;

(iv)discuss, review and approve the use of any SYNGAP1 Co-Co Product Marks in any packages and labels for a SYNGAP1 Co-Co Product;

(v)establish policies and procedures and a joint promotional review Working Group (“Promotional Working Group”), for review of promotional materials for any SYNGAP1 Co-Co Product in the Territory;

(vi)review and discuss the Pricing Guidelines for each SYNGAP1 Co-Co Product in the Territory;

(vii)facilitate the flow of information between the Parties with respect to the Commercialization of a SYNGAP1 Co-Co Product, including any Manufacturing updates related to commercial supply;

(viii)review and approve Third Party subcontractors with respect to any work to be conducted by such subcontractor under a SYNGAP1 Co-Commercialization Plan; and

(ix)perform such other functions as expressly set forth in this Agreement or as the JSC may request from time to time.

3.6Working Groups. From time to time, the JSC, or a subcommittee (each a “Committee ”) may establish and delegate duties to working groups (each a “Working Group”) on an “as-needed” basis to oversee particular projects or activities, which delegations shall be reflected in the minutes of the meetings of the applicable Committee. Such Working Groups may be established on an ad hoc basis for purposes of a specific project, for the life of the applicable Product or on such other basis as the establishing Committee may determine, and shall be constituted and shall operate as the establishing Committee may determine, provided that each Working Group and its activities shall be subject to the oversight, review and approval of, and, shall report to, the Committee that established such Working Group. In no event shall the authority of any Working Group exceed that of the Committee that established it, as specified in this Article 3. For clarity, the Working Groups shall be a forum for discussion and shall be able to make recommendations to the Committees, but shall have no decision-making authority.

(a)Decision-making Generally. Where this Agreement provides that a matter is subject to the approval of JDC, JCC, a subcommittee or Working Group, such approval requirement shall be met by the process set forth in this Section 3.7 . The JSC, JDC and JCC shall endeavor to make decisions by consensus, with the representatives of each Party having, collectively, one (1) vote on behalf of that Party (which vote shall, with respect to the JSC, be exercised by the respective JSC Co-Chairs ). Deadlocks in the case of JDC, JCC, subcommittees and Working Groups shall be referred to the JSC for final disposition. If the JSC cannot reach consensus on a matter before it within [***] (each a “Deadlocked Matter”), then either Party may refer such Deadlocked Matter to the Executive Officers for discussion and attempted resolution. If the Executive Officers are unable to resolve such Deadlocked Matter within [***] after referral thereof by the JSC, then:

(i)Any Deadlocked Matter pertaining to a matter escalated to the JSC pursuant to Section 14.2(b) shall be resolved pursuant to Section 17.4(c);

(ii)Acadia will have the tie-breaking vote with respect to any Deadlocked Matter relating to the MECP2 Research Program or [***] Research Program, provided, however, that Acadia may not exercise its tie-breaking vote to (A) cause Stoke to undertake any activities in addition to those included under the then-current applicable Research Plan and Research Budget without Stoke’s consent, unless Acadia agrees to pay for the costs associated with such additional activities, or (B) change the FTE Rate with respect to FTEs performing activities under a Research Plan;

(iii)Acadia will have the tie-breaking vote with respect to any Deadlocked Matter relating to the Licensed Products, including all decisions related to Development (subject to (i)(A) and (B) above relating to the MECP2 and [***] Research Programs), Manufacture and regulatory activities with respect thereto (for further clarity, all matters not related to Development, including all Commercialization matters with respect to Licensed Products, do not fall within the purview of Article 3, and Acadia has sole decision-making authority with respect thereto, subject to compliance with the terms of this Agreement);

(iv)On a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, any Deadlocked Matter relating to the Development of such SYNGAP1 Co-Co Product and arising prior to the first Regulatory Approval for such SYNGAP1 Co-Co Product shall be resolved in accordance with Section 17.4(c), including:

(A)any such Deadlocked Matter relating to the Manufacture of such SYNGAP1 Co-Co Product used in connection with such Development activities; and

(B)any such Deadlocked Matter relating to preparation and submission of Regulatory Materials in connection with the performance of such Development activities pertaining to such SYNGAP1 Co-Co Product (except as otherwise provided in Section 3.7(a)(v)(B) below);

(v)On a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, Acadia will have the tie-breaking vote with respect to any Deadlocked Matter relating to such SYNGAP1 Co-Co Product arising after the first Regulatory Approval for such SYNGAP1 Co-Co Product, or any Deadlocked Matter relating to the Commercialization of such SYNGAP1 Co-Co Product, regardless of if that matter arises before the first Regulatory Approval of such SYNGAP1 Co-Co Product, including:

(A)any such Deadlocked Matter relating to the Manufacture of such SYNGAP1 Co-Co Product (including commercial supply pursuant to Section 7.7) used in connection with Commercialization activities;

(B)any Deadlocked Matter pertaining to (x) the Regulatory Strategy for, or obtaining or maintaining Regulatory Approval of such SYNGAP1 Co-Co Product, including the timing or selection of the jurisdictions in the Territory for which Regulatory Approval will be sought for such SYNGAP1 Co-Co Product or (y) for each country, beginning

with MAA submission and thereafter, the preparation and submission of Regulatory Materials for such SYNGAP1 Co-Co Product in such country; and

(C)any Deadlocked Matter relating to the Commercialization of such SYNGAP1 Co-Co Product, including the SYNGAP1 Co-Commercialization Plan and the SYNGAP1 Co-Commercialization Budget (and any amendments thereto), activities relating to SYNGAP1 Co-Co Product Materials (including negotiations with a Regulatory Authority and decision making with respect to the SYNGAP1 Co-Co Product label), Pricing Matters (including Pricing and Reimbursement Approvals and Pricing Guidelines), and disputes related to Patent Term Extensions in connection with SYNGAP1 Co-Co Products arising under Section 14.7;

provided, however, that (i) Acadia may not exercise its tie-breaking authority to (A) reduce Stoke’s Minimum Participation Rights or (B) change any FTE Rate mutually agreed upon by the Parties for any FTEs performing activities under a SYNGAP1 Co-Commercialization Plan ; (ii) any Deadlocked Matter relating to an Excess Commercialization Overage shall be resolved in accordance with Section 17.4(c); and (iii) neither Party shall be permitted to cause the other Party to take any action that would result in a violation of Applicable Laws.

(b)Authority. The JSC, JDC, JCC and each subcommittee and Working Group have only the powers assigned expressly to them in this Article 3 and elsewhere in this Agreement, and do not have any power to amend, modify or waive compliance with this Agreement. Each Party retains the rights, powers and discretion granted to it under this Agreement and neither Party may delegate or vest such rights, powers or discretion in the JSC, JDC or JCC unless expressly provided for in this Agreement or the Parties expressly so agree in writing. No Committee shall have the power to amend, waive or modify any term of this Agreement, and no decision of any Committee shall be in contravention of any terms and conditions of this Agreement. It is understood and agreed that issues to be formally decided by the JSC are limited to those specific issues that are expressly provided in this Agreement to be decided by the JSC.

3.8Discontinuation. The JSC, JDC and any subcommittee or Working Group, as applicable, will disband, or if it is still in place for other Programs, shall have no further authority hereunder with respect to Licensed Products Directed Against a Target upon the first approval of an MAA for a Licensed Product Directed Against such Target in the Territory (for clarity, the Licensed Products are outside of the scope of the JCC’s authority during the entirety of the Term). Additionally, and without limiting the other provisions of this Agreement, in the event Stoke or its Affiliates acquires a Competing Product with respect to a MECP2 or [***] following completion of the relevant time period in Section 2.5, the JSC and other Committees shall automatically disband as to such Target upon Stoke’s initiation of a GLP tox study for such Competing Product, and Acadia will have no further information sharing or reporting obligations to Stoke with respect thereto except for Commercialization reports as set forth in Section 5.5(c) and reports as set forth in Section 5.5(c) applied mutatis mutandis to Development activities, provided that such reports will be limited to the level of detail necessary to confirm Acadia’s financial and diligence obligations herein. With respect to a particular SYNGAP1 Co-Co Product, the JSC, JDC, JCC and any subcommittee or Working Group pertaining thereto will disband with respect to such SYNGAP1 Co-Co Product, and shall have no further authority hereunder, upon the first to occur of: (i) the Development Opt-Out Date; (ii) the Commercialization Opt-Out Date; and (iii) the end of the Term. For the avoidance of doubt, once the JSC disbands per the foregoing, Acadia shall

have sole decision-making authority for Developing, Commercializing and all other matters for all Licensed Products for which the JSC has disbanded.

4.1Research Programs and Plans . On a Target-by-Target basis, the Parties shall conduct research program for such Target during the applicable Research Term, with the goal of identifying one or more Clinical Candidates Directed Against such Target for further Development and Commercialization as a Product as set forth herein (the “MECP2 Research Program ”, the “[***] Research Program ” and the “SYNGAP1 Research Program,” respectively). Each Research Program shall be conducted pursuant to a research plan and budget detailing: (a) the activities to be undertaken by Stoke in the conduct such Research Program, which activities shall include preclinical research through IND-enabling toxicology studies, (b) the modality(ies) (i.e., class of compound) of Molecules that will be researched under the Research Plan, (c) the timeframes in which such activities are expected to be completed, and (d) the criteria for a Molecule to meet in order to be considered as a potential Molecule (such criteria the “Critical Success Factors ,” such plan the “MECP2 Research Plan,” “[***] Research Plan ” and “SYNGAP1 Research Plan ,” respectively, and such budget the “MECP2 Research Budget ,” “[***] Research Budget ” and “SYNGAP1 Research Budget ,” respectively). The initial Research Plan and corresponding Research Budget for each Research Program are attached hereto as Schedule 4.1 . During the Research Term for a given Target, each Party shall have the right to propose updates or amendments to the applicable Research Plan and Research Budget, provided that any such updates or amendments shall be subject to review and discussion by the JDC, and review and approval by the JSC. Without limiting the JDC’s rights to review and discuss and the JSC’s rights to review and approve any updates or amendments to a Research Plan or Research Budget, and subject to the terms and conditions of this Agreement, Stoke shall have the right, without seeking JDC review or JSC approval, to make operational decisions with respect to the performance of any research activity assigned to it to the extent consistent with the then-current Research Plan and Research Budget.

4.2Diligence . On a Research Program-by-Research Program basis, during the applicable Research Term, Stoke shall conduct the Research Program in accordance with this Agreement. Without limiting the foregoing, on a Research Plan-by-Research Plan basis, Stoke shall use Commercially Reasonable Efforts to conduct (itself or through its Affiliates or by permitted subcontracting) its obligations under such Research Plan in accordance with the timeframes set forth therein. Stoke shall conduct each Research Program in a good scientific manner, in accordance with GLP, GMP and GCP, as applicable, and in compliance with Applicable Laws. For clarity, for a given Research Program, Stoke shall not be required to perform any work which is not included in the applicable then-current Research Plan and corresponding Research Budget approved in accordance with this Agreement.

4.3Research Term Extension. Acadia shall have the exclusive option at its sole discretion to extend the Research Term with respect to a Research Program by an additional [***], exercisable by written notice to Stoke at any time prior to the expiration of the then-current Research Term, up to [***] times, for a maximum Research Term of [***] with respect to such Research Program.

(a)MECP2 Research Program and [***] Research Program. For each of the MECP2 Research Programs and [***] Research Programs, Acadia shall reimburse Stoke for all of Stoke’s Research Costs incurred in the conduct of the relevant Research Plan in accordance with the Research Budget. With respect to each MECP2 Research Plan and [***] Research Plan, within [***] after the end of each [***] during the applicable Research Term, Stoke shall send a report to Acadia describing all of Stoke’s Research Costs incurred under such Research Plan for such [***] and an invoice for such Research Costs. Acadia may reasonably request additional supporting documentation for Stoke’s Research Costs described in such reports and Stoke shall provide such documentation (e.g. out-of-pocket cost breakdowns and general allocation of FTEs). Acadia shall pay all such invoiced amounts within [***] after receipt of any such invoice from Stoke. With respect to any MECP2 or [***] Research Program, reimbursement of any Stoke Research Costs in excess of the aggregate amount budgeted in the relevant Research Budget shall be subject to approval by the JSC.

(b)SYNGAP1 Research Program. For the SYNGAP1 Research Program, the Parties shall each fund fifty percent (50%) of Stoke’s Research Costs incurred in the conduct of the relevant SYNGAP1 Research Plan in accordance with the SYNGAP1 Research Budget. Within [***] after the end of each [***] during the Research Term for the SYNGAP1 Research Program Stoke shall send a report to Acadia describing all of Stoke’s Research Costs incurred under the SYNGAP1 Research Plan for such [***] and an invoice for fifty percent (50%) of such Research Costs. Acadia may reasonably request additional supporting documentation for Stoke’s Research Costs described in such reports and Stoke shall provide such documentation (e.g. out-of-pocket cost breakdowns and general allocation of FTEs). Acadia shall pay all such invoiced amounts within [***] after receipt of any such invoice from Stoke.

(c)Permitted Research Overage. With respect to each Research Plan, Stoke shall use Commercially Reasonable Efforts to ensure that the actual costs and expenses for such research activities in a Calendar Year do not exceed [***] of the estimated allocated costs and expenses budgeted for such activity for such Calendar Year as set forth in the applicable Research Budget (i.e., the costs and expenses for the performance of a specific activity described in the Research Plan may exceed the estimated allocated costs and expenses therefor as set forth in the Research Budget by up to [***] (the “Permitted Research Overage”) and such costs and expenses, to the extent such costs and expenses are within the Permitted Research Overage and would otherwise have been included as Research Costs but for the budget overage, shall be included as Research Costs). If Stoke believes that the actual costs and expenses in relation to a particular research activity in a Calendar Year will exceed the allocated budget (plus the Permitted Research Overage) for such activity during such Calendar Year as set forth in the applicable Research Budget, Stoke may request the JSC to review and approve an amendment to the applicable Research Budget before incurring such excess cost (“Excess Research Overage”). In the event that the JSC does not approve an increase in the applicable Research Budget for such activity, Stoke shall be solely responsible for the costs and expenses it incurs which are in excess of the applicable Research Budget (plus the Permitted Research Overage) (and any such Excess Research Overage shall not be Research Costs hereunder); provided that, to the extent such Excess Research Overage is attributable to reasonable activities performed as a direct result of (i) a change in Applicable Law, (ii) a force majeure or (iii) activities required by a Regulatory Authority, and

in each case of (i), (ii) or (iii), as applicable, such excess costs and expenses would otherwise have been included as Research Costs but for the budget overage, then such Excess Research Overage shall be included in Research Costs.

4.5Subcontractors. Subject to the remainder of this Section 4.5, Stoke may engage subcontractors to perform its obligations under a Research Plan, which engagement shall be pursuant to a written agreement that is consistent with the terms and conditions of this Agreement (including without limitation Article 10 and Article 14 ), provided such subcontractor is (i) listed in the SYNGAP1 Research Plan, or (ii) consented to by Acadia, which consent shall not be unreasonably withheld or delayed. In all cases, Stoke shall ensure that (a) it remains responsible for the work allocated to such subcontractors to the same extent it would if it had done such work itself, (b) the subcontractor undertakes in writing obligations of confidentiality and non-use regarding Confidential Information that are at least as protective as those undertaken by such Party with respect to Confidential Information pursuant to Article 10 , and (c) the subcontractor undertakes in writing to assign or exclusively license back (with the right to sublicense through multiple tiers) all intellectual property arising out of such subcontracted activities, in each case in the course of performing any such work under the applicable Research Plan, to Stoke such that Stoke shall Control such intellectual property. Without limiting the generality of the foregoing, Stoke may subcontract any of its obligations under the applicable Research Plan to a university or academic institution on reasonable and customary terms , provided that, (1) Stoke shall use reasonable efforts to ensure that such subcontracting relationship is consistent with, and such university or academic institution abides by, the terms and obligations set forth in this Section 4.5 (or such revisions to such terms or obligations as the Parties may mutually agree) and (2) neither the United States government nor any agency thereof has funded or will fund any part of such subcontracting relationship. Furthermore, Stoke shall provide to Acadia an unredacted copy of any and all such written agreements with such subcontractors.

(a)Records. Stoke shall maintain, or cause to be maintained, during the applicable Research Term and for a reasonable period of time thereafter that is consistent with industry standards, complete and accurate written (or electronic) records of its activities under each Research Plan in sufficient detail and in a good scientific manner appropriate for scientific, patent and regulatory purposes, which records shall reasonably reflect all work performed by or on behalf of Stoke under the applicable Research Plan (“Research Plan Records”), which Research Plan Records shall be the Confidential Information of Stoke (subject to the terms of Section 4.6(d) below).

(b)Acadia Right to Audit. With respect to a given Research Program, Acadia shall have the right to audit the relevant Research Plan Records to ensure compliance with this Agreement, exercisable during the applicable Research Term and for one year thereafter, on reasonable prior written notice and no more than once per Calendar Year absent cause.

(c)Results; Reports. For each Research Program, for each Calendar Quarter during the applicable Research Term, Stoke shall provide the JDC with an update and summary of the research activities, data, results and analyses (“Results”) generated by it (or on its behalf) in conducting activities under the relevant Research Plan to date.

(d)Ownership; Confidentiality. Each Party shall own all rights, title and interest (including all intellectual property rights) in and to the Know-How (including Results) generated by it (or on its behalf) in connection with a Research Program in accordance with Section 14.1. Such Know-How shall in each case be subject to the rights and obligations of the Parties under this Agreement, including Article 9 and the licenses granted hereunder. With respect to a Research Program, for (i) the MECP2 and [***] Research Programs, all Results for such Research Program shall be deemed the Confidential Information of Acadia (and Acadia shall be deemed the disclosing Party and Stoke the receiving Party for the purposes of Article 10 regardless of who first actually disclosed), and (ii) the SYNGAP1 Research Program, all Results for such Research Program shall deemed be the Confidential information of both Parties, in each case regardless of whether contained in Research Plan Records and provided that (x) Stoke shall have a limited, non-exclusive, non-transferrable (except in connection with a permitted assignment of this Agreement as set forth in Section 17.1(a)) and sublicensable right (subject to Section 2.2(a)(i) applied mutatis mutandis with respect to Stoke) to use such of the Results as are generally applicable to Stoke’s proprietary technology platform, TANGO, for identifying Antisense Oligonucleotides and other compounds for use in treating severe genetic diseases, solely for internal research purposes to improve such platform; and (y) Stoke shall have a limited, non-exclusive, non-transferrable (except in connection with a permitted assignment of this Agreement as set forth in Section 17.1(a)) and sublicensable right (subject to Section 2.2(a)(i) applied mutatis mutandis with respect to Stoke) to use such Results for any purpose, subject in each case ((x) and (y)) to Sections 2.1, 2.5, 4.6(d), Article 10 and other applicable terms and conditions under this Agreement. For clarity, the foregoing sentence does not limit Acadia’s rights to the Results or use thereof for any purpose, subject to the applicable terms and conditions under this Agreement.

(e)Clinical Candidate Selection Process. In addition to reporting the Results in accordance with Section 4.6(c) above, on a Research Program-by-Research Program basis, Stoke shall provide the JDC a written data package containing: (a) the identity of each ASO or other compound Directed Against the relevant Target identified by Stoke during the conduct of the applicable Research Plan that [***] (each such Molecule a “Molecule”), (b) a summary of all preclinical data generated in the Research Program for such Molecule(s), (c) an intellectual property assessment, including an analysis of the patentability of each Molecule (including a prior art search and analysis) and (d) any other relevant supporting information and analysis pertaining to such Molecule(s) (each such notice a “Clinical Candidate Notice”). For clarity, a Molecule that should have been identified in such written data package but was not for whatever reason, shall nonetheless be considered a Molecule for the purposes of this Agreement. Each such Clinical Candidate Notice shall be provided by Stoke to the JDC in draft form (provided that items (a)-(d) above shall only be provided in such draft to the extent they exist at such time) no fewer than [***] prior to the anticipated end of the Research Term (which draft form shall not constitute a Clinical Candidate Notice for the purposes of this Agreement) and in final form upon the conclusion of the Research Term. Within [***] after the issuance of a Clinical Candidate Notice for a Research Program, the JDC shall meet to discuss the Molecule(s) identified in the Clinical Candidate Notice and shall recommend to the JSC which Molecule(s) to select for the conduct of GLP Tox Studies under the Research Plan. Within [***] after the JSC’s receipt of the JDC’s recommendation, the JSC may select one or more Molecules (without being limited to the Molecules that were recommended by the JDC) for the conduct of GLP Tox Studies under the Research Plan. Following the conduct of such GLP Tox Studies, Stoke shall report the results of such studies to the JDC and, within [***] thereof, the JDC shall meet to discuss such results and shall recommend to the JSC

which Molecule(s) to select as Clinical Candidates (as defined below) for further Development and Commercialization under this Agreement. Within [***] after the JSC’s receipt of the JDC’s recommendation, the JSC may select such one or more Molecules (without being limited to the Molecules that were recommended by the JDC) for such Research Program for further Development and Commercialization under this Agreement (each such Molecule as selected by the JSC a “Clinical Candidate”). During such aforementioned [***] and [***] periods, the Parties, via the JSC or JDC, will consider and discuss the information, and analyses, including that Stoke will provide direct access to Stoke’s and its Affiliates’ scientists or other relevant personnel involved in the conduct of the relevant Research Plan as reasonably requested by JSC or JDC. For clarity, with respect to each Research Program, the JSC may select one or more Molecules as Clinical Candidates for further Development and Commercialization as set forth herein, provided that if following the initial selection of Clinical Candidates by the JSC pursuant to the aforementioned [***] period, Acadia (with respect to the MECP2 and [***] Programs), or either Party (with respect to the SYNGAP1 Program), desires to select a Molecule that was not previously selected as a Clinical Candidate for such Research Program as a Clinical Candidate, then such Party shall notify the JSC in writing and the JSC shall determine whether or not to select such Molecule as a Clinical Candidate. Notwithstanding anything herein to the contrary, any dispute involving whether or not a Molecule is a Molecule shall be resolved in accordance with Section 3.7. Without limiting the scope of the selection process above, Stoke shall have and retain all rights in and to any Molecules that are not Molecules generated by Stoke in the conduct of a Research Plan (and, for clarity, such Molecules shall be Stoke’s Confidential Information, subject to the terms and conditions of this Agreement including Section 2.5).

4.7Failure to Identify Molecules or Clinical Candidates. If the conduct of the Research Program fails to generate any Molecules during the applicable Research Term, or if JSC fails to select at least one (1) Clinical Candidate for a Research Program in accordance with Section 4.6(e), then at the request of Acadia, the Parties will negotiate in good faith towards an extension of the applicable Research Term (without limiting Acadia’s options to extend the Research Term pursuant to Section 4.3), and if the Research Term is not further extended (including following Acadia’s options to extend the Research Term pursuant to Section 4.3), then [***].

(a)MECP2 Research Program Transfer. Within [***] following the JSC’s selection of one or more Clinical Candidates from the MECP2 Research Program in accordance with Section 4.6(e), Stoke shall transfer to Acadia (i) Stoke’s existing Know-How and documentation for the synthesis, conjugation, formulation and manufacturing of the Clinical Candidate(s); (ii) any existing material of the Clinical Candidate(s); and (iii) all Results pertaining to such Clinical Candidate(s) and other Stoke MECP2 Know-How relating to such Clinical Candidate(s) and manufacture thereof (including, for example, Know-How from Stoke’s other research programs to the extent necessary or generally useful in the manufacture of ASOs) (such transfer the “MECP2 Technology Transfer”), in each case, to the extent not already in the possession of Acadia. Acadia shall reimburse Stoke for its Internal Costs and External Costs in connection with performing such activities. In addition, for a period of [***] following the

completion of such transfer, Stoke shall provide Acadia with technical and scientific assistance as reasonably requested by Acadia and in an amount not to exceed [***] FTE hours, provided that Acadia will reimburse Stoke for any Internal Costs incurred in providing such assistance.

(b)[***] Research Program Transfer. Within [***] following the JSC’s selection of one or more Clinical Candidates for the [***] Research Program in accordance with Section 4.6(e), Stoke shall transfer to Acadia (i) Stoke’s existing Know-How and documentation for the synthesis, conjugation, formulation and manufacturing of the Clinical Candidate(s); (ii) any existing material of the Clinical Candidate(s); and (iii) all Results pertaining to such Clinical Candidate(s) and other Stoke [***] Know-How relating to such Clinical Candidate(s) and manufacture thereof (including, for example, Know-How from Stoke’s other research programs to the extent necessary or generally useful in the manufacture of ASOs) (“[***] Technology Transfer ”), in each case, to the extent not already in the possession of Acadia. Acadia shall reimburse Stoke for its Internal Costs and External Costs in connection with performing activities under the technology transfer plan. In addition, for a period of [***] following the completion of such transfer, Stoke shall provide Acadia with technical and scientific assistance as reasonably requested by Acadia and in an amount not to exceed [***] FTE hours, provided that Acadia will reimburse Stoke for any Internal Costs incurred in providing such assistance.

(a)Clinical Candidate Development; Responsibility . Subject to the terms and conditions of this Agreement, for each of the MECP2 and [***] Targets, Acadia will be responsible for carrying out and funding the Development (subject to Stoke carrying out those activities assigned to Stoke under the applicable Research Plan as described above) of the Clinical Candidates Directed Against such Targets in the Territory (the “MECP2 Development Program ” and “[***] Development Program,” respectively). Before Acadia conducts any Development activities for Licensed Products for the MECP2 and [***] Targets, Acadia must have a Development Plan in place. Acadia shall conduct each Development Program pursuant to a plan setting forth, with respect to each Clinical Candidate for such Development Program, (i) the specific Development activities (including Clinical Trials) to be conducted by Acadia, (ii) planned timelines for conducting such Development activities, and (iii) a strategy and timeline for obtaining Regulatory Approval of a Licensed Product corresponding to such Clinical Candidate throughout the Territory (the “MECP2 Development Plan ” and “[***] Development Plan,” respectively). Acadia will submit an initial Development Plan for each Development Program to the JDC for review and comment within [***] following the relevant MECP2 Technology Transfer or [***] Technology Transfer. Following review and comment by the JDC, the JDC shall submit the initial Development Plan for a Development Program to the JSC for the JSC’s review and approval. For clarity, during the Research Term or prior to the conclusion of a Research Program, Acadia may simultaneously perform certain Development activities (e.g., natural history studies) for the Licensed Products with respect to the MECP2 and [***] Targets, in each case, pursuant to a Development Program and corresponding Development Plan.

(b)Updates. Acadia shall update each Development Plan at least annually, which update shall be submitted to the JDC for review and comment, and to the JSC for review and approval. Once approved by the JSC, each updated Development Plan shall become effective and supersede the previous Development Plan as of the date of such approval or at such other time as decided by the JSC.

(c)Diligence. With respect to each Development Program for MECP2 and [***] Targets, Acadia shall use Commercially Reasonable Efforts to [***]. On a Development Program-by-Development Program basis, Acadia shall use Commercially Reasonable Efforts to conduct (itself or through its Affiliates or Sublicensees) such Development Program in accordance with the Development Plan, including the timeframes set forth therein. Acadia shall conduct each Development Program in a good scientific manner, in accordance with GLP, GMP and GCP, as applicable, and in compliance with Applicable Laws.

(d)Development Records. Acadia shall maintain complete, current and accurate records of the Development activities it conducts under a Development Program in good scientific manner appropriate for regulatory and patent purposes. Acadia shall document all non-clinical studies and Clinical Trials in formal written study reports according to Applicable Laws and national and international guidelines (e.g., ICH, GCP, GLP, and GMP).

(e)Development Reports. Acadia shall keep Stoke, via the JDC, reasonably informed as to the progress and results of its and its Affiliates’ and Sublicensees’ Development activities under this Agreement for each Development Program (“Development Records”). Without limiting the foregoing, Acadia shall provide Stoke with regular reports (but in any event no less than every [***]) summarizing its Development of Licensed Products under each Development Program and the results of such Development. Such reports shall be at a level of detail sufficient to enable Stoke to determine Acadia’s compliance with its diligence obligations under Section 5.2(c). Without limiting the foregoing, Acadia may respond to Stoke’s reasonable questions or requests for additional information relating to such Development activities for each Development Program.

(f)Stoke Right to Audit. With respect to a given Development Program, Stoke shall have the right to audit the relevant Development Records to ensure compliance with this Agreement on reasonable prior written notice and no more than once per Calendar Year absent cause.

(a)Responsibility. For each of the MECP2 and [***] Programs, following the completion of the applicable MECP2 Technology Transfer or [***] Technology Transfer, (i) Acadia shall be solely responsible, at its sole expense, for all regulatory activities necessary to obtain and maintain Regulatory Approval of the applicable Licensed Products in the Field in the Territory, and (ii) Acadia will own all Regulatory Materials for such Licensed Products in the Field in the Territory, including all Regulatory Approvals, and will be responsible for the payment of fees and all other associated regulatory costs for such Licensed Products in the Field in the Territory.

(b)Stoke Obligations. Upon Acadia’s request, Stoke shall provide reasonable and timely access, use and support of its then-existing regulatory and technical documents relating to any Licensed Products to assist Acadia’s submission of any IND or other Regulatory Material. Acadia shall reimburse Stoke for the Internal Costs and External Costs incurred by Stoke in providing assistance pursuant to this Section 5.3(b).

(c)Notification of Threatened Action; Remedial Actions. Acadia shall promptly notify Stoke of any information it receives regarding any threatened or pending action, inspection or communication by any Regulatory Authority that may affect the safety or efficacy claims of any Licensed Products or the continued marketing of any Licensed Product. Without limiting the foregoing, Acadia shall promptly notify Stoke if it obtains information indicating that any Licensed Product may be subject to any recall, corrective action or other regulatory action taken by virtue of Applicable Law.

5.4Manufacturing; Acadia Responsibilities. For each of the MECP2 and [***] Programs, following the completion of the applicable MECP2 Technology Transfer or [***] Technology Transfer , Acadia shall be responsible, itself or through Affiliates or Third Party contract manufacturers, for the Manufacture and supply of the applicable Licensed Products for use in all Development and Commercialization under this Agreement, and for all CMC activities for Licensed Products in the Field in the Territory, at Acadia’s sole cost (and Stoke shall be responsible for such CMC activities until completion of the applicable technology transfer in accordance with the applicable Research Plan). The Manufacture of such Licensed Products, including all process and formulation development in connection therewith, including CMC activities, shall be conducted in compliance with this Agreement and all Applicable Laws.

(a)Responsibility. Subject to the terms and conditions of this Agreement, Acadia (and its Affiliates and Sublicensees, as applicable) shall be responsible, at its sole cost and expense, for the Commercialization of all Licensed Products in the Field in the Territory.

(b)Diligence. Following receipt of Regulatory Approval for a Licensed Product in a Major Market, Acadia (and its Affiliates and Sublicensees, as applicable) shall use Commercially Reasonable Efforts to [***]. Acadia shall conduct all such Commercialization in a good scientific manner, in accordance with GLP, GMP and GCP, as applicable, and in compliance with Applicable Laws.

(c)Commercialization Reports. Acadia shall provide to Stoke an annual report on its Commercialization of the Licensed Products in the Territory. Each such report shall summarize Acadia’s and its Affiliates’ and sublicensees’ significant Commercialization activities with respect to the Licensed Products throughout the Territory and will be at a level of detail sufficient to enable Stoke to determine Acadia’s compliance with its diligence obligations in Section 5.5(b). Without limiting the foregoing, Acadia shall timely respond to Stoke’s representatives’ reasonable questions or requests for additional information relating to such Commercialization activities.

(d)Patent Marking. Acadia shall mark all Licensed Products in accordance with the applicable patent marking laws and shall require all of its Affiliates and Sublicensees to do the same.

5.6Trademarks. Acadia will solely own all right, title and interest in and to any trademarks adopted for use with the Licensed Products in the Field in the Territory, and will be responsible for the registration, filing, maintenance and enforcement thereof. Neither Stoke nor any of its Affiliates will at any time do or authorize to be done any act or thing which is likely to materially impair the rights of Acadia therein, and will not at any time claim any right of interest in or to such marks or the registrations or applications therefor. Neither Stoke nor any of its Affiliates will use Acadia’s or any of its Affiliates’ trademarks or any confusingly similar trademarks in a manner that might amount to infringement , dilution, unfair competition or passing off of any of Acadia’s or any of its Affiliates’ trademarks without Acadia’s consent.

