Calculation of Filing Fee Table

FORM S-8

(Form Type)

ClearPoint Neuro, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

Security Type	Security Class Title	Fee Calculation Rule	Amount Registered (1)	Proposed Maximum Offering Price Per Share (4)	Maximum Aggregate Offering Price (4)	Fee Rate	Amount of Registration Fee
Equity	Common Stock, par value $0.01 per share (2)	Other (4)	300,000	$10.60	$3,180,000	$0.0001531	$486.86
Equity	Common Stock, par value $0.01 per share (3)	Other (4)	700,000	$10.60	$7,420,000	$0.0001531	$1,136.00
Total Offering Amounts					$10,600,000		$1,622.86
Total Fees Previously Paid							—
Total Fee Offsets							—
Net Fee Due							$1,622.86

(1)Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover an indeterminate number of additional shares of common stock, no par value per share (the “Common Stock”), of ClearPoint Neuro, Inc. (the “Company”), which become issuable under the ClearPoint Neuro, Inc. Amended and Restated 2021 Employee Stock Purchase Plan (the “ESPP”) and the ClearPoint Neuro, Inc. Sixth Amended and Restated 2013 Incentive Compensation Plan (the “Incentive Compensation Plan”) by reason of any stock splits, stock dividends, reorganizations, mergers, consolidations, recapitalizations or other similar transactions.

(2)To be issued under the ESPP.

(3)To be issued under the Incentive Compensation Plan.

SMRH:4902-4981-5883.2	-1-
		80VE-404774

(4)Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) under the Securities Act, based on the average of the high and low sales prices of the Common Stock on the Nasdaq Capital Market on August 28, 2025, which date is within five business days prior to the filing of this Registration Statement.

SMRH:4902-4981-5883.2	-2-
		80VE-404774