SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. __)*

                            NPS PHARMACEUTICALS, INC.
                                (Name of Issuer)

                                     COMMON
                         (Title of Class of Securities)

                                    62936P103
                                 (CUSIP Number)

                                 APRIL 30, 2010
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the Rule pursuant to which this Schedule
is filed:

     [X]  Rule 13d - 1(b)

     [ ]  Rule 13d - 1(c)

     [ ]  Rule 13d - 1(d)

*    The remainder of this cover page shall be filled out for a reporting
     person's initial filing on this form with respect to the subject class of
     securities, and for any subsequent amendment containing information which
     would alter disclosures provided in a prior cover page.

     The information required on the remainder of this page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes.)



CUSIP No 62936P103                     13G                     Page 2 of 7 Pages

- --------------------------------------------------------------------------------
1    NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY):

     Columbia Wanger Asset Management, L.P.
     04-3519872
- --------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)

     (a)  [ ]
     (b)  [ ]
- --------------------------------------------------------------------------------
3    SEC USE ONLY

- --------------------------------------------------------------------------------
4    CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
- --------------------------------------------------------------------------------
                     5    SOLE VOTING POWER

                          5,180,409
                     -----------------------------------------------------------
 NUMBER OF SHARES    6    SHARED VOTING POWER
BENEFICIALLY OWNED
 BY EACH REPORTING        0
    PERSON WITH      -----------------------------------------------------------
                     7    SOLE DISPOSITIVE POWER

                          5,508,009
                     -----------------------------------------------------------
                     8    SHARED DISPOSITIVE POWER

                          0
- --------------------------------------------------------------------------------
9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     5,508,009
- --------------------------------------------------------------------------------
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
     Instructions)

     [ ]
- --------------------------------------------------------------------------------
     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     11.36%
- --------------------------------------------------------------------------------
12   TYPE OF REPORTING PERSON (See Instructions)

     IA
- --------------------------------------------------------------------------------



ITEM 1(A). NAME OF ISSUER:

     NPS Pharmaceuticals, Inc.

ITEM 1(B). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

     550 Hills Drive
     3rd Floor
     Bedminster, NJ 07921
     United States

ITEM 2(A). NAME OF PERSON FILING:

     Columbia Wanger Asset Management, L.P.

ITEM 2(B). ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:

     227 West Monroe Street, Suite 3000, Chicago, IL 60606.

ITEM 2(C). CITIZENSHIP:

     Delaware

ITEM 2(D). TITLE OF CLASS OF SECURITIES:

     Common



ITEM 2(E). CUSIP NUMBER:

    62936P103

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13D-1(B), OR 13D-2(B) OR
        (C), CHECK WHETHER THE PERSON FILING IS A:

     (a)  [ ]  Broker or dealer registered under Section 15 of the Exchange Act.

     (b)  [ ]  Bank as defined in Section 3(a)(6) of the Exchange Act.

     (c)  [ ]  Insurance company as defined in Section 3(a)(19) of the Exchange
               Act.

     (d)  [ ]  Investment company registered under Section 8 of the Investment
               Company Act.

     (e)  [X]  An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

     (f)  [ ]  An employee benefit plan or endowment fund in accordance with
               Rule 13d-1(b)(1)(ii)(F).

     (g)  [ ]  A parent holding company or control person in accordance with
               Rule 13d-1(b)(1)(ii)(G).

     (h)  [ ]  A savings association as defined in Section 3(b) of the Federal
               Deposit Insurance Act.

     (i)  [ ]  A church plan that is excluded from the definition of an
               investment company under Section 3(c)(14) of the Investment
               Company Act.

     (j)  [ ]  Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

     If this statement is filed pursuant to Rule 13d-1(c), check this box. [ ]

ITEM 4. OWNERSHIP:

     With respect to the beneficial ownership of the reporting person, see Items
     5 through 11 of the cover pages to this Schedule 13G, which are
     incorporated herein by reference.

ITEM 5. OWNERSHIP OF 5 PERCENT OR LESS OF A CLASS:

     If this statement is being filed to report the fact that as of the date
     hereof the reporting person has ceased to be the beneficial owner of more
     than five percent of the class of securities, check the following [ ].

ITEM 6. OWNERSHIP OR MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

     The shares reported herein include shares held by Columbia Acorn Trust
     (CAT), a Massachusetts business trust that is advised by the reporting
     person. CAT holds 9.00% of the shares of the Issuer.



ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
        SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL
        PERSON:

     Not Applicable.

ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:

     Not Applicable.

ITEM 9. NOTICE OF DISSOLUTION OF GROUP:

     Not Applicable.



ITEM 10. CERTIFICATION:

     By signing below each of the undersigned certifies that, to the best of
     such undersigned's knowledge and belief, the securities referred to above
     were acquired and are held in the ordinary course of business and were not
     acquired and are not for the purpose of or with the effect of changing or
     influencing the control of the issuer of the securities and were not
     acquired and are not held in connection with or as a participant in any
     transaction having that purpose or effect.

                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Dated: May 10, 2010

COLUMBIA WANGER ASSET MANAGEMENT, L.P.


By: /s/ Bruce H. Lauer
    -----------------------------------------
    Bruce H. Lauer
    Senior Vice President and Secretary,
    WAM Acquisition GP, Inc., General Partner



                                                                    Exhibit 99.1

                      EXHIBIT 99.1 - JOINT FILING AGREEMENT

The undersigned hereby agree that they are filing this statement jointly
pursuant to Rule 13d-1(k)(1). Each of them is responsible for the timely filing
of such Schedule 13G and any amendments thereto, and for the completeness and
accuracy of the information concerning such person contained therein; but none
of them is responsible for the completeness or accuracy of the information
concerning the other persons making the filing, unless such person knows or has
reason to believe that such information is inaccurate.

In accordance with Rule 13d-1(k)(1) promulgated under the Securities and
Exchange Act of 1934, as amended, the undersigned hereby agree to the joint
filing with each other on behalf of each of them of to such a statement on
Schedule 13G with respect to the common stock of beneficially owned by each of
them. This Joint Filing Agreement shall be included as an exhibit to such
Schedule 13G.

Dated: May 10, 2010

COLUMBIA WANGER ASSET MANAGEMENT, L.P.


By: /s/ Bruce H. Lauer
    -----------------------------------------
    Bruce H. Lauer
    Senior Vice President and Secretary,
    WAM Acquisition GP, Inc., General Partner

COLUMBIA ACORN TRUST


By: /s/ Bruce H. Lauer
    ---------------------------------------
    Bruce H. Lauer
    Vice President, Treasurer and Secretary