(a)SYNGAP1 Co-Development Plan. Subject to Section 6.3, with respect to each Clinical Candidate resulting from the SYNGAP1 Research Program and selected by the JSC for further Development and Commercialization in accordance with Section 4.6(e), promptly after such selection, the JDC shall prepare, subject to review and approval by the JSC, a written plan and budget detailing the Development objectives and the activities to be undertaken by both Parties in the Development a SYNGAP1 Co-Co Product corresponding to such Clinical Candidate in the Territory (each such plan and budget, as approved by the JSC, the “SYNGAP1 Co-Development Plan ” and “SYNGAP1 Co-Development Budget”). Before either Party conducts any Development activities for SYNGAP1 Co-Co Products (other than those activities set forth in the SYNGAP1 Research Plan), there must be a SYNGAP1 Co-Development Plan in place. Each SYNGAP1 Co-Development Plan shall include: (a) in reasonable detail the planned Development activities for such SYNGAP1 Co-Co Product in the Territory, (b) an overall strategy for obtaining, supporting, and maintaining Regulatory Approval of such SYNGAP1 Co-Co Product in the Territory, (c) a timeline showing the key Development activities and timeframes in which such activities are expected to be completed, (d) a Lead Regulatory Party, as described in Section 6.9(a), (e) with respect to any other Development activity included in the plan, a Party to lead such Development activity (e.g., a Clinical Trial) (the “Lead Development Party ”) and (f) a plan for conducting a technology transfer of Know-How Controlled by Stoke and pertaining to such SYNGAP1 Co-Co Product to Acadia to support Acadia’s Development activities for such SYNGAP1 Co-Co Product under the plan. With respect to designating a Lead Development Party for a particular activity, the JSC will take into consideration the relative capabilities of each Party to operationally lead such activity. Subject to Section 6.2 and Section 6.9(a), the Parties may elect to conduct Development activities jointly and allocate specific operational activities in accordance with the applicable SYNGAP1 Co-Development Plan. If a particular Development activity is

allocated to both Parties to perform jointly under the SYNGAP1 Co-Development Plan, then both Parties shall conduct such activity in collaboration with each other as directed by the JDC.

(b)Updates and Amendments . On at least an annual basis during the Term (or more frequently as may be required), the JDC shall update or amend the current version of each SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget based on currently available information and data. The JDC shall submit any such update or amendment to the JSC for review and approval. Each such update or amendment shall become effective and shall supersede the previous applicable SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget only upon approval thereof by the JSC. Notwithstanding anything to the contrary herein, if either Party proposes to include new or revised Development activities in a current SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget because those Development activities are required by a Regulatory Authority in the Territory, then the JSC shall approve the inclusion of such Development activities the SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget. Without limiting the JDC’s rights to review and discuss and the JSC’s right to approve each update or amendment to a SYNGAP1 Co-Development Plan or SYNGAP1 Co-Development Budget, the Lead Development Party to whom a particular Development activity is allocated under a SYNGAP1 Co-Development Plan shall have the right, without seeking JDC review or JSC approval, to make operational decisions with respect to the performance of such Development activity to the extent consistent with such SYNGAP1 Co-Development Plan and the SYNGAP1 Co-Development Budget.

(c)Diligence. Each Party shall use Commercially Reasonable Efforts to conduct (itself or through its Affiliates or by permitted subcontracting) the activities assigned to it under the then-current SYNGAP1 Co-Development Plan in accordance with the timeframes set forth therein. Each Party shall conduct such activities in a good scientific manner, in accordance with GLP, GMP and GCP, as applicable, and in compliance with Applicable Laws. All Development activities (other than those activities set forth in the SYNGAP1 Research Plan), including Clinical Trials, for SYNGAP1 Co-Co Products in the Territory shall be conducted solely as set forth in the relevant SYNGAP1 Co-Development Plan, and the Parties shall not perform any Development activities in the Territory for any SYNGAP1 Co-Co Product other than those set forth in the applicable SYNGAP1 Co-Development Plan. In the event a Party wishes to conduct a Development activity with respect to a SYNGAP1 Co-Co Product that is not included in the current applicable SYNGAP1 Co-Development Plan or SYNGAP1 Research Plan, e.g., with respect to a new formulation or indication, then such Party may propose such new Development activity to the JDC for consideration.

(a)With respect to any Clinical Trials of a SYNGAP1 Co-Co Product to be conducted pursuant to a SYNGAP1 Co-Development Plan, the Lead Development Party shall prepare and submit to the JDC for review, discussion and approval the protocol (and any amendments thereto) for any such Clinical Trial.

(b)The Lead Development Party for a given Clinical Trial under a SYNGAP1 Co-Development Plan shall act as the sponsor of such Clinical Trial. The Lead Development Party shall be responsible for obtaining all necessary approvals and clearances, including IRB approvals,

INDs and other Regulatory Approvals and customs clearances necessary for the conduct of such Clinical Trial, and the Lead Development Party shall ensure that all such approvals and clearances are obtained prior to initiating performance of the applicable Clinical Trial. The Lead Development Party shall ensure that the Clinical Trial is performed in accordance with the protocol and all Applicable Law, including GCPs.

(c)The Lead Development Party for a given Clinical Trial under a SYNGAP1 Co-Development Plan shall be responsible for selecting the Clinical Trial sites and principal investigators and entering into clinical trial agreements in connection therewith. The clinical trial agreements shall require the Clinical Trial sites to comply with all Applicable Laws and will contain provisions in accordance with industry standards, including those relating to confidentiality, data and results , intellectual property and publications; provided that, in all cases, such agreement shall require that all Know-How specifically related to the SYNGAP1 Co-Co Product, including improvements or modifications thereof, shall be assigned to the Lead Development Party (and shall, as between the Parties, be owned as provided for herein).

(d)The Lead Development Party for a given Clinical Trial under a SYNGAP1 Co-Development Plan shall prepare and obtain the patient informed consent forms for the Clinical Trials, which shall comply with Applicable Law. The Lead Development Party shall ensure that all patient authorizations and consents in connection with the Clinical Trials permit, in accordance with Applicable Law, sharing of clinical trial data with the other Party in accordance with this Agreement.

(e)Each Party or its representatives may, for actual cause or based upon a reasonable belief of non-compliance with a SYNGAP1 Co-Development Plan, this Agreement or Applicable Law, perform audits of the other Party or its Affiliates and any Clinical Trial sites engaged, or other facilities used, by such other Party or its Affiliates, Sublicensees or vendors to conduct its obligations under such SYNGAP1 Co-Development Plan (provided that with respect to audits of a Third Party or the facilities of a Third Party, such audit may only be conducted to the extent permitted under the applicable Party’s agreement with such Third Party; provided that in negotiating such agreement, the applicable Party shall use Commercially Reasonable Efforts to obtain such rights for the other Party), to ensure that such Clinical Trials are conducted in compliance with such SYNGAP1 Co-Development Plan and all Applicable Laws. No later than [***] following the completion of any such audit, the auditing Party will provide the other Party with a written summary of its findings in English, including any deficiencies or other areas of remediation that the auditing Party reasonably identifies during such audit, and the Parties shall promptly meet to discuss such findings and proposed remedial actions. If the Parties agree on a proposed remedial action, the non-auditing Party will use Commercially Reasonable Efforts to remediate any such deficiencies within [***] following agreement upon the remedial actions (or such longer time as may be reasonably necessary so long as the non-auditing Party continues to use such Commercially Reasonable Efforts to remediate such deficiencies), at the non-auditing Party’s cost and expense. If the non-auditing Party is unable to remediate such deficiencies within a reasonable period and the auditing Party reasonably determines, based on such deficiencies, that a site engaged to conduct activities pursuant to such SYNGAP1 Co-Development Plan is inadequate to continue performing in the applicable Clinical Trial, then without limiting any other remedies under the Agreement, the non-auditing Party will work with the auditing Party in good faith to wind-down activities at such site as promptly as practicable.

6.3 Clinical Supply. Unless otherwise determined by the JSC, with respect to each SYNGAP1 Co-Co Product, Stoke shall be responsible, by itself or through one or more Third Party contract manufacturers (each a “CMO”), to Manufacture and supply to each Party, its Affiliates and Sublicensees such SYNGAP1 Co-Co Product for Development in the Territory. Within [***] after the selection of a Clinical Candidate resulting from the SYNGAP1 Research Program, the Parties shall negotiate in good faith and enter into an agreement pursuant to which the supplying Party would supply the corresponding SYNGAP1 Co-Co Product to each Party for use in performing Development activities under the applicable SYNGAP1 Co-Development Plan at a transfer price equal to the supplying Party’s Manufacturing Cost (without any markup) (each a “SYNGAP1 Co-Co Clinical Supply Agreement”). With respect to each SYNGAP1 Co-Co Clinical Supply Agreement , the Parties shall negotiate in good faith and enter into an agreement governing the quality control of the product Manufactured pursuant to such agreement.

(a)Sharing . On a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, the Parties shall share all Development Costs for such SYNGAP1 Co-Co Product equally (50:50), as set forth in Section 9.6.

(b)Permitted Development Overage. With respect to each SYNGAP1 Co-Development Plan, the Party that is responsible for the performance of activities described in the SYNGAP1 Co-Development Plan shall use Commercially Reasonable Efforts to ensure that the actual costs and expenses for such Development activities in a Calendar Year do not exceed [***] of the estimated allocated costs and expenses budgeted for such activity with respect to such Party for such Calendar Year as set forth in the applicable SYNGAP1 Co-Development Budget (i.e., the costs and expenses for the performance of a specific activity described in the SYNGAP1 Co-Development Plan may exceed the estimated allocated costs and expenses therefor as set forth in the SYNGAP1 Co-Development Budget by up to [***] (the “Permitted Development Overage ”) and such costs and expenses, to the extent such costs and expenses are within the Permitted Development Overage and would otherwise have been included as Development Costs but for the budget overage, shall be included as Development Costs). If either Party believes that the actual costs and expenses in relation to a particular Development activity in a Calendar Year will exceed the allocated budget (plus the Permitted Development Overage) for such activity during such Calendar Year as set forth in the applicable SYNGAP1 Co-Development Budget, such Party may request the JSC to review and approve an amendment to the applicable SYNGAP1 Co-Development Budget before incurring such excess cost (“Excess Development Overage ”). In the event that the JSC does not approve an increase in the SYNGAP1 Co-Development Budget for such activity with respect to such Party, the Party requesting approval shall be solely responsible for the costs and expenses it incurs which are in excess of the applicable SYNGAP1 Co-Development Budget (plus the Permitted Development Overage) (and any such Excess Development Overage shall not be Development Costs hereunder); provided that, to the extent such Excess Development Overage is attributable to reasonable activities performed as a direct result of (i) a change in Applicable Law, (ii) a Force Majeure or (iii) activities required by a Regulatory Authority, and in each case of (i), (ii) or (iii), as applicable, such excess costs and expenses would otherwise have been included as Development Costs but for the budget overage, then such Excess Development Overage shall be included in Development Costs.

6.5Co-Development Reports . At each JDC meeting, (a) Stoke shall provide the JDC a summary of the progress and results of Development activities for any SYNGAP1 Co-Co Product for which Stoke is the Lead Development Party or Lead Regulatory Party or otherwise responsible for, and (b) Acadia shall provide the JDC a summary of the progress and results of Development activities for any SYNGAP1 Co-Co Product for which Acadia is the Lead Development Party or Lead Regulatory Party or otherwise responsible for. Without limiting the foregoing, Acadia and Stoke shall each provide the JDC with a written report summarizing the Development activities for the SYNGAP1 Co-Co Products conducted by or on behalf of each Party since the last JDC meeting, including, as applicable (i) patient enrollment and the ongoing status of all Clinical Trials, in each case, under any SYNGAP1 Co-Development Plan, (ii) the status of each pending and proposed Regulatory Material submission and Regulatory Approval for each SYNGAP1 Co-Co Product for the Territory, and (iii) the conduct of material Medical Affairs activities (e.g., attendance at industry conferences), in each case to the extent not already provided.

6.6Standards of Conduct; Development Records . Acadia and Stoke shall perform, and each shall ensure that their Affiliates and licensees and permitted sublicensees (as applicable), and subcontractors perform, all Development activities under the SYNGAP1 Co-Development Plan in a good scientific manner, in accordance with GMP and GCP, as applicable, and in compliance with Applicable Laws. Each Party and its Affiliates shall maintain written or electronic records, in sufficient detail, in a good scientific manner (in accordance with GLP, GCP, and GMP, as applicable), and appropriate for regulatory and patent purposes, and that are complete and accurate in all material respects and reflect all Development work performed and results achieved, in each case, by or on behalf of such Party and its Affiliates under this Agreement.

6.7Access to Data. In addition to its adverse event and safety data reporting obligations set forth in Section 6.10 , each Party shall promptly provide the other Party with copies of all data and results and all supporting documentation (e.g., protocols, Investigator’s Brochures, case report forms, analysis plans) Controlled by such Party that are generated by or on behalf of such Party or its Affiliates, Sublicensees, or subcontractors, as applicable, in the Development of each SYNGAP1 Co-Co Product, to the extent necessary or reasonably useful for the performance of the other Party’s Development activities.

6.8Assumed Development Activities. Subject to any applicable SYNGAP1 Co-Co Clinical Supply Agreement, if (i) either Party anticipates that it is likely to, or has, defaulted on its obligations to timely perform one or more material Development activities allocated to such Party under a SYNGAP1 Co-Development Plan, and such failure delays the performance of such matters for a period of more than [***] beyond the timeline set forth in such SYNGAP1 Co-Development Plan, such Party shall so notify the other Party regarding such anticipated or actual failure to perform, or (ii) either Party has defaulted on its obligations to perform one or more material Development activities allocated to such Party under a SYNGAP1 Co-Development Plan, and such failure delays the performance of such matters for a period of more than [***] beyond the timeline set forth in such SYNGAP1 Co-Development Plan, the other Party may provide written notice of such failure to the defaulting Party then, in either case (clause (i) or (ii)), upon the effective date of the receipt of such notice as described in clause (i) or (ii), the defaulting Party shall have a [***] period (or such longer time as may be reasonably necessary so long as the defaulting Party continues to use diligent efforts to remediate such default pursuant to a plan of remediation) to commence the performance of such Development activities in accordance with the

terms hereof and the applicable SYNGAP1 Co-Development Plan, or, if it is not possible to commence performance during such time period due to factors outside that Party’s control (e.g., force majeure), to commence steps needed to resolve the causes of such delayed performance, and to commence performance as soon as reasonably practicable (the “Development Activities Cure Period”). If (x) the defaulting Party has not commenced such performance or such steps to resolve the causes of the delay (as the case may be) during the applicable Development Activities Cure Period, (y) the defaulting Party notifies the non-defaulting Party in writing that the defaulting Party anticipates that it shall be unable to perform such Development activities, or (z) the defaulting Party does not perform such Development activities in accordance with the applicable SYNGAP1 Co-Development Plan or otherwise in accordance with this Article 6 , within a reasonable period of time in accordance with the terms hereof, then, in each case ((x)-(z)), the non-defaulting Party may, upon written notice to the defaulting Party, assume those Development activities that are the subject of such default by the defaulting Party (the “Assumed Development Activities”). In connection with the defaulting Party’s failure to perform such activities or default of such obligations and the non-defaulting Party’s assumption thereof and without limiting the other rights and remedies that the non-defaulting Party may have hereunder, at law or in equity:

(a)the defaulting Party shall work collaboratively and in good faith with the non-defaulting Party, and make its personnel reasonably available to the non-defaulting Party, in each case, in order to (i) transfer of any applicable technology, materials, or contracts with subcontractors to the other Party that are necessary or reasonably useful for the performance of the applicable Assumed Development Activities, and (ii) provide such other assistance so as to enable the non-defaulting Party to assume performance of the applicable Assumed Development Activities;

(b)the non-defaulting Party shall thereafter have the right to make operational decisions with respect to the performance of such Assumed Development Activities as if such activities were assigned to such non-defaulting Party under the then-current SYNGAP1 Co-Development Plan (provided that the decision-making authority with respect to such activities shall remain subject to Article 3 in all respects);

(c)the JDC shall update the applicable SYNGAP1 Co-Development Plan to allocate performance of the Assumed Development Activities to the non-defaulting Party; and

(d)for the avoidance of doubt, Development Costs incurred in connection with the performance of Assumed Development Activities shall be shared equally (50:50) by the Parties as set forth in Section 9.6.

(a)Regulatory Responsibilities. The Parties will share responsibility for leading regulatory matters relating to the SYNGAP1 Co-Co Products, as described in this Section 6.9 (each Party, when designated as provided herein to provide such leadership with respect to designated activities is the “Lead Regulatory Party” with respect to such activities). With respect to each SYNGAP1 Co-Co Product, Acadia shall (x) lead the overall strategy for obtaining Regulatory Approval of such SYNGAP1 Co-Co Product (including labeling for such SYNGAP1 Co-Co Product), including by selecting the jurisdictions within which MAAs will be pursued and

the timing and order in which such approvals will be sought (“Regulatory Strategy”), and will be the Lead Regulatory Party with respect to such strategic activities with respect to such SYNGAP1 Co-Co Product, (y) be the Lead Regulatory Party with respect to the submission of any MAA for such SYNGAP1 Co-Co Product, and (z) following the first Regulatory Approval of such SYNGAP1 Co-Co Product, be the Lead Regulatory Party in connection with such SYNGAP1 Co-Co Product and with respect to Commercialization and regulatory activities (including post-marketing studies). Subject to the foregoing, the JSC shall designate a Party to lead all other pre-Regulatory Approval regulatory matters relating to each SYNGAP1 Co-Co Product in accordance with the applicable SYNGAP1 Co-Development Plan (each Party in such capacity will be deemed the Lead Regulatory Party with respect to such activities). The Lead Regulatory Party shall be responsible for (i) filing for in its name, and owning, all Regulatory Materials relating to regulatory activities with respect to such SYNGAP1 Co-Co Product in the relevant country, (ii) overseeing, monitoring, and coordinating all regulatory actions, communications and filings with, and submissions to, each Regulatory Authority with respect to such activities; and (iii) interfacing, corresponding, and meeting with each Regulatory Authority with respect to such activities, in each case consistent with the Regulatory Strategy and applicable SYNGAP1 Co-Development Plan or SYNGAP1 Co-Commercialization Plan.

(b)Cooperation and Coordination. With respect to each SYNGAP1 Co-Co Product, at the Lead Regulatory Party’s request, the other Party shall diligently cooperate with the Lead Regulatory Party in connection with any Regulatory Materials and other regulatory compliance related activities with respect to such SYNGAP1 Co-Co Product, including harmonization of any Regulatory Material submissions.

(i)Prompt Disclosures. Each Party shall inform the other Party within [***], or such shorter time as is necessary to comply with the reporting requirements of any applicable Regulatory Authority or under Applicable Laws, of notification of any action by, or notification or other information that it receives (directly or indirectly) from any Regulatory Authority in the Territory to the extent such information: (A) raises any material concerns regarding the safety or efficacy of a SYNGAP1 Co-Co Product; (B) indicates or suggests a potential material liability of either Party to Third Parties in connection with a SYNGAP1 Co-Co Product; (C) is reasonably likely to lead to a clinical hold, recall, market withdrawal, or field alert with respect to a SYNGAP1 Co-Co Product; or (D) relates to expedited and periodic reports of adverse events with respect to a SYNGAP1 Co-Co Product, or SYNGAP1 Co-Co Product complaints, and may have an adverse impact on the receipt or maintenance of Regulatory Approval or the continued Commercialization of a SYNGAP1 Co-Co Product. The Parties shall reasonably cooperate with and assist each other in complying with regulatory obligations and communications, including by providing to the applicable Lead Regulatory Party, within two (2) Business Days after a request, such information and documentation that is in the other Party’s possession as may be necessary or helpful for such Lead Regulatory Party to prepare a response to an inquiry from a Regulatory Authority in the Territory with respect to a SYNGAP1 Co-Co Product. Each Party shall also promptly provide the other Party with a copy of all correspondence received from a Regulatory Authority in the Territory specifically regarding the matters referred to above (translated into English, if applicable). In addition, the Lead Regulatory Party shall allow the other Party a reasonable opportunity to review and comment on the Lead Regulatory Party’s

proposed response to any Material Communications with any Regulatory Authority in the Territory with respect to any SYNGAP1 Co-Co Product in advance of the transmission of such response, and the Lead Regulatory Party shall reasonably consider all comments timely provided by the other Party in connection therewith.

(ii)Other Disclosures. Without limiting Section 6.9(c)(i), each Party shall promptly disclose to the other Party the following regulatory information:

(A)Regulatory Actions . All material information Controlled by such Party pertaining to actions taken by Regulatory Authorities related to a SYNGAP1 Co-Co Product in the Territory, including any notice, audit notice, notice of initiation by Regulatory Authorities of investigations, inspections, detentions, seizures, or injunctions concerning a SYNGAP1 Co-Co Product in the Territory, notice of violation letter (i.e., an untitled letter), warning letter, service of process, or other inquiry; provided that a Party shall be entitled to redact those portions thereof to the extent not related to a SYNGAP1 Co-Co Product.

(B)Regulatory Non-Compliance. All information Controlled by such Party pertaining to notices from Regulatory Authorities in the Territory of non-compliance with Applicable Laws in connection with a SYNGAP1 Co-Co Product, including receipt of a warning letter or other notice of alleged material non-compliance from any Regulatory Authority relating to a SYNGAP1 Co-Co Product; provided that a Party shall be entitled to redact those portions thereof to the extent not related to a SYNGAP1 Co-Co Product.

(d)Regulatory Meetings. The Lead Regulatory Party shall provide the other Party with reasonable advance notice of all substantive meetings with the Regulatory Authorities pertaining to a SYNGAP1 Co-Co Product, or with as much advance notice as practicable under the circumstances. Upon the other Party’s request, the Lead Regulatory Party shall include the other Party in the preparation and strategy for such substantive meeting and in any discussions and actions relating to the outcome thereof. The other Party shall participate (including attending in person as applicable) in all such meetings if required by the applicable Regulatory Authority, and otherwise, to the extent permitted by Applicable Laws and by the applicable Regulatory Authorities, shall have the right to participate provided that such participation shall be limited to up to two (2) representatives of the other Party.

(i)Regulatory Filings. The Lead Regulatory Party for a country shall provide the other Party with a copy of all proposed material Regulatory Material submissions to be submitted to any Regulatory Authority in the country for a SYNGAP1 Co-Co Product for the other Party’s review and comment sufficiently in advance of, but in any event, unless not practicable, at least [***] prior to, the Lead Regulatory Party’s submission thereof, and the Lead Regulatory Party for the country shall reasonably consider incorporating any reasonable comments received from the other Party into such Regulatory Materials.

(ii)Other Submissions. In addition, the Lead Regulatory Party shall provide the other Party with written notice of each of the following events with regard to a SYNGAP1 Co-Co Product throughout the Territory (to the extent not already provided pursuant

to Section 6.9(e)(i)), within a reasonable period of time, but in any event, unless not practicable, at least [***], following the occurrence thereof (a) the submission of any applications for Regulatory Approval of a SYNGAP1 Co-Co Product to any Regulatory Authority in the country, and (b) receipt of or denial of Regulatory Approval for a SYNGAP1 Co-Co Product (or inquiries from the applicable Regulatory Authority related to the Regulatory Approval process); provided that in all cases the Lead Regulatory Party shall inform the other Party of any such event under (a) or (b) prior to any public disclosure of such event by the Lead Regulatory Party.

(f)Right of Reference. Subject to the rules of the relevant Regulatory Authority and the terms of this Agreement, each Party hereby grants to the other Party a “Right of Reference ,” as that term is defined in 21 C.F.R. § 314.3(b) (or any successor rule or analogous Applicable Laws recognized outside of the United States) to, and a right to copy, access, and otherwise use, all information and data relating to any SYNGAP1 Co-Co Product in any Regulatory Material or Regulatory Approval Controlled by such Party during the Term , solely for the other Party’s or its Affiliates’ use in the Development and Commercialization of the SYNGAP1 Co-Co Products during the Term in accordance with this Agreement. All such information and data contained in any such Regulatory Materials or Regulatory Approvals shall be considered Confidential Information of such Party and subject to the terms of Article 10 . If requested by the other Party, such Party shall provide a signed statement to this effect in accordance with 21 C.F.R. § 314.50(g)(3) (or any successor rule or analogous Applicable Laws outside of the United States) to give effect to the intent of this Section 6.9(f).

6.10Pharmacovigilance and Adverse Event Reporting. The Parties shall cooperate with regard to the reporting and handling of safety information involving the SYNGAP1 Co-Co Products in accordance with the Applicable Laws, regulatory requirements, and regulations on pharmacovigilance and clinical safety. The Lead Regulatory Party for a SYNGAP1 Co-Co Product in a given country shall be responsible for all processing of information related to any adverse events for such SYNGAP1 Co-Co Product for such country. Each Party shall provide to the other Party the relevant safety information it receives (either directly or indirectly) related to a SYNGAP1 Co-Co Product within such time to ensure that all regulatory requirements and timelines are met in the respective Territories. No later than [***] prior to the first IND submission, unless mutually agreed in writing by the Parties, the Parties shall negotiate in good faith and enter into one or more (as appropriate) written Pharmacovigilance Agreements for the SYNGAP1 Co-Co Products, which agreements shall define the pharmacovigilance responsibilities of the Parties and include safety data exchange procedures governing the exchange of information affecting the SYNGAP1 Co-Co Products (e.g ., serious adverse events, emerging safety issues) to enable each Party to comply with all of its legal and regulatory obligations related to such SYNGAP1 Co-Co Products (each a “Pharmacovigilance Agreement”). Between the execution of this Agreement and the execution of the Pharmacovigilance Agreement, each Party shall provide to the other Party within [***], any and all known information that may impact human safety with respect to the SYNGAP1 Research Program and SYNGAP1 Co-Co Products. Acadia shall own and maintain, and be responsible for, the global safety database for each SYNGAP1 Co-Co Product. In the event of any inconsistency between the terms of this Agreement and the Pharmacovigilance Agreement , the terms of this Agreement shall prevail and govern, except to the extent such conflicting terms relating directly to the pharmacovigilance responsibilities of the Parties (including the exchange of safety data), in which case the terms of the Pharmacovigilance Agreement shall prevail and govern.

(a)Notification and Determination. In the event that any Governmental Authority threatens in writing or initiates any action to remove a SYNGAP1 Co-Co Product from the market (in whole or in part) in the Territory, the Party receiving notice thereof shall notify the other Party of such communication immediately, but in no event later than [***] after receipt thereof. Notwithstanding the foregoing, in all cases the Lead Regulatory Party for a SYNGAP1 Co-Co Product in a country shall determine whether to initiate any recall, withdrawal, or field alert of such SYNGAP1 Co-Co Product in such country, including the scope of such recall or withdrawal (e.g., a full or partial recall, or a temporary or permanent recall) or field alert. Before the Lead Regulatory Party initiates a recall, withdrawal, or field alert for a SYNGAP1 Co-Co Product in a country, the Parties shall use reasonable efforts to promptly meet and discuss in good faith the reasons therefor, provided that such discussions shall not delay any action that such Lead Regulatory Party reasonably believes should be taken in relation to any actual or potential recall, withdrawal, or field alert. In the event of any such recall, withdrawal, or field alert, the Lead Regulatory Party for the applicable country shall determine the necessary actions to be taken and shall implement such action. Without limiting the foregoing, either Party shall have the right to propose that a recall, withdrawal, or field alert for a SYNGAP1 Co-Co Product should be initiated by such Party, but the Lead Regulatory Party for the applicable country shall have the right to make the final decision as to whether or not to initiate the recall, withdrawal, or field alert.

(b)Cost Allocation . All Internal Costs and External Costs associated with implementing a recall, withdrawal, or field alert with respect to a SYNGAP1 Co-Co Product shall be shared equally (50:50) by the Parties as Other Expenses, in accordance with Section 9.6(a) in the event of such a recall of a SYNGAP1 Co-Co Product in the Territory.

(a)Co-Commercialization Plan. Subject to Section 7.7, with respect to each SYNGAP1 Co-Co Product, no later than [***] prior to the anticipated First Commercial Sale of such SYNGAP1 Co-Co Product in the Territory, the JCC shall prepare in good faith, subject to review and approval by the JSC, a commercially reasonable written plan and budget detailing the Commercialization objectives and the activities to be undertaken by both Parties in the Commercialization of such SYNGAP1 Co-Co Product in the Territory, which plan and budget shall be subject to review and approval by the JSC (each such plan and budget, as approved by the JSC, the “SYNGAP1 Co-Commercialization Plan ” and “SYNGAP1 Co-Commercialization Budget”); provided that each SYNGAP1 Co-Commercialization Plan shall be consistent with the following: (i) Acadia shall lead the global Commercialization Strategy and related strategic activities throughout the Territory for each SYNGAP1 Co-Co Product, and (ii) Stoke shall have the right to [***] (the “Stoke Minimum Participation Rights”). Each SYNGAP1 Co-Commercialization Plan shall contain a three (3) year rolling annual plan for the global Commercialization activities for the applicable SYNGAP1 Co-Co Product in the Territory and the SYNGAP1 Co-Commercialization Budget shall include a three (3) year financial forecast

reflecting reasonably anticipated Commercialization Costs in accordance with the SYNGAP1 Co-Commercialization Plan.

(b)Updates and Amendments . On at least an annual basis during the Term (or more frequently as may be required), the JCC shall update or amend the then-current version of each SYNGAP1 Co-Commercialization Plan and SYNGAP1 Co-Commercialization Budget based on currently available information and data. The JCC shall submit any such update or amendment to the JSC for review and approval. Each such update or amendment shall become effective and shall supersede the previous applicable SYNGAP1 Co-Commercialization Plan and SYNGAP1 Co-Commercialization Budget only upon approval thereof by the JSC. Notwithstanding anything to the contrary herein, the Parties acknowledge and agree that to the extent a Regulatory Authority requires certain Commercialization activities, then the JSC shall approve the inclusion of such Commercialization activities in the SYNGAP1 Co-Commercialization Plan and SYNGAP1 Co-Commercialization Budget. Without limiting the JCC’s rights to review and discuss and the JSC’s right to approve each update or amendment to a SYNGAP1 Co-Commercialization Plan or SYNGAP1 Co-Commercialization Budget, the Lead Commercialization Party to whom a particular Commercialization activity is allocated under a SYNGAP1 Co-Commercialization Plan shall have the right, without seeking JCC review or JSC approval, to make operational decisions with respect to the performance of such Commercialization activity to the extent consistent with such SYNGAP1 Co-Commercialization Plan and the SYNGAP1 Co-Commercialization Budget.

(c)Medical Affairs. With respect to a given SYNGAP1 Co-Co Product, approximately [***] before the anticipated submission of the first MAA filing seeking Regulatory Approval for such SYNGAP1 Co-Co Product in the Territory, the applicable SYNGAP1 Co-Commercialization Plan shall be updated to include a plan for conducting Medical Affairs with respect to such SYNGAP1 Co-Co Product in the Territory. The Parties acknowledge and agree that Commercialization and Medical Affairs activities are separate activities and are subject to different Applicable Laws, regulatory requirements and obligations in various jurisdictions throughout the Territory, and that the Parties intend to comply with such Applicable Laws, regulatory requirements and obligations, as applicable.

(i)Lead Commercialization Party. Acadia shall lead the global Commercialization strategy (“Commercialization Strategy ”) and related strategic activities throughout the Territory for each SYNGAP1 Co-Co Product. Subject to Acadia’s lead role with respect to strategic issues, the Parties will share responsibility for leading execution with respect to specific commercial activities relating to the SYNGAP1 Co-Co Products as set forth herein (each Party, with respect to such specified activities is the “Lead Commercialization Party”). Unless otherwise so designated by the JSC, with respect to specific commercial activities under SYNGAP1 Co-Commercialization Plan, the Lead Commercialization Party shall be whichever Party has been assigned responsibility for executing such specific commercial activities under the SYNGAP1 Co-Commercialization Plan. If a particular Commercialization activity is allocated to both Parties to perform jointly under a SYNGAP1 Co-Commercialization Plan, then both Parties shall coordinate to jointly conduct such activity in collaboration with each other. All Commercialization activities for SYNGAP1 Co-Co Products in the Territory shall be conducted

solely as set forth in the relevant SYNGAP1 Co-Commercialization Plan, and the Parties shall not perform any Commercialization activities in the Territory for any SYNGAP1 Co-Co Product other than those set forth in the applicable SYNGAP1 Co-Commercialization Plan. In the event a Party wishes to conduct a Commercialization activity with respect to a SYNGAP1 Co-Co Product that is not included in the current applicable SYNGAP1 Co-Commercialization Plan, then such Party may propose such new Commercialization activity to the JCC for consideration.

