0001144204-12-062119.txt : 20121114 0001144204-12-062119.hdr.sgml : 20121114 20121114120219 ACCESSION NUMBER: 0001144204-12-062119 CONFORMED SUBMISSION TYPE: 10-Q PUBLIC DOCUMENT COUNT: 11 CONFORMED PERIOD OF REPORT: 20120930 FILED AS OF DATE: 20121114 DATE AS OF CHANGE: 20121114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ENTREMED INC CENTRAL INDEX KEY: 0000895051 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 581959440 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 10-Q SEC ACT: 1934 Act SEC FILE NUMBER: 000-20713 FILM NUMBER: 121202310 BUSINESS ADDRESS: STREET 1: 9640 MEDICAL CNTR DR STREET 2: STE 200 CITY: ROCKVILLE STATE: MD ZIP: 20850 BUSINESS PHONE: 3012179858 MAIL ADDRESS: STREET 1: 9640 MEDICAL CNTR SR STREET 2: STE 200 CITY: ROCKVILLE STATE: MD ZIP: 20850 10-Q 1 v326286_10q.htm 10-Q

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

 

FORM 10-Q

 

x        QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the quarterly period ended September 30, 2012

 

¨        TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the transition period from ___________ to _____________.

 

Commission file number 0-20713

 

ENTREMED, INC.

(Exact name of registrant as specified in its charter)

 

Delaware   58-1959440
(State or other jurisdiction of   (I.R.S. Employer Identification No.)
incorporation or organization)    

 

9640 Medical Center Drive

Rockville, Maryland

(Address of principal executive offices)

 

20850

(Zip code)

 

(240) 864-2600

(Registrant’s telephone number, including area code)

 

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

 

YES x       NO ¨

 

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).

 

YES x       NO ¨

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

 

Large accelerated filer ¨   Accelerated filer ¨   Non-accelerated filer ¨   Smaller reporting
company þ

 

Indicate by checkmark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

 

YES ¨        NO x

 

Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the most recent practicable date.

 

Class   Outstanding at November 8, 2012
Common Stock $.01 Par Value   22,503,393

 

 
 

 

ENTREMED, INC.

Table of Contents

 

    PAGE
     
PART I. FINANCIAL INFORMATION  
     
Item 1 — Consolidated Financial Statements  
     
Consolidated Balance Sheets as of September 30, 2012 (unaudited) and December 31, 2011 4
     
Consolidated Statements of Operations for the Three and Nine Months Ended September 30, 2012 and 2011 (unaudited) 5
     
Consolidated Statements of Cash Flows for the Nine Months Ended September 30, 2012 and 2011 (unaudited) 6
     
Notes to Consolidated Financial Statements (unaudited) 7
     
Item 2 — Management’s Discussion and Analysis of Financial Condition and Results of Operations 12
     
Item 3 — Quantitative and Qualitative Disclosures About Market Risk 20
     
Item 4 — Controls and Procedures 20
     
Part II.  OTHER INFORMATION  
     
Item 1 — Legal Proceedings 21
     
Item 1A –   Risk Factors 21
     
Item 2 —     Unregistered Sales of Equity Securities and Use of Proceeds 21
     
Item 3 — Defaults upon Senior Securities 21
     
Item 4 — Removed and Reserved 21
     
Item 5 — Other Information 21
     
Item 6 — Exhibits 22
     
SIGNATURES 23

 

2
 

 

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

 

This report contains certain forward-looking statements within the meaning of Section 27A of the Securities Exchange Act of 1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements also may be included in other statements that we make. All statements that are not descriptions of historical facts are forward-looking statements. These statements can generally be identified by the use of forward-looking terminology such as “believes,” “expects,” “intends,” “may,” “will,” “should,” or “anticipates” or similar terminology. These forward-looking statements include, among others, statements regarding our business strategy, the timing of our clinical trials, our cash position and future expenses, and our future revenues.

 

Our forward-looking statements are based on information available to us today, and we will not update these statements.

