-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, A02Hof7UYHNHnPHOOf4q75naHI6mKV/mcToEXFGsssObdYYiVZWG4s7DYhxZG95v rfDjp5TewS+BjppAW0eTkw== 0000947871-00-000247.txt : 20000327 0000947871-00-000247.hdr.sgml : 20000327 ACCESSION NUMBER: 0000947871-00-000247 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20000324 GROUP MEMBERS: CADUCEUS TRUST GROUP MEMBERS: FINSBURY WORLDWIDE PHARMACEUTICAL TRUST GROUP MEMBERS: ORBIMED ADVISERS INC /CT GROUP MEMBERS: ORBIMED ADVISERS INC. GROUP MEMBERS: ORBIMED ADVISORS LLC GROUP MEMBERS: PHARMA/WHEALTH GROUP MEMBERS: WORLDWIDE HEALTH SCIENCES PORTFOLIO SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: ALEXION PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000899866 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 133648318 STATE OF INCORPORATION: DE FISCAL YEAR END: 0731 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: SEC FILE NUMBER: 005-47771 FILM NUMBER: 577832 BUSINESS ADDRESS: STREET 1: 25 SCIENCE PARK STREET 2: STE 360 CITY: NEW HAVEN STATE: CT ZIP: 06511 BUSINESS PHONE: 2037761790 MAIL ADDRESS: STREET 1: 25 SCIENCE PARK STREET 2: STE 360 CITY: NEW HAVEN STATE: CT ZIP: 06511 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISERS INC /CT CENTRAL INDEX KEY: 0001033248 STANDARD INDUSTRIAL CLASSIFICATION: [] FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: 41 MADISON AVENUE 40TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10010 BUSINESS PHONE: 2126850800 FORMER COMPANY: FORMER CONFORMED NAME: MEHTA & ISALY ASSET MANAGEMENT INC DATE OF NAME CHANGE: 19970212 SC 13G/A 1 AMENDMENT NO. 1 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 Amendment No. 1 ALEXION PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 0015351109 (CUSIP Number) February 7, 2000 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: |_| Rule 13d-1 (b) |x| Rule 13d-1 (c) |_| Rule 13d-1 (d) * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). CUSIP No. 0015351109 (1) Name of Reporting Person S.S. or I.R.S. Identification No. of Above Person OrbiMed Advisers Inc. ---------------------------------------------------------------------- (2) Check the Appropriate Box if a Member of Group (See Instructions) [ ] (a) [ ] (b) ---------------------------------------------------------------------- (3) SEC Use Only ---------------------------------------------------------------------- (4) Citizenship or Place of Organization British Virgin Islands ---------------------------------------------------------------------- Number of (5) Sole Voting Power 0 Shares Beneficially ------------------------------------------------------------- Owned by (6) Shared Voting Power 614,300 Each Reporting ------------------------------------------------------------- Person (7) Sole Dispositive Power 0 With ------------------------------------------------------------- (8) Shared Dispositive Power 614,300 ---------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned by Each Reporting Person 614,300 ---------------------------------------------------------------------- (10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ---------------------------------------------------------------------- (11) Percent of Class Represented by Amount in Row (9) 4.2% ---------------------------------------------------------------------- (12) Type of Reporting Person (See Instructions) IA ---------------------------------------------------------------------- CUSIP No. 0015351109 (1) Name of Reporting Person S.S. or I.R.S. Identification No. of Above Person OrbiMed Advisors LLC ---------------------------------------------------------------------- (2) Check the Appropriate Box if a Member of Group (See Instructions) [ ] (a) [ ] (b) ---------------------------------------------------------------------- (3) SEC Use Only ---------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware ---------------------------------------------------------------------- Number of (5) Sole Voting Power 0 Shares Beneficially ------------------------------------------------------------- Owned by (6) Shared Voting Power 614,300 Each Reporting ------------------------------------------------------------- Person (7) Sole Dispositive Power 0 With ------------------------------------------------------------- (8) Shared Dispositive Power 614,300 ---------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned by Each Reporting Person 614,300 ---------------------------------------------------------------------- (10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ---------------------------------------------------------------------- (11) Percent of Class Represented by Amount in Row (9) 4.2% ---------------------------------------------------------------------- (12) Type of Reporting Person (See Instructions) CO ---------------------------------------------------------------------- CUSIP No. 0015351109 (1) Name of Reporting Person S.S. or I.R.S. Identification No. of Above Person Worldwide Health Sciences Portfolio ---------------------------------------------------------------------- (2) Check the Appropriate Box if a Member of Group (See Instructions) [ ] (a) [ ] (b) ---------------------------------------------------------------------- (3) SEC Use Only ---------------------------------------------------------------------- (4) Citizenship or Place of Organization New York ---------------------------------------------------------------------- Number of (5) Sole Voting Power 0 Shares Beneficially ------------------------------------------------------------- Owned by (6) Shared Voting Power 614,300 Each Reporting ------------------------------------------------------------- Person (7) Sole Dispositive Power 0 With ------------------------------------------------------------- (8) Shared Dispositive Power 614,300 ---------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned by Each Reporting Person 614,300 ---------------------------------------------------------------------- (10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ---------------------------------------------------------------------- (11) Percent of Class Represented by Amount in Row (9) 4.2% ---------------------------------------------------------------------- (12) Type of Reporting Person (See Instructions) IV ---------------------------------------------------------------------- CUSIP No. 