(ii)Commercialization Diligence Obligations. Following receipt of Regulatory Approval of a SYNGAP1 Co-Co Product in a Major Market within the Territory, each Party shall use Commercially Reasonable Efforts to perform, or cause to be performed, the activities for such SYNGAP1 Co-Co Product assigned to it in the applicable SYNGAP1 Co-Commercialization Plan in such Major Market and pursuant to this Agreement. Each Party shall conduct such activities in a good scientific manner, in accordance with GLP, GMP and GCP, as applicable, and in compliance with Applicable Laws.

(a)Sharing . On a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, the Parties shall share all Commercialization Costs for such SYNGAP1 Co-Co Product equally (50:50) in accordance with Section 9.6.

(b)Permitted Commercialization Overage. With respect to each SYNGAP1 Co-Commercialization Plan, the Party that is responsible for the performance of activities described in the SYNGAP1 Co-Commercialization Plan shall use Commercially Reasonable Efforts to ensure that the actual costs and expenses for such Commercialization activities in a Calendar Year do not exceed [***] of the estimated allocated costs and expenses budgeted for such activity with respect to such Party for such Calendar Year as set forth in the applicable SYNGAP1 Co-Commercialization Budget (i.e., the costs and expenses for the performance of a specific activity described in the SYNGAP1 Co-Commercialization Plan may exceed the estimated allocated costs and expenses therefor as set forth in the SYNGAP1 Co-Commercialization Budget by up to [***] (the “Permitted Commercialization Overage ”) and such costs and expenses, to the extent such costs and expenses are within the Permitted Commercialization Overage and would otherwise have been included as Commercialization Costs but for the budget overage, shall be included as Commercialization Costs). If either Party believes that the actual costs and expenses in relation to a particular Commercialization activity in a Calendar Year will exceed the allocated budget (plus the Permitted Commercialization Overage) for such activity during such Calendar Year as set forth in the applicable SYNGAP1 Co-Commercialization Budget, such Party may request the JSC to review and approve an amendment to the applicable SYNGAP1 Co-Commercialization Budget before incurring such excess cost (“Excess Commercialization Overage ”). In the event that the JSC does not approve an increase in the SYNGAP1 Co-Commercialization Budget for such activity with respect to such Party, the Party requesting approval shall be solely responsible for the costs and expenses it incurs which are in excess of the applicable SYNGAP1 Co-Commercialization Budget (plus the Permitted Commercialization Overage) (and any such Excess Commercialization Overage shall not be Commercialization Costs hereunder); provided that, to the extent such Excess Commercialization Overage is attributable to reasonable activities performed as a direct result of (i) a change in Applicable Law, (ii) a Force Majeure or (iii) activities required by a Regulatory Authority, and in each case of (i), (ii) or (iii),

as applicable, such excess costs and expenses would otherwise have been included as Commercialization Costs but for the budget overage, then such Excess Commercialization Overage shall be included in Commercialization Costs. For clarity, the process for increase the then-current SYNGAP1 Co-Commercialization Budget with respect to a Permitted Commercialization Overage is separate from and does not limit the JSC’s ability to independently amend the then-current SYNGAP1 Co-Commercialization Plan to add new activities and to update the SYNGAP1 Co-Commercialization Budget accordingly.

7.3Assumed Commercialization Activities. Subject to any applicable SYNGAP1 Co-Co Clinical Supply Agreement or SYNGAP1 Co-Co Commercial Supply Agreement, if (i) either Party anticipates that it is likely to, or has, defaulted on its obligations to timely perform one or more material Commercialization activities allocated to such Party under a SYNGAP1 Co-Commercialization Plan, and such failure delays the performance of such matters for a period of more than [***] beyond the timeline set forth in such SYNGAP1 Co-Commercialization Plan, such Party shall so notify the other Party regarding such anticipated or actual failure to perform, or (ii) either Party has defaulted on its obligations to perform one or more material Commercialization activities allocated to such Party under a SYNGAP1 Co-Commercialization Plan and such failure delays the performance of such matters for a period of more than [***] beyond the timeline set forth in such SYNGAP1 Co-Commercialization Plan, the other Party may provide written notice of such failure to the defaulting Party and, in either case (clause (i) or (ii)), the defaulting Party shall have a [***] period (or such longer time as may be reasonably necessary so long as the defaulting Party continues to use diligent efforts to remediate such default pursuant to a plan of remediation) to commence the performance of such Commercialization activities in accordance with the terms hereof and the applicable SYNGAP1 Co- Commercialization Plan, or, if it is not possible to commence performance during such time period due to factors outside that Party’s control (e.g., force majeure), to commence steps needed to resolve the causes of such delayed performance, and to commence performance as soon as reasonably practicable (the “Commercialization Activities Cure Period”). If (a) the defaulting Party has not commenced such performance or such steps to resolve such causes of the delay (as the case may be) during the applicable Commercialization Activities Cure Period, (b) the defaulting Party notifies the non-defaulting Party in writing that the defaulting Party anticipates that it shall be unable to perform such Commercialization activities, or (c) the defaulting Party does not perform such Commercialization activities in accordance with the applicable SYNGAP1 Co-Commercialization Plan or otherwise in accordance with this Article 7 , within a reasonable period of time in accordance with the terms hereof, then, in each case ((a)-(c)), the non-defaulting Party may, upon written notice to the defaulting Party, assume those Commercialization activities that are the subject of such default by the defaulting Party (the “Assumed Commercialization Activities”). In connection with the defaulting Party’s failure to perform such activities or default of such obligations and the non-defaulting Party’s assumption thereof, and without limiting the other rights and remedies that the non-defaulting Party may have hereunder, at law or in equity:

(a)the defaulting Party shall work collaboratively and in good faith with the non-defaulting Party, and make its personnel reasonably available to the non-defaulting Party, in each case, in order to (i) transfer of any applicable technology, materials, or contracts with subcontractors to the other Party that are necessary or reasonably useful for the performance of the applicable Assumed Commercialization Activities and (ii) provide such other assistance so as to

enable the non-defaulting Party to assume performance of the applicable Assumed Commercialization Activities;

(b)the non-defaulting Party shall thereafter have the right to make operational decisions with respect to the performance of such Assumed Commercialization Activities as if such activities were assigned to such non-defaulting Party under the then-current SYNGAP1 Co-Commercialization Plan (provided that the decision-making authority with respect to such activities shall remain subject to Article 3 in all respects);

(c)the applicable JSC subcommittee shall update the applicable SYNGAP1 Co-Commercialization Plan to allocate performance of the Assumed Commercialization Activities to the non-defaulting Party; and

(d)for the avoidance of doubt, Commercialization Costs incurred in connection with the performance of Assumed Commercialization Activities shall be shared equally (50:50) by the Parties as set forth in Section 9.6.

7.4Pricing Matters. With respect to each SYNGAP1 Co-Co Product, the JSC shall, as and to the extent consistent with Applicable Law, provide a global pricing strategy for such SYNGAP1 Co-Co Product in the Territory, including establishing various pricing bands for each country in the Territory (collectively, the “Pricing Guidelines ”). Acadia, as Lead Regulatory Party from and after first Regulatory Approval of a SYNGAP1 Co-Co Product and Lead Commercialization Party with respect to all strategic Commercialization matters, will be responsible for conducting all Pricing Matters in such country in accordance with the Pricing Guidelines, including negotiating, obtaining, and maintaining all Pricing and Reimbursement Approvals for the SYNGAP1 Co-Co Products in the relevant country. To the extent permitted by Applicable Law, Acadia, as the Lead Commercialization Party for each country, shall have the right and responsibility for establishing and modifying the terms and conditions with respect to the sale of such SYNGAP1 Co-Co Product to customers in such country, including any terms and conditions relating to the price at which the such SYNGAP1 Co-Co Product will be sold to customers (including discounts, rebates and other forms of price concessions); provided that, in connection therewith, the following shall apply:

(a)in those countries where Regulatory Authorities issue Pricing and Reimbursement Approvals for such SYNGAP1 Co-Co Product, such pricing decisions and terms shall in all cases comply with all applicable Pricing and Reimbursement Approvals from the applicable Regulatory Authorities in the country of sale; and

(b)such pricing decisions and terms shall, to the extent permitted by Applicable Law, also comply with the Pricing Guidelines (but subject in all cases to Section 7.4(a), if applicable, which shall control in the event of a conflict).

7.5Commercialization Reports . At each JCC meeting, (a) Stoke shall provide the JCC a summary of the progress and results of Commercialization activities for any SYNGAP1 Co-Co Product for which Stoke is the Lead Commercialization Party or otherwise responsible for, (b) Acadia shall provide the JCC a summary of the progress and results of Commercialization activities for any SYNGAP1 Co-Co Product for which Acadia is the Lead Commercialization

Party or otherwise responsible for. Without limiting the foregoing, at each meeting of the JCC, each Party shall provide to the JCC a summary of sales forecasts, sales performance reports, and other information for such SYNGAP1 Co-Co Product, as applicable.

7.6Standards of Conduct; Compliance. Each Party shall perform, or shall ensure that each of its Affiliates, Sublicensees, and subcontractors perform, all Commercialization activities in a professional and ethical business manner and in compliance with Applicable Laws, the Approved Labeling, and the applicable SYNGAP1 Co-Commercialization Plan.

7.7Commercial Supply. With respect to each SYNGAP1 Co-Co Product, reasonably in advance of, but at least [***] prior to, the anticipated First Commercial Sale thereof, the JCC shall determine a plan for the Manufacture and supply to each Party, its Affiliates and Sublicensees of such SYNGAP1 Co-Co Product for Commercialization in the Territory. If, pursuant to such plan, Acadia will conduct some or all commercial manufacturing of the SYNGAP1 Co-Co Product (including supplying Stoke, its Affiliates or Sublicensees), then the JCC will prepare a plan (each such plan a “SYNGAP1 Co-Co Technology Transfer Plan”) and Stoke shall transfer to Acadia or its CMO (subject to Section 2.2(b)(ii)) the Stoke SYNGAP1 Know-How (including, for example, Know-How from Stoke’s other research programs to the extent necessary or generally useful in the manufacture of ASOs) with respect to the manufacture of such SYNGAP1 Co-Co Product as set forth in the plan, the cost of which transfer shall be shared by the Parties equally (50:50) as an Other Expense. To the extent necessary while the commercial manufacturing process for the SYNGAP1 Co-Co Product is being transferred and validated, Stoke will, upon on a transitional basis (not to exceed [***] after first Regulatory Approval of such SYNGAP1 Co-Co Product in the Territory), provide commercial supplies of the SYNGAP1 Co-Co Product following the first Regulatory Approval thereof in the Territory, subject to the terms and conditions set forth in the relevant SYNGAP1 Co-Co Clinical Supply Agreement . As applicable, the Parties shall negotiate in good faith and enter into an agreement pursuant to which a Party would supply the SYNGAP1 Co-Co Product to the other Party, its Affiliates and Sublicensees for use in performing Commercialization activities under the applicable SYNGAP1 Co-Commercialization Plan at a transfer price equal to such Party’s Manufacturing Cost (each a “SYNGAP1 Co-Co Commercial Supply Agreement”). With respect to each SYNGAP1 Co-Co Commercial Supply Agreement , the Parties shall negotiate in good faith and enter into an agreement governing the quality control of the product Manufactured pursuant to such agreement.

7.8SYNGAP1 Co-Co Product Materials. With respect to each SYNGAP1 Co-Co Product, unless otherwise agreed to by the Parties, the Parties shall jointly create and develop and provide to the JCC and JSC for approval all SYNGAP1 Co-Co Product Materials to be used in the Promotion of such SYNGAP1 Co-Co Product in each country in the Territory where the SYNGAP1 Co-Co Product is being Commercialized. All such SYNGAP1 Co-Co Product Materials shall be in accordance with the relevant Approved Labeling and Regulatory Approval, and in compliance with all Applicable Laws. Acadia, as Lead Commercialization Party for a country, shall own all rights, title, and interests in and to such SYNGAP1 Co-Co Product Materials in such country, excluding any Stoke Housemarks. The Parties agree that, to the extent permitted under Applicable Laws, all SYNGAP1 Co-Co Product Materials shall include Acadia Housemarks and Stoke Housemarks with equal prominence.

(a)Ownership. With respect to each SYNGAP1 Co-Co Product, unless otherwise agreed to by the Parties, the Parties shall jointly develop and provide to the JCC and JSC for approval of the SYNGAP1 Co-Co Product Marks for such SYNGAP1 Co-Co Product to be used in any country in the Territory where the SYNGAP1 Co-Co Product is being Commercialized. In addition, the Parties may mutually agree to jointly develop and adopt certain distinctive colors, logos, images, symbols, and trade dress to be used (in addition to the SYNGAP1 Co-Co Product Marks) in connection with the Commercialization of such SYNGAP1 Co-Co Product.

(b)Lead Party; Trademark License . The relevant SYNGAP1 Co-Commercialization Plan shall set forth a Lead Commercialization Party to own all rights, title, and interests in and to any SYNGAP1 Co-Co Product Marks for the relevant SYNGAP1 Co-Co Product in a country, including all Trademark registrations and applications therefor and all goodwill associated therewith, but expressly excluding Stoke Housemarks or Acadia Housemarks. To the extent the non-Lead Commercialization Party acquires any rights, title, or interests in or to any such SYNGAP1 Co-Co Product Mark (including any Trademark registration or application therefore or goodwill associated with any such SYNGAP1 Co-Co Product Mark), the non-Lead Commercialization Party shall, and hereby does, assign the same to the Lead Commercialization Party. With respect to any SYNGAP1 Co-Co Product Marks, (i) the relevant Lead Commercialization Party shall have, assert, or acquire any rights, title, or interests in or to any such SYNGAP1 Co-Co Product Marks or the goodwill pertaining thereto, and (ii) each Party recognizes and agrees that all goodwill developed by virtue of the use of such SYNGAP1 Co-Co Product Marks inures to the benefit of the associated Lead Commercialization Party; provided that (A) Acadia reserves all rights, title or interests in and to Acadia Housemarks, and all goodwill developed by virtue of the use of Acadia Housemarks inures to the benefit of Acadia, regardless of which Party uses Acadia Housemarks in which region, and (B) Stoke reserves all rights, title or interests in and to Stoke Housemarks, and all goodwill developed by virtue of the use of Stoke Housemarks inures to the benefit of Stoke, regardless of which Party uses Stoke Housemarks in which region. Upon a Party’s reasonable request from time to time, the other Party shall provide to such Party for its review all materials that include any SYNGAP1 Co-Co Product Marks, provided that all subsequent uses of any materials already provided to such Party for review may be used without additional review.

(c)Use . Each Party agrees that it and its Affiliates and Sublicensees shall ensure that each SYNGAP1 Co-Co Product that is sold bearing any SYNGAP1 Co-Co Product Mark is of a high quality consistent with industry standards for global pharmaceutical and biologic therapeutic products . Each Party agrees that it and its Affiliates and Sublicensees shall (i) not use any SYNGAP1 Co-Co Product Marks in a way that might materially prejudice their distinctiveness or validity or the goodwill therein and shall include the trademark registration symbol ® or ™ as appropriate; (ii) ensure that each use of the SYNGAP1 Co-Co Product Marks is in accordance with the guidelines with respect to manner of use set forth in the applicable SYNGAP1 Co-Commercialization Plan; (iii) not directly or indirectly, attack, dispute , or contest the validity of or ownership of any SYNGAP1 Co-Co Product Mark anywhere in the Territory or any registrations issued or issuing with respect thereto; and (iv) not use any trademarks or trade names so resembling any SYNGAP1 Co-Co Product Mark as to be likely to cause confusion or deception.

(d)Registration, Maintenance, and Enforcement . The relevant Lead Commercialization Party shall have the sole right to register, maintain, and enforce the SYNGAP1 Co-Co Product Marks during the Term, provided that Acadia shall have the sole right to register, maintain, and enforce Acadia Housemarks and Stoke shall have the sole right to register, maintain, and enforce Stoke Housemarks regardless of where they are used. All costs of such registration, maintenance, and enforcement efforts shall be shared by the Parties equally (50:50) as Other Expenses to the extent such costs relate to registration, maintenance, and enforcement in the Territory of the SYNGAP1 Co-Co Product Marks used in connection with the Commercialization of the relevant SYNGAP1 Co-Co Product in the Territory (the “Trademark Costs”).

7.10Patent Marking. Each of Acadia and Stoke shall mark all SYNGAP1 Co-Co Products (or the packaging, inserts or by way of a product website) in accordance with the applicable patent marking laws, and shall require all of its Affiliates and Sublicensees to do the same.

7.11Copyright License . Subject to the terms and conditions of this Agreement, each Party hereby grants to the other Party a non-exclusive license, with the right to grant sublicenses through multiple tiers without the prior written consent of such Party, to use such Party’s copyrights solely to perform Medical Affairs activities with respect to the SYNGAP1 Co-Co Products in the Territory in accordance with this Agreement, the Medical Affairs plan and the Co-Commercialization Plan.

(a)Development Opt-Out Right. On a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, Stoke may elect to opt-out (“Development Opt-Out,” and such right to Development Opt-Out, the “Development Opt-Out Right”, and Stoke the “Development Opt-Out Party”) of the global Development and Commercialization of such SYNGAP1 Co-Co Product hereunder by written notice to Acadia within each of the following time period (such period the “Development Opt-Out Window”): commencing on or after the Initiation of the first Phase I/II Clinical Trial for such SYNGAP1 Co-Co Product and ending [***] after the delivery of top line results from the first Phase III Clinical Trial of such SYNGAP1 Co-Co Product (meaning, the audited, quality-controlled tables, listings and figures, in reasonable and customary form, reflecting all results from such Clinical Trial) to the JSC. Stoke may exercise its Development Opt-Out Right upon [***] prior written notice to Acadia of such election during the Development Opt-Out Window (the “Development Opt-Out Notice”). Despite the exercise by Stoke of its Development Opt-Out Right in accordance with the foregoing sentence, Stoke shall remain responsible for the performance of its obligations as set forth in this Agreement and the SYNGAP1 Co-Development Plan and the sharing of the corresponding Development Costs incurred in the performance of such activities for a period ending [***] after the receipt of the Development Opt-Out Notice by Acadia (the “Development Opt-Out Date”, and Acadia referred to as the “Primary Party” after the Development Opt-Out Date with respect to the SYNGAP1 Program).

(b)Effects of Development Opt-Out. Subject to the remainder of this Section 8.1(b), from and after the Development Opt-Out Date: (i) the SYNGAP1 Co-Co Product shall cease to be a SYNGAP1 Co-Co Product and shall be deemed a “SYNGAP1 Opt-Out Product,” and Sections 5.2(c)-(f) and Sections 5.3-5.6 shall apply mutatis mutandis with respect to the further Development and Commercialization of such SYNGAP1 Co-Co Product by the Primary Party, (ii) the Development Opt-Out Party shall continue to be responsible for fifty percent (50%) of all Development Costs to the extent actually incurred by or on behalf of the Parties or are committed to through the Development Opt-Out Date, (iii) the Development Opt-Out Party shall not be responsible for any further Development Costs, Commercialization Costs or Other Expenses incurred with respect to the SYNGAP1 Opt-Out Product after the Development Opt-Out Date; (iv) the Primary Party shall pay to the Development Opt-Out Party milestone payments as set forth in Section 9.4 for such SYNGAP1 Opt-Out Product and royalties with respect to Net Sales of such SYNGAP1 Opt-Out Product as set forth in Section 9.5; (v) the license granted by Acadia to Stoke under Section 2.1(c)(ii) shall immediately terminate with respect to such SYNGAP1 Opt-Out Product as of the Development Opt-Out Date, and the license granted by Stoke to Acadia under Section 2.1(c)(i) shall survive the Development Opt-Out and immediately become exclusive with respect to such SYNGAP1 Opt-Out Product, including with respect to Stoke and its Affiliates (subject to applicable Antitrust Filings and related government approvals or clearances, provided that the Parties shall reasonably cooperate with each other in connection with the Antitrust Filings); (vi) the Parties shall agree upon a written transition plan (an “Development Opt-Out Transition Plan”) setting forth all of the wind-down and other activities necessary or reasonably useful to transition all Development and Commercialization activities with respect to such SYNGAP1 Opt-Out Product, and any accompanying technology transfer activities further described in Section 8.1(c) (collectively, the “Development Opt-Out Transition Activities”); (vii) each Party shall carry out the Development Opt-Out Transition Activities assigned to it in the Development Opt-Out Transition Plan and the Parties shall share equally all costs as specified in such Development Opt-Out Transition Plan as if the same were Development Costs hereunder; (viii) the Development Opt-Out Party shall assign and transfer (where applicable) to the Primary Party all INDs, Regulatory Filings, Regulatory Approvals, Regulatory Materials, copies of material correspondence and conversation logs, pre-clinical and clinical study reports, clinical study protocols, and all data (in the format in which it is maintained by Stoke) pertaining solely to the SYNGAP1 Opt-Out Product, and shall grant the Primary Party a right of reference to all Regulatory Materials with respect to such SYNGAP1 Opt-Out Product necessary for the further Development and Commercialization thereof; and (ix) as soon as practicable, Stoke shall take all steps necessary to transfer to Acadia or its designee ownership of all such assigned INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials, including submitting to each applicable Regulatory Authority a letter or other necessary documentation (with a copy to Acadia) notifying such Regulatory Authority of the transfer of such ownership of the applicable INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials; provided that if it is not feasible under Applicable Laws for Stoke to transfer to Acadia any such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials, Stoke shall hold such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials in its name for the benefit of Acadia and shall grant, and hereby does grant to Acadia an exclusive, royalty-free license and right of reference to use such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials in connection with Development and Commercialization of the SYNGAP1 Opt-Out Product and authorize Acadia or its designee to conduct regulatory activities with applicable Regulatory Authorities

relating to such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials. Notwithstanding anything herein to the contrary, in the event that Stoke exercises its Development Opt-Out Right, the JSC, JDC, JCC and any subcommittees and Working Groups, except to the extent required by the Development Opt-Out Transition Plan to facilitate the Development Opt-Out Transition Activities, shall immediately disband with respect to the applicable SYNGAP1 Co-Co Product effective as of the date of the Development Opt-Out Notice. For avoidance of doubt, the Development Opt-Out Party shall remain fully liable for all of its accrued and unpaid liabilities as of the Development Opt-Out Date (even if such accrued and unpaid liabilities are only determined with certainty after such date).

(c)Development Opt-Out Program Transfer. Within [***] following the Development Opt-Out Date, the Development Opt-Out Party shall transfer to the Primary Party with respect to the applicable SYNGAP1 Opt-Out Product, (i) the Development Opt-Out Party’s existing Know-How and documentation for the synthesis, conjugation, formulation and manufacturing of the SYNGAP1 Opt-Out Product; (ii) any existing material of the SYNGAP1 Opt-Out Product; and (iii) all results and other Development Opt-Out Party Know-How relating to such SYNGAP1 Opt-Out Product and manufacture of such SYNGAP1 Opt-Out Product (such transfer the “SYNGAP1 Development Technology Transfer”), in each case, to the extent requested by the Primary Party. In addition, for a period of [***] following the completion of such transfer, the Development Opt-Out Party shall provide the Primary Party with technical and scientific assistance as reasonably requested by the Primary Party, provided that the Primary Party reimburses the Development Opt-Out Party for its Internal Costs incurred in providing such assistance.

(a)Commercialization Opt-Out Right. On a SYNGAP1 Co-Co Product-by-SYNGAP1 Co-Co Product basis, provided that Stoke has not exercised its Development Opt-Out Right for such SYNGAP1 Co-Co Product, Stoke may, at any time following the First Commercial Sale of such SYNGAP1 Co-Co Product, elect to opt-out (“Commercialization Opt-Out ,” and such right to Commercialization Opt-Out, the “Commercialization Opt-Out Right”) of the global Development and Commercialization of such SYNGAP1 Co-Co Product hereunder. Stoke may exercise its Commercialization Opt-Out Right by providing [***] prior written notice to Acadia of such election (the “Commercialization Opt-Out Notice,” the effective date of such notice is the “Commercialization Opt-Out Date” and such [***] period is the “Opt-Out Period”). Despite the exercise by Stoke of the Commercialization Opt-Out Right in accordance with the foregoing sentence, Stoke shall remain responsible for the performance of its obligations as set forth in this Agreement, the relevant SYNGAP1 Co-Development Plan and the relevant SYNGAP1 Co-Commercialization Plan during the entire Opt-Out Period, and for the sharing of the corresponding Development Costs and Commercialization Costs incurred in the performance of such activities; provided that, Stoke may at its option, on written notice to Acadia provided within [***] after the Commercialization Opt-Out Notice, elect to receive the Opt-Out milestones and royalties as described in Section 8.2(b) below, before the end of the Opt-Out Period, in lieu of sharing costs and revenues as described in Section 9.6, for the last [***] of the Opt-Out Period (the end of such [***] or [***] month period as elected by Stoke is the “Commercialization Opt-Out Cross-Over Date”), and if such option is elected, Stoke will continue to be obligated to perform any activities ascribed to Stoke under the SYNGAP1 Co-Development Plan or SYNGAP1

Co-Commercialization Plan during the remaining [***] of the Opt-Out Period, to the extent requested by Acadia; provided that, Acadia shall reimburse Stoke for its Internal Costs incurred in connection with the performance of such activities during such three (3) month period plus [***].

(b)Effects of Commercialization Opt-Out. Subject to the remainder of this Section 8.2(b), if Stoke exercises the Commercialization Opt-Out Right, then from and after the Commercialization Opt-Out Cross-Over Date (i) the SYNGAP1 Co-Co Products shall cease to be SYNGAP1 Co-Co Products and shall be deemed “SYNGAP1 Opt-Out Products,” and Sections 5.3-5.6 shall apply mutatis mutandis with respect to the further Commercialization of such SYNGAP1 Co-Co Product by Acadia (ii) Acadia shall pay to Stoke royalties with respect to Net Sales of such SYNGAP1 Opt-Out Product as set forth in Section 9.5 and there shall be no further cost sharing under this Agreement with respect to such SYNGAP1 Opt-Out Products, including that Stoke shall not be responsible for any further Commercialization Costs or Other Expenses incurred with respect to the SYNGAP1 Opt-Out Product; (iii) the license of the Acadia SYNGAP1 Technology with respect to the SYNGAP1 Opt-Out Products from Acadia to Stoke under Section 2.1(c)(ii) shall immediately terminate as of the Commercialization Cross-Over Opt-Out Date, and the license of the Stoke SYNGAP1 Technology with respect to the SYNGAP1 Opt-Out Products from Stoke to Acadia under Section 2.1(c)(i) shall survive the Commercialization Opt-Out and immediately become exclusive, including with respect to Stoke and its Affiliates (subject to applicable Antitrust Filings and related government approvals or clearances, provided that the Parties shall reasonably cooperate with each other in connection with the Antitrust Filings); (iv) the Parties shall agree upon a written transition plan (an “Commercialization Opt-Out Transition Plan”) setting forth all of the wind-down and other activities necessary or reasonably useful to transition all Development, Medical Affairs and Commercialization activities, and any accompanying technology transfer activities further described in Section 8.2(c) (collectively, the “Commercialization Opt-Out Transition Activities”); (v) each Party shall carry out the Commercialization Opt-Out Transition Activities assigned to it in the Commercialization Opt-Out Transition Plan and the Parties shall share equally all costs as specified in such Development Opt-Out Transition Plan as if the same were Commercialization Costs hereunder; (vi) Stoke shall assign and transfer (where applicable) to Acadia all INDs, Regulatory Filings, Regulatory Approvals, Regulatory Materials, copies of material correspondence and conversation logs, pre-clinical and clinical study reports, clinical study protocols, and all data (in the format in which it is maintained by Stoke) pertaining solely to the SYNGAP1 Opt-Out Product, and shall grant Acadia a right of reference to all Regulatory Materials with respect to such SYNGAP1 Opt-Out Product necessary for the further Development and Commercialization thereof; and (vii) as soon as practicable, Stoke shall take all steps necessary to transfer to Acadia or its designee ownership of all such assigned INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials, including submitting to each applicable Regulatory Authority a letter or other necessary documentation (with a copy to Acadia) notifying such Regulatory Authority of the transfer of such ownership of the applicable INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials; provided that if it is not feasible under Applicable Laws for Stoke to transfer to Acadia any such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials, Stoke shall hold such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials in its name for the benefit of Acadia and shall grant, and hereby does grant to Acadia an exclusive, royalty-free license and right of reference to use such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials in connection with Development and Commercialization of the SYNGAP1 Opt-Out Product and authorize Acadia or its designee to conduct regulatory activities with applicable Regulatory

Authorities relating to such INDs, Regulatory Filings, Regulatory Approvals and Regulatory Materials. Notwithstanding anything herein to the contrary, in the event Stoke exercises its Commercialization Opt-Out Right, the JSC, JDC, JCC and any subcommittees and Working Groups shall immediately disband with respect to such SYNGAP1 Opt-Out Product effective as of the date of the Commercialization Opt-Out Notice. For avoidance of doubt, Stoke shall remain fully liable for all of its accrued and unpaid liabilities as of the Commercialization Opt-Out Cross-Over Date (even if such accrued and unpaid liabilities are only determined with certainty after such date).

(c)Commercialization Opt-Out Program Transfer. Within [***] following the Commercialization Opt-Out Cross-Over Date, as applicable, Stoke shall transfer to Acadia (i) Stoke’s existing Know-How and documentation for the synthesis, conjugation, formulation and manufacturing of the SYNGAP1 Opt-Out Products; (ii) any existing material of the SYNGAP1 Opt-Out Products; and (iii) all results and other Commercialization Opt-Out Party Know-How relating to such SYNGAP1 Opt-Out Products and manufacture of such SYNGAP1 Opt-Out Product (such transfer the “SYNGAP1 Commercialization Technology Transfer”), in each case, to the extent requested by Acadia. In addition, for a period of [***] following the completion of such transfer, Stoke shall provide Acadia with technical and scientific assistance as reasonably requested by Acadia, provided that Acadia reimburses Stoke for its Internal Costs incurred in providing such assistance.

9.1Upfront Fee. In partial consideration of Stoke’s granting of the licenses and rights to Acadia hereunder, Acadia shall pay to Stoke a one-time, non-refundable and non-creditable upfront payment of sixty million Dollars ($60,000,000) (the “Upfront Payment”) within [***] following the Effective Date.

(a)Development Milestones for MECP2 Licensed Products. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, following the first achievement by Acadia, its Affiliate or Sublicensee of each Development Milestone Event set forth in the table below by a first MECP2 Licensed Product, Acadia shall make the corresponding one-time, non-refundable, non-creditable Development Milestone Payment to Stoke in accordance with Section 9.7(a).

Each of the foregoing Development Milestone Payments in this Section 9.2(a) shall be payable a maximum of one (1) time with respect to all MECP2 Licensed Products regardless of the number of times the applicable Development Milestone Event was achieved by such MECP2 Licensed Products. [***]. Solely by way of first example, if [***]. Solely by way of second example, if [***]. For the avoidance of doubt, the maximum amount payable by Acadia pursuant to this Section 9.2(a) for all MECP2 Licensed Products is [***].

(b)Sales Milestones for MECP2 Licensed Products. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, following the first achievement by Acadia, its Affiliate or Sublicensee of each Sales Milestone Event set forth in the table below on a MECP2 Licensed Product-by-MECP2 Licensed Product basis after the Effective Date, Acadia shall make the corresponding one-time, non-refundable, non-creditable Sales Milestone Payment to Stoke in accordance with Section 9.7(b).

Each of the foregoing Sales Milestone Payments in this Section 9.2(b) shall be payable a maximum of one (1) time with respect to each MECP2 Licensed Product, regardless of the number of times the applicable Sales Milestone Event was achieved by such MECP2 Licensed Product. For the avoidance of doubt, the maximum total amount payable under this Section 9.2(b) shall not exceed [***] with respect to each MECP2 Licensed Product. If more than one Sales Milestone Event is achieved in the same Calendar Year, Acadia shall pay Stoke all Sales Milestone Payments for such Sales Milestone Events achieved in such Calendar Year in accordance with this Section 9.2(b).