 

Actual results could differ materially from those currently anticipated due to a number of factors, including: the risk that we may be unable to continue as a going concern as a result of our inability to raise sufficient capital for our operational needs; the possibility that we may be delisted from trading on the Nasdaq Capital Market; the volatility of our common stock; the difficulty of executing our business strategy in China; our inability to enter into strategic partnerships for the development, commercialization, manufacturing and distribution of our proposed product candidate; risks relating to the need for additional capital and the uncertainty of securing additional funding on favorable terms; declines in actual sales of Thalomid® resulting in reduced royalty payments; risks associated with our product candidates; any early-stage products under development; results in preclinical models are not necessarily indicative of clinical results; uncertainties relating to preclinical and clinical trials, including delays to the commencement of such trials; the lack of success in the clinical development of any of our products; dependence on third parties; and risks relating to the commercialization, if any, of our proposed products (such as marketing, safety, regulatory, patent, product liability, supply, competition and other risks). Such factors, among others, could have a material adverse effect upon our business, results of operations and financial condition. We caution readers not to place undue reliance on any forward-looking statements, which only speak as of the date made. Additional information about the factors and risks that could affect our business, financial condition and results of operations, are contained in our filings with the U.S. Securities and Exchange Commission (“SEC”), which are available at www.sec.gov.

 

3
 

 

PART I. FINANCIAL INFORMATION

 

ITEM 1. CONSOLIDATED FINANCIAL STATEMENTS

 

EntreMed, Inc.

Consolidated Balance Sheets

(Unaudited)

 

   September 30, 2012   December 31, 2011 
   (Unaudited)     
ASSETS          
Current assets:          
Cash and cash equivalents  $8,812,133   $1,080,630 
Accounts receivable, net of allowance for doubtful accounts of $12,536 and $13,036 at September 30, 2012 and December 31, 2011,  respectively   -    1,932,742 
Prepaid expenses and other   238,797    193,657 
Total current assets   9,050,930    3,207,029 
           
Property and equipment, net   21,322    24,621 
Other assets   17,427    4,184 
Total assets  $9,089,679   $3,235,834 
           
LIABILITIES AND STOCKHOLDERS' EQUITY          
Current liabilities:          
Accounts payable  $484,526   $453,329 
Payable to related party   55,685    - 
Accrued liabilities   185,935    250,762 
Total current liabilities   726,146    704,091 
           
Commitments and contingencies   -    - 
           
Stockholders' equity :          
           
Convertible preferred stock, $1.00 par  value; 5,000,000 shares authorized and 0 and 3,350,000 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively (liquidation value - $0 and $33,500,000 at September 30, 2012 and December 31, 2011, respectively)   -    3,350,000 
Common stock, $.01 par value: 170,000,000 shares authorized at September 30, 2012 and December 31, 2011: 22,582,938 and 12,237,644 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively   225,829    122,376 
Additional paid-in capital   409,142,766    385,879,634 
Treasury stock, at cost:  79,545 shares held at September 30, 2012 and December 31, 2011   (8,034,244)   (8,034,244)
Accumulated deficit   (392,970,818)   (378,786,023)
Total stockholders' equity   8,363,533    2,531,743 
Total liabilities and stockholders' equity  $9,089,679   $3,235,834 

 

See accompanying notes.

 

4
 

 

EntreMed, Inc.

Consolidated Statements of Operations

(Unaudited)

 

   Three Months Ended   Nine Months Ended 
   September 30,
2012
   September 30,
2011
   September 30,
2012
   September 30,
2011
 
Revenues:                    
Royalties  $-   $-   $-   $8,852 
Other   -    -    -    - 
   $-   $-   $-   $8,852 
                     
Costs and expenses:                    
Research and development   623,092    703,456    1,880,629    3,051,437 
General and administrative   564,626    556,601    2,262,874    2,529,604 
    1,187,718    1,260,057    4,143,503    5,581,041 
                     
Interest expense   -    -    10,041,292    - 
Other income (expense)   -    (48,320)   -    9,173 
                     
Net Loss   (1,187,718)   (1,308,377)   (14,184,795)   (5,563,016)
                     
Dividends on Series A convertible preferred stock   -    (251,250)   (335,000)   (753,750)
                     
Net loss attributable to common shareholders  $(1,187,718)  $(1,559,627)  $(14,519,795)  $(6,316,766)
                     
Net loss per share (basic and diluted)  $(0.05)  $(0.13)  $(0.81)  $(0.54)
Weighted average number of common shares outstanding (basic and diluted)   22,503,393    12,004,435    17,897,231    11,654,078 

 

See accompanying notes.

 

5
 

 

EntreMed, Inc.

