SC 13G/A

UNITED STATES	OMB APPROVAL
SECURITIES AND EXCHANGE COMMISSION	OMB Number: 3235-0145
Washington, D.C. 20549	Expires: December 31, 2005
SCHEDULE 13G	Estimated average burden hours per response. . 11

Under the Securities Exchange Act of 1934
(Amendment No. 1-Final Amendment)*

ViroPharma Incorporated

(Name of Issuer)

Common Stock, par value $.002 per share

(Title of Class of Securities)

928241108

(CUSIP Number)

December 31, 2005

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

o	Rule 13d-1(b)
ý	Rule 13d-1(c)
o	Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

This final Amendment is being filed pursuant to Rule 13d-2 under the Securities Exchange Act of 1934, as amended.

Item 1(a).	Name of Issuer:
	ViroPharma Incorporated (“ViroPharma”)
Item 1(b).	Address of Issuer’s Principal Executive Offices:
	397 Eagleview Boulevard, Exton, Pennsylvania, 19341
Item 2(a).	Name of Person Filing
Item 2(b).	Address of Principal Business Office
Item 2(c).	Citizenship
	This Schedule 13G is filed on behalf of Kings Road Investments Ltd., Polygon Global Opportunities Master Fund, Polygon Investments Ltd., Polygon Investment Management Ltd., Polygon Investment Partners LLP, Polygon Investment Partners LP, Polygon Investment Partners GP, LLC, Mr. Reade E. Griffith, Mr. Alexander E. Jackson and Mr. Patrick G. G. Dear (the “Reporting Persons”).
	Polygon Global Opportunities Master Fund (the “Master Fund”)
	c/o Polygon Investment Partners LLP
	10 Duke of York Square
	London SW3 4LY
	United Kingdom
	Citizenship: Cayman Islands, British West Indies
	Kings Road Investments Ltd. (“KRIL”)
	c/o Polygon Investment Partners LP
	598 Madison Avenue
	14th Floor
	New York, New York 10022
	Citizenship: Cayman Islands, British West Indies
	Polygon Investments Ltd. (the “Investment Manager”)
	c/o Polygon Investment Partners LLP
	10 Duke of York Square
	London SW3 4LY
	United Kingdom
	Citizenship: Cayman Islands, British West Indies
	Polygon Investment Management Limited (“PIML”)
	c/o Polygon Investment Partners LLP
	10 Duke of York Square
	London SW3 4LY
	United Kingdom
	Citizenship: United Kingdom
	Polygon Investment Partners LLP (the “UK Investment Manager”)
	10 Duke of York Square
	London SW3 4LY
	United Kingdom
	Citizenship: United Kingdom

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	Polygon Investment Partners LP (the “US Investment Manager”)
	598 Madison Avenue
	14th Floor
	New York, New York 10022
	Citizenship: Delaware
	Polygon Investment Partners GP, LLC (the “General Partner”)
	c/o Polygon Investment Partners LP
	598 Madison Avenue
	14th Floor
	New York, New York 10022
	Citizenship: Delaware
	Reade E. Griffith (“Mr. Griffith”)
	c/o Polygon Investment Partners LLP
	10 Duke of York Square
	London SW3 4LY
	United Kingdom
	Citizenship: United States
	Alexander E. Jackson (“Mr. Jackson”)
	c/o Polygon Investment Partners LP
	598 Madison Avenue
	14th Floor
	New York, New York 10022
	Citizenship: United States
	Patrick G. G. Dear (“Mr. Dear”)
	c/o Polygon Investment Partners LLP
	10 Duke of York Square
	London SW3 4LY
	United Kingdom
	Citizenship: United Kingdom
Item 2(d).	Title of Class of Securities:
	Common stock, par value $.002 per share, of ViroPharma (“Common Stock”).
Item 2(e).	The Common Stock has the following CUSIP number: 928241108
Item 3.	Not Applicable.
Item 4.	Amount Beneficially Owned:
	As of December 31, 2005, the Reporting Persons may be collectively deemed to be beneficial owner of less than 5% of Common Stock and are no longer required to file a Schedule 13G with respect to Common Stock. This Schedule 13G is being filed in fulfillment of the Reporting Persons’ obligations under Section 13G of the Act and the rules promulgated thereunder.
	Percent of Class:
	Less than 5%.

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Item 5.	Ownership of Five Percent or Less of a Class
	If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ý
Item 6.	Ownership of More than Five Percent on Behalf of another Person
	Not Applicable.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company.
	See Exhibit 1.
Item 8.	Identification and Classification of Members of the Group.
	See Exhibit 2.
Item 9.	Notice of Dissolution of the Group.
	Not Applicable.
Item 10.	Certification.
	By signing below each of the undersigned certifies that, to the best of such person’s knowledge and belief, the securities referred to above were acquired in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

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SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, each of the undersigned certify that the information set forth in this statement is true, complete and correct.

Date: February 14, 2006	POLYGON GLOBAL OPPORTUNITIES MASTER FUND
	By Polygon Investment Partners LLP, its investment manager
	By	/s/ Patrick G. G. Dear
	Name: Patrick G. G. Dear
	Title: Principal
Date: February 14, 2006	KINGS ROAD INVESTMENTS LTD.
	By Polygon Investment Partners LLP, its investment manager
	By	/s/ Patrick G. G. Dear
	Name: Patrick G. G. Dear
	Title: Principal
Date: February 14, 2006	POLYGON INVESTMENTS LTD.
	By	/s/ Patrick G. G. Dear
	Name: Patrick G. G. Dear
	Title: Principal
Date: February 14, 2006	POLYGON INVESTMENT MANAGEMENT LIMITED
	By	/s/ Patrick G. G. Dear
	Name: Patrick G. G. Dear
	Title: Principal
Date: February 14, 2006	POLYGON INVESTMENT PARTNERS LLP
	By	/s/ Patrick G. G. Dear
	Name: Patrick G. G. Dear
	Title: Principal

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Date: February 14, 2006	POLYGON INVESTMENT PARTNERS LP
	By	/s/ Patrick G. G. Dear
	Name: Patrick G. G. Dear
	Title: Principal
Date: February 14, 2006	POLYGON INVESTMENT PARTNERS GP, LLC
	By	/s/ Patrick G. G. Dear
	Name: Patrick G. G. Dear
	Title: Principal
Date: February 14, 2006		/s/ Reade E. Griffith
	Reade E. Griffith
Date: February 14, 2006		/s/ Alexander E. Jackson
	Alexander E. Jackson
Date: February 14, 2006		/s/ Patrick G. G. Dear
	Patrick G. G. Dear

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Exhibit Index

Exhibit 1  Identification and Classification of the Subsidiaries Which Acquired the Security Being Reported on by the Parent Holding Company.

Exhibit 2  Identification of Members of the Group.

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EX-1

Exhibit 1

Identification and Classification of the Subsidiaries
Which Acquired the Security Being Reported on by the Parent Holding Company.

Polygon Global Oppurtunities Master Fund

1

EX-2

Exhibit 2

Identification of Members of the Group.

Polygon Global Opportunities Master Fund

Kings Road Investments Ltd.

Polygon Investments Ltd.

Polygon Investment Management Limited

Polygon Investment Partners LLP

Polygon Investment Partners LP

Polygon Investment Partners GP, LLC

Reade E. Griffith

Alexander E. Jackson

Patrick G. G. Dear

1