(i)Royalty Rates. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, subject to the remainder of this Section 9.2(c), Acadia shall make quarterly non-refundable, non-creditable royalty payments to Stoke on the aggregate Net Sales, on a MECP2 Licensed Product-by - MECP2 Licensed Product basis, sold in the Territory in a given Calendar Year, calculated by multiplying the applicable royalty rate set forth below by such Net Sales. The applicable royalty rates set forth in the table below will apply only to that portion of the Net Sales during a given Calendar Year that falls within the indicated range. Net Sales of each MECP2 Licensed Product throughout the Territory will be aggregated for purposes of determining the royalty tiers and royalties, provided that if no royalty is payable on a given unit of MECP2 Licensed Product (i.e., following the expiration of the MECP2 Royalty Term for such MECP2 Licensed Product in a given country), then the Net Sales of such unit of MECP2 Licensed Product shall not be included in Net Sales for purposes of determining the royalty tiers and royalties due hereunder. All royalty payments, and associated reports, shall be made in accordance with Section 9.7(c).

(ii)MECP2 Royalty Term. Net Sales of a given MECP2 Licensed Product in a given country shall only be included in aggregate Net Sales for purposes of determining the royalty tiers and royalty payments due pursuant to this Section 9.2(c) during the period beginning on the First Commercial Sale of such MECP2 Licensed Product in such country and ending upon the later of: (A) the tenth (10^th ) anniversary of the date of the First Commercial Sale of such MECP2 Licensed Product in such country; (B) the expiration of the last Valid Claim that Cover such MECP2 Licensed Product in such country; and (C) the expiration of all Regulatory Exclusivities for such MECP2 Licensed Product in such country (“MECP2 Royalty Term”).

(A)No Valid Claim. On an MECP2 Licensed Product-by-MECP2 Licensed Product and country-by-country basis, the applicable royalty rate set forth in Section 9.2(c)(i) as applied to Net Sales of such MECP2 Licensed Product in such country shall be reduced by [***] during any Calendar Quarter of the MECP2 Royalty Term in which there is not at least one (1) Valid Claim that Covers such MECP2 Licensed Product, and all Regulatory Exclusivities for such MECP2 Licensed Product have expired, in such country, subject to Section 9.2(c)(iii)(D).

(B)Generic Drug or Biosimilar Product. If during any Calendar Quarter during the MECP2 Royalty Term, on an MECP2 Licensed Product-by-MECP2 Licensed Product and country-by-country basis, the aggregate number of units of Generic Drug or Biosimilar Products with respect to such MECP2 Licensed Product sold during such Calendar Quarter in such country, in the market segment in which such MECP2 Licensed Product competes in such country, equals or exceeds [***] of the aggregate units of the sum of all such Generic Drug or Biosimilar Products and such MECP2 Licensed Product sold in such Calendar Quarter in such country (as determined by data obtained from a mutually agreed upon Third Party source), then the applicable royalty rate set forth in Section 9.2(c)(i) as applied to Net Sales of such MECP2 Licensed Product in such country shall be reduced by [***] for such Calendar Quarter, subject to Section 9.2(c)(iii)(D).

(C)Third Party In-License Payments. On an MECP2 Licensed Product-by-MECP2 Licensed Product and country-by-country basis, if Acadia, its Affiliates or Sublicensees obtain a license or similar rights to Patent Rights of a Third Party or Third Parties in order to Develop, Manufacture or Commercialize such MECP2 Licensed Product in such country the during any Calendar Quarter during the Royalty Term for such MECP2 Licensed Product (“MECP2 Third Party License(s)”), then, subject to Section 9.2(c)(iii)(D), Acadia shall have the right to credit [***] of the royalties payable under such MECP2 Third Party

License(s) with respect units of MECP2 Licensed Product against royalties payable hereunder with respect to the same units of MECP2 Licensed Product.

(D)Royalty Floor. The reductions of Sections 9.2(c)(iii)(A), 9.2(c)(iii)(B) and 9.2(c)(iii)(C) are cumulative, provided that in no event shall the royalty rate applicable to Net Sales of the MECP2 Licensed Product during any Calendar Quarter in the Royalty Term in a country fall below a rate that is [***] of the royalty rate otherwise payable pursuant to Section 9.2(c)(i). Acadia may carry forward any such reductions permitted in accordance with Section 9.2(c)(iii)(A), Section 9.2(c)(iii)(B) and Section 9.2(c)(iii)(C) that are incurred or accrued in a Calendar Quarter but that are not applied against royalties due to Stoke for such MECP2 Licensed Product in such country in such Calendar Quarter as a result of the foregoing floor and apply such amounts against royalties due to Stoke for such MECP2 Licensed Product in such country in any subsequent Calendar Quarter (subject to the minimum floor set forth in this Section 9.2(c)(iii)(D)) until the amount of such reduction has been fully applied against royalties due to Stoke for such MECP2 Licensed Product in such country.

(a)Development Milestones for [***] Licensed Products. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, following the first achievement by Acadia, its Affiliate or Sublicensee of each Development Milestone Event set forth in the table below by a first [***] Licensed Product, Acadia shall make the corresponding one-time, non-refundable, non-creditable Development Milestone Payment to Stoke in accordance with Section 9.7(a).

Each of the foregoing Development Milestone Payments in this Section 9.3(a) shall be payable a maximum of one (1) time with respect to all [***] Licensed Products regardless of the number of times the applicable Development Milestone Event was achieved by such [***] Licensed Products. [***]. Solely by way of first example, if [***]. Solely by way of second example, if [***]. For the avoidance of doubt, the maximum amount payable by Acadia pursuant to this Section 9.3(a) for all [***] Licensed Products is [***].

(b)Sales Milestones for [***] Licensed Products. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, following the first achievement by Acadia, its Affiliate or Sublicensee of each Sales Milestone Event set forth in the table below on a [***] Licensed Product-by-[***] Licensed Product basis after the Effective Date, Acadia shall

make the corresponding one-time, non-refundable, non-creditable Sales Milestone Payment to Stoke in accordance with Section 9.7(b).

Each of the foregoing Sales Milestone Payments in this Section 9.3(b) shall be payable a maximum of one (1) time with respect to each [***] Licensed Product, regardless of the number of times the applicable Sales Milestone Event was achieved by such [***] Licensed Product. For the avoidance of doubt, the maximum total amount payable under this Section 9.3(b) shall not exceed [***] with respect to each [***] Licensed Product. If more than one Sales Milestone Event is achieved in the same Calendar Year, Acadia shall pay Stoke all Sales Milestone Payments for such Sales Milestone Events achieved in such Calendar Year in accordance with this Section 9.3(b).

(i)Royalty Rates. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, subject to the remainder of this Section 9.3(c), Acadia shall make quarterly non-refundable, non-creditable royalty payments to Stoke on the aggregate Net Sales, on a [***] Licensed Product-by-[***] Licensed Product basis, sold in the Territory in a given Calendar Year, calculated by multiplying the applicable royalty rate set forth below by such Net Sales. The applicable royalty rates set forth in the table below will apply only to that portion of the Net Sales during a given Calendar Year that falls within the indicated range. Net Sales of each [***] Licensed Product throughout the Territory will be aggregated for purposes of determining the royalty tiers and royalties, provided that if no royalty is payable on a given unit of [***] Licensed Product (i.e., following the expiration of the [***] Royalty Term for such [***] Licensed Product in a given country), then the Net Sales of such unit of [***] Licensed Product shall not be included in Net Sales for purposes of determining the royalty tiers and royalties due hereunder. All royalty payments, and associated reports, shall be made in accordance with Section 9.7(c).

(ii)[***] Royalty Term. Net Sales of a given [***] Licensed Product in a given country shall only be included in aggregate Net Sales for purposes of determining the royalty tiers and royalty payments due pursuant to this Section 9.3(c) during the period beginning on the First Commercial Sale of such [***] Licensed Product in such country and ending upon the later of: (i) the tenth (10^th) anniversary of the date of the First Commercial Sale of such [***]

Licensed Product in such country; (ii) the expiration of the last Valid Claim that Covers such [***] Licensed Product in such country; and (iii) the expiration of all Regulatory Exclusivities for such [***] Licensed Product in such country (“[***] Royalty Term”).

(A)No Valid Claim. On an [***] Licensed Product-by-[***] Licensed Product and country-by-country basis, the applicable royalty rate set forth in Section 9.3(c)(i) as applied to Net Sales of such [***] Licensed Product in such country shall be reduced by [***] during any Calendar Quarter of the [***] Royalty Term in which there is not at least one (1) Valid Claim that Covers such [***] Licensed Product, and all Regulatory Exclusivities for such [***] Licensed Product have expired, in such country, subject to Section 9.3(c)(iii)(D).

(B)Generic Drug or Biosimilar Product. If during any Calendar Quarter during the [***] Royalty Term, on an [***] Licensed Product-by-[***] Licensed Product and country-by-country basis, the aggregate number of units of Generic Drug or Biosimilar Products with respect to such [***] Licensed Product sold during such Calendar Quarter in such country, in the market segment in which such [***] Licensed Product competes in such country, equals or exceeds [***] of the aggregate units of the sum of all such Generic Drug or Biosimilar Products and such [***] Licensed Product sold in such Calendar Quarter in such country (as determined by data obtained from a mutually agreed upon Third Party source), then the applicable royalty rate set forth in Section 9.3(c)(i) as applied to Net Sales of such [***] Licensed Product in such country shall be reduced by [***] for such Calendar Quarter, subject to Section 9.3(c)(iii)(D).

(C)Third Party In-License Payments. On an [***] Licensed Product-by-[***] Licensed Product and country-by-country basis, if Acadia, its Affiliates or Sublicensees obtain a license or similar rights to Patent Rights of a Third Party or Third Parties in order to Develop, Manufacture or Commercialize such [***] Licensed Product in such country the during any Calendar Quarter during the Royalty Term for such [***] Licensed Product (“[***] Third Party License(s)”), then, subject to Section 9.3(c)(iii)(D), then, subject to Section 9.3(c)(iii)(D), Acadia shall have the right to credit [***] of the royalties payable under such [***] Third Party License(s) with respect units of [***] Licensed Product against royalties payable hereunder with respect to the same units of [***] Licensed Product.

(D)Royalty Floor. The reductions of Sections 9.3(c)(iii)(A), 9.3(c)(iii)(B) and 9.3(c)(iii)(C) are cumulative, provided that in no event shall the royalty rate applicable to Net Sales of the [***] Licensed Product during any Calendar Quarter in the Royalty Term in a country fall below a rate that is [***] of the royalty rate otherwise payable pursuant to Section 9.3(c)(i). Acadia may carry forward any such reductions permitted in accordance with Section 9.3(c)(iii)(A), Section 9.3(c)(iii)(B) and Section 9.3(c)(iii)(C) that are incurred or accrued in a Calendar Quarter but that are not applied against royalties due to Stoke for such [***] Licensed Product in such country in such Calendar Quarter as a result of the foregoing floor and apply such amounts against royalties due to Stoke for such [***] Licensed Product in such country in any subsequent Calendar Quarter (subject to the minimum floor set forth in this Section 9.3(c)(iii)(D)) until the amount of such reduction has been fully applied against royalties due to Stoke for such [***] Licensed Product in such country.

(a)Development Milestones for SYNGAP1 Co-Co Products and SYNGAP1 Opt-Out Products. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, following the first achievement by either Party (or its Affiliate or Sublicensee) of each Development Milestone Event set forth in the table below by a first SYNGAP1 Co-Co Product or SYNGAP1 Opt-Out Product, Acadia shall make the corresponding one-time, non-refundable, non-creditable Development Milestone Payment to Stoke, which payment amount shall be reduced by [***] if such achievement is by a SYNGAP1 Opt-Out Product, in accordance with Section 9.7(a).

Each of the foregoing Development Milestone Payments in this Section 9.4(a) shall be payable a maximum of one (1) time with respect to all SYNGAP1 Co-Co Products and SYNGAP1 Opt-Out Products regardless of the number of times the applicable Development Milestone Event was achieved by such SYNGAP1 Co-Co Products or such SYNGAP1 Opt-Out Products. [***]. Solely by way of first example, if [***]. Solely by way of second example, if [***]. For the avoidance of doubt, the maximum amount payable by Acadia pursuant to this Section 9.4(a) is [***] with respect to all SYNGAP1 Co-Co Products.

(b)Sales Milestones for SYNGAP1 Co-Co Products and SYNGAP1 Opt-Out Products. In further consideration for the licenses and other rights granted to Acadia herein by Stoke, with respect to each SYNGAP1 Co-Co Product and each SYNGAP1 Opt-Out Product, following the first achievement by Acadia of each Sales Milestone Event set forth in the table below by such SYNGAP1 Co-Co Product or SYNGAP1 Opt-Out Product, Acadia shall make the corresponding one-time, non-refundable, non-creditable Sales Milestone Payment to Stoke, which payment amount shall be reduced by [***] if such achievement is by a SYNGAP1 Opt-Out Product, in accordance with Section 9.7(b).

Each of the foregoing Sales Milestone Payments in this Section 9.4(b) shall be payable a maximum of one (1) time with respect to each SYNGAP1 Co-Co Product and each SYNGAP1 Opt-Out Product, regardless of the number of times the applicable Sales Milestone Event was achieved by

such SYNGAP1 Co-Co Product or SYNGAP1 Opt-Out Product. For the avoidance of doubt, the maximum total amount payable under this Section 9.4(b) shall not exceed [***] with respect to a SYNGAP1 Co-Co Product. If more than one Sales Milestone Event is achieved in the same Calendar Year with respect to a SYNGAP1 Co-Co Product or SYNGAP1 Opt-Out Product, Acadia shall pay Stoke all Sales Milestone Payments for such Sales Milestone Events achieved in such Calendar Year in accordance with this Section 9.4(b).

(a)Royalty Rates. In further consideration for the licenses and other rights granted to the Primary Party herein by the Opt-Out Party, subject to the remainder of this Section 9.5(a), the Primary Party shall make quarterly non-refundable, non-creditable royalty payments to the Opt-Out Party on the aggregate Net Sales, on a SYNGAP1 Opt-Out Product-by-SYNGAP1 Opt-Out Product basis, sold in the Territory in a given Calendar Year, calculated by multiplying the applicable royalty rate set forth below by such Net Sales. The applicable royalty rates set forth in the table below will apply only to that portion of the Net Sales during a given Calendar Year that falls within the indicated range. Net Sales of each SYNGAP1 Opt-Out Product throughout the Territory will be aggregated for purposes of determining the royalty tiers and royalties, provided that if no royalty is payable on a given unit of SYNGAP1 Opt-Out Product (i.e., following the expiration of the SYNGAP1 Royalty Term for such SYNGAP1 Opt-Out Product in a given country), then the Net Sales of such unit of SYNGAP1 Opt-Out Product shall not be included in Net Sales for purposes of determining the royalty tiers and royalties due hereunder. All royalty payments, and associated reports, shall be made in accordance with Section 9.7(c).

(i)For each SYNGAP1 Opt-Out Product, if the Opt-Out Party provided a Development Opt-Out Notice on or after the Initiation of the first Phase I/II Clinical Trial for such SYNGAP1 Co-Co Product, and prior to the Initiation of the first Phase III Clinical Trial for such SYNGAP1 Co-Co Product:

(ii)For each SYNGAP1 Opt-Out Product, if the Opt-Out Party provided a Development Opt-Out Notice after the Initiation of the first Phase III Clinical Trial for such SYNGAP1 Co-Co Product and on or within [***] after the delivery of top line results from the first Phase III Clinical Trial of such SYNGAP1 Co-Co Product (meaning, the audited, quality-controlled tables, listings and figures, in reasonable and customary form, reflecting all results from such Clinical Trial) to the JSC:

(iii)For each SYNGAP1 Opt-Out Product after Stoke exercises a Commercialization Opt-Out:

(b)SYNGAP1 Royalty Term. Net Sales of a given SYNGAP1 Opt-Out Product in a given country shall only be included in aggregate Net Sales throughout the Territory for purposes of determining the royalty tiers and royalty payments due pursuant to this Section 9.5(b) during the period beginning on the First Commercial Sale of such SYNGAP1 Opt-Out Product in such country and ending upon the later of: (i) the tenth (10^th) anniversary of the date of the First Commercial Sale of such SYNGAP1 Opt-Out Product in such country; (ii) the expiration of the last Valid Claim that Covers such SYNGAP1 Opt-Out Product in such country; and (iii) the expiration of all Regulatory Exclusivities for such SYNGAP1 Opt-Out Product in such country (“SYNGAP1 Royalty Term”).

(i)No Valid Claim . On an SYNGAP1 Opt-Out Product-by-SYNGAP1 Opt-Out Product and country-by-country basis, the applicable royalty rate set forth in Section 9.5(a) as applied to Net Sales of such SYNGAP1 Opt-Out Product in such country shall be reduced by [***] during any Calendar Quarter of the SYNGAP1 Royalty Term in which there is not at least one (1) Valid Claim that Covers such SYNGAP1 Opt-Out Product, and all Regulatory Exclusivities for such SYNGAP1 Opt-Out Product have expired, in such country, subject to Section 9.5(c)(iv).

(ii)Generic Drug or Biosimilar Product. If during any Calendar Quarter during the SYNGAP1 Royalty Term, on an SYNGAP1 Opt-Out Product-by-SYNGAP1 Opt-Out Product and country-by-country basis, the aggregate number of units of Generic Drug or Biosimilar Products with respect to such SYNGAP1 Opt-Out Product sold during such Calendar Quarter in such country, in the market segment in which such SYNGAP1 Opt-Out Product competes in such country, equals or exceeds [***] of the aggregate units of the sum of all such Generic Drug or Biosimilar Products and such SYNGAP1 Opt-Out Product sold in such Calendar

Quarter in such country (as determined by data obtained from a mutually agreed upon Third Party source), then the applicable royalty rate set forth in Section 9.5(a) as applied to Net Sales of such SYNGAP1 Opt-Out Product in such country shall be reduced by [***] for such Calendar Quarter, subject to Section 9.5(c)(iv).

(iii)Third Party In-License Payments . On an SYNGAP1 Opt-Out Product-by-SYNGAP1 Opt-Out Product and country-by-country basis, if it is necessary for the Primary Party, its Affiliates or Sublicensees to maintain or obtain a license or similar rights to Patent Rights of a Third Party or Third Parties in order to Develop, Manufacture or Commercialize such SYNGAP1 Opt-Out Product in such country during any Calendar Quarter during the Royalty Term for such SYNGAP1 Opt-Out Product (“SYNGAP1 Third Party License(s)”), then, subject to Section 9.5(c)(iv), the Primary Party shall have the right to credit [***] of the royalties payable under such SYNGAP1 Third Party License(s) with respect units of SYNGAP1 Opt-Out Product against royalties payable hereunder with respect to the same units of SYNGAP1 Opt-Out Product. If Acadia exercises its right to terminate pursuant to Section 15.2, the foregoing credit mechanism shall not apply to payments made under any Stoke Existing In-License.

(iv)Royalty Floor. The reductions of Sections 9.5(c)(i), 9.5(c)(ii) and 9.5(c)(iii) are cumulative, provided that in no event shall the royalty rate applicable to Net Sales of the SYNGAP1 Opt-Out Product during any Calendar Quarter in the SYNGAP1 Royalty Term in a country fall below a rate that is [***] of the royalty rate otherwise payable pursuant to Section 9.5(a) during any Calendar Quarter during the Royalty Term during which the Opt-Out Party is obligated to pay royalties under the Stoke Existing In-License agreements, as applicable with respect to the Opt-Out Party and with respect to such SYNGAP1 Opt-Out Product. The Primary Party may carry forward any such reductions permitted in accordance with Section 9.5(c)(i), Section 9.5(c)(ii) and 9.5(c)(iii) that are incurred or accrued in a Calendar Quarter but that are not applied against royalties due to the Opt-Out Party for such SYNGAP1 Opt-Out Product in such country in such Calendar Quarter as a result of the foregoing floor and apply such amounts against royalties due to the Opt-Out Party for such SYNGAP1 Opt-Out Product in such country in any subsequent Calendar Quarter (subject to the minimum floor set forth in this Section 9.5(c)(iv)) until the amount of such reduction has been fully applied against royalties due to the Opt-Out Party for such SYNGAP1 Opt-Out Product in such country.

(a)Generally. With respect to each SYNGAP1 Co-Co Product, (i) on a worldwide basis, the Parties shall share all Development Costs on the basis of fifty percent (50%) to Acadia and fifty percent (50%) to Stoke; (ii) on a worldwide basis, the Parties shall share all Commercialization Costs on the basis of fifty percent (50%) to Acadia and fifty percent (50%) to Stoke; (iii) on a worldwide basis, the Parties shall share all Other Expenses on the basis of fifty percent (50%) to Acadia and fifty percent (50%) to Stoke, and (iv) on a worldwide basis, the Parties shall share SYNGAP1 Co-Co Product Net Revenues, in each case, received pursuant to this Agreement for such SYNGAP1 Co-Co Product, on the basis of fifty percent (50%) to Acadia and fifty percent (50%) to Stoke, in each case ((i), (ii), (iii), and (iv)), which shall be paid as set forth in Section 9.6(b). Notwithstanding the financial definitions herein, the Parties acknowledge and agree that no single item of cost or expense, and no revenue, shall be included or deducted more than one time in the calculation of Development Costs, Commercialization Costs, Other Expenses,

Manufacturing Costs or SYNGAP1 Co-Co Product Net Sales or Sublicensee Revenues, if inclusion therein would result in a duplication or double-counting of the same cost or expense or the same revenue.

(b)Calculation and Payment of Shared Costs and Revenues. During the Term, the following shall apply:

(i)Within [***] after the end of each Calendar Quarter, each Party shall provide to the other Party and the financial managers, in a format to be mutually agreed by the financial managers, (A) an interim activity-based statement of its (and its Affiliates’) Development Costs and Other Expenses, including an itemized breakdown of the calculation of each element (including Internal Costs, External Costs, Manufacturing Costs and Third Party Co-Co In-License Payments) included in the Development Costs (each, an “Interim Development Cost Report”) and (B) an interim activity-based statement of its (and its Affiliates) Commercialization Costs (each, an “Interim Commercialization Cost Report” and, together with the corresponding Interim Development Cost Report, the “Interim Cost Reports”), including an itemized breakdown of the calculation of each element of the Commercialization Costs (including Internal Costs, Manufacturing Costs and Third Party Co-Co In-License Payments), in each case of (A) and (B), to the extent incurred in such Calendar Quarter (or a good faith estimate of any portions thereof where actuals are not known as of such time and, to the extent possible, determine if the actuals are projected to be within [***] of such estimated amounts). The Interim Costs Reports shall be in a format to be agreed upon by the financial managers. To the extent that any such Development Costs, Other Expenses or Commercialization Costs reported pursuant to this Section 9.6(b)(i) were estimated, the relevant Party shall provide actual cost information in the Development Cost Report, or the Commercialization Cost Report, as applicable, pursuant to Section 9.6(b)(ii) below.

(ii)Within [***] after the end of each Calendar Quarter, each Party shall provide to the other Party and the financial managers, in a format to be mutually agreed by the financial managers, (A) a detailed, activity-based statement of its (and its Affiliates’) Development Costs and Other Expenses, including an itemized breakdown of the calculation of each element (including Internal Costs, Manufacturing Costs and Third Party Co-Co In-License Payments) included in the Development Costs (each, a “Development Cost Report”) and (B) a detailed, activity-based statement of its (and its Affiliates) Commercialization Costs (each, a “Commercialization Cost Report” and, together with the corresponding Development Cost Report, the “Cost Reports ”), including an itemized breakdown of the calculation of each element of the Commercialization Costs (including Internal Costs, External Costs, Manufacturing Costs and Third Party Co-Co In-License Payments), in each case of (A) and (B), to the extent incurred in such Calendar Quarter (or a good faith estimate of any portions thereof where actuals are not known as of such time and, to the extent possible, determine if the actuals are projected to be within [***] of such estimated amounts). The Costs Reports shall be in a format to be agreed upon by the financial managers. To the extent that any such Development Costs, Other Expenses or Commercialization Costs reported pursuant to this Section 9.6(b)(ii) were estimated, the relevant Party shall provide actual cost information with the next Calendar Quarter’s quarterly Development Cost Report, or Commercialization Cost Report, as applicable, and the provisions of Section 9.6(b)(iii) shall apply to properly allocate between the Parties any amount by which such actual costs exceeded or were less than the estimated costs. For clarity, Development Costs, Other Expenses and Commercialization Costs for each Calendar Quarter may include accruals/estimates,

and those accruals/estimates will be trued up to actual costs each Calendar Quarter as part of the cost reporting for the following Calendar Quarter.

(iii)Within [***] after the end of each Calendar Quarter, the financial managers shall provide to Acadia, Stoke and the JSC a written report (each, a “Cost Reconciliation Report”) setting forth, in a format to be mutually agreed by the financial managers, the calculations of (A) the Development Costs and Other Expenses, and each Party’s share of such Development Costs and Other Expenses, and (B) the Commercialization Costs and each Party’s share of such Commercialization Costs. Such Cost Reconciliation Report shall include for such Calendar Quarter, the (1) total Development Costs, total Other Expenses and total Commercialization Costs incurred by each Party, and each Party’s respective proportionate share thereof, and (2) the net payment due from one Party to the other Party in accordance with Section 9.6(a). Each Party shall promptly, following receipt of each Cost Reconciliation Report, issue an invoice to the other Party for any such net payment due to such Party from such other Party in accordance with Section 9.6(a). Any net payment owed from one Party to the other Party shall be paid within [***] following receipt of such invoice; provided that if a Party disputes an amount provided in such Cost Reconciliation Report, then such disputed amount shall be reviewed by the JSC provided, however, that in the event that the JSC is unable to resolve the issue, then notwithstanding Section 3.7, either Party shall have the right to have an independent auditor examine the applicable records in order to resolve such issue pursuant to Section 9.8, which determination shall be binding on the Parties absent manifest error, and any net payment owed with respect to the undisputed amounts shall be paid within such [***] period (and the disputed amount, if determined to be owed, shall be paid within [***] of resolution of the dispute). If requested by Acadia or Stoke, any invoices or other supporting documentation for any payments to a Third Party that individually exceed [***] shall be promptly provided.

(iv)Within [***] after the end of each Calendar Quarter, each Party shall provide to the other Party and the financial managers, in a format to be mutually agreed by the financial managers, (A) an interim statement of its (and each of its Affiliate’s) SYNGAP1 Co-Co Product Net Revenues with respect to the applicable SYNGAP1 Co-Co Product for the Territory (including the calculation thereof, including a breakdown of SYNGAP1 Co-Co Product Net Revenues (and the calculation thereof)) and (B) an interim statement of Sublicensee Revenues for such Calendar Quarter with respect to the applicable SYNGAP1 Co-Co Product for the Territory, in each case (A) and (B), the interim statement may include a good faith estimate of any portions thereof where actual revenues are not known as of such time and, to the extent possible, determine if the actual revenues are projected to be within [***] of such estimated amounts, as well as details of any adjustments to be made to the amounts submitted in the previous Calendar Quarter in the previous Revenue Report or Revenue Reconciliation Report (each, an “Interim Revenue Report”). The Interim Revenue Report shall be in a format to be agreed upon by the financial managers.

(v)Within [***] after the end of each Calendar Quarter, each Party shall provide to the other Party and the financial managers, in a format to be mutually agreed by the financial managers, (A) a detailed statement of its (and each of its Affiliate’s) SYNGAP1 Co-Co Product Net Revenues with respect to the applicable SYNGAP1 Co-Co Product for the Territory (including the calculation thereof, including a breakdown of SYNGAP1 Co-Co Product Net Revenues (and the calculation thereof)) and (B) a detailed statement of Sublicensee Revenues for

such Calendar Quarter with respect to the applicable SYNGAP1 Co-Co Product for the Territory, as well as details of any adjustments to be made to the amounts submitted in the previous Calendar Quarter in the Interim Revenue Report (each, a “Revenue Report”). The Revenue Report shall be in a format to be agreed upon by the financial managers.

(vi)Within [***] after the end of each Calendar Quarter, the financial managers shall provide to Acadia, Stoke and the JSC a written report (each, a “Revenue Reconciliation Report ”) setting forth, in a format to be mutually agreed by the financial managers prior to the First Commercial Sale of the SYNGAP1 Co-Co Product in the Territory, (A) the total SYNGAP1 Co-Co Product Net Sales and Sublicensee Revenues for the applicable SYNGAP1 Co-Co Product for the Territory, the amount of SYNGAP1 Co-Co Product Net Sales and Sublicensee Revenues for the applicable SYNGAP1 Co-Co Product for the Territory recognized by each Party, and each Party’s share of such SYNGAP1 Co-Co Product Net Sales and Sublicensee Revenues for the applicable SYNGAP1 Co-Co Product for the Territory, and (B) the net payment due from one Party to the other Party in accordance with Section 9.6(a). Each Party shall promptly, following receipt of each Revenue Reconciliation Report, issue an invoice to the other Party for any such net payment due to such Party from such other Party in accordance with Section 9.6(a). Any net payment owed from one Party to the other Party shall be paid within [***] following receipt of such invoice; provided that if a Party disputes an amount provided in such Revenue Reconciliation Report, then such disputed amount shall be reviewed by the JSC (provided, however, that in the event that the JSC is unable to resolve the issue, then notwithstanding Section 3.7(a), either Party shall have the right to have an independent auditor examine the applicable records in order to resolve such issue pursuant to Section 9.8, which determination shall be binding on the Parties absent manifest error), and any net payment owed with respect to the undisputed amounts shall be paid within such [***] period (and the disputed amount, if determined to be owed, shall be paid within [***] of resolution of the dispute).

(vii)All costs and expenses and revenues pursuant to this Section 9.6 shall be recorded and reported consistent with U.S. GAAP, consistently applied, and shall be reported in Dollars (with currency conversions as set forth in Section 9.7(d)).

(viii)The financial managers may determine to consolidate the Cost Reconciliation Report and Revenue Reconciliation Report in order to result in one net payment by the applicable Party. In addition, if agreed to by the Parties (such agreement not to be unreasonably withheld, conditioned or delayed), the Parties shall have the right to reconcile amounts within the Cost Reconciliation Report and Revenue Reconciliation Report at the local country level, on a case-by-case basis; provided that any such amounts shall not also be counted in Section 9.6(a) in order to avoid duplication.

(ix)The Parties acknowledge and agree that the Manufacturing Costs and FTE Rate represent fair market value for the provision of the applicable services for which such amounts are paid and represent arms’-length negotiated amounts. The FTE Rate shall be reviewed annually by the Parties and may be adjusted by mutual written agreement of the Parties to the extent the Parties mutually determine that an adjustment is necessary to comply with the arm’s-length standard under Applicable Law.

(x)Notwithstanding anything to the contrary set forth herein, (A) when calculating the Parties’ Commercialization Costs, Development Costs and Other Expenses, any amount of, or in respect of, recoverable VAT incurred by each Party (or its Affiliates) in respect of any item of expenditure or cost that forms a component of such calculations shall be excluded and (B) when calculating SYNGAP1 Co-Co Product Net Sales and Sublicensee Revenues , any amount of, or in respect of, VAT in respect of any item of revenue that forms a component of such calculations shall be excluded.

(xi)Each Party shall consider in good faith other reasonable procedures proposed by the other Party for sharing applicable financial information hereunder in order to permit each Party to close its books periodically in a timely manner.

(c)Costs other than Allowable Costs . For the avoidance of doubt, except as provided in connection with the SYNGAP1 Research Costs , each Party shall be solely responsible for any costs and expenses (including any payments arising under any agreements between such Party (or its Affiliates) and Third Party licensors, including such payments arising from the grant of rights to, or exercise of rights by, the other Party (or any of its Affiliates or sublicensees) hereunder) incurred by it (or its Affiliate) in connection with the Development, Manufacture or Commercialization of a SYNGAP1 Co-Co Product, other than such costs and expenses that are included in the Development Costs, Other Expenses or Commercialization Cost as set forth in this Agreement (which shall be shared by the Parties as set forth in this Section 9.6(c)).

