Exhibit 22.1

Subsidiary Guarantors

As of December 31, 2021, each of the following subsidiaries of Enbridge Inc. (“Enbridge”), both of which are indirect, wholly-owned subsidiaries of Enbridge, has fully and unconditionally guaranteed on an unsecured, joint and several basis, each of the registered debt securities of the Company listed below:

Subsidiary Guarantors

1.Spectra Energy Partners, LP, a Delaware limited partnership

2.Enbridge Energy Partners, L.P., a Delaware limited partnership

Registered Debt Securities of Enbridge Guaranteed by each of the Subsidiary Guarantors

1.Floating Rate Senior Notes due 2022

2.2.900% Senior Notes due 2022

3.0.550% Sustainability-Linked Senior Notes due 2023

4.Floating Rate Senior Notes due 2023

5.4.000% Senior Notes due 2023

6.3.500% Senior Notes due 2024

7.2.500% Senior Notes due 2025

8.4.250% Senior Notes due 2026

9.1.600% Sustainability-Linked Senior Notes due 2026

10.3.700% Senior Notes due 2027

11.3.125% Senior Notes due 2029

12.2.500% Sustainability-Linked Senior Notes due 2033

13.4.500% Senior Notes due 2044

14.5.500% Senior Notes due 2046

15.4.000% Senior Notes due 2049

16.3.400% Senior Notes due 2051