Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in Registration Statements on this Form S-1 of our report dated March 31, 2022, relating to the consolidated financial statements of Biostage Inc., appearing in its Annual Report on Form 10-K for the year ended December 31, 2021 and to the reference to us under the heading “Experts” in such Registration Statement.

/s/ Wei, Wei & Co., LLP

Flushing, New York

June 21, 2022

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