(a)Development Milestone Payments. Acadia shall provide Stoke with written notice of the achievement of each Development Milestone Event within [***] thereafter (with the except of [***]). Following receipt of such notification, Stoke shall invoice Acadia for the amount of the applicable Development Milestone Payment, and Acadia shall make the corresponding Development Milestone Payment within [***] after receipt of such invoice.

(b)Sales Milestone Payments. Following the First Commercial Sale of a Product, within [***] of the end of each Calendar Year, Acadia shall notify Stoke of each Sales Milestone Event achieved with respect to such Calendar Year. Following receipt of such notification, Stoke shall invoice Acadia for the amount of the applicable Sales Milestone Payment(s), and Acadia shall make the corresponding Sales Milestone Payment(s) within [***] after receipt of such invoice.

(c)Royalty Payments. During the Term, with respect to each Licensed Product, following the First Commercial Sale of such Licensed Product, Acadia shall furnish to Stoke a written report for each Calendar Quarter showing the Net Sales of such Licensed Product in the Territory during the reporting Calendar Quarter and the royalties payable under this Agreement pursuant to Section 9.2(c), Section 9.3(c) or Section 9.4 in sufficient detail to allow Stoke to verify the amount of royalties paid by Acadia with respect to such Calendar Quarter. Each such report for a Licensed Product shall include, on a country-by-country basis, the total gross amount invoiced for the Licensed Product sold, the Net Sales of the Licensed Product, and the total royalties (in USD) payable for the Licensed Product. Reports shall be due no later than [***] following the end of each Calendar Quarter. The corresponding royalties shown to have accrued

by each report provided under this Section 9.7(c) shall be due and payable on the date such report is due.

(d)Payment Currency; Exchange Rate; No Offset. All payments to be made under this Agreement shall be made in Dollars. Payments to a Party shall be made by electronic wire transfer of immediately available funds to the account of the other Party, as designated in writing to the paying Party. If any currency conversion is required in connection with the calculation of amounts payable hereunder, such conversion shall be made using a rate of exchange at the average actual foreign currency exchange rate for the month in which the expense is incurred or sale made according to the exchange rates utilized by the applicable Party in its own internal accounting system, consistently applied. Unless otherwise agreed to by the Parties, neither Party shall have the right to offset any payment that is owed by the other Party but not paid against any payments owed by such Party, if any, under this Agreement.

(e)Late Payments. Any undisputed payments or portions thereof due hereunder that are not paid on the date such payments are due under this Agreement shall bear interest at a rate equal to the lesser of: (i) [***] the prime rate as published by The Wall Street Journal or any successor thereto on the first day of each Calendar Quarter in which such payments are overdue or (ii) the maximum rate permitted by Applicable Law ; in each case calculated on the number of days such payment is delinquent (provided that if the payment is disputed, such interest shall be calculated from the time that the dispute is resolved), compounded monthly.

(f)Blocked Currency. If by Applicable Laws in a country or jurisdiction in the Territory conversion into Dollars or transfer of funds of a convertible currency to the United States becomes materially restricted, forbidden or substantially delayed, then Acadia shall promptly notify Stoke and, thereafter, amounts accrued in such country or jurisdiction shall be paid to Stoke (or its designee) in such country or jurisdiction in local currency by deposit in a local bank designated by Stoke and to the credit of Stoke, unless the Parties otherwise agree.

9.8Records and Audit Rights. Each Party shall keep complete, true and accurate books of account and records for the purpose of determining the amounts payable under this Agreement. Such books and records shall be kept at the principal place of business of each Party, as the case may be, for at least [***] (or such longer period as required by applicable Law) following the end of the Calendar Year to which they pertain. Each Party (the “Audited Party ”) shall make such account and records available, on reasonable notice sent by the other Party (the “Auditing Party”), for inspection during normal business hours, with not less than [***] advance written notice, by an independent certified public accounting firm nominated by such and reasonably acceptable for the Audited Party, for the purpose of verifying the accuracy of any statement or report given by the Audited Party and to verify the accuracy of the payments due hereunder for any Calendar Year. Such auditor shall advise the Parties simultaneously promptly upon its completion of its audit whether or not the payments due hereunder have been accurately recorded, calculated, and reported, and, if not, the amount of such discrepancy. Except in the case of willful misconduct or fraud, (a) a Party’s financial records with respect to a given period of time shall only be subject to one (1) audit per Calendar Year, and (b) the Auditing Party’s right to perform an audit pertaining to any Calendar Year shall expire [***] after the end of such Calendar Year. The auditor shall be required to keep confidential all information learned during any such inspection, and to disclose to the Auditing Party only such details as may be necessary to report

the accuracy of the Audited Party’s statement or report. The Auditing Party shall be responsible for the auditor’s costs, unless the auditor certifies that an overpayment to, or an underpayment by, the Audited Party that resulted from a discrepancy in a report that the Audited Party provided to the Auditing Party during the applicable audit period, which underpayment or overpayment was more than [***] of the amount set forth in such report or [***], whichever is greater, in which case the Audited Party shall bear the full cost of such audit. If such accounting firm correctly identifies a discrepancy made during such period, any unpaid amounts or overpaid amounts that are discovered shall be paid/refunded promptly but in any event within [***] of the date of delivery of such accounting firm’s written report so correctly concluding, or as otherwise agreed upon by the Parties. The Auditing Party shall treat all financial information subject to review under this Section 9.8 in accordance with the confidentiality and non-use provisions of Article 10 , and shall cause its accounting firm to enter into an acceptable confidentiality agreement with the Audited Party obligating it to retain all such information in confidence pursuant to such confidentiality agreement. Upon the expiration of [***] following the end of any Calendar Year, royalty calculations and joint Development Cost sharing calculations with respect to such Calendar Year shall be binding and conclusive upon both parties. Unless an audit is ongoing with respect to such period, the Parties shall be released from any liability or accountability with respect to said calculations for such Calendar Year.

(a)VAT. Any consideration due under this Agreement is exclusive of VAT. If any VAT will be chargeable on any of the transactions contemplated under this Agreement and is payable to the respective tax authority by the Party making the supply or providing the service for VAT purposes, upon receipt of a valid invoice in accordance with the applicable VAT law from the supplying or service providing Party, the other Party shall pay such VAT in addition to the consideration otherwise due.

(b)Withholding Taxes. Any Party (the “Paying Party”) required to make a payment pursuant to this Agreement to the other Party (the “Payee”) shall be entitled to deduct or withhold from the amount payable the tax for which the Paying Party is liable to deduct or withhold under any provisions of applicable tax law. If any Paying Party determines that applicable tax laws require withholding of any taxes, such Paying Party shall immediately notify the Payee in writing of the potential for withholding of taxes and cooperate with such Payee in good faith before undertaking any such withholding of taxes so as to reduce or eliminate any potential obligation for such withholding of taxes to the greatest extent possible, including with respect to obtaining the benefit of any present or future treaty against double taxation or refund or reduction in such taxes. Without limiting the foregoing, each Paying Party shall make any such required withholding payments in a timely manner and shall subtract the amount thereof from the payments made to Payee. Such Paying Party shall promptly (as available) submit to the Payee appropriate proof of payment of the taxes as well as the official receipts within a reasonable period of time. Notwithstanding the foregoing, if any Paying Party assigns this Agreement or changes its domicile, and, as a result, any additional taxes are required to be withheld with respect to payments made to Payee, such Paying Party shall be responsible for all such additional withholding taxes and shall pay the Payee such increased amounts as are necessary to ensure that such Payee receives the same amount as it would have received had no such assignment or change in domicile been made.

(c)Tax Cooperation. Each Party shall provide the other with reasonable assistance to enable the recovery, as permitted by Applicable Law, of withholding taxes, VAT or similar obligations resulting from payments made under this Agreement, such recovery to be for the benefit of the Party bearing such withholding tax or VAT.

10.1Confidential Information. For purposes of this Agreement, “Confidential Information” of a Party means all proprietary or confidential Know-How or other scientific, marketing, financial or commercial information and materials, whether or not patentable and in any form (written, oral, photographic, electronic, magnetic, or otherwise), including information or materials of Third Parties, that one Party or any of its Affiliates discloses or otherwise makes available to the other Party or its Affiliates pursuant to this Agreement. The terms and conditions of this Agreement shall be the Confidential Information of both Parties.

10.2Duty of Confidence; Exceptions. E ach Party agrees that, during the Term and for a period of [***] thereafter, it shall keep confidential and shall not publish or otherwise disclose and shall not use for any purpose other than as provided for in this Agreement (including for the exercise of the rights and licenses granted to such Party hereunder, but it being understood that this parenthetical itself shall not create or imply any rights or licenses not expressly granted under this Agreement) any Confidential Information of the other Party, except to the extent expressly agreed in writing by the other Party. The foregoing confidentiality and non-use obligations shall not apply to any portion of the disclosing Party’s Confidential Information that the receiving Party can demonstrate by competent written proof:

(a)was in the lawful knowledge and possession of the receiving Party prior to the time it was disclosed to the receiving Party, or was otherwise developed independently by or for the receiving Party without use of or reference to the disclosing Party’s Confidential Information, as evidenced by written records kept in the ordinary course of business, or other documentary proof of actual use by the receiving Party;

(b)was generally available to the public or otherwise part of the public domain at the time of its disclosure to the receiving Party;

(c)became generally available to the public or otherwise part of the public domain after its disclosure and other than through any act or omission of the receiving Party in breach of this Agreement; or

(d)was disclosed to the receiving Party, other than under an obligation of confidentiality, by a Third Party who, to the knowledge of the receiving Party, had no obligation to the disclosing Party not to disclose such information to others.

Any combination of features or disclosures shall not be deemed to fall within the foregoing exclusions merely because individual features are published or available to the general public or in the rightful possession of the receiving Party unless the combination itself and principle of operation are published or available to the general public or in the rightful possession of the receiving Party.

10.3Authorized Disclosures. Notwithstanding Section 10.2, a Party may disclose Confidential Information belonging to the other Party if and to the extent such disclosure is reasonably necessary in the following instances:

(a)filing, prosecuting, maintaining or listing Patent Rights in accordance Article 14;

(b)filing, prosecuting, or maintaining Regulatory Materials and Regulatory Approvals for the Products as permitted by this Agreement;

(e)to actual or potential acquirors , investment bankers, investors, lenders, or other similar sources of financing solely for the purpose of evaluating or carrying out an actual or potential investment, or acquisition, in each case under a written agreement containing obligations of confidentiality and non-use at least as stringent as those herein; provided that the receiving Party will be liable for any breaches of its obligations of confidentiality and non-use hereunder by any of its actual or potential acquirors , investment bankers, investors, lenders, or other financial partners; and

(f)to its and its Affiliates’ employees, consultants, advisors (including accountants and attorneys), contractors, agents, collaborators and Sublicensees, in each case on a need-to-know basis to exercise its rights or perform its obligations in accordance with the terms of this Agreement, and in each case under a written agreement containing obligations of confidentiality and non-use at least as stringent as those herein (or without such agreement for recipients that are financial or legal advisors under a professional code of conduct giving rise to an obligation of confidentiality and non-use at least as restrictive as those set forth in this Agreement), provided that the receiving Party will be liable for any breaches of its obligations of confidentiality and non-use hereunder by any of its or its Affiliates’ employees, consultants, advisors (including accountants and attorneys), contractors, agents, collaborators and Sublicensees.

Notwithstanding the foregoing, in the event that a Party is required to make a disclosure of the other Party’s Confidential Information pursuant to Section 10.3(c)-(d), it will, except where impracticable, promptly inform the other Party of the disclosure that is being sought in order to provide the other Party an opportunity to challenge or limit the disclosure obligations, and, if requested by the other Party, cooperate in all reasonable respects with the other Party’s efforts to obtain confidential treatment or a protective order with respect to any such disclosure, at the other Party’s expense. In any such event, each Party agrees to take all reasonable action to minimize disclosure of the other Party’s Confidential Information. Any information disclosed pursuant to this Section 10.3 shall remain, subject to Section 10.2, the Confidential Information of the disclosing Party and subject to the restrictions set forth in this Agreement, including the foregoing provisions of this Article 10.

(a)SYNGAP1 Co-Co Products. The Parties will jointly develop a global publication strategy for the SYNGAP1 Co-Co Products, including a strategy for the publication of data generated under this Agreement from the conduct of Clinical Trials for SYNGAP1 Co-Co Products.

(b)Other Publications. Subject to Section 11.1(a), the following restrictions shall apply with respect to disclosure by any Party of Confidential Information in any publication or presentation with respect to the Research Programs, Development Programs, Targets, Products or their testing:

(i)both Parties acknowledge that it is their policy for the studies and results thereof to be registered and published in accordance with their internal guidelines; and

(ii)a Party (“Publishing Party”) shall provide the other Party with a copy of any proposed material publication or presentation at least [***] (or [***] in the case of a manuscript) prior to submission for publication so as to provide such other Party with an opportunity to recommend any changes it reasonably believes are necessary to continue to maintain the Confidential Information disclosed by the other Party to the Publishing Party in accordance with the requirements of this Agreement. The incorporation of such recommended changes shall not be unreasonably refused; and if such other Party notifies (“Publishing Notice”) the Publishing Party in writing, within such [***] period (or [***] period in the case of a manuscript) after receipt of the copy of the proposed publication, presentation, or manuscript, that such publication or presentation in its reasonable judgment (i) contains an invention, solely or jointly conceived or reduced to practice by the other Party, for which the other Party reasonably desires to obtain patent protection or (ii) could be expected to have a material adverse effect on the commercial value of any Confidential Information disclosed by the other Party to the Publishing Party, the Publishing Party shall prevent such publication or delay such publication for a mutually agreeable period of time. In the case of inventions, a delay shall be for a period reasonably sufficient to permit the timely preparation and filing of a patent application(s) on such invention, and in no event less than [***] from the date of the Publishing Notice.

(c)Re-Publication. Notwithstanding anything to the contrary in this Section 11.1, the contents of any press release or other publication that has been reviewed and approved by a reviewing Party in accordance with this Section 11.1 may be re-released by such reviewing Party or Publishing Party without a requirement for re-approval.

(a)The Parties have mutually approved a joint press release attached hereto as Schedule 11.2 with respect to this Agreement and either Party may make subsequent public disclosure of the contents of such press release. Each Party agrees not to issue any press release or other public statement, whether oral or written, disclosing the terms hereof or any of the activities conducted hereunder without the prior written consent of the other Party (such consent

not to be unreasonably withheld, conditioned or delayed), except as provided herein. Notwithstanding the foregoing, any disclosure that is required by Applicable Laws (including the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934 , as amended) or the rules of any Securities Regulator or the securities regulations of any other jurisdiction, shall be in accordance with Sections 10.3 and 11.2(b), as applicable. Without limiting the foregoing, each Party agrees to provide to the other Party a copy of any public announcement covered by this Section 11.2(a) as soon as reasonably practicable under the circumstances prior to its scheduled release. In the event that Stoke desires to make a public announcement regarding any payment under Article 9 (or the occurrence of the activity related thereto), Stoke will provide Acadia with no less than [***], or shorter period if required by Applicable Law, in which to review and approve such announcement, such approval not to be unreasonably withheld, conditioned or delayed.

(b)Securities Filings. The Parties hereby acknowledge and agree that either Party may be required by Applicable Laws to submit a copy of this Agreement to the US Securities and Exchange Commission or its foreign equivalent (each, a “Securities Regulator ”). If a Party is required by Applicable Laws to submit a description of the terms of this Agreement to or file a copy of this Agreement with any Securities Regulator, such Party agrees to consult and coordinate with the other Party with respect to such disclosure and, if applicable, the preparation and submission of a confidential treatment request for this Agreement. Notwithstanding the foregoing, if a Party is required by Applicable Laws to submit a description of the terms of this Agreement to or file a copy of this Agreement with any Securities Regulator and such Party has (i) promptly notified the other Party in writing of such requirement and any respective timing constraints, (ii) provided copies of the proposed disclosure or filing to the other Party reasonably in advance of such filing or other disclosure and (iii) given the other Party a reasonable time under the circumstances to comment upon and request confidential treatment for such disclosure, then such Party will have the right to make such disclosure or filing at the time and in the manner reasonably determined by its counsel to be required by Applicable Laws or the applicable Securities Regulator. If a Party seeks to make a disclosure or filing as set forth in this Section 11.2(b) and the other Party provides comments within the respective time periods or constraints specified herein, the Party seeking to make such disclosure or filing will reasonably consider such comments and use good faith efforts to incorporate such comments in the disclosure or filing; provided that prior to making any such filing of this Agreement, the Parties shall reasonably cooperate and use good faith efforts to agree on a redacted form of this Agreement to be so filed.

12.1Mutual Representations and Warranties. Each of Acadia and Stoke represent and warrant, as of the Effective Date, that:

(a)it is duly organized and validly existing under in the Applicable Laws of the jurisdiction of its incorporation or formation, as applicable, has full corporate, limited liability company or other power and authority, as applicable, to enter into this Agreement and to carry out the provisions hereof, and has sufficient facilities, experienced personnel or other capabilities (including via Affiliates or Third Parties) to enable it to perform its obligations under this Agreement;

(b)it is duly authorized to execute and deliver this Agreement and to perform its obligations hereunder, and each individual executing this Agreement on its behalf has been duly authorized to do so by all requisite corporate, limited liability company or other action, as applicable; and

(c)this Agreement is legally binding upon it and enforceable in accordance with its terms (except as the enforceability thereof may be limited by bankruptcy, bank moratorium or similar laws affecting creditors’ rights generally and laws restricting the availability of equitable remedies and may be subject to general principles of equity whether or not such enforceability is considered in a proceeding at law or in equity) and the execution, delivery and performance of this Agreement by it have been duly authorized by all necessary corporate action and do not and shall not: (i) conflict with, or constitute a default or result in a breach under, any agreement , instrument or understanding, oral or written, to which it is a party or by which it may be bound, or violate any Applicable Law; or (ii) require any consent or approval of its stockholders or similar.

12.2Stoke Representations and Warranties. Stoke represents and warrants to Acadia that, as of the Effective Date:

(a)Stoke is the sole and exclusive owner of, or otherwise Controls pursuant to an Stoke Existing In-License, the Stoke MECP2 Technology, Stoke [***] Technology and Stoke SYNGAP1 Technology licensed to Acadia hereunder in the Territory, and the Stoke MECP2 Technology, Stoke [***] Technology and Stoke SYNGAP1 Technology licensed to Acadia hereunder are free and clear of liens, charges or encumbrances other than licenses and rights granted to Third Parties that are not inconsistent with the rights and licenses granted to Acadia under this Agreement;

(b)Neither Stoke or its Affiliates are in breach or default under the Stoke Existing In-License and neither Stoke nor its Affiliates have received any written notice of breach or default with respect to any Stoke Existing In-License. Stoke has met and will continue to meet all of its obligations to the licensor (including payment, diligence and reporting requirements) under the Stoke Existing In-License and will remain in good standing under the Stoke Existing In-License. In addition, Stoke will not amend the Stoke Existing In-License without Acadia’s prior written consent. In the event that Stoke breaches the Stoke Existing In-License, Stoke will promptly notify Acadia of such breach and Acadia may cure such breach on behalf of Stoke, provided that Acadia may offset the costs of curing such breach against the amounts due hereunder. In the event that the Stoke Existing In-License is terminated by Stoke or the upstream licensor, Stoke will fully cooperate and support Acadia’s efforts to obtain a direct license from such upstream licensor.

(c)Stoke has the right, power and authority to grant the rights and licenses granted to Acadia hereunder, has obtained all necessary consents and fulfilled all necessary conditions, if any, to grant the rights and licenses to Acadia hereunder, and neither Stoke nor its Affiliates have granted any rights (or other encumbrances) to any Third Party with respect to the Stoke Patents that would prevent, limit or conflict with the rights and licenses granted to Acadia hereunder;

(d)all Stoke Patents that as of the Effective Date are issued or subject to a pending application for issuance are: (i) to the extent issued, subsisting and not invalid or unenforceable, in whole or in part; (ii) other than any Patent Rights in-licensed to Stoke pursuant to the Stoke Existing In-License as of the Effective Date, solely and exclusively owned by Stoke, free of any encumbrance, lien or claim of ownership by any Third Party; (iii) to the extent subject to a pending application for issuance, being diligently prosecuted in the respective patent offices in which such applications have been filed in accordance with Applicable Laws and, to Stoke’s knowledge, all relevant references, documents and information have been presented to the relevant patent examiner at the relevant patent office; and (iv) to Stoke’s knowledge, filed and maintained properly and correctly, and no applicable fees applicable thereto when due and payable, as may be or have been extended, have gone unpaid;

(e)Stoke has complied with all Applicable Laws, including any duties of candor to applicable patent offices, in connection with the filing, prosecution and maintenance of the Stoke Patents;

(f)Stoke has obtained from each inventor of the Stoke Patents (other than any Patent Rights in-licensed to Stoke pursuant to the Stoke Existing In-License as of the Effective Date) each such inventor’s entire right, title and interest in and to the Stoke Patents and each such agreement is valid and enforceable;

(g)Schedule 1.107 sets forth a true, correct and complete list of all Stoke Existing In-License(s), Schedule 1.110 sets forth a true, correct and complete list of all Stoke MECP2 Patents as of the Effective Date and each such Patent Right is owned solely by Stoke, Schedule 1.113 sets forth a true, correct and complete list of all Stoke [***] Patents as of the Effective Date and each such Patent Right is owned solely by Stoke, and Schedule 1.116 sets forth a true, correct and complete list of all Stoke SYNGAP1 Patents as of the Effective Date and each such Patent Right is owned solely by Stoke or in-licensed by Stoke under the Stoke Existing In-License;

(h)there are no pending or threatened (in writing) adverse actions, suits or proceedings against Stoke involving the Stoke MECP2 Technology, Stoke [***] Technology, or Stoke SYNGAP1 Technology and, to Stoke’s knowledge, there is no reasonable basis for any such action or suit;

(i)the inventions claimed by the Stoke Patents (i) were not conceived, discovered, developed , or otherwise made in connection with any research activities funded, in whole or in part, by the federal government of the United States or any agency thereof and (ii) are not a “subject invention” as that term is described in 35 U.S.C. Section 201(e), and (iii) are not otherwise subject to the provisions of the Patent and Trademark Law Amendments Act of 1980, as amended, codified at 35 U.S.C. §§ 200-212, as amended, as well as any regulations promulgated pursuant thereto, including in 37 C.F.R. part 401;

(j)to Stoke’s knowledge, the Stoke Existing In-License is not applicable to the MECP2 or [***] Programs;

(k)Stoke has not given any written notice to any Third Party asserting infringement by such Third Party of any of the Stoke Patents existing as of the Effective Date and, to Stoke’s knowledge, there is no unauthorized use, infringement or misappropriation of the Stoke Patents; and

(l)Stoke has disclosed to Acadia all safety and regulatory information in Stoke’s or its Affiliates’ possession or control relating to any ASO in Stoke’s or its Affiliates’ possession or control that, to Stoke’s knowledge or reasonable belief, is Directed Against a Target.

(a)Employees, Consultants and Contractors . Each Party represents, warrants and covenants that it and its Affiliates have obtained from each of its and their respective former and current employees, consultants and contractors, and shall obtain from each of its and their respective future employees, consultants and contractors, in each case who have conceived, discovered, invented or created or who may conceive, discover, invent or create any of such Party’s Collaboration Technology, written agreements containing obligations of confidentiality and non-use and an assignment to such Party or its applicable Affiliates of all of such Person’s rights to such Collaboration Technology such that no such employee, contractor or consultant shall retain any rights thereto that would prevent or conflict with the other Party’s rights of ownership, license or use thereof or thereto, as the case may be, contemplated under this Agreement.

(b)Debarment. Each Party represents, warrants and covenants to the other Party that neither it nor its officers, employees, agents, consultants or any other person used by such Party in the performance of the respective research and Development activities under this Agreement is: (a) debarred or disqualified under the U.S. Federal Food, Drug and Cosmetic Act ; (b) listed by any government or regulatory agencies as ineligible to participate in any government healthcare programs or government procurement or non-procurement programs (as that term is defined in 42 U.S.C. § 1320a-7b(f)), or excluded, debarred, suspended or otherwise made ineligible to participate in any such program ; or (c) convicted of a criminal offense related to the provision of healthcare items or services, or is subject to any such pending action. Each Party shall not during the Term knowingly, employ or use, directly or indirectly, including through Affiliates the services of any such person . In the event that either Party becomes aware of the debarment or disqualification or threatened debarment or disqualification of any person providing services to such Party, directly or indirectly, including through Affiliates or Sublicensees, which directly or indirectly relate to activities contemplated under this Agreement, such Party shall promptly notify the other Party in writing and such Party shall cease employing, contracting with, or retaining any such person to perform any such services.

(c)Data Privacy. Each Party shall: (i) comply with all applicable data protection and privacy laws, rules and regulations (including the United States Department of Health and Human Services privacy rules under the Health Insurance Portability and Accountability Act (HIPAA ) and the General Data Protection Regulation (Regulation (EU) 2016/679) (GDPR), as any of the foregoing may be amended from time to time) (“Data Protection Laws”) with respect to the collection, use, transfer, storage, destruction, aggregation or other use of subject health information or other Personal Data (as defined in the applicable Data Protection Laws, collectively, “Personal Data”) in connection with its activities

under or in connection with this Agreement, including the Development and Commercialization of any Licensed Product hereunder, (ii) implement appropriate and reasonable security processes and controls in connection with its activities under or in connection with this Agreement so as to protect the security and privacy of Personal Data in accordance with Data Protection Laws, and (iii) take such steps as necessary to comply with Data Protection Laws to permit such Party to disclose Personal Data to the other Party and to permit the other Party to use and disclose such Personal Data for its own purposes in accordance with this Agreement.

(d)Sunshine Act. Each Party acknowledges that, under the provisions of Section 1128G of the Social Security Act , 42 U.S.C. § 1320a-7h and other similar provisions of Applicable Law, such Party may be required to disclose certain payments and other transfers of value provided to health care professionals and institutions, including payments, reimbursements, materials or equipment made or provided under or in connection with this Agreement or the development plans. Each Party will provide the other Party with all reasonable information in its Control related to the activities hereunder necessary for the other Party to comply with such Applicable Laws in the form reasonably requested by the requesting Party and at such times as the requesting Party may reasonably request to satisfy its obligations.

(e)Statements to Regulatory Authorities. Neither Party shall, with respect to any Development or Commercialization activities conducted hereunder, commit an act, make a statement or fail to act or make a statement, that would be or create an untrue statement of material fact or fraudulent statement to any Regulatory Authority with respect to the exploitation of Products.

(f)Violations; Exclusions Lists. With respect to the activities contemplated under this Agreement , during the Term, neither Party will engage, directly or indirectly, in any transactions, or otherwise deal with, except to the extent permissible under applicable United States law or other Applicable Law, any country or Person targeted by United States or other relevant economic sanctions Applicable Law, including any Person designated on the Specially Designated Nationals List. In addition, each Party agrees that it will not use (and will cause its Affiliates and Third Party contractors not to use) any Person (including any employee, officer, director or Third Party contractor) who is (or has been) on the Exclusions Lists, or who is (or has been) in Violation, in the performance of any activities hereunder. Each Party certifies to the other Party that, as of the Effective Date, it has screened itself, and its officers and directors (and its Affiliates and Third Party contractors (acting in connection with this Agreement) and their respective officers and directors) against the Exclusions Lists and that it has informed the other Party in writing whether it, or any of its officers or directors (or any of its Affiliates or any of their respective officers and directors) has been in Violation. After the Effective Date, each Party will notify the other Party in writing immediately if any such Violation occurs or comes to its attention. For purposes of this Section 12.3(f), “Violation ” means that a Party or any of its officers or directors or any other personnel of such Party (or other permitted agents of such Party performing activities hereunder, including any of such Party’s Affiliates, sublicensees or Third Party contractors and their respective officers and directors) has been: (a) convicted of any of the felonies identified among the exclusion authorities listed on the U.S. Department of Health and Human Services, Office of Inspector General (OIG) website, including 42 U.S.C. § 1320a-7(a) (http://oig.hhs.gov/exclusions/authorities.asp); (b) identified in the OIG List of Excluded Individuals /Entities (LEIE) database (http://exclusions.oig.hhs.gov/) or the U.S. General Services

Administration’s list of Parties Excluded from Federal Programs (http://www.epls.gov); or (c) listed by any U.S. federal agency as being suspended, debarred, excluded or otherwise ineligible to participate in federal procurement or non-procurement programs, including under 21 U.S.C. § 335a (http://www.fda.gov/ora/compliance_ref/debar/) (each of (a), (b) and (c), collectively, the “Exclusions Lists”).

(i)in connection with its activities under or in connection with this Agreement strictly comply with the OECD Anti-Bribery Convention on combating bribery of foreign public officials in international business transactions, the United States Foreign Corrupt Practices Act of 1977 , the United Kingdom Bribery Act 2010 and any other equivalent Applicable Laws in the Territory for the prevention of fraud, corruption, racketeering, money laundering and terrorism, in each case as may be amended from time to time (such Applicable Law, the “Anti-Corruption Laws ”), including such Party’s own internal policies in connection therewith. Each Party shall require any Affiliates, contractors, subcontractors, distributors or other persons or entities that provide services to such Party in connection with this Agreement to comply with such Party’s obligations under this Section;

(ii)not, in the performance of this Agreement, directly or indirectly, make any payment, or offer or transfer anything of value, or agree or promise to make any payment or offer or transfer anything of value, to a Public Official or any other Third Party with the purpose of influencing decisions related to either Party or its business in a manner that would violate Anti-Corruption Laws;

(iii)no later than forty-five (45) days following the end of each Calendar Year, verify in writing that to the best of its knowledge, there have been no violations of Anti-Corruption Laws in the performance of this Agreement or shall provide details of any exception to the foregoing; and

(iv)maintain records (financial and otherwise) and supporting documentation related to the subject matter of this Agreement in order to document or verify compliance with the provisions of this Section 12.3(g) and upon request of the other Party, up to once per year and upon reasonable advance notice, shall provide the other Party or its representative with access to such records for purposes of verifying compliance with the provisions of this Section 12.3(g).

For purposes of this Section 12.3(g), “Public Official ” means (i) any officer, employee or representative of any regional, federal, state, provincial, county or municipal government or government department, agency or other division; (ii) any officer, employee or representative of any commercial enterprise that is owned or controlled by a government, including any state-owned or controlled veterinary, laboratory or medical facility; (iii) any officer, employee or representative of any public international organization, such as the African Union, the International Monetary Fund, the United Nations or the World Bank; and (iv) any person acting in an official capacity for any government or government entity, enterprise or organization identified above.

(h)Compliance Program. In connection with this Agreement, each Party has implemented and agrees to maintain and enforce a compliance and ethics program designed to prevent and detect violations of Applicable Law, including the Federal Food, Drug, and Cosmetic Act (21 U.S.C. § 301 et seq.), the Public Health Service Act (42 U.S.C. § 201 et seq.), the Anti-Kickback Statute (42 U.S.C. § 1320a-7b), Civil Monetary Penalty Statute (42 U.S.C. § 1320a-7a), the False Claims Act (31 U.S.C. § 3729 et seq.) and anti-corruption Applicable Law, throughout its operations (including subsidiaries) and the operations of its contractors and subcontractors that have responsibility for products , payments or services provided under this Agreement. Each Party agrees to comply with the other Party’s internal code of conduct for such program. The Alliance Managers will facilitate discussions and the sharing of information and experiences between the Parties respective compliance and ethics organizations.

12.4Disclaimer. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, NEITHER PARTY MAKES ANY REPRESENTATIONS OR EXTENDS ANY WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY, QUALITY, FITNESS FOR A PARTICULAR PURPOSE, NONINFRINGEMENT, OR VALIDITY OF PATENT CLAIMS. NOTHING IN THIS AGREEMENT SHALL BE CONSTRUED AS A REPRESENTATION MADE OR WARRANTY GIVEN BY EITHER PARTY THAT EITHER PARTY SHALL BE SUCCESSFUL IN OBTAINING ANY PATENTS OR THAT ANY PATENTS SHALL ISSUE BASED ON A PENDING APPLICATION. WITHOUT LIMITING THE RESPECTIVE RIGHTS AND OBLIGATIONS OF THE PARTIES EXPRESSLY SET FORTH HEREIN, EACH PARTY SPECIFICALLY DISCLAIMS ANY GUARANTEE THAT THE PRODUCTS SHALL BE SUCCESSFUL, IN WHOLE OR IN PART.