Consolidated Statements of Cash Flows

(Unaudited)

 

   NINE MONTHS ENDED
SEPTEMBER 30,
 
   2012   2011 
CASH FLOWS FROM OPERATING ACTIVITIES          
Net loss  $(14,184,795)  $(5,563,016)
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation and amortization   15,117    33,587 
Stock-based compensation expense   746,104    565,948 
Net gain on sale of assets   -    (8,180)
Realized gain on sale of short-term investment   -    (993)
Non-cash interest   10,041,292    - 
Changes in operating assets and liabilities:          
Accounts receivable   1,932,742    2,750,447 
Prepaid expenses and other   (58,383)   41,515 
Accounts payable   31,197    (859,065)
Payable to related party   55,685    - 
Accrued liabilities   (64,827)   (326,986)
Net cash used in operating activities   (1,485,868)   (3,366,743)
           
CASH FLOWS FROM INVESTING ACTIVITIES          
Proceeds from sale of assets   -    56,500 
Proceeds from sale of short-term investment   -    26,809 
Purchases of furniture and equipment   (11,818)   (6,001)
Net cash (used in) provided by investing activities   (11,818)   77,308 
           
CASH FLOWS FROM FINANCING ACTIVITIES          
Proceeds from issuance of convertible notes and warrants   10,000,000    - 
Debt issuance costs   (683,955)   - 
Stock issuance costs   (88,855)   (164,964)
Repayment of loan   -    (757,471)
Net proceeds from sale of common stock or exercise of options and warrants   1,999    1,312,063 
Net cash provided by financing activities   9,229,189    389,628 
           
Net increase (decrease) in cash and cash equivalents   7,731,503    (2,899,807)
Cash and cash equivalents at beginning of period   1,080,630    4,885,972 
Cash and cash equivalents at end of period  $8,812,133   $1,986,165 
           
Supplemental disclosure of cash flow information:          
Cash paid during the period for interest  $-   $7,145 
           
Non-cash financing activity:          
Common stock issued in connection with conversion of convertible notes and accrued interest  $10,144,658   $- 
           
Common stock issued in connection with conversion of preferred stock  $3,500,000   $- 

 

See accompanying notes.

 

6
 

 

ENTREMED, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

September 30, 2012 (unaudited)

 

1.Basis of Presentation

 

The accompanying consolidated financial statements include the accounts of EntreMed, Inc. (the Company or EntreMed) and its subsidiaries, Miikana Therapeutics, Inc. (Miikana) and EntreMed (Beijing) Co., Ltd. (EntreMed China). EntreMed China is a non-stock Chinese entity with 100% of its interest owned by EntreMed. EntreMed China received approval for a business license from the Beijing Industry and Commercial Administration in August 2012 and has entered into a lease for operating facilities in Beijing. All inter-company balances and transactions have been eliminated in consolidation. The Company refers to EntreMed and its consolidated subsidiaries.

 

The accompanying unaudited consolidated financial statements have been prepared in accordance with U. S. generally accepted accounting principles for interim financial information and in accordance with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, such consolidated financial statements do not include all of the information and disclosures required by U. S. generally accepted accounting principles for complete consolidated financial statements. In the opinion of management, all adjustments (consisting of normal recurring accruals) considered necessary for a fair presentation have been included. Operating results for the three and nine-month periods ended September 30, 2012 are not necessarily indicative of the results that may be expected for the year ending December 31, 2012. For further information, refer to our audited consolidated financial statements and footnotes thereto included in our Form 10-K for the year ended December 31, 2011.

 

Material subsequent events have been considered for disclosure and recognition through the filing date of these consolidated financial statements.

 

Liquidity Risks and Management’s Plans

 

The accompanying consolidated financial statements have been prepared on a going-concern basis, which contemplates the realization of assets and satisfaction of liabilities in the normal course of business. Since inception, the Company has incurred significant losses from operations and has incurred an accumulated deficit of $393.0 million.  The Company expects to continue to incur operating losses, for the foreseeable future due to, among other factors, its continuing clinical activities. The proceeds from the issuance of the Company’s $10 million convertible notes, and warrants to purchase 1,739,132 shares of the Company’s common stock (the “Strategic Financing”) in February 2012 allow the Company to have sufficient cash to meet its cash requirements for at least the next 12 months. At the Company’s 2012 annual stockholders’ meeting held on April 30, 2012, the stockholders approved the Strategic Financing transaction, and the convertible notes automatically converted into common stock on May 1, 2012 (See Note 2). The Company will continue to exercise tight controls over operating expenditures. The Company will continue to pursue opportunities, as required, to raise additional capital and will also actively pursue non- or less-dilutive arrangements in China to support the Company’s dual-country approach to drug development.

 

7
 

 

The Company previously reported that on November 22, 2011, the Company received a letter from the Listing Qualifications Staff (the “Staff”) of the Nasdaq Stock Market (“Nasdaq”), notifying the Company that it did not comply with Nasdaq Listing Rule 5550(b)(1) (the “Rule”), which requires the Company to maintain a minimum of $2.5 million in stockholders’ equity for continued listing on the Nasdaq Capital Market if it does not otherwise meet the other requirements under the Nasdaq Capital Market continued listing rules. On May 4, 2012, the Company received a letter from the Staff stating that the Company regained compliance with the Rule.

