<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created by RR Donnelley IM Processor 6.0.0.0 using Fujitsu Interstage XWand-->
<xbrl xmlns:msf4="http://www.massmutual.com/20121226" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dei="http://xbrl.sec.gov/dei/2012-01-31" xmlns:rr="http://xbrl.sec.gov/rr/2012-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.xbrl.org/2003/instance">
  <link:schemaRef xlink:type="simple" xlink:href="msf4-20121226.xsd" />
  <context id="Duration_03Apr2011_02Apr2012">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0000916053</identifier>
    </entity>
    <period>
      <startDate>2011-04-03</startDate>
      <endDate>2012-04-02</endDate>
    </period>
  </context>
  <context id="Duration_03Apr2011_02Apr2012S000027024_Member">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0000916053</identifier>
      <segment>
        <xbrldi:explicitMember dimension="dei:LegalEntityAxis">msf4:S000027024Member</xbrldi:explicitMember>
      </segment>
    </entity>
    <period>
      <startDate>2011-04-03</startDate>
      <endDate>2012-04-02</endDate>
    </period>
  </context>
  <rr:ProspectusDate contextRef="Duration_03Apr2011_02Apr2012">2012-04-02</rr:ProspectusDate>
  <dei:EntityRegistrantName contextRef="Duration_03Apr2011_02Apr2012">MASSMUTUAL SELECT FUNDS</dei:EntityRegistrantName>
  <dei:EntityCentralIndexKey contextRef="Duration_03Apr2011_02Apr2012">0000916053</dei:EntityCentralIndexKey>
  <dei:DocumentCreationDate contextRef="Duration_03Apr2011_02Apr2012">2012-12-26</dei:DocumentCreationDate>
  <dei:DocumentEffectiveDate contextRef="Duration_03Apr2011_02Apr2012">2012-12-26</dei:DocumentEffectiveDate>
  <dei:DocumentPeriodEndDate contextRef="Duration_03Apr2011_02Apr2012">2011-12-31</dei:DocumentPeriodEndDate>
  <dei:AmendmentFlag contextRef="Duration_03Apr2011_02Apr2012">false</dei:AmendmentFlag>
  <dei:DocumentType contextRef="Duration_03Apr2011_02Apr2012">Other</dei:DocumentType>
  <msf4:SupplementTextBlock contextRef="Duration_03Apr2011_02Apr2012">&lt;p align="center" style="font-family: 'Times New Roman'; font-size: medium; margin-top: 0px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;&lt;b&gt;MASSMUTUAL SELECT FUNDS&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;&lt;p align="center" style="font-family: 'Times New Roman'; font-size: medium; margin-top: 0px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;&lt;b&gt;Supplement dated December&amp;nbsp;26, 2012 to the&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;&lt;p align="center" style="font-family: 'Times New Roman'; font-size: medium; margin-top: 0px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;&lt;b&gt;Prospectus dated April&amp;nbsp;2, 2012&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;&lt;p style="font-family: 'Times New Roman'; font-size: medium; margin-top: 12px; margin-bottom: 0px; text-indent: 4%;"&gt;&lt;font size="2"&gt;This supplement provides new and additional information beyond that contained in the Prospectus and any previous supplements. It should be retained and read in conjunction with the Prospectus and any previous supplements.&lt;/font&gt;&lt;/p&gt;&lt;p style="font-family: 'Times New Roman'; font-size: medium; margin-top: 12px; margin-bottom: 0px; text-indent: 4%;"&gt;&lt;font size="2"&gt;&lt;i&gt;Effective immediately, the following information replaces similar information found in the fifth paragraph under&amp;nbsp;&lt;/i&gt;&lt;b&gt;&lt;i&gt;Principal Investment Strategies&amp;nbsp;&lt;/i&gt;&lt;/b&gt;&lt;i&gt;on page 23 for the&amp;nbsp;&lt;/i&gt;&lt;b&gt;&lt;i&gt;BlackRock Global Allocation Fund&lt;/i&gt;&lt;/b&gt;&lt;i&gt;:&lt;/i&gt;&lt;/font&gt;&lt;/p&gt;&lt;p style="font-family: 'Times New Roman'; font-size: medium; margin-top: 12px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;The Fund may seek to provide exposure to the investment returns of real assets that trade in the commodity markets, including precious metals, agriculture, energy, livestock, or