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  <!-- Generated by Workiva -->
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    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001977434</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0000946581</own:issuerCik>
      <own:issuerName>TAKE-TWO INTERACTIVE SOFTWARE, INC.</own:issuerName>
      <own:secFileNumber>001-34003</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>110 West 44th Street</com:street1>
        <com:city>New York</com:city>
        <com:stateOrCountry>NY</com:stateOrCountry>
        <com:zipCode>10036</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>6465362842</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ZMC Advisors, L.P.</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Affiliate</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Merrill Lynch, Pierce, Fenner &amp; Smith Incorporated</own:name>
        <own:address>
          <com:street1>555 California Street</com:street1>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>208969</own:noOfUnitsSold>
      <own:aggregateMarketValue>46842491.04</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>185666663</own:noOfUnitsOutstanding>
      <own:approxSaleDate>06/01/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/01/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Performance Share Awards</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>163666</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/01/2026</own:paymentDate>
      <own:natureOfPayment>Compensation</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/01/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>16091</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/01/2026</own:paymentDate>
      <own:natureOfPayment>Compensation</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/03/2024</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>16966</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/01/2026</own:paymentDate>
      <own:natureOfPayment>Compensation</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/02/2025</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>12246</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/01/2026</own:paymentDate>
      <own:natureOfPayment>Compensation</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Zelnick/Belzberg Living Trust</own:name>
        <own:address>
          <com:street1>110 West 44th Street</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>03/02/2026</own:saleDate>
      <own:amountOfSecuritiesSold>52054</own:amountOfSecuritiesSold>
      <own:grossProceeds>11158758.72</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Zelnick/Belzberg Living Trust</own:name>
        <own:address>
          <com:street1>110 West 44th Street</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>03/03/2026</own:saleDate>
      <own:amountOfSecuritiesSold>7946</own:amountOfSecuritiesSold>
      <own:grossProceeds>1701495.26</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>The Zelnick/Belzberg Living Trust</own:name>
        <own:address>
          <com:street1>110 West 44th Street</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>05/26/2026</own:saleDate>
      <own:amountOfSecuritiesSold>44292</own:amountOfSecuritiesSold>
      <own:grossProceeds>9833328.63</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Wendy Jay Belzberg 2012 Family Trust</own:name>
        <own:address>
          <com:street1>110 West 44th Street</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>05/26/2026</own:saleDate>
      <own:amountOfSecuritiesSold>5708</own:amountOfSecuritiesSold>
      <own:grossProceeds>1271817.04</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Zelnick Belzberg Charitable Trust</own:name>
        <own:address>
          <com:street1>110 West 44th Street</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>05/26/2026</own:saleDate>
      <own:amountOfSecuritiesSold>20000</own:amountOfSecuritiesSold>
      <own:grossProceeds>4448884.7</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:remarks>Sales under 10b5-1 Plan to pay taxes upon vesting of restricted units.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>06/01/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>11/17/2025</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>Strauss Zelnick</own:signature>
    </own:noticeSignature>
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</own:edgarSubmission>