(a)By Stoke. Subject to Section 13.1(c), Stoke shall defend, indemnify and hold harmless Acadia and its Affiliates, and their respective directors, officers, employees and agents (each, a “Acadia Indemnitee ”) from and against any and all costs, fees, expenses, losses, liabilities and damages, including reasonable legal expenses and attorneys’ fees (collectively, “Losses ”) to which any Acadia Indemnitee may become subject as a result of any claim, demand, action or other proceeding by any Third Party (a “Claim”) to the extent such Losses arise out of : (i) the gross negligence or willful misconduct of Stoke or its Affiliates in connection with its activities under this Agreement; or (ii) the breach of this Agreement by Stoke or the breach of representations, warranties and covenants made hereunder by Stoke; except, in each case, to the extent such Losses result from (x) matters subject to clause (i) or (ii) of Section 13.1(b) or (y) a Acadia Indemnitee’s negligence.

(b)By Acadia. Subject to Section 13.1(c), Acadia shall defend, indemnify and hold harmless Stoke, its Affiliates, and their respective directors, officers, employees and agents (each, an “Stoke Indemnitee ”) from and against any and all Losses to which any Stoke Indemnitee may become subject as a result of any Claim to the extent such Losses arise out of: (i) the gross negligence or willful misconduct of Acadia or its Affiliates in connection with its activities under

this Agreement; (ii) the breach of this Agreement by Acadia or the breach of representations, warranties and covenants made hereunder by Acadia; except, in each case, to the extent such Losses result from (x) matters subject to clause (i) or (ii) of Section 13.1(a) or (y) a Stoke Indemnitee’s negligence.

(c)Procedure. A Party that intends to claim indemnification under this Section 13.1 (the “Indemnitee”) shall promptly notify the other Party (the “Indemnitor ”) in writing of any Claim in respect of which the Indemnitee intends to claim such indemnification. The failure to deliver written notice to the Indemnitor within a reasonable time after the commencement of any action with respect to a Claim shall only relieve the Indemnitor of its indemnification obligations under this Section 13.1 if and to the extent the Indemnitor is actually and materially prejudiced thereby. The Indemnitor has sole control of the defense or settlement thereof. The Indemnitee shall cooperate fully with the Indemnitor and its legal representatives in the investigation of any action with respect to a Claim covered by this indemnification. The Indemnitee may participate at its expense in the Indemnitor’s defense of and settlement negotiations for any Claim with counsel of the Indemnitee’s own selection. The Indemnitor shall not settle any Claim without the prior written consent of the Indemnitee, not to be unreasonably withheld, conditioned or delayed. So long as the Indemnitor is actively defending the Claim in good faith, the Indemnitee shall not settle or compromise any such Claim without the prior written consent of the Indemnitor. If the Indemnitor does not assume and conduct the defense of the Claim as provided above: (i) the Indemnitee may defend against, consent to the entry of any judgment, or enter into any settlement with respect to such Claim in any manner the Indemnitee may deem reasonably appropriate (and the Indemnitee need not consult with, or obtain any consent from, the Indemnitor in connection therewith); and (ii) the Indemnitor shall remain responsible to indemnify the Indemnitee as provided in this Section 13.1.

13.2Losses in the Territory. All Losses arising from any Third Party Claim relating to the Exploitation of a SYNGAP1 Co-Co Product in the Territory, including fees and disbursements to counsel, incurred by either Party in connection with the defense of any such Third Party Claim brought in the Territory, shall be shared equally (50:50) by the Parties as an Other Expense in accordance with Section 9.6(a); provided that such Other Expenses shall not include Losses of a Party or its Affiliate to the extent such Losses are: (a) caused by a breach of this Agreement by such Party or Affiliate; or (b) caused by the negligence or willful misconduct of such Party or its Affiliate.

13.3Limitation of Liability. NEITHER PARTY NOR THEIR RESPECTIVE AFFILIATES SHALL BE LIABLE TO THE OTHER PARTY OR ITS AFFILIATES FOR ANY SPECIAL, CONSEQUENTIAL, INCIDENTAL, PUNITIVE OR INDIRECT DAMAGES, OR FOR ANY LOSS OF PROFITS OR REVENUE (AND, FOR CLARITY, NEITHER PARTY NOR ANY OF THEIR RESPECTIVE AFFILIATES SHALL BE ENTITLED TO RECOVER FOR ANY LOST PROFIT OR LOST REVENUE DAMAGES WHETHER SUCH DAMAGES ARE CLAIMED AS DIRECT OR INDIRECT DAMAGES), ARISING FROM OR RELATING TO THIS AGREEMENT, WHETHER IN CONTRACT, WARRANTY, TORT, NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES. NOTWITHSTANDING THE FOREGOING, NOTHING IN THIS SECTION 13.3 IS INTENDED TO OR SHALL LIMIT OR RESTRICT THE INDEMNIFICATION RIGHTS OR OBLIGATIONS OF ANY PARTY FOR ANY LOSSES

FROM THIRD PARTY CLAIMS UNDER THIS ARTICLE 13 OR BREACH OF A PARTY’S CONFIDENTIALITY OBLIGATIONS UNDER Article 10.

13.4Insurance. During the Term , each Party shall maintain such types and amounts of liability insurance (including, with respect to Acadia, self-insurance) as is normal and customary in the industry generally for similarly situated parties and adequate to cover its obligations under this Agreement. Except with respect to self-insurance, each Party shall provide the other Party with evidence of such insurance upon request. Such insurance shall not be construed to create a limit of either Party’s liability with respect to its indemnification obligations under this Article 13 or otherwise.

(a)Inventorship. Inventorship as between the Parties shall be determined in accordance with U.S. patent laws. All such determinations shall be documented to ensure any patent applications and patents reflect appropriate inventorship. Ownership of the Collaboration Technology shall follow inventorship. The Parties intend and agree that ownership, Prosecution and Maintenance of all Collaboration Know-How and patentable inventions arising under this Agreement shall be governed by this Article 14 and that, except as expressly set forth herein, it is the Parties’ intention to use Commercially Reasonable Efforts to Prosecute and Maintain Patent Rights Covering all such Know-How and inventions.

(b)Disclosure. Each Party shall promptly disclose to the other Party all Collaboration Know-How that it conceives, discovers, develops or otherwise makes in the course of performing any activities or exercising any rights under this Agreement, whether solely or jointly with others (in any event, prior to the filing of any patent application with respect to any patentable invention), including all invention disclosures or other similar documents submitted to such Party by it or its Affiliates, or subcontractors or its or their respective directors, officers, employees or agents relating thereto. Each Party shall also promptly respond to reasonable requests from the other Party for additional information relating thereto.

(c)Assignment Obligation. Each Party shall cause all employees, independent contractors, consultants, and others who perform activities for such Party under this Agreement to be under an obligation to assign to such Party their rights in and to any Collaboration Technology and all intellectual property rights therein, except where Applicable Laws requires otherwise. Each Party shall use reasonable efforts to promptly disclose to the other Party all Collaboration Technology, including any invention disclosures, or other similar documents, submitted to it by its employees, agents or independent contractors describing such Collaboration Technology, and all information relating to such Collaboration Technology to the extent necessary or useful for the preparation, filing and maintenance of any Patent Rights with respect to such Collaboration Technology.

(a)Composition. Within [***] after the Effective Date, the Parties shall establish a committee to facilitate discussion and cooperation between the Parties with respect to intellectual property matters contemplated by this Article 14 (the “JPC”). Each Party shall initially appoint at least one (1) employee of such Party as representatives to the JPC, each such representative (a) having sufficient seniority and expertise in the prosecution, maintenance, enforcement and defense of Patent Rights to participate on the JPC, and (b) to be duly authorized under their respective company’s internal governance procedures to carry out the activities given to them under this Agreement. The JPC may change its size from time to time by mutual, unanimous consent of its members; provided that the JPC shall consist at all times of an equal number of representatives of each of Stoke and Acadia. Each Party may replace one or more of its JPC representatives at any time in its sole discretion upon written notice to the other Party. If agreed by the JPC, the JPC may invite non-members to participate in the discussions and meetings of the JPC; provided that such participants are under obligations of confidentiality consistent with this Agreement.

(b)Specific Responsibilities of the JPC. In addition to its general responsibility of providing a forum for the discussion of intellectual property matters contemplated by this Article 14, the JPC shall in particular be responsible for: (i) making initial determinations of inventorship in accordance with the terms of Section 14.1; (ii) discussing (but not approving) overall strategies for the Prosecution and Maintenance and enforcement of the Stoke Patents, Acadia Patents and Joint Collaboration Patents that are not SYNGAP1 Product Patents; and (iii) with respect to any SYNGAP1 Product Patents for which the Parties are jointly controlling Prosecution and Maintenance, (w) selecting lead patent counsel, (x) discussing and determining strategies for the Prosecution and Maintenance and enforcement of the SYNGAP1 Product Patents, (y) reviewing and commenting on substantive filings and documents related to the Prosecution and Maintenance of the such SYNGAP1 Product Patents, and (z) instructing lead patent counsel with respect to Prosecution and Maintenance of such SYNGAP1 Product Patents. The JPC shall endeavor to make decisions by consensus, with the representatives of each Party having, collectively, one (1) vote on behalf of that Party. If the JPC is unable to reach consensus on any decision before it, then the matter shall be escalated to the JSC, and if the JSC is unable to reach consensus on any decision before it, then such decision will be resolved in accordance with Section 3.7(a).

(c)Meetings. The JPC will meet at least once per Calendar Quarter (or more or less frequently as the Parties may otherwise mutually agree), with the location for such meetings to be determined by the JPC. The JPC may meet in person or, alternatively, the JPC may meet by means of teleconference, videoconference or other similar communications equipment. Each Party will bear the expense of its respective JPC members’ participation in JPC meetings. The JPC shall be responsible for keeping reasonably detailed written minutes of all meetings of the JPC.

(d)Duration of the JPC. The JPC shall endure for the Term, and if mutually agreed to by the Parties, after the end of the Term (for such period of time as agreed to by the Parties).

(a)Stoke Patents . As between the Parties, Stoke shall have the right to control the Prosecution and Maintenance of the Stoke MECP2 Patents , Stoke [***] Patents and Stoke SYNGAP1 Patents , other than the Licensed Product Patents and SYNGAP1 Product Patents (the “Stoke Patents”) at its sole expense and in accordance with the remainder of this Section 14.3(a) and subject to Section 14.3(b). Stoke shall keep Acadia reasonably informed of the status of the Stoke Patents and shall promptly provide Acadia with all correspondence received from any patent authority in connection therewith. In addition, Stoke shall provide Acadia with drafts of all proposed filings and correspondence to any patent authority with respect to the Stoke Patents for Acadia’s review with reasonable time for Acadia to provide comments prior to the submission of such proposed filings and correspondences, and Stoke shall consider Acadia’s reasonable comments in good faith. If Stoke intends to allow any Stoke Patent to lapse or become abandoned, it will notify and consult with Acadia with respect to such decision or intention at least [***] prior to the date upon which the subject matter of such Patent Right will become unpatentable or such Patent Right will lapse or become abandoned (or such other reasonable time under the circumstances if Stoke became aware of such matters with less than [***] remaining prior to such deadline), and, if after such consultation between the Parties, Stoke still intends not to Prosecute and Maintain such Patent Right, Acadia will take into consideration, in good faith, Stoke’s reasonable, objective rationale for deciding not to Prosecute or Maintain such Patent Right , and Acadia will thereupon have the right (but not the obligation) to assume the Prosecution and Maintenance of such Patent Right in Stoke’s name and at Acadia’s cost, subject to the foregoing information sharing obligation and review and comment rights applied mutatis mutandis.

(i)Generally. Subject to Section 14.3(b)(ii) and Section 14.3(b)(iii), Stoke will have the first right to Prosecute and Maintain the Licensed Product Patents and SYNGAP1 Product Patents using patent counsel reasonably acceptable to Acadia. Stoke will Prosecute and Maintain such Licensed Product Patents and SYNGAP1 Product Patents that are solely owned by Stoke in Stoke’s name and will Prosecute and Maintain such Licensed Product Patents and SYNGAP1 Product Patents that are that are Joint Collaboration Patents in both Parties’ names. Stoke will bear the costs of such Prosecution and Maintenance. Stoke shall use Commercially Reasonable Efforts to file Patent Rights that claim the composition of each Molecule, which claims the Parties acknowledge and agree may be directed to a class of compounds, a broad genus formula or a Markush group that encompasses such Molecule or its use. Stoke shall keep Acadia reasonably informed of the status of the Licensed Product Patents and SYNGAP1 Product Patents and shall promptly provide Acadia with all correspondence received from any patent authority in connection therewith. In addition, Stoke shall provide Acadia with drafts of all proposed filings and correspondence to any patent authority with respect to the Licensed Product Patents and SYNGAP1 Product Patents for Acadia’s review with reasonable time for Acadia to provide comments prior to the submission of such proposed filings and correspondences, and Stoke shall consider Acadia’s reasonable comments in good faith. If Stoke in any country decides not to file any such Licensed Product Patent or SYNGAP1 Product Patent, or intends to allow such Patent Right to lapse or become abandoned, it will notify and consult with Acadia with respect to such decision or intention at least [***] prior to the date upon which the subject matter of such Patent Right will become unpatentable or such Patent Right will

lapse or become abandoned (or such other reasonable time under the circumstances if Stoke became aware of such matters with less than [***] remaining prior to such deadline), and in such event, such Licensed Product Patent or SYNGAP1 Product Patent shall be Prosecuted and Maintained in accordance with Section 14.3(b)(ii) or Section 14.3(b)(iii), as applicable.

(ii)Acadia Right to Prosecute Licensed Product Patents. On an MECP2 Program and [***] Program basis, upon a first IND acceptance for a Licensed Product for such Program and for the remainder of the Term, Acadia will have the first right to Prosecute and Maintain the respective Licensed Product Patents for the such Program using patent counsel reasonably acceptable to Stoke, provided that with respect to any Licensed Product Patent that claims a class of compounds, a broad genus formula or a Markush group that encompasses a Molecule of such Program or its use, Stoke shall, at Acadia’s request, file a continuation or divisional of such Licensed Product Patent that claims the explicit structure of such Molecule, and Acadia shall only have the first right to Prosecute and Maintain such continuation or divisional (if any) (“Molecule Specific Patent”). Acadia will Prosecute and Maintain such Licensed Product Patents that are Stoke Patents solely in Stoke’s name, will Prosecute and Maintain such Licensed Product Patents that are Joint Collaboration Patents in both Parties’ names. Acadia will bear the costs of such Prosecution and Maintenance. If Acadia in any country decides not to file any such Licensed Product Patent, or intends to allow such Patent Right to lapse or become abandoned, it will notify and consult with Stoke with respect to such decision or intention at least [***] prior to the date upon which the subject matter of such Patent Right will become unpatentable or such Patent Right will lapse or become abandoned (or such other reasonable time under the circumstances if Acadia became aware of such matters with less than [***] remaining prior to such deadline), and in such event, Acadia shall permit Stoke, at Stoke’s discretion and at its sole expense, to Prosecute and Maintain such Licensed Product Patent, subject to the foregoing information sharing obligation and review and comment rights applied mutatis mutandis. The Parties shall in good faith cooperate through the JPC to effect the foregoing.

(iii)Joint Prosecution of SYNGAP1 Product Patents. For the SYNGAP1 Program, upon a first IND acceptance for a SYNGAP1 Co-Co Product and for the remainder of the Term, the Parties shall jointly control the Prosecution and Maintenance of the SYNGAP1 Product Patents using outside patent counsel mutually acceptable to the Parties, provided that with respect to a SYNGAP1 Product Patent that claims a class of compounds, a broad genus formula or a Markush group that encompasses a Molecule of such Program or its use, Stoke shall file a continuation or divisional of such SYNGAP1 Product Patent that claims the explicit structure of such Molecule, and the Parties shall only jointly control the Prosecution and Maintenance of such continuation or divisional (if any) (such continuation or divisional a “SYNGAP1 Molecule Specific Patent”). For any such Patent Rights, the JPC will appoint a lead patent counsel to Prosecute and Maintain such Patent Rights in accordance with directions provided by the JPC, provided that (a) such lead patent counsel will be mutually agreed to by both Parties in writing (and be subject to the continuing acceptance of each Party), a Party’s agreement not to be unreasonably delayed or withheld, except that a Party shall have no obligation to agree to a lead patent counsel who (or whose firm) has a conflict of interest with respect to such Party, and (b) each Party shall have the right, at its sole cost, to retain independent patent counsel to advise such Party on the Prosecution and Maintenance of such Patent Rights. The lead patent counsel will take direction from the JPC regarding the Prosecution and Maintenance of the SYNGAP1 Product Patents, will be required to promptly provide the JPC copies of all substantive

filings and documents related to the Prosecution and Maintenance of such Patent Rights with sufficient opportunity to review and comment thereon, and will incorporate any comments of the JPC relating thereto. With respect to any response to a communication received from a patent office (such as an office action), the JPC will draft instructions to the lead patent counsel for preparing such response within [***] of the date of the applicable patent office communication.

(c)Patents Solely Owned by Acadia. Subject to Section 14.3(b), as between the Parties, Acadia shall have the first right, but not the obligation, to Prosecute and Maintain the Acadia SYNGAP1 Patents and any Collaboration Patents solely owned by Acadia (“Acadia Patents ”), and Acadia shall bear the cost of such Prosecution and Maintenance . Acadia shall keep Stoke reasonably informed of the status of all such Collaboration Patents and shall promptly provide Stoke with all correspondence received from any patent authority in connection therewith. In addition, Acadia shall promptly provide Stoke with drafts of all proposed filings and correspondence to any patent authority with respect to any such Collaboration Patents for Stoke’s review and comment prior to the submission of such proposed filings and correspondences, and Acadia shall consider Stoke’s reasonable comments in good faith. Acadia shall notify Stoke of its intention to suspend or cease any Prosecution and Maintenance of any such Collaboration Patents and in such event, Acadia shall permit Stoke, at Stoke’s discretion and at its sole expense, to continue Prosecution and Maintenance of such Collaboration Patent, subject to the foregoing information sharing obligation and review and comment rights applied mutatis mutandis.

(d)Joint Patents. Subject to Section 14.3(b), the Parties shall determine in good faith which Party has the first right, but not the obligation, to Prosecute and Maintain all Joint Collaboration Patents. The Party handling the Prosecution and Maintenance of a given Joint Collaboration Patent shall keep the other Party reasonably informed of the status of such Joint Collaboration Patent and shall promptly provide such other Party with all correspondence received from any patent authority in connection therewith. In addition, the prosecuting Party shall promptly provide the other Party with drafts of all proposed filings and correspondence to any patent authority with respect to such Joint Collaboration Patent for such other Party’s review and comment prior to the submission of such proposed filings and correspondences, and the prosecuting Party shall consider the other Party’s reasonable comments in good faith. The prosecuting Party shall notify the other Party of its intention to suspend or cease any Prosecution and Maintenance of any such Joint Collaboration Patent and in such event, the prosecuting Party shall permit the other Party, at its discretion and at its sole expense, to continue Prosecution and Maintenance of such Joint Collaboration Patent subject to the foregoing information sharing obligation and review and comment rights applied mutatis mutandis.

(e)Cooperation of the Parties . Each Party shall cooperate fully with the other Party in the Prosecution and Maintenance of Patents under this Section 14.3 at its own cost, including by: (i) executing all papers and instruments, or requiring its employees or contractors, to execute such papers and instruments, to enable the other Party to apply for and to Prosecute and Maintain the applicable Patent Rights in any country as permitted by this Section 14.3 and (ii) promptly informing the other Party of any matters coming to such Party’s attention that may affect the Prosecution and Maintenance of any such Patent Rights.

(a)Notice. Each Party shall notify the other within [***] of becoming aware of any alleged or threatened infringement by a Third Party of any of Stoke Patents, Acadia Patents or Joint Collaboration Patents , which infringing activity involves the using, making, importing, offering for sale or selling any Product in the Field in the Territory, and any related declaratory judgment, opposition or similar action alleging the invalidity, unenforceability or non-infringement of any of the Stoke Patents, Acadia Patents or Collaboration Patents (collectively “Infringement”).

(i)As between the Parties, on a Licensed Product-by-Licensed Product basis, upon acceptance of a first IND for such Licensed Product, Acadia shall have the first right to bring and control any legal action to enforce the Licensed Product Patents, SYNGAP1 Product Patents, Acadia Patents and Joint Collaboration Patents in connection with any Infringement with respect to an MECP2 Licensed Product, [***] Licensed Product or SYNGAP1 Opt-Out Product, at Acadia’s own expense. Acadia shall keep Stoke reasonably informed of the status of such enforcement efforts for such Patent Rights. Stoke may, at its own expense, be represented in any such action by counsel of its own choice with respect to such enforcement. If Acadia does not bring such legal action within a commercially reasonable period of time (but not less than [***]) after the notice provided pursuant to Section 14.4(a), Stoke may bring and control any legal action to enforce the Licensed Product Patents, SYNGAP1 Product Patents, Acadia Patents and Joint Collaboration Patents at its own expense as it reasonably determines appropriate. In such case, Stoke shall keep Acadia reasonably informed of the status of such enforcement efforts, and Acadia may, at its own expense, be represented in any such action by counsel of its own choice with respect to such enforcement. Notwithstanding the foregoing, to the extent a Molecule Specific Patent(s) has been filed with respect to the relevant Licensed Product pursuant to Section 14.3(b)(ii), then Acadia’s first right to enforce shall only apply to such Molecule Specific Patent(s).

(ii)Subject to Section 14.4(b)(i), as between the Parties, on a Licensed Product-by-Licensed Product basis, Stoke shall have the first right to bring and control any legal action to enforce the Licensed Product Patents for which Acadia does not have the first right to enforce pursuant to Section 14.4(b)(i) in connection with any Infringement with respect to an MECP2 Licensed Product, [***] Licensed Product or SYNGAP1 Opt-Out Product at Stoke’s own expense. Stoke shall keep Acadia reasonably informed of the status of such enforcement efforts for such Patent Rights. Acadia may, at its own expense, be represented in any such action by counsel of its own choice with respect to such enforcement. If Stoke does not bring such legal action within a commercially reasonable period of time (but not less than three (3) months) after the notice provided pursuant to Section 14.4(a), Acadia may bring and control any legal action to enforce such Licensed Product Patents in connection with such Infringement at its own expense as it reasonably determines appropriate (and in such case, Acadia shall keep Stoke reasonably informed of the status of such enforcement efforts, and Stoke may, at its own expense, be represented in any such action by counsel of its own choice with respect to such enforcement), provided that if Stoke provides a reasonable, objective rationale for not pursuing or continuing to pursue such legal action (including a substantive concern regarding counter-claims by the infringing Third Party with respect to Patent Rights owned or Controlled by Stoke), then the Parties

shall consider and discuss in good faith Stoke’s reasonable comments and concerns and Acadia shall not have the right to bring and control such legal action without Stoke’s consent, such consent not to be unreasonably withheld.

(i)As between the Parties, Acadia shall have the first right to bring and control any legal action to enforce the SYNGAP1 Product Patents, Acadia Patents and Joint Collaboration Patents in connection with any Infringement with respect to a SYNGAP1 Co-Co Product. Acadia shall keep Stoke reasonably informed of the status of such enforcement efforts. Stoke may be represented in any such action by counsel of its own choice with respect to such enforcement. If Acadia does not bring such legal action within a commercially reasonable period of time (but not less than [***]) after the notice provided pursuant to Section 14.4(a), Stoke may bring and control any legal action to enforce the SYNGAP1 Product Patents, Acadia Patents and Joint Collaboration Patents in connection with such Infringement as it reasonably determines appropriate. In such case, Stoke shall keep Acadia reasonably informed of the status of such enforcement efforts, and Acadia may be represented in any such action by counsel of its own choice with respect to such enforcement. Notwithstanding the foregoing, to the extent a SYNGAP1 Molecule Specific Patent(s) has been filed with respect to the relevant SYNGAP1 Co-Co Product pursuant to Section 14.3(b)(iii), then Acadia’s first right to enforce shall only apply to such SYNGAP1 Molecule Specific Patent(s).

(ii)Subject to Section 14.4(c)(i), as between the Parties, Stoke shall have the first right to bring and control any legal action to enforce the SYNGAP1 Product Patents for which Acadia does not have the first right to enforce pursuant to Section 14.4(c)(i) in connection with any Infringement with respect to a SYNGAP1 Co-Co Product. Stoke shall keep Acadia reasonably informed of the status of such enforcement efforts. Acadia may be represented in any such action by counsel of its own choice with respect to such enforcement. If Stoke does not bring such legal action within a commercially reasonable period of time (but not less than [***]) after the notice provided pursuant to Section 14.4(a), Acadia may bring and control any legal action to enforce such SYNGAP1 Product Patents in connection with such Infringement at its own expense as it reasonably determines appropriate (and in such case, Acadia shall keep Stoke reasonably informed of the status of such enforcement efforts, and Stoke may be represented in any such action by counsel of its own choice with respect to such enforcement), provided that if Stoke provides a reasonable, objective rationale for not pursuing or continuing to pursue such legal action (including a substantive concern regarding counter-claims by the infringing Third Party with respect to Patent Rights owned or Controlled by Stoke), then the Parties shall consider and discuss in good faith Stoke’s reasonable comments and concerns and Acadia shall not have the right to bring and control such legal action without Stoke’s consent, such consent not to be unreasonably withheld.

(iii)Except as expressly set forth herein, all Internal Costs and External Costs incurred by the Parties in connection with any suit or other action brought by a Party under this Section 14.4(c) shall be considered “Shared Patent Enforcement Costs” that shall be shared equally (50:50) between the Parties as an Other Expense.

(i)Any recoveries resulting from enforcement action relating to a claim of Infringement regarding the SYNGAP1 Co-Co Product, whether by settlement or judgment, shall be allocated as follows: (A) first, each Party shall be reimbursed its External Costs incurred in conducting, or cooperating with, such action; provided that if amounts recovered are insufficient to reimburse all such External Costs incurred by both Parties, then such recovered amounts shall be shared pro rata in proportion to the relative amount of such External Costs incurred by each Party and (B) second, the balance of such recovered amounts shall be split equally (50:50) between the Parties.

(ii)Any recoveries resulting from enforcement action relating to a claim of Infringement with respect to a Licensed Product, whether by settlement or judgment, shall be first applied against payment of each Party’s costs and expenses in connection therewith; provided that if amounts recovered are insufficient to reimburse all such costs and expenses incurred by both Parties, then such recovered amounts shall be shared pro rata in proportion to the relative amount of such costs and expenses incurred by each Party. Any remaining recovery shall be allocated as follows: (A) the enforcing Party shall receive [***] and (B) the non-enforcing Party shall receive [***].

(e)Cooperation. At the request and expense of the Party bringing an action under this Section 14.4 , the other Party shall provide reasonable assistance in connection therewith, including by executing reasonably appropriate documents, cooperating in discovery and joining as a party to the action if required by Applicable Laws to pursue such action. In connection with any such enforcement action, the Party bringing the action shall not enter into any settlement admitting the invalidity or non-infringement of, or otherwise impairing the other Party’s rights in the applicable Patent Rights without the prior written consent of the other Party.

14.5Hatch-Waxman. Notwithstanding any provision to the contrary set forth in this Agreement, if a Party receives a written notice letter including any “patent certification” filed in the U.S. under 21 U.S.C. §355(j)(2)(A)(vi)(IV) for a Product pursuant to the Hatch-Waxman Act, or its equivalent in a country other than the U.S., with respect to any activities under this Agreement in the Field, then such Party will immediately provide the other Party with a copy of such notice letter (“H-W Notice Letter”). Following delivery of such H-W Notice Letter, the Parties will meet and discuss such certification, including any necessary consents from Third Party licensors with respect thereto. For each Product, Acadia shall have the first right to bring suit within a [***] period from the date of such certification. If Acadia does not bring suit with respect to a H-W Notice Letter in the Territory within [***] following receipt thereof, then Stoke shall have the right to bring suit with respect to a H-W Notice Letter in the Territory.

14.6CREATE Act. Notwithstanding anything to the contrary in this Article 14, neither Party will have the right to make an election under the CREATE Act when exercising its rights under this Article 14 without the prior written consent of the other Party, which will not be unreasonably withheld, conditioned or delayed. With respect to any such permitted election, the Parties will use reasonable efforts to cooperate and coordinate their activities with respect to any submissions, filings or other activities in support thereof. The Parties acknowledge and agree that this Agreement is a “joint research agreement” as defined in the CREATE Act. Notwithstanding

the foregoing, the other Party’s consent under this Section 14.6 will not be required in connection with an obviousness-type double patenting rejection in any patent application claiming a Collaboration Patents and Joint Collaboration Patent, or uses thereof.

14.7Patent Term Extensions . Acadia will have the full and exclusive right and discretion to determine and control all filings of requests for patent term extensions, supplementary protection certificates, or equivalents thereto in any country in the Territory, (“Patent Term Extensions”), in each case where applicable to a Licensed Product; provided that Stoke’s prior written consent shall be required if Acadia desires to designate a Stoke Patent (other than a Licensed Product Patent) for such Patent Term Extension. In the event that Acadia exercises its termination right pursuant to Section 15.2, Stoke shall have the full and exclusive right and discretion to determine and control all filings of requests for Patent Term Extensions under the Acadia Patents with respect to the Terminated Product or SYNGAP1 Terminated Product, as applicable, subject to Acadia’s prior written consent. The JPC shall determine which Patent Term Extensions to seek in any country in the Territory applicable to a SYNGAP1 Co-Co Product and with respect to the SYNGAP1 Product Patents, Acadia SYNGAP1 Patents, Stoke SYNGAP1 Patents and Joint Collaboration Patents, provided that in the event of any dispute then the matter shall be resolved in accordance with Section 3.7(a)(v). All costs and expenses relating to the Patent Term Extensions will be born solely by Acadia with respect to the Licensed Products and shall be a shared Other Expense with respect to any SYNGAP1 Co-Co Product. Upon request of Acadia and at Acadia’s cost and expense, Stoke will provide support, assistance, and all necessary documents, in full executed form if needed, to Acadia for the purpose of supporting, filing, obtaining, and maintaining Patent Term Extensions for Licensed Products in accordance with the foregoing.

15.1Term . This Agreement shall be effective as of the Effective Date, and shall continue, unless terminated earlier as set forth herein, in effect as follows (the “Term”):

(a)with respect to Licensed Products, on a country-by-country and Product-by-Product basis until the expiration of the MECP2 Royalty Term, [***] Royalty Term or SYNGAP1 Royalty Term, as applicable, for such Licensed Product and such country. On a country-by-country and Licensed Product-by-Licensed Product basis, upon the expiration of the applicable royalty term for such Licensed Product and such country, the relevant license to Acadia pursuant to Section 2.1(a), Section 2.1(b) or Section 2.1(c)(i) in such country shall become fully paid-up, royalty-free, perpetual and irrevocable for use with the Licensed Product in the form as such Licensed Product exists as of the effective date of expiration in such country; and

(b)with respect to each SYNGAP1 Co-Co Product, until the date on which the Parties have agreed to permanently abandon the further Development and Commercialization of such SYNGAP1 Co-Co Product under this Agreement.

15.2Unilateral Termination by Acadia. Following the first anniversary of the Effective Date, Acadia shall have the right to terminate this Agreement (with or without cause) (a)

in its entirety, or (b) on a Program-by-Program basis, or (c) on a Product-by-Product basis, in each case (a)-(c) at any time by giving one hundred twenty (120) days’ advance written notice to Stoke.

15.3Termination by Mutual Agreement. The Parties shall have the right to terminate this Agreement in its entirety (or in part) upon mutual written agreement. In such case, the Parties shall agree in writing on the effects of such termination (including the costs of transition or wind-down of activities), and the provisions of Section 15.6 shall not apply (unless otherwise mutually agreed to by the Parties).

