Calculation of Filing Fee Tables

S-8

Silence Therapeutics plc

Table 1: Newly Registered Securities

	Security Type	Security Class Title	Fee Calculation Rule	Amount Registered	Proposed Maximum Offering Price Per Unit	Maximum Aggregate Offering Price	Fee Rate	Amount of Registration Fee
1	Equity	Ordinary Shares, nominal value GBP 0.05 per share, to be issued upon the exercise of options to be granted under the 2023 Equity Incentive Plan with Non-Employee Sub-Plan and CSOP Sub-Plan	Other	2,834,037	$ 1.79	$ 5,072,927.00	0.0001381	$ 700.58
Total Offering Amounts:						$ 5,072,927.00		$ 700.58
Total Fee Offsets:								$ 0.00
Net Fee Due:								$ 700.58

Offering Note

¹ (A) These shares may be represented by the Silence Therapeutics plc (the "Registrant's") American Depositary Shares ("ADSs"). Each ADS represents three ordinary shares, nominal value GBP0.05 per share ("Ordinary Shares"). The Registrant's ADSs issuable upon deposit of the Ordinary Shares registered hereby have been registered under a separate registration statement on Form F-6 (File No. 333-248217). (B) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall also cover any additional Ordinary Shares and ADSs of the Registrant that become issuable under the Registrant's 2023 Equity Incentive Plan with Non-Employee Sub-Plan and CSOP Sub-Plan (the "2023 EIP") by reason of any share dividend, share split (sub-division), recapitalization or other similar transaction. (C) Estimated in accordance with Rules 457(c) and 457(h) solely for purposes of calculating the registration fee on the basis of $1.79 per Ordinary Share (or $5.37 per ADS), the average of the high and low prices of the ADSs as reported on the Nasdaq Global Market on February 26, 2026. (D) Represents 2,834,037 additional Ordinary Shares that were add to the shares authorized for issuance under the Registrant's 2023 EIP on January 1, 2026 pursuant to an annual "evergreen" increase provision contained in the 2023 EIP. The number of shares reserved for issuance under the 2023 EIP will automatically increase on January 1st each year, starting on January 1, 2024, and continuing through January 1, 2033, by an amount which is the lesser of (a) five percent (5%) of the total number of Ordinary Shares of the Registrant outstanding on December 31st of the immediately preceding calendar year; and (b) a smaller number of shares determined by the Registrant's board of directors. Prior to January 1, 2026, the board of directors approved an annual increase equal to 2% of the aggregate number of Ordinary Shares outstanding on December 31, 2025 to the 2023 EIP, which is 2,834,037 shares.

Table 2: Fee Offset Claims and Sources ☑Not Applicable

		Registrant or Filer Name	Form or Filing Type	File Number	Initial Filing Date	Filing Date	Fee Offset Claimed	Security Type Associated with Fee Offset Claimed	Security Title Associated with Fee Offset Claimed	Unsold Securities Associated with Fee Offset Claimed	Unsold Aggregate Offering Amount Associated with Fee Offset Claimed	Fee Paid with Fee Offset Source
Rule 457(p)
Fee Offset Claims	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Fee Offset Sources	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A