0015351109 (1) Name of Reporting Person S.S. or I.R.S. Identification No. of Above Person Caduceus Capital Trust ---------------------------------------------------------------------- (2) Check the Appropriate Box if a Member of Group (See Instructions) [ ] (a) [ ] (b) ---------------------------------------------------------------------- (3) SEC Use Only ---------------------------------------------------------------------- (4) Citizenship or Place of Organization Bermuda ---------------------------------------------------------------------- Number of (5) Sole Voting Power 0 Shares Beneficially ------------------------------------------------------------- Owned by (6) Shared Voting Power 614,300 Each Reporting ------------------------------------------------------------- Person (7) Sole Dispositive Power 0 With ------------------------------------------------------------- (8) Shared Dispositive Power 614,300 ---------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned by Each Reporting Person 614,300 ---------------------------------------------------------------------- (10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ---------------------------------------------------------------------- (11) Percent of Class Represented by Amount in Row (9) 4.2% ---------------------------------------------------------------------- (12) Type of Reporting Person (See Instructions) OO ---------------------------------------------------------------------- CUSIP No. 0015351109 (1) Name of Reporting Person S.S. or I.R.S. Identification No. of Above Person Finsbury Worldwide Pharmaceutical Trust ---------------------------------------------------------------------- (2) Check the Appropriate Box if a Member of Group (See Instructions) [ ] (a) [ ] (b) ---------------------------------------------------------------------- (3) SEC Use Only ---------------------------------------------------------------------- (4) Citizenship or Place of Organization United Kingdom ---------------------------------------------------------------------- Number of (5) Sole Voting Power 0 Shares Beneficially ------------------------------------------------------------- Owned by (6) Shared Voting Power 614,300 Each Reporting ------------------------------------------------------------- Person (7) Sole Dispositive Power 0 With ------------------------------------------------------------- (8) Shared Dispositive Power 614,300 ---------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned by Each Reporting Person 614,300 ---------------------------------------------------------------------- (10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ---------------------------------------------------------------------- (11) Percent of Class Represented by Amount in Row (9) 4.2% ---------------------------------------------------------------------- (12) Type of Reporting Person (See Instructions) OO ---------------------------------------------------------------------- CUSIP No. 0015351109 (1) Name of Reporting Person S.S. or I.R.S. Identification No. of Above Person PHARMA/wHEALTH ---------------------------------------------------------------------- (2) Check the Appropriate Box if a Member of Group (See Instructions) [ ] (a) [ ] (b) ---------------------------------------------------------------------- (3) SEC Use Only ---------------------------------------------------------------------- (4) Citizenship or Place of Organization Luxembourg ---------------------------------------------------------------------- Number of (5) Sole Voting Power 0 Shares Beneficially ------------------------------------------------------------- Owned by (6) Shared Voting Power 614,300 Each Reporting ------------------------------------------------------------- Person (7) Sole Dispositive Power 0 With ------------------------------------------------------------- (8) Shared Dispositive Power 614,300 ---------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned by Each Reporting Person 614,300 ---------------------------------------------------------------------- (10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ---------------------------------------------------------------------- (11) Percent of Class Represented by Amount in Row (9) 4.2% ---------------------------------------------------------------------- (12) Type of Reporting Person (See Instructions) OO ---------------------------------------------------------------------- Item 1. Issuer (a) Alexion Pharmaceuticals, Inc. (b) 25 Science Park, Suite 360 New Haven, CT 06511 Item 2. Persons Filing (a) Name of Persons Filing: OrbiMed Advisers Inc. OrbiMed Advisors LLC Worldwide Health Sciences Portfolio Caduceus Trust Finsbury Worldwide Pharmaceutical Trust PHARMA/wHEALTH (b) Address of Principal Offices: c/o OrbiMed Advisors Inc. 767 Third Avenue, 6th Floor New York, New York 10010 (c) Citizenship: Please refer to Item 4 on each cover sheet for each filing person (d) Title of Class of Securities: Common Stock (e) CUSIP Number: 0015351109 Item 3. Not Applicable Item 4. Ownership Please see Items 5, 6, 7, 8, 9, and 11 for each cover sheet for each filing entity. Item 5. Ownership of Five Percent or Less of a Class If this statement is being filed to report the fat that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of a class of securities, check the following [X]. Item 6. Ownership of More than Five Percent on Behalf of Another Person Not applicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company Not applicable. Item 8. Identification and Classification of Members of the Group Not Applicable. Item 9. Notice of Dissolution of Group Not Applicable. Item 10. Certification By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: March 20, 2000 ORBIMED ADVISERS INC. By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: President ORBIMED ADVISORS LLC By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Managing Member WORLDWIDE HEALTH SERVICES PORTFOLIO By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Director CADUCEUS CAPITAL TRUST By: /s/ Deborah O'Donnel ---------------------------- Name: Deborah O'Donnel Title: Secretary FINSBURY WORLDWIDE PHARMACEUTICAL TRUST By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Director PHARMA/wHEALTH By:/s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Director -----END PRIVACY-ENHANCED MESSAGE-----