(a)Termination for Material Breach. If either Acadia or Stoke is in material breach of this Agreement, the non-breaching Party may give written notice to the breaching Party specifying the claimed particulars of such breach, and in such event, if the breach is not cured within [***] after receipt of such notice (provided that if any breach, other than a payment breach, is not reasonably curable within such [***] cure period, then such cure period will be extended for an additional period of up to [***] (for a total cure period of [***]), the non-breaching Party shall have the right thereafter to terminate this Agreement in its entirety with immediate effect by giving written notice of such termination to the breaching Party; provided that with respect to (i) a Licensed Product, Stoke shall be permitted to terminate this Agreement pursuant to this Section 15.4(a) (and only after completion of the process set forth in Section 15.4(a)(i) if invoked) solely as a result of (A) Acadia’s material failure to make timely payments to Stoke or (B) Acadia’s material failure to use Commercially Reasonable Efforts to Develop or Commercialize the relevant Licensed Product and (ii) a SYNGAP1 Co-Co Product, each Party shall be permitted to terminate this Agreement pursuant to this Section 15.4(a) (and only after completion of the process set forth in Section 15.4(a)(i) if invoked) solely as a result of (A) a Party’s material failure to make timely payments to the other Party or (B) a Party’s material failure to use Commercially Reasonable Efforts to Develop or Commercialize the relevant SYNGAP1 Co-Co Product, and in each case ((i) and (ii) above) including a failure to timely cure during the time periods set forth this Section 15.4(a) (and only after completion of the process set forth in Section 15.4(a)(i) if invoked), and for no other reason. Notwithstanding the foregoing:

(i)if the allegedly breaching Party disputes in good faith the existence, materiality or cure of the applicable material breach and provides written notice of such dispute to the other Party within [***] after receipt of notice of the applicable material breach or notice of termination, as applicable, then the matter will be addressed under the dispute resolution provisions in Section 17.4 and the termination will not become effective unless and until it has been finally determined under Section 17.4 that the allegedly breaching Party is in material breach of any of its obligations under this Agreement and has failed to cure the same (which cure period shall commence following such final determination). During the pendency of such a dispute , all of the terms of this Agreement will remain in effect and the Parties will continue to perform all of their respective obligations hereunder; and,

(ii)If a Party is the breaching Party, and such material breach is limited to one or more Programs, Products or countries, the non-breaching Party shall only have the right to terminate this Agreement solely with respect to each such Program, Product or country to which the material breach relates.

(b)Termination for Patent Challenge. In the event that a Party or any of its Affiliates directly takes any action, or knowingly provides financial or other assistance (including direct legal or technical advice) to any Third Party, to challenge in a court or administrative proceeding any claim in any Stoke MECP2 Patent, Stoke [***] Patent, Stoke SYNGAP1 Patent, Acadia SYNGAP1 Patents or other Acadia Patents as being invalid, unenforceable or otherwise not patentable, the other Party shall have the right to immediately terminate this Agreement in its entirety or with respect to the Program to which the challenged patent relates, including the rights with respect thereto of any Sublicensee, upon [***] prior written notice to such Party; provided that the other Party shall not have the right to terminate this Agreement (x) if such Party withdraws or causes to be withdrawn such action within such [***] period or (y) if such Party (or its Affiliate) or such Third Party challenged the Stoke MECP2 Patent, Stoke [***] Patent, Stoke SYNGAP1 Patent , Acadia SYNGAP1 Patents or other Acadia Patents in defense of claims raised by or on behalf of other Party (or its Affiliate) against such Party (or its Affiliate) or such Third Party, or otherwise in connection with an assertion of a cross-claim or a counter-claim . In the event that the other Party notifies such Party in writing that any of such Party’s Sublicensees directly takes any action, or knowingly provides financial or other assistance (including direct legal or technical advice) to any Third Party, to challenge in a court or administrative proceeding any claim in any Stoke MECP2 Patent, Stoke [***] Patent, Stoke SYNGAP1 Patent, Acadia SYNGAP1 Patents or other Acadia Patents as being invalid, unenforceable or otherwise not patentable, then such Party shall terminate such Sublicensee’s sublicense in its entirety, unless (A) such action by such Sublicensee is withdrawn within [***] after the other Party’s notice to such Party thereof or (B) such Sublicensee (or its affiliate ) or such Third Party challenged the Stoke MECP2 Patent, Stoke [***] Patent, Stoke SYNGAP1 Patent , Acadia SYNGAP1 Patents or other Acadia Patents in defense of claims raised by or on behalf of the other Party (or its Affiliate) against such Sublicensee (or its affiliate ) or such Third Party, or otherwise in connection with an assertion of a cross-claim or a counter-claim.

(i)Right to Terminate. Each Party shall have the right to terminate this Agreement effective immediately upon delivery of written notice to the other Party in the event that (A) such other Party files in any court or agency pursuant to any statute or regulation of any jurisdiction a petition in bankruptcy or insolvency or for reorganization or similar arrangement for the benefit of creditors or for the appointment of a receiver or trustee of such other Party or its assets, (B) such other Party is served with an involuntary petition against it in any insolvency proceeding and such involuntary petition has not been stayed or dismissed within [***] of its filing, or (C) such other Party makes an assignment of substantially all of its assets for the benefit of its creditors.

(ii)Rights in Bankruptcy. For purposes of Section 365(n) of the US Bankruptcy Code (the “Bankruptcy Code”) and any similar Applicable Laws in any other jurisdiction, all rights and licenses granted under or pursuant to this Agreement by Stoke and Acadia are, and shall otherwise be deemed to be, for purposes of the Bankruptcy Code or any comparable provision of any Applicable Laws in any other jurisdiction, rights to “intellectual property” (as defined in Section 101(35A) of the Bankruptcy Code) or any comparable provision of any Applicable Laws in any other jurisdiction. The Parties agree that each Party, as licensee of such rights under this Agreement, shall retain and may fully exercise all of its rights and elections

under the Bankruptcy Code or any comparable provision of any Applicable Laws in any other jurisdiction. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party under the Bankruptcy Code or any comparable provision of any Applicable Laws in any other jurisdiction, the other Party shall be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property and all embodiments of such intellectual property, which, if not already in such other Party’s possession, shall be promptly delivered to such other Party (A) upon any such commencement of a bankruptcy proceeding upon such other Party’s written request therefor, unless such Party elects to continue to perform all of its obligations under this Agreement, or (B) if not delivered under clause (A), following the rejection of this Agreement by such Party upon written request therefor by such other Party. The Parties agree that they intend the following rights to extend to the maximum extent permitted by law, including for purposes of the Bankruptcy Code or any comparable provision of any Applicable Laws in any other jurisdiction: (1) the right of access to any intellectual property (including all embodiments thereof) of the licensor, or any Third Party with whom the licensor contracts to perform an obligation of such licensor under this Agreement which is necessary for the Development, Manufacture or Commercialization of the Licensed Product; (2) the right to contract directly with any Third Party described in (1) to complete the contracted work and (3) the right to cure any default under any such agreement with a Third Party and set off the costs thereof against amounts payable to such licensor under this Agreement. The provisions of this Section 15.4(c)(ii) shall be (x) without prejudice to any rights a Party may have arising under any applicable insolvency statute or other Applicable Laws and (y) effective only to the extent permitted by Applicable Law.

15.5Full Force and Effect During Notice Period. This Agreement shall remain in full force and effect during any applicable termination notice period (“Termination Notice Period ”), and each Party shall continue to perform all of its obligations under this Agreement then in effect in accordance with the terms and conditions of this Agreement (including that each Party shall also continue to bear its share of all applicable costs with respect to any SYNGAP1 Co-Co Product incurred during the Termination Notice Period). For clarity, (a) if any Net Sales of Licensed Product are made during the termination notice period , then the corresponding royalty payment is accrued and Acadia shall remain responsible for the payment of such amounts even if the due date of such payment may come after the effective date of the termination, and (b) Acadia shall still be obligated to make any Development Milestone Payment and Sales Milestone Payment to Stoke with respect to any milestone event achieved during the period commencing on the date of notice of termination of this Agreement and ending on the effective date of termination of this Agreement.

(a)Effects of termination generally.Subject to the remainder of this Section 15.6, upon termination of this Agreement in its entirety:

(i)Licenses. All licenses granted hereunder will terminate; provided that such licenses will continue as necessary for the Parties to complete the orderly wind-down of their activities under this Agreement in accordance with Applicable Laws and as otherwise required in accordance with Section 15.6(a)(ii). With the exception of such wind-down activities, each Party shall immediately cease and shall cause its Affiliates, Sublicensees and subcontractors, each as applicable, to immediately cease, all Development, Manufacturing and Commercialization

activities hereunder. In the event of termination of this Agreement with respect to a Program pursuant to Section 15.2 by Acadia or Section 15.4 by Stoke, all Results pertaining to the Program shall be deemed the Confidential Information of Stoke.

(ii)Wind-Down. Promptly following receipt by the applicable Party of a notice of termination under Section 15.2, Section 15.4(a) or Section 15.4(b), the Parties will begin to wind-down their respective activities under this Agreement. The Parties will establish an appropriate Working Group to coordinate such wind-down.

(iii)Destruction of Confidential Information . Each receiving Party shall destroy (at the disclosing Party’s written request) all such Confidential Information of the receiving Party in its possession as of the effective date of expiration or termination (with the exception of one copy of such Confidential Information, which may be retained by the legal department of the receiving Party to confirm compliance with the non‑use and non‑disclosure provisions of this Agreement), and any Confidential Information of the disclosing Party contained in its laboratory notebooks or databases, provided that each receiving Party may retain and continue to use such Confidential Information of the disclosing Party to the extent necessary to exercise any surviving rights, licenses or obligations under this Agreement. Notwithstanding the foregoing, a receiving Party shall not be required to destroy any computer files created during automatic system back up that are subsequently stored securely by it and not readily accessible to its employees, consultants, or others who received the Disclosing Party’s Confidential Information under this Agreement provided that such copies remain subject to the confidentiality and non-use provisions of this Agreement.

(iv)Sublicense Survival. Any permitted sublicense granted by Acadia or its Affiliate to a Third Party under this Agreement shall survive the termination of this Agreement; provided that, in the case where termination of this Agreement is for Acadia’s uncured material breach pursuant to Section 15.4(a), such Sublicensee did not cause such uncured material breach and provided further that such Sublicensee is not in breach of its sublicense agreement. If permitted under such a surviving sublicense, effective upon termination of this Agreement, such sublicense shall become a direct license from Stoke, provided that, at a minimum, such Sublicensee shall be subject to the relevant diligence and payment obligations set forth in this Agreement.

15.7Consequences of Termination in Part. Upon any termination of this Agreement pursuant to Section 4.7, Section 15.2, Section 15.4(a) or Section 15.4(b) in part, then Section 15.6 shall apply accordingly, but solely with view to the terminated Program(s), Product(s) or country(ies).

(a)Upon termination of this Agreement in whole or in part by Acadia pursuant to Section 15.2 or by either Party pursuant to Section 15.4, with respect to any MECP2 Licensed Product or [***] Licensed Product containing or comprising a Clinical Candidate (or any modification or derivative thereof) for which this Agreement is terminated (in the form existing as of the effective date of termination or any modified form so long as such modification itself does not incorporate or use proprietary technology of Acadia that is not already licensed to Stoke) (each a “Terminated Product ”), effective upon the date of such termination (i) Acadia hereby grants

Stoke an exclusive license, with the right to grant sublicenses through multiple tiers, under all Know-How and Patent Rights Controlled by Acadia (including Acadia’s interest in any Collaboration Patents) and that are necessary or useful to research, Develop, make, Manufacture, have made, distribute, use, promote, market, sell, offer for sale, have sold, export, import, and otherwise Commercialize and Exploit such Terminated Product in the Field in the Territory; such license, to the extent that it constitutes a sublicense of any Know-How or Patent Rights of a Third Party, shall be subject to the applicable terms of Acadia’s license agreement with such Third Party with respect to such Know-How or Patent Rights only if Acadia disclosed them to Stoke in writing prior to termination and Stoke elected in writing to receive such sublicense under such terms; (ii) the transition provisions of Section 8.1(b)(vi)-(ix) or 8.2(b)(iv)-(vii), as applicable, shall apply mutatis mutandis , as applicable, with respect to Acadia and Stoke with respect to the Terminated Product; (iii) Acadia hereby assigns to Stoke or its designee all Regulatory Materials, copies of material correspondence and conversation logs, pre-clinical and clinical study reports, clinical study protocols, and all data (in the format in which it is maintained by Acadia), in each case, that are related to the Terminated Product and Controlled by Acadia or its Affiliates as of the effective date of termination and Acadia shall take all steps necessary to transfer to Stoke or its designee ownership of all such assigned Regulatory Materials, including submitting to each applicable Regulatory Authority a letter or other necessary documentation (with a copy to Stoke) notifying such Regulatory Authority of the transfer of such ownership of the applicable Regulatory Materials; provided that if it is not feasible under Applicable Laws for Acadia to transfer to Stoke any such Regulatory Materials, Acadia shall hold such Regulatory Materials in its name for the benefit of Stoke and shall grant, and hereby does grant to Stoke an exclusive, royalty-free license and right of reference to use such Regulatory Materials in connection with Development and Commercialization of the Terminated Product and authorize Stoke or its designee to conduct regulatory activities with applicable Regulatory Authorities relating to such Regulatory Materials; (iv) Stoke shall pay Acadia royalties on the Net Sales of such Terminated Product (with related definitions and duration of payment applied mutatis mutandis) at the rate of (a) [***], if, at the time of such termination, the applicable Terminated Product has not entered a Phase I/II Clinical Trial, (b) [***], if at the time of such termination, the Terminated Product has entered into a Phase I/II Clinical Trial but has not entered a Phase III Clinical Trial, and (c) [***], if at the time of such termination, the Terminated Product has entered into a Phase III Clinical Trial, provided that in each case (a)-(c) the rates shall be reduced by [***] in the event of termination by Stoke pursuant to Section 15.4; and (v) Stoke shall be solely responsible for and shall pay (or reimburse if applicable) Acadia for any post-termination amounts owed to a Third Party in consideration for Stoke’s sublicense in subsection (i) to such Third Party’s Know-How or Patent Rights with respect to the Terminated Product in the event that Stoke elects in writing to receive a sublicense to the applicable Third Party Know-How or Patent Rights after Acadia’s disclosure to Stoke of the terms thereof pursuant to subsection (i).

15.9Reduced Payments In Lieu of Termination. On a Licensed Product-by- Licensed Product basis, with respect to Stoke’s material breach of any of its obligations under this Agreement with respect thereto as determined pursuant to Section 15.4(a) (and after completion of the process set forth in Section 15.4(a)(i) if invoked), Acadia shall have the right, at its option and by written notice to Stoke, in lieu of exercising its right to terminate this Agreement with respect to such Licensed Product under Section 15.4(a), to instead continue this Agreement with respect to such Licensed Product in accordance with its terms, and in which case: (a) at Acadia’s option, the JSC will coordinate wind-down of Stoke’s activities with respect to such Licensed

Product, and (b) from and after such time as Acadia delivers such written notice to Stoke, any and all amounts thereafter payable by Acadia for a Licensed Product applicable to such Licensed Product hereunder (including milestone payments and royalties) shall be reduced by [***] (and for clarity, any floors on any such milestone payments and royalties hereunder will not apply). Notwithstanding the foregoing, Acadia’s exercise of its rights under this Section 15.9 with respect to a Licensed Product shall (i) constitute a waiver by Acadia of any right hereunder or under Applicable Law to recover damages caused by such material breach by Stoke, and (ii) not affect the Parties’ respective rights and obligations (including, without limitation, milestone payments and royalties) with respect to any other Licensed Products.

(a)Upon termination of this Agreement in whole or in part by Acadia pursuant to Section 15.2, or by either Party pursuant to Section 15.4 (Acadia terminating pursuant to Section 15.2, or the breaching Party pursuant to Section 15.4, the “Terminated Party”, and the other Party the “Continuing Party”), with respect to any SYNGAP1 Co-Co Product containing or comprising a Clinical Candidate (or any modification or derivative thereof) for which this Agreement is terminated (in the form existing as of the effective date of termination) (each a “SYNGAP1 Terminated Product”), effective upon the date of such termination: (i) Sections 5.2(c)-(f) and Sections 5.3-5.6 shall apply mutatis mutandis with respect to the further Development and Commercialization of such SYNGAP1 Terminated Product by the Continuing Party; (ii) the Terminated Party hereby grants the Continuing Party an exclusive license, with the right to grant sublicenses through multiple tiers, under certain Know-How and Patent Rights Controlled by the Terminated Party (including the Terminated Party’s interest in any Collaboration Patents) and that are necessary to research, Develop, make, Manufacture, have made, distribute, use, promote, market, sell, offer for sale, have sold, export, import, and otherwise Commercialize and Exploit such SYNGAP1 Terminated Product in the Field in the Territory; such license, to the extent that it constitutes a sublicense of any Know-How or Patent Rights of a Third Party, shall be subject to the applicable terms of the Terminated Party’s license agreement with such Third Party with respect to such Know-How or Patent Rights only if the Terminated Party disclosed them to the Continuing Party in writing prior to termination and the Continuing Party elected in writing to receive such sublicense under such terms; (iii) the transition provisions of Section 8.1(b)(vi)-(ix) or 8.2(b)(iv)-(vii), as applicable, shall apply mutatis mutandis, as applicable, with respect to the Terminated Party and the Continuing Party with respect to the SYNGAP1 Terminated Product; including that the Terminated Party hereby assigns to the Continuing Party or its designee all Regulatory Materials, copies of material correspondence and conversation logs, pre-clinical and clinical study reports, clinical study protocols, and all data (in the format in which it is maintained by the Terminated Party), in each case, that are related to the SYNGAP1 Terminated Product and Controlled by the Terminated Party or its Affiliates as of the effective date of termination and the Terminated Party shall take all steps necessary to transfer to the Continuing Party or its designee ownership of all such assigned Regulatory Materials, including submitting to each applicable Regulatory Authority a letter or other necessary documentation (with a copy to the Continuing Party) notifying such Regulatory Authority of the transfer of such ownership of the applicable Regulatory Materials; provided that if it is not feasible under Applicable Laws for the Terminated Party to transfer to the Continuing Party any such Regulatory Materials, the Terminated Party shall hold such Regulatory Materials in its name for the benefit of the Continuing Party and shall grant, and hereby does grant to the Continuing Party an exclusive, royalty-free license and right of

reference to use such Regulatory Materials in connection with Development and Commercialization of the Terminated Product and authorize the Continuing Party or its designee to conduct regulatory activities with applicable Regulatory Authorities relating to such Regulatory Materials; (iv) the Continuing Party shall pay the Terminated Party royalties on the Net Sales of such SYNGAP1 Terminated Product as set forth below in Section 15.10(b), Section 15.10(c) or Section 15.10(d), as applicable, and where the Continuing Party is Acadia, Acadia shall pay Stoke milestones in connection with such SYNGAP1 Terminated Product, to the extent applicable, as set forth below in Section 15.10(d), in each case with related definitions and duration of payments applied mutatis mutandis; (v) if the effective date of termination for the SYNGAP1 Terminated Product is prior to the First Commercial Sale of such SYNGAP1 Terminated Product, then the Terminated Party shall remain responsible for the performance of its obligations as set forth in this Agreement and the relevant SYNGAP1 Co-Development Plan and the sharing of the corresponding Development Costs incurred in the performance of such activities for a period ending [***] after the date of notice of such termination under Section 15.2 or Section 15.4 (and after completion of the process set forth in Section 15.4(a)(i) if invoked); (vi) if the effective date of termination for the SYNGAP1 Terminated Product is after the First Commercial Sale of such SYNGAP1 Terminated Product, then the Terminated Party shall remain responsible for the performance of its obligations as set forth in this Agreement, the applicable SYNGAP1 Co-Development Plan and applicable SYNGAP1 Co-Commercialization Plan for a period ending [***] after the date of notice of such termination under Sections 15.2 or 15.4(and after completion of the process set forth in Section 15.4(a)(i) if invoked), and for the sharing of the corresponding Development Costs and Commercialization Costs incurred in the performance of such activities; (vii) the Terminated Party shall not be responsible for any further Development Costs, Commercialization Costs or Other Expenses incurred with respect to the SYNGAP1 Terminated Product after such [***] or [***] period, as applicable; and (viii) the Continuing Party shall be solely responsible for and shall pay (or reimburse if applicable) the Terminated Party for any post-termination amounts owed to a Third Party in consideration for the Continuing Party’s sublicense in subsection (i) to such Third Party’s Know-How or Patent Rights with respect to the SYNGAP1 Terminated Product in the event that the Continuing Party elects in writing to receive a sublicense to the applicable Third Party Know-How or Patent Rights after the Terminated Party’s disclosure to the Continuing Party of the terms thereof pursuant to subsection (ii).

(b)In the event Stoke is the Continuing Party and Acadia is the Terminated Party due to Acadia termination pursuant to Section 15.2, the applicable royalty rates payable to Acadia shall be as set forth below. For clarity, Stoke shall not owe any milestones, including any Development Milestones or Sales Milestones as set forth in Section 9.4, in connection with such SYNGAP1 Terminated Product.

(i)For each SYNGAP1 Terminated Product for which Acadia provided a notice of termination on or after the Initiation of the first Phase I/II Clinical Trial for such

SYNGAP1 Terminated Product, and prior to the Initiation of the first Phase III Clinical Trial for such SYNGAP1 Terminated Product:

(ii)For each SYNGAP1 Terminated Product for which Acadia provided a notice of termination after the Initiation of the first Phase III Clinical Trial for such SYNGAP1 Terminated Product and on or within [***] after the delivery of top line results from the first Phase III Clinical Trial of such SYNGAP1 Terminated Product (meaning, the audited, quality-controlled tables, listings and figures, in reasonable and customary form, reflecting all results from such Clinical Trial) to the JSC:

(iii)For each SYNGAP1 Terminated Product for which Acadia provided a notice of termination following the First Commercial Sale of such SYNGAP1 Terminated Product:

(c)In the event Stoke is the Continuing Party and Acadia is the Terminated Party due to Stoke termination for breach pursuant to Section 15.4(a), the applicable royalty rates payable to Acadia shall be as set forth in Section 15.10(b) but reduced by [***]. For clarity, Stoke shall not owe any milestones, including any Development Milestones or Sales Milestones as set forth in Section 9.4, in connection with such SYNGAP1 Terminated Product.

(d)In the event Acadia is the Continuing Party and Stoke is the Terminated Party due to Acadia termination for breach pursuant to Section 15.4(a), the applicable royalty rates payable to Stoke shall be as set forth below. In addition, Acadia shall pay to Stoke [***] of the Development Milestones and Sales Milestones as set forth in Section 9.4 in connection with such SYNGAP1 Terminated Product, to the extent applicable, but further reduced by [***].

(i)For a SYNGAP1 Terminated Product for which Acadia provided a notice of termination on or after the Initiation of the first Phase I/II Clinical Trial for such SYNGAP1 Terminated Product, and prior to the Initiation of the first Phase III Clinical Trial for such SYNGAP1 Terminated Product:

(iii)For each SYNGAP1 Terminated Product for which Acadia provided a notice of termination following the First Commercial Sale of such SYNGAP1 Terminated Product:

15.11Survival. Expiration or termination of this Agreement shall not relieve the Parties of any obligation accruing prior to such expiration or termination. Without limiting the foregoing, the provisions of Sections 2.3, 2.4, 4.6(a), 4.6(b), 4.6(d), 5.6, Article 9 (with respect to any payment obligation accruing prior to expiration or termination), Article 10, Article 11, 12.3(b), 12.3(d), 12.4, Article 13, Section 14.1, Section 14.4 (with respect to legal actions pending as of the date of expiration or termination), 15.6, 15.7, 15.8, 15.10, 15.11, 15.12, Article 16, 17.2, 17.3, 17.4, 17.6, 17.7, 17.8, 17.9, 17.10, 17.11, 17.12, 17.15, and 17.16 shall survive the expiration or termination of this Agreement.

15.12Termination Not Sole Remedy. Termination is not the sole remedy under this Agreement and, whether or not termination is effected and notwithstanding anything contained in this Agreement to the contrary, all other remedies shall remain available except as expressly agreed to otherwise herein.

16.1Tax Partnership with Respect to SYNGAP1 Co-Co Product . It is expressly agreed that Stoke and Acadia shall be independent contractors and that neither Party is assuming liability through, and nothing herein is intended to create, any partnership or agency arrangement between Stoke and Acadia for tax purposes in any jurisdiction in which any activities contemplated by this Agreement and associated agreements are undertaken; provided, however, that the Parties intend that the arrangement between the Parties with respect to SYNGAP1 Co-Co Products shall be treated as a partnership for United States federal and state income tax purposes only (the “Tax Partnership”), and in connection therewith, Acadia is authorized and shall file an election with the United States Internal Revenue Service (and any applicable state Governmental Authority in the United States) to the extent necessary for the arrangement hereunder to be treated as a partnership for United States federal income tax purposes (and state income tax purposes, as applicable). Except as otherwise agreed to by Stoke and Acadia in writing, neither Acadia nor Stoke shall file any returns or take any tax reporting positions inconsistent with the characterization of the Parties’ arrangement with respect to SYNGAP1 Co-Co Product as a Tax Partnership. Notwithstanding anything in the foregoing to the contrary, the Tax Partnership shall not include the MECP2 Licensed Products, [***] Licensed Products or SYNGAP1 Opt-Out Products.

16.2Tax Information Sharing. Each Party shall cooperate in providing any information reasonably requested by the other Party to enable such other Party to report the transactions contemplated by this Agreement on any required tax returns (including information returns), to respond to any request for information from the United States Internal Revenue Service or other taxing authority and to comply with its financial reporting obligations in connection with the financial reporting for taxes. In connection the foregoing, Acadia shall use commercially reasonable efforts to provide Stoke with estimates of its share of the Tax Partnership’s profit and loss in advance of Stoke’s annual Form 10-K filing deadline.

16.3Tax Returns of Tax Partnership . Acadia shall prepare, or cause to be prepared, and file on a timely basis with the appropriate authorities, annual income and other required tax returns for the Tax Partnership, including IRS Form 1065 and any similar tax returns filed with any state or local jurisdiction, and Stoke shall reasonably cooperate with Acadia in connection

therewith, including by timely providing to Acadia all documents and information in Stoke’s control or possession that are reasonably requested by Acadia and that are required to accurately fill out the Tax Partnership tax return (including any related information returns) by Acadia or any of its Affiliates, it being understood that Stoke shall have the right to make appropriate redactions of information unrelated to activities undertaken pursuant to this Agreement. Schedule 16.3 sets forth the procedures to be used in allocating tax items of the Tax Partnership to Acadia and Stoke. Stoke shall have the right to review any tax returns of the Tax Partnership prepared, or caused to be prepared, by Acadia, in each case in advance of their submission and Acadia shall obtain Stoke’s consent to the filing of such return, including with respect to any elections or other determinations made in such returns, which consent shall not be unreasonably withheld, conditioned or delayed. Acadia shall have all powers needed to perform its duties, including the power to retain all attorneys and accountants of its choice in connection therewith, and to make any US federal, state, or local tax elections with Stoke’s consent, which shall not be unreasonably withheld, conditioned or delayed. Notwithstanding the foregoing, the tax elections listed in Schedule 16.3 shall not require Stoke’s consent. The Tax Partnership shall apply the traditional method of allocation under Section 704(c) for any contributions of property deemed to be made to the Tax Partnership, except as otherwise agreed by Stoke and Acadia in writing. Acadia shall take steps to have the Tax Partnership elect under Section 6221(b) of the U.S. Internal Revenue Code (the “Tax Code”), as amended by the Bipartisan Budget Act of 2015, P.L. 114-74 (together with any subsequent amendments thereto, Treasury Regulations promulgated thereunder, and published administrative interpretations thereof, collectively, the “BBA ”) (such election, the “6221(b) election ”) not to be subject to partnership-level audit proceedings. Acadia is hereby designated the “partnership representative ” of the Tax Partnership for all years governed by this Agreement and the “designated individual” shall be an officer or employee of Acadia. To the extent that the Tax Partnership is not eligible to make the 6221(b) election, (a) Acadia shall represent the Tax Partnership in any disputes, controversies or proceedings with the Internal Revenue Service or with any state or local taxing authority and is hereby authorized to take any and all actions that it is permitted to take when acting in that capacity, (b) Stoke shall have the right to participate in all material tax proceedings (including for the avoidance of doubt audits) of the Tax Partnership and shall have the right to consent to the settlement thereof (such consent not to be unreasonably withheld, conditioned or delayed), (c) Stoke shall have the right to be notified of all tax proceedings, (d) the Tax Partnership shall make the election provided by Section 6226 of the Tax Code in respect of any underpayments of tax resulting from an audit of the Tax Partnership and (e) the foregoing provisions related to the BBA shall survive termination of this Agreement and the termination of the Tax Partnership, and shall remain binding on each Party for the period of time necessary to resolve with the Internal Revenue Service (or any other applicable taxing authority) all tax matters relating to the Tax Partnership.

16.4Additional Matters. Notwithstanding Section 16.1 or any other provision of this Agreement, the Parties do not intend to create a partnership under the laws of any jurisdiction, except the Parties intend to create a Tax Partnership, and the Parties shall take positions accordingly for accounting and tax purposes with any applicable Governmental Authority in any other jurisdiction in which any activities contemplated by this Agreement and associated agreements are undertaken. To the extent that the activities contemplated by this Agreement are treated in any such other jurisdiction as a partnership for purposes of computing Acadia’s or Stoke’s tax liability in such jurisdiction, the Parties agree that, to the extent permissible under the Applicable Laws of such jurisdiction, items of partnership income and deduction will be allocated

in a manner that, as close as possible, places the Parties in the same position as if no deemed partnership were created.

(a)Assignment. This Agreement may not be assigned or otherwise transferred (however structured, whether by merger, acquisition, sale of all or substantially all of its assets to which this Agreement relates or otherwise), in whole or in part, nor, except as expressly provided hereunder, may any right or obligation hereunder be assigned or transferred, by either Party without the prior written consent of the other Party; provided, however, that (i) either Party may, without such consent, assign this Agreement and its rights and obligations hereunder, in whole or in part, to any of its Affiliates; provided that the assigning Party shall continue to remain fully responsible for the actions or inactions of such Affiliate, (ii) either Party may, without such consent, assign this Agreement and its rights and obligations hereunder, to its successor in interest in connection with (x) a Change of Control (or similar transaction) or (y) a sale of all or substantially all of its assets related to this Agreement. Written notice of any permitted assignment of this Agreement shall be promptly provided to the non-assigning Party and any permitted assignee shall assume all rights and obligations of its assignor under this Agreement. Any attempted assignment not in accordance with this Section 17.1 shall be void.

(b)Change of Control. Whether or not this Agreement is assigned pursuant to Section 17.1(a), the Parties agree as follows: the rights to Patent Rights, Know-How or other intellectual property rights of any successor-in-interest of a Party as a result of a Change of Control of such Party or any Person that becomes an Affiliate of a Party through any Change of Control of such Party, that were controlled by such successor or Person (and not such Party or any of its Affiliates prior to such Change of Control) immediately prior to such Change of Control (other than as a result of a license or other grant of rights, covenant or assignment by such Party or its other Affiliates to, or for the benefit of, such Person), will not be deemed to be “Controlled” by such Party for purposes of this Agreement and will be automatically excluded from the rights licensed to the other Party under this Agreement, provided in each case except to the extent that any such Patent Rights, Know-How or other intellectual property rights (x) are actually used in the course of such Party’s or such Third Party successor-in-interest’s performance of activities under this Agreement, or (y) was otherwise licensed or sublicensed (as applicable) by such Third Party to such Party, or any Persons that were Affiliates of such Party prior to such Change of Control (as applicable) (such excluded Know-How, Patent Rights or other intellectual property rights , “Acquiring Person Intellectual Property”).

17.2Severability. Should one or more of the provisions of this Agreement become void or unenforceable as a matter of Applicable Law, then this Agreement shall be construed as if such provision were not contained herein and the remainder of this Agreement shall be in full force and effect, and the Parties will use their best efforts to substitute for the invalid or unenforceable provision a valid and enforceable provision which conforms as nearly as possible with the original intent of the Parties.

17.3Governing Law; English Language. This Agreement shall be governed by and construed in accordance with the laws of the State of New York without reference to any rules of conflict of laws. This Agreement was prepared in the English language, which language shall govern the interpretation of, and any dispute regarding, the terms of this Agreement.