industrial metals. The Fund may obtain such exposure through, among other things, investments in issuers in commodities-related industries or in other investment vehicles that invest directly in commodities, commodities-related companies, or commodities-related investments, such as exchange-traded funds. The Fund may, but will not necessarily, invest in commodity-linked derivative instruments, including futures contracts, options, and swaps. In order to earn qualifying income under applicable tax rules from commodities and certain commodities-related investments, the Fund may invest up to 25% of its total assets in the MassMutual Select Cayman Global Allocation Fund I, Ltd. (the "Select Cayman Fund"), which was formed in the Cayman Islands and is a wholly-owned subsidiary of the Fund.&lt;/font&gt;&lt;/p&gt;&lt;br/&gt;&lt;center&gt;&lt;b&gt;PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE&lt;/b&gt;&lt;/center&gt;</msf4:SupplementTextBlock>
  <msf4:SupplementTextBlock contextRef="Duration_03Apr2011_02Apr2012S000027024_Member">&lt;p align="center" style="font-family: 'Times New Roman'; font-size: medium; margin-top: 0px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;&lt;b&gt;MASSMUTUAL SELECT FUNDS&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;&lt;p align="center" style="font-family: 'Times New Roman'; font-size: medium; margin-top: 0px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;&lt;b&gt;Supplement dated December&amp;nbsp;26, 2012 to the&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;&lt;p align="center" style="font-family: 'Times New Roman'; font-size: medium; margin-top: 0px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;&lt;b&gt;Prospectus dated April&amp;nbsp;2, 2012&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;&lt;p style="font-family: 'Times New Roman'; font-size: medium; margin-top: 12px; margin-bottom: 0px; text-indent: 4%;"&gt;&lt;font size="2"&gt;This supplement provides new and additional information beyond that contained in the Prospectus and any previous supplements. It should be retained and read in conjunction with the Prospectus and any previous supplements.&lt;/font&gt;&lt;/p&gt;&lt;p style="font-family: 'Times New Roman'; font-size: medium; margin-top: 12px; margin-bottom: 0px; text-indent: 4%;"&gt;&lt;font size="2"&gt;&lt;i&gt;Effective immediately, the following information replaces similar information found in the fifth paragraph under&amp;nbsp;&lt;/i&gt;&lt;b&gt;&lt;i&gt;Principal Investment Strategies&amp;nbsp;&lt;/i&gt;&lt;/b&gt;&lt;i&gt;on page 23 for the&amp;nbsp;&lt;/i&gt;&lt;b&gt;&lt;i&gt;BlackRock Global Allocation Fund&lt;/i&gt;&lt;/b&gt;&lt;i&gt;:&lt;/i&gt;&lt;/font&gt;&lt;/p&gt;&lt;p style="font-family: 'Times New Roman'; font-size: medium; margin-top: 12px; margin-bottom: 0px;"&gt;&lt;font size="2"&gt;The Fund may seek to provide exposure to the investment returns of real assets that trade in the commodity markets, including precious metals, agriculture, energy, livestock, or industrial metals. The Fund may obtain such exposure through, among other things, investments in issuers in commodities-related industries or in other investment vehicles that invest directly in commodities, commodities-related companies, or commodities-related investments, such as exchange-traded funds. The Fund may, but will not necessarily, invest in commodity-linked derivative instruments, including futures contracts, options, and swaps. In order to earn qualifying income under applicable tax rules from commodities and certain commodities-related investments, the Fund may invest up to 25% of its total assets in the MassMutual Select Cayman Global Allocation Fund I, Ltd. (the "Select Cayman Fund"), which was formed in the Cayman Islands and is a wholly-owned subsidiary of the Fund.&lt;/font&gt;&lt;/p&gt;&lt;br/&gt;&lt;center&gt;&lt;b&gt;PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE&lt;/b&gt;&lt;/center&gt;</msf4:SupplementTextBlock>
</xbrl>