(a)Early Resolution. The Parties shall negotiate in good faith and use reasonable efforts to settle any dispute, controversy or claim arising from or related to this Agreement, including the formation, existence, validity, enforceability, performance, interpretation, breach, or termination hereof or thereof (a “Dispute”). Subject to Section 3.7 and Section 17.4(c), if any Dispute arises between the Parties, either Party may refer the Dispute to Executive Officers of each Party for resolution. If, after [***] after the notice of Dispute, such Executive Officers have not succeeded in negotiating a resolution of the Dispute, and a Party wishes to pursue the matter, each such Dispute, controversy or claim that is not an “Excluded Claim” (defined in Section 17.4(b)) shall be submitted for binding arbitration administered by the International Chamber of Commerce (“ICC”) pursuant to its Arbitration Rules in effect at the time such Dispute arises (the “ICC Arbitration Rules”). The option to arbitrate under this Section 17.4(a) shall extend to any claims by or against the Parties and their respective Affiliates and any agents, principals, officers, directors, or employees of either of the Parties or their respective Affiliates.

(b)Arbitration. Any arbitration that the Parties decide to pursue shall be conducted by a single neutral arbitrator experienced in the business of pharmaceuticals. If the issues in dispute involve scientific, technical or commercial matters, the arbitrator chosen hereunder may engage experts that have educational training or industry experience sufficient to demonstrate a reasonable level of relevant scientific, medical and industry knowledge, as necessary to help resolve the dispute. The Parties shall select the arbitrator promptly following the initiation of the arbitration. If the Parties are unable or fail to agree upon the arbitrator within [***] following the initiation of arbitration, the arbitrator shall be appointed by ICC. The arbitration shall be conducted in New York, New York, and all proceedings and communications shall be in English. Except to the extent necessary to enforce a legal right or as may be required by law, neither a Party nor an arbitrator may disclose the existence, content, or results of an arbitration without the prior written consent of both Parties. Each Party shall bear its own costs and expenses and attorneys’ fees and an equal share of the arbitrator’s fees and any administrative fees of arbitration. Any arbitration findings or rulings made under this Section 17.4(b) shall be final and binding on the Parties and may be enforced in any court of competent jurisdiction. As used in this Section 17.4 , the term “Excluded Claim ” means a dispute , controversy or claim that concerns (i) the validity or infringement of a patent, trademark, copyright or trade secret, or (ii) any antitrust, anti-monopoly or competition Applicable Laws or regulation, whether or not statutory. Any action concerning Excluded Claims identified in the foregoing clauses (i) or (ii) may be brought in any court having jurisdiction.

(c)Baseball Arbitration. Any Deadlocked Matters referred to this Section 17.4(c) for resolution in accordance with Section 3.7 shall be submitted to and finally resolved by the following provisions in this Section 17.4(c) (the “baseball-style” arbitration). The Parties will select and agree upon a mutually acceptable single arbitrator with at least ten (10) years’

experience in the licensing, development and commercialization of pharmaceutical products, including biologics, who is independent of each Party (i.e., not a current or former employee, consultant, officer, or director or current stockholder of either Party or their respective Affiliates and who does not otherwise have any current or previous business relationship with either Party or their respective Affiliates), within [***] following the end of the [***] period during which the Executive Officers failed to resolve such Deadlocked Matter, provided that if the Parties are unable or fail to agree upon the arbitrator within [***], the arbitrator shall be appointed by the Judicial Arbitration and Mediation Services (“JAMS”) within [***]. The arbitration shall be conducted in accordance with the JAMS procedures to the extent consistent with this Section 17.4(c). Within [***] after the selection of the arbitrator, each Party will submit to the arbitrator and the other Party such Party’s proposal on the terms pertaining to such Deadlocked Matter. Within [***] after receiving each Parties’ proposal, the arbitrator will select as final and binding the proposal such arbitrator believes is consistent with the successful advancement of the relevant Program(s) and the successful Development and Commercialization of relevant Products, in each case, consistent with the express terms and conditions of this Agreement and, to the extent determinable, consistent with the intent of the Parties when this Agreement was entered into; provided the arbitrator may not alter the terms of this Agreement, and the arbitrator will not have the authority to modify either Party’s proposal. The decision of the arbitrator will be final and binding on the Parties. The Parties agree that the arbitrator’s decision may be enforced in any court of competent jurisdiction.

(d)Confidentiality . Except to the extent necessary to comply with Applicable Law, legal process, or a court order or to enforce a final settlement agreement or secure enforcement of any arbitration award, the Parties agree that the existence, terms and content of any arbitration, all information and documents disclosed in any arbitration or evidencing any arbitration results, award, judgment or settlement, or the performance thereof, and any allegations, statements and admissions made or positions taken by either Party in any arbitration, shall be treated and maintained in confidence and are not intended to be used or disclosed for any other purpose or in any other forum.

(e)Equitable Relief. Nothing in this Section 17.4 shall preclude either Party from seeking equitable relief or interim or provisional relief from a court of competent jurisdiction, including a temporary restraining order, preliminary injunction or other interim equitable relief, concerning a dispute either prior to or during any arbitration if necessary to protect the interests of such Party or to preserve the status quo pending the arbitration proceeding.

17.5Force Majeure. Neither Party shall be responsible to the other for any failure or delay in performing any of its obligations under this Agreement or for other nonperformance hereunder (excluding, in each case, the obligation to make payments when due) if such delay or nonperformance is caused by strike, fire, flood, earthquake, accident, war, act of terrorism, pandemics, act of God or of the government of any country or of any local government, or by any other cause unavoidable or beyond the control of any Party hereto. In such event, such affected Party shall use Commercially Reasonable Efforts to resume performance of its obligations and shall keep the other Party informed of actions related thereto.

17.6Extension to Affiliates. Except as expressly set forth otherwise in this Agreement, each Party shall have the right to extend the rights and immunities granted in this Agreement to one or more of its Affiliates. All applicable terms and provisions of this Agreement, except this

right to extend, shall apply to any such Affiliate to which this Agreement has been extended to the same extent as such terms and provisions apply to the Party extending such rights and immunities. For clarity, a Party extending the rights and immunities granted hereunder shall remain primarily liable for any acts or omissions of its Affiliates.

17.7Waivers and Amendments. The failure of a Party to insist upon strict performance of any provision of this Agreement or to exercise any right arising out of this Agreement shall neither impair that provision or right nor constitute a waiver of that provision or right, in whole or in part, in that instance or in any other instance. Any waiver by a Party of a particular provision or right shall be in writing, shall be as to a particular matter and, if applicable, for a particular period of time and shall be signed by such Party. No provision of this Agreement may be amended or modified other than by a written document signed by authorized representatives of each Party.

17.8Relationship of the Parties. Nothing contained in this Agreement shall be deemed to constitute a partnership, joint venture, or legal entity of any type between Stoke and Acadia, or to constitute one as the agent of the other. Each Party shall act solely as an independent contractor, and nothing in this Agreement shall be construed to give any Party the power or authority to act for, bind or commit the other.

17.9Notices. All notices, consents or waivers under this Agreement shall be in writing and will be deemed to have been duly given when delivered in person, transmitted by email (receipt verified) or by express courier service (signature required) to the Party to which it is directed at its address or email shown below (or to such other addresses and fax numbers as a Party may designate by notice). This Section 17.9 is not intended to govern the day-to-day business communications necessary between the Parties in performing their obligations under the terms of this Agreement.

Stoke Therapeutics, Inc.
45 Wiggins Avenue
Bedford, MA 01730
Email: [***]
Attention: Legal

17.10Further Assurances. Acadia and Stoke hereby covenant and agree without the necessity of any further consideration, to execute, acknowledge and deliver any and all documents and take any ministerial action as may be reasonably necessary to carry out the intent and purposes of this Agreement.

17.11No Third Party Beneficiary Rights. This Agreement is not intended to and shall not be construed to give any Third Party any interest or rights (including any Third Party beneficiary rights) with respect to or in connection with any agreement or provision contained herein or contemplated hereby, except as otherwise expressly provided for in this Agreement.

17.12Entire Agreement. This Agreement, including all Exhibits and Schedules hereto, and each Pharmacovigilance Agreement, SYNGAP1 Co-Co Clinical Supply Agreement and SYNGAP1 Co-Co Commercial Supply Agreement set forth the entire agreement and understanding of the Parties as to the subject matter hereof and supersedes all proposals, oral or written, and all other communications between the Parties with respect to such subject matter. The Parties acknowledge and agree that, as of the Effective Date, all Confidential Information disclosed pursuant to the Confidentiality Agreement by a Party or its Affiliates to the extent related to the subject matter hereof shall be included in the Confidential Information subject to this Agreement and the Confidentiality Agreement is hereby superseded to the extent related to the subject matter hereof, provided that the foregoing shall not relieve any Person of any right or obligation accruing under the Confidentiality Agreement prior to the Effective Date. “Confidentiality Agreement ” means the Non-Disclosure Agreement between Stoke and Acadia dated July 7, 2020 as amended.

17.13Counterparts. This Agreement may be executed in two (2) or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. A facsimile or scanned copy of this Agreement that includes a Party’s signature will be deemed an original. Facsimile, PDF or other electronic execution and delivery of this Agreement by any Party shall constitute a legal, valid and binding execution and delivery of this Agreement by such Party.

17.14Expenses. Each Party shall pay its own costs, charges and expenses incurred in connection with the negotiation, preparation and signing of this Agreement.

(a)Construction. The Parties hereto acknowledge and agree that (i) each Party and its counsel reviewed and negotiated the terms and provisions of this Agreement and have contributed to its revision, (ii) the rule of construction to the effect that any ambiguities are resolved against the drafting Party shall not be employed in the interpretation of this Agreement, and (iii) the terms and provisions of this Agreement shall be construed fairly as to all Parties hereto and not in a favor of or against any Party, regardless of which Party was generally responsible for the preparation of this Agreement.

(b)Interpretation. Whenever the context may require, any pronoun shall include the corresponding masculine, feminine and neuter forms. The words “include”, “includes” and “including” shall be deemed to be followed by the phrase “without limitation”. The word “will” shall be construed to have the same meaning and effect as the word “shall” and vice versa . The word “any” shall mean “any and all” unless otherwise clearly indicated by context. The term “or” will be interpreted in the inclusive sense commonly associated with the term “and/or.” Unless the context requires otherwise, (i) any definition of or reference to any agreement , instrument or other document herein shall be construed as referring to such agreement, instrument or other document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth herein or therein), (ii) any reference to any Applicable Laws herein shall be construed as referring to such Applicable Laws as from time to time enacted, repealed or amended, (iii) any reference herein to any Person shall be construed to include the Person’s successors and permitted assigns, (iv) the words “herein”, “hereof” and “hereunder”, and words of similar import, shall be construed to refer to this Agreement in its entirety and not to any particular provision hereof, and (v) all references herein to Articles, Sections, Exhibits or Schedules, unless otherwise specifically provided, shall be construed to refer to Articles, Sections, Exhibits and Schedules of this Agreement. The headings of Articles and Sections of this Agreement are for ease of reference only and shall not affect the meaning or interpretation of this Agreement in any way.

17.16Cumulative Remedies. No remedy referred to in this Agreement is intended to be exclusive unless explicitly stated to be so, and each shall be cumulative and in addition to any other remedy referred to in this Agreement or otherwise available under law.

17.17Export. This Agreement is made subject to any restrictions concerning the export of products or technical information from the United States or other countries which may be imposed upon or related to Stoke or Acadia from time to time. Each Party agrees that it will not export, directly or indirectly, any technical information acquired from the other Party under this Agreement or any products using such technical information to a location or in a manner that at the time of export requires an export license or other Governmental Authority approval, without first obtaining the written consent to do so from the appropriate Governmental Authority.

IN WITNESS WHEREOF, the Parties intending to be bound have caused this Agreement to be executed by their duly authorized representatives as of the Effective Date.

List of Exhibits and Schedules

Schedule 1.67	Manufacturing Cost
Schedule 1.107	Stoke Existing In-License
Schedule 1.110	Stoke MECP2 Patents
Schedule 1.113	Stoke [***] Patents
Schedule 1.116	Stoke SYNGAP1 Patents
Schedule 4.1	Initial Research Plans and Research Budgets
Schedule 11.2	Press Release
Schedule 16.3	Partnership Tax Related Provisions

“Manufacturing Cost ” means the fully burdened cost of Manufacturing the applicable SYNGAP1 Co-Co Product (or other component(s) contained therein or placebo, as applicable), including any devices and other delivery technologies that are packaged or otherwise distributed with such SYNGAP1 Co-Co Product, which equals the sum of (a) Direct Costs and Indirect Costs (each as defined below) incurred by a Party, (b) the amounts paid by a Party to a Third Party contract manufacturer as invoiced to such Party, including any fees paid to such Third Party as prepayments or to reserve capacity for the Clinical Candidate or SYNGAP1 Co-Co Product and any cancellation or early termination fees (provided that the Party incurring any cancellation or early termination fees used commercially reasonable efforts to mitigate such fees), and any value-added tax or similar tax due for amounts paid to such Third Party directly attributable to such Clinical Candidate or SYNGAP1 Co-Co Product, and any capital expenditures to the extent incurred for the Clinical Candidate or SYNGAP1 Co-Co Product, (c) the Parties shall share depreciation of any internal capital expenditures, if any, to the extent incurred for the Clinical Candidate or SYNGAP1 Co-Co Product, and (d) direct distribution expense (including without limitation, freight, postage, shipping, customs, duties and insurance charges) incurred for such Clinical Candidate or SYNGAP1 Co-Co Product, except to the extent such expenses were included in calculating Net Sales without any mark-up; provided that any Direct Costs or Indirect Costs incurred by a Party to supervise and coordinate the foregoing activities performed by a Third Party. Manufacturing Cost shall include costs incurred with respect to, or as a result of, spoilage, and obsolescence, of inventory associated with such SYNGAP1 Co-Co Product as well as failed or destroyed batches of SYNGAP1 Co-Co Product except to the extent attributable to a Party’s or any of its Affiliates’ negligence or willful misconduct. Notwithstanding anything to the contrary contained herein, Manufacturing Costs shall exclude any and all costs incurred in connection with establishing, or otherwise causing to become operational, any Manufacturing facilities, including any validation, technology transfer (other than the Manufacturing technology transfer costs as included under Other Expenses) and licensure costs, and such costs shall be borne solely by the Party who is establishing or operationalizing (itself or through its Affiliate or Third Party contract manufacturer) such Manufacturing facilities, and ownership of any capital equipment for Manufacturing shall reside with the Party that ultimately paid for such capital equipment (factoring in any reimbursements between the Parties).

For purposes of this Schedule 1.67 , “Direct Costs” equals the sum of the following as incurred for the applicable Clinical Candidate or SYNGAP1 Co-Co Product:

(a)Direct labor, based on the actual hours or like methodology consumed by manufacturing, facility, and customer service personnel for the Clinical Candidate or SYNGAP1 Co-Co Product applied at an average hourly wage rate that is designed to approximate actual cost for each employee’s position.

(b)Direct labor fringe benefits, including, compensation expense (other than wages included in direct labor cost in clause (x)(i)), payroll taxes and benefits allocated based on a proportionate percentage of direct labor costs applied to the Clinical Candidate or SYNGAP1 Co-Co Product to

total actual plant-wide labor costs, plus Clinical Candidate-specific or SYNGAP1 Co-Co Product-specific travel.

(c)Materials and supplies for making the applicable Clinical Candidate or SYNGAP1 Co-Co Product, based on actual costs including any applicable freight, taxes, duties, customs or import fees, less any discounts or free goods.

(d)Other costs directly associated with or actually consumed for the applicable Clinical Candidate or SYNGAP1 Co-Co Product, including handling, storage, distribution, and transportation costs, facility costs, depreciation, waste removal, miscellaneous supplies, outside testing, consulting fees, occupancy costs, maintenance, rent, insurance, site service support, warehouse, customer services including order entry, billing and adjustments, inquiry and credit and collection, serialization, return and recall management, but for clarity, excluding in each case any such amounts to the extent included as a deduction in calculating Net Sales, as applicable.

For purposes of this Schedule 1.67 , “Indirect Costs” equals the sum of the following as incurred for the applicable Clinical Candidate or SYNGAP1 Co-Co Product:

(i)Plant support services, which includes quality control , process sciences, quality assurance, regulatory and validation. All general costs for each plant support service department, which includes, labor, payroll taxes, fringe benefits, materials and supplies, outside testing, consulting fees, contractor costs, depreciation, maintenance and occupancy costs, shall be allocated to the cost of such Clinical Candidate or SYNGAP1 Co-Co Product based on the proportion of actual labor hours consumed by each plant support service department on the Clinical Candidate or SYNGAP1 Co-Co Product to total actual labor hours consumed by each plant support service department on all of the applicable Party’s products.

(ii)Overhead costs required to support the Manufacture of such Clinical Candidate or SYNGAP1 Co-Co Product. These overhead costs are allocated either based on actual labor hours, average headcount, space occupied, or other activity-based method, solely to the extent such allocation is attributable to the Clinical Candidate or SYNGAP1 Co-Co Product and not to other products. Overhead costs primarily include general materials and supplies, consulting costs, and other labor costs such as general plant maintenance, management, engineering, janitorial services and administration, information services, human relations, travel and training, and vacation, holiday, personal and sick time, general facility costs which include facility services and supplies, utilities, rent, real estate taxes, depreciation, general and preventative maintenance, insurance and waste removal.

(a)“Adjusted Capital Account ” has the meaning set forth in Section 1.4(f) of this Schedule 16.3.

(c)“Book ” means the method of accounting prescribed for compliance with the capital account maintenance rules set forth in Section 1.704-1(b)(2)(iv) of the Treasury Regulations, as distinguished from any accounting method which a Party may adopt for other purposes such as financial reporting.

(d)“Capital Account ” has the meaning set forth in Section 1.4(a) of this Schedule 16.3.

(e)“Capital Contribution” means, for each Partner, such Partner’s cash or property deemed contributed to the Tax Partnership.

(g)“Gross Asset Value” means, with respect to any asset of the Tax Partnership, the asset’s adjusted basis for federal income tax purposes, adjusted to reflect any adjustments required or permitted by Sections 1.704-1(b)(2)(iv)(d) through (g), (m) and (s) of the Treasury Regulations , as determined by the Partner Representative and mutually agreed upon by the Partners; provided, that in the case of any asset (other than cash) deemed contributed to the Tax Partnership, the initial Gross Asset Value of such property shall be equal to the fair market value of such asset as of the date of contribution, as determined by the Partnership Representative and mutually agreed upon by the Partners.

(h)“Net Income” and “Net Losses ” shall mean the Book income, gain, loss, deductions and credits of the Tax Partnership in the aggregate or separately stated, as appropriate, as of the close of each Taxable Year on the Tax Partnership’s tax return filed for federal income tax purposes (or other allocation period).

(i)“Partner” shall refer to a Party in its capacity as a member of the Tax Partnership.

(k)“Percentage Interest” shall mean each Partner’s respective interest as determined in accordance with Section 9.5(b) of the Agreement.

(m)“Taxable Year” means the Tax Partnership’s Fiscal Year or such other year as may be required by Section 706 of the Tax Code.

(n)“Treasury Regulations” means regulations (whether in final, proposed or temporary form) promulgated by the U.S. Department of the Treasury under the Tax Code, as amended.

(a)The amount of any Capital Contributions deemed contributed by each Partner to the Tax Partnership shall be determined by the Partnership Representative and mutually agreed upon by the Partners, including the deemed Capital Contributions addressed in (b) below.

(b)Each Partner shall be deemed to have contributed to the Tax Partnership its share of costs borne by such Partner, as determined by the Partnership Representative.

(a)The Tax Partnership shall maintain a separate capital account for each Partner according to the rules set forth in Section 1.704-1(b)(2)(iv) of the Treasury Regulations (a “Capital Account”).

(i) shall be increased by (A) the deemed Capital Contributions by such Partner to the Tax Partnership (net of liabilities secured by the contributed property that the Tax Partnership is considered to assume or take subject to under Section 752 of the Tax Code), and (B) such Partner’s distributive share of Net Income and other items of income and gain allocated to such Partner, and

(ii) shall be decreased by (A) the amount of money deemed distributed to such Partner by the Tax Partnership, (B) the fair market value of property (as determined by the Partnership Representative and mutually agreed upon by the Partners) deemed distributed to such Partner by the Tax Partnership (net of liabilities secured by the distributed property that the Partner is considered to assume or take subject to under Section 752 of the Tax Code )and (C) such Partner’s distributive share of Net Losses and other items of loss and deduction allocated to such Partner.

(c)Any Milestone Payment under Section 9.4 of the Agreement shall be treated as additional contingent consideration for the licenses and rights granted by Stoke to Acadia with respect to the SYNGAP1 Co-Co Products under the Agreement. For purposes of maintaining the

Capital Accounts of the Partners, a Milestone Payment (other than any portion treated as interest for US federal income tax purposes) shall be taken into account as an increase in the adjusted basis and fair market value of the property contributed by Acadia to the Tax Partnership and a commensurate increase in the fair market value of the property contributed by Stoke to the Tax Partnership.

(d)Other adjustments shall be made to the Capital Accounts of the Partners to accord with the regulations promulgated under Section 704(b) of the Tax Code as mutually agreed upon by the Partners.

(e)The Capital Account of each Partner as of the date of the Agreement shall be equal to the amount reflected on Annex 1 to this Schedule 16.3.

(f)With respect to any Partner, the balance of such Partner’s Capital Account as of the end of the relevant fiscal year or other period, may be adjusted in accordance with the provisions of Regulations Section 1.704-1(b)(2)(ii)(d) (an “Adjusted Capital Account”).

(a)Non-Liquidating Distributions. For purposes of maintaining Partners’ Capital Accounts, any payments made to the Partners in accordance with the provisions of Section 9.6(b) of the Agreement shall be treated as distributions described in Section 1.4(b)(ii) of this Schedule 16.3. Such distributions shall be deemed to have been made for tax purposes with respect to a Calendar Quarter when the amounts due or from each Party, as determined under Sections 9.6(b)(iii) and 9.6(b)(vi) of the Agreement, are paid.

(b)Liquidating Distribution. Upon the termination of the Agreement, the distribution or division of assets pursuant to the applicable governing provisions of the Agreement shall be treated as distributions in liquidation of the Tax Partnership.

(c)Withholding for Taxes. In the manner described in Section 9.9(b) of the Agreement , any Partner is authorized to withhold from distributions described in Section 1.5(a) or Section 1.5(b) of this Schedule 16.3 that are made or deemed made to the Partners, and with respect to allocations pursuant to Section 1.6 of this Schedule 16.3 to the Partners, and to pay over to any federal, state, local or foreign government, any such taxes as are required to be deducted or withheld under any provision of Applicable Law. Any amounts so withheld shall be treated as actually distributed pursuant to Section 9.6(b) of the Agreement and Section 1.5(a) or Section 1.5(b) of this Schedule 16.3, to the extent applicable.

(a)In the event any Partner unexpectedly receives any adjustments, allocations or distributions described in Sections 1.704-1(b)(2)(ii)(d)(4), 1.704-1(b)(2)(ii)(d)(5) or 1.704-1(b)(2)(ii)(d)(6) of the Treasury Regulations, items of income (including gross income) and gain shall be specially allocated to such Partner in an amount and manner sufficient to eliminate the deficit balance in such Partner’s Capital Account (in excess of (i) the amount such Partner is obligated to restore upon liquidation of the Tax Partnership or upon liquidation of such Partner’s interest in the Tax Partnership and (ii) such Partner’s share of the Minimum Gain (as defined in Section 1.704-2 of the Treasury Regulations )) created by such adjustments, allocations or distributions as quickly as possible. Additionally, there are hereby incorporated herein such special allocation provisions governing the allocation of income, deduction, gain, and loss for U.S. federal income tax purposes as may be necessary under, and in the manner required by, the Treasury Regulations to ensure that this Schedule 16.3 complies with all requirements of Section 1.704-2 of the Treasury Regulations relating to “minimum gain ” and “partner nonrecourse debt minimum gain ” and the allocation and chargeback of so-called “nonrecourse deductions” and “partner nonrecourse deductions”, including a “qualified income offset”.

(b)If the allocation of Net Loss (or items of loss or deduction) to a Partner as provided in Section 1.6 of this Schedule 16.3 would create or increase an Adjusted Capital Account deficit, then there shall be allocated to such Partner only that amount of Net Loss (or items of loss or deduction) as will not create or increase an Adjusted Capital Account deficit. The Net Loss (or items of loss or deduction) that would, absent the application of the preceding sentence, otherwise be allocated to such Partner shall be allocated to the other Partner, subject to the limitations of this Section 1.7(b).

(c)Any special allocations pursuant to Section 1.7(a) or Section 1.7(b) shall be taken into account by the Partners in computing subsequent Book allocations under the Agreement so that the net amount of the Book items allocated to each Partner shall, to the extent permitted under the Tax Code and Treasury Regulations, be equal to the net amount that would have been allocated to each Partner if such special allocations had not occurred.

(a)Except as otherwise provided in this Section 1.8(a) and Section 1.8(b) of this Schedule 16.3 , for U.S. federal income tax purposes, all items of income gain, loss deduction and credit shall be allocated among the Partners in the same manner the corresponding Book item was allocated pursuant to Section 1.6(a) or Section 1.7(a) of this Schedule 16.3 . In the case of contributed property, items of income, gain, loss, deduction and credit, as determined for federal income tax purposes, shall be allocated first in a manner consistent with the requirements of Section 704(c) of the Tax Code to take into account the difference between the Gross Asset Value of such property and its adjusted tax basis at the time of contribution. If the Gross Asset Value of any asset of the Tax Partnership is adjusted pursuant to the terms of this Schedule 16.3 , then subsequent allocations of income, gain, loss, deduction and credit, as determined for federal

income tax purposes, shall be allocated with respect to such assets so as to take into account such adjustment in the same manner as under Section 704(c) of the Tax Code and the Treasury Regulations promulgated thereunder.

(b)The method under Section 704(c) of the Tax Code and the Treasury Regulations promulgated thereunder shall be the “traditional method” (as described in Section 1.704-3 of the Treasury Regulations), unless otherwise agreed by both Partners. For the sake of clarity, the allocations required by Section 1.7 and this Section 1.8(b) of this Schedule 16.3 are solely for purposes of federal, state and local income taxes and will not affect the allocation of Net Income or Net Losses as between the Partners or any Partner’s Capital Account.

(a)The Partnership Representative shall prepare and file, or cause to be prepared and filed, all necessary U.S. federal, state or local income tax returns for the Tax Partnership. Within 120 days after the end of each Taxable Year, the Partnership Representative shall submit a copy of such tax return to Stoke for its review and consent, not to be unreasonably withheld, conditioned or delayed. The Partnership Representative shall not unreasonably refuse to incorporate any comments from Stoke on such Tax Return that are submitted by Stoke no fewer than 30 days prior to the due date of such tax return. The Partnership Representative shall cause the Tax Partnership to furnish each Partner with an IRS Form K-1 for such Taxable Year. In addition, the Partnership Representative shall deliver or cause to be delivered not later than the 45th day after the end of each Taxable Year to each Partner all information that is reasonably necessary for the preparation of such Partner’s federal income tax returns and any state, local and foreign income tax returns that such Partner is required to file, and related financial reporting obligations of such Partner with respect to its ownership of the Tax Partnership.

The Partnership Representative will determine whether to make or revoke any available election pursuant to the Tax Code, provided, however, that any action on the part of the Partnership Representative with respect to such election in its capacity as Partnership Representative shall require the prior written consent of Stoke if such action would reasonably be expected to have a disproportionate adverse impact on Stoke. Notwithstanding the foregoing, nothing in the Agreement or this Schedule 16.3 shall prevent the Partnership Representative from making any of the following elections:

(i)Adoption of any method of accounting within the meaning of Section 446 of the Tax Code, provided that such method is adopted in good faith and would be reasonable if all Partners were corporations subject to tax on their income at the same tax rate under Section 11(b) of the Tax Code;

(iii)An election for the Tax Partnership to be treated as a partnership under Treasury Regulations § 301.7701-3 (or any comparable provision of state or local tax law, in each case, if necessary).

(b)The Partners hereby agree to cooperate in good faith regarding any matters related to any tax elections or tax reporting positions of the Tax Partnership.

(c)In the event that the Tax Partnership is ineligible to make an election out of the BBA under §6221(b), then the Partnership Representative is authorized to (i) represent the Tax Partnership (at the Tax Partnership’s expense) in connection with all examinations of the Tax Partnership’s affairs by U.S. federal (and any applicable state) income tax authorities, including resulting administrative and judicial proceedings, and to expend Tax Partnership funds for professional services and costs associated therewith, (ii) take any other actions permitted or necessary under the BBA, and (iii) make any available election under the BBA, including an election under Section 6226 of the Tax Code to push out any adjustments to the Partners, provided that the Partnership Representative shall keep the other Partners reasonably informed, shall provide the other Partners the opportunity to participate in any such matters, and shall not make an election under the BBA that could reasonably be anticipated to have a disproportionate adverse impact on a Partner without such Partner’s consent (such consent not to be unreasonably withheld, conditioned or delayed). Each Partner agrees to (i) cooperate with the Partnership Representative as reasonably requested by the Partnership Representative with respect to the conduct of such proceedings and (ii) provide any information necessary to allow the Partnership Representative to make any election or decision permitted under the BBA. The Partnership Representative will, in its reasonable discretion, determine whether the Tax Partnership (either on its own behalf or on behalf of the Partners) will contest or continue to contest any tax deficiencies assessed or proposed to be assessed by any taxing authority provided, however, that the Partnership Representative shall keep the other Partners reasonably informed and shall not agree or consent to compromise or settle such matters without the prior written consent of any affected Partner, which consent shall not be unreasonably delayed, conditioned or withheld. Any deficiency for taxes imposed on any Partner (including penalties, additions to tax or interest imposed with respect to such taxes) will be paid by such Partner, and if paid by the other Partner, will be recoverable from such Partner (including by offset against distributions otherwise payable to such Partner). The Partners agree to cooperate in good faith to notify each other regarding any tax notices or audits relating to the Tax Partnership.

Aggregate Annual Net Sales in the Territory	Royalty Rate
Portion of Net Sales in a given Calendar Year less than or equal to [***]	[***]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to [*]	[**]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to [*]	[***]
Portion of Net Sales in a given Calendar Year greater than [***]	[***]

STOKE THERAPEUTICS, INC.

By:		/s/ Edward M. Kaye
Name:		Edward M. Kaye
Title:		Chief Executive Officer

By:		/s/ Huw M. Nash
Name:		Huw M. Nash
Title:		Chief Operating Officer & Chief Business Officer

ACADIA PHARMACEUTICALS INC.

By:		/Stephen R. Davis
Name:		Stephen R. Davis
Title:		Chief Executive Officer


Definition	Section
Acadia	Preamble
Acadia Indemnitee	13.1(a)
Acadia Patents	14.3(c)
Acquired COC Program	2.5(b)(ii)
Acquiring Person COC Program	2.5(b)(i)
Agreement	Preamble
Alliance Manager	3.1

Development Milestone Event	Development Milestone Payment
[***]	[$***]
[***]	[$***]
[***]	[***]
[***]	[***]
[***]	[***]
[***]	[***]

Sales Milestone Event (each MECP2 Licensed Product)	Sales Milestone Payment
[***]	[***]
[***]	[***]
[***]	[***]


Aggregate Annual Net Sales of a MECP2 Licensed Product in the Territory	Royalty Rate
Portion of Net Sales in a given Calendar Year less than or equal to [***]	[***]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to [*]	[***]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to *]	[***]
Portion of Net Sales in a given Calendar Year greater than [***]	[***]

Sales Milestone Event (each [***] Licensed Product)	Sales Milestone Payment
[***]	[***]
[***]	[***]
[***]	[***]


Aggregate Annual Net Sales of a [***] Licensed Product in the Territory	Royalty Rate
Portion of Net Sales in a given Calendar Year less than or equal to [***]	[***]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to [*]	[***]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to [*]	[***]
Portion of Net Sales in a given Calendar Year greater than [***]	[***]

Sales Milestone Event (each SYNGAP1 Co-Co Product and each SYNGAP1 Opt-Out Product)	Sales Milestone Payment
[***]	[***]
[***]	[***]
[***]	[***]

Aggregate Annual Net Sales of the SYNGAP1 Opt-Out Product in the Territory	Royalty Rate
Portion of Net Sales in a given Calendar Year less than or equal to [***]	[***]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to [*]	[***]
Portion of Net Sales in a given Calendar Year greater than [*] but less than or equal to [*]	[***]
Portion of Net Sales in a given Calendar Year greater than [***]	[***]