 

2.Strategic Financing

 

As described in Note 1 and in connection with the Strategic Financing, on January 20, 2012, the Company entered into a Convertible Note and Warrant Purchase Agreement (the “Purchase Agreement”) with certain strategic accredited investors (the “Investors”), pursuant to which the Company issued and sold to the Investors, in a private placement, subordinated mandatorily convertible promissory notes (collectively, the “Notes”) with an aggregate principal amount of $10 million. The Company also issued warrants (the “2012 Warrants”) to the Investors to purchase an aggregate of 1,739,132 shares of the Company's common stock, par value $0.01 per share (“Common Stock”). The 2012 Warrants cover a number of shares of common stock equal to 20% of the principal amount of the Notes purchased by each Investor, divided by $1.15.  The 2012 Warrants have an exercise price of $1.40 per share and shall be exercisable on or after July 29, 2012 and expire five years after the exercisable date. The relative fair value of the 2012 Warrants issued is $2,155,527, calculated using the Black-Scholes-Merton valuation model value of $1.58 with an expected and contractual life of 5.5 years, an assumed volatility of 103%, and a risk-free interest rate of 0.71%. In February 2012, the 2012 Warrants were recorded as additional paid-in-capital and a discount on the Notes. For the nine-month period ended September 30, 2012, the debt discount of $2,155,527 has been fully amortized as non-cash interest expense as a result of the conversion of the Notes.

 

The Strategic Financing was completed on February 2, 2012 (the “Closing”). The Company received net proceeds of approximately $9.3 million. The Company paid one of the investors a fee in the amount of 6% of the aggregate amount invested in the Strategic Financing, for the investor’s due diligence, role in structuring and negotiating the transaction and as reimbursement for the investor’s fees incurred in connection with the Strategic Financing. Through September 30, 2012 and December 31, 2011, the Company incurred $683,955 and $19,733 of debt issuance costs that were deferred and recorded as other current assets. All debt issuance costs have been fully amortized and recorded as interest expense upon conversion of the Notes in the second quarter of 2012. Non-cash interest expense related to the amortization of debt issuance costs, which includes the fee paid to the investor, was $683,955 for the nine-month period ended September 30, 2012.

 

The Company received approval of the Strategic Financing from the Company's stockholders at the 2012 annual stockholders meeting held on April 30, 2012. On May 1, 2012, the Notes, including accrued interest of $144,658, automatically and immediately converted into 8,821,431 shares of common stock and the 2012 Warrants became exercisable on or after July 29, 2012.  The Notes bore an interest rate of 6% and converted at a conversion price of $1.15 per share.  The conversion price reflects the 10-day average closing sale price of the Company’s Common Stock ending on January 20, 2012.

 

8
 

 

The Notes were not convertible, and the Warrants were not exercisable, prior to receiving stockholder approval. The Notes contain a contingent beneficial conversion feature as the conversion price of the shares was less than the share price on the date of the Notes issuance. The beneficial conversion feature is valued at $7,057,153 and was recorded as non-cash interest expense and additional paid-in-capital in the second quarter of 2012, upon removal of the contingency and conversion of the Notes on May 1, 2012.

 

Pursuant to the terms of the Purchase Agreement, the Company has granted registration rights to the Investors. The Company filed a resale registration statement, which became effective on August 8, 2012, covering the shares of Common Stock underlying the Notes and upon exercise of the Warrants.

 

The Company granted representatives of the Investors, the right to designate up to two members of the Company’s Board of Directors (each, an “Investor Designee”) or to designate a board observer in lieu of an Investor Designee. In the event either representative declines to designate an Investor Designee, the other shall have the right to designate a second Investor Designee. Pursuant to the terms of the Purchase Agreement, the Investors’ board representation rights shall decrease ratably in proportion to their ownership of Common Stock, such that the percentage of the Board of Directors represented by the Investors Designees shall not exceed the Investors’ proportionate percentage equity ownership in the Company at any time.

 

3.Related Party Transactions

 

On October 31, 2012, EntreMed China obtained the necessary approvals to establish a bank account in Beijing. The Board of Directors has approved a transfer of $3,000,000 to EntreMed China from the EntreMed, Inc. to capitalize its wholly-owned subsidiary, of which $500,000 was advanced on October 31, 2012. Prior to establishing a bank account, EntreMed China incurred certain startup and initial operating expenses, which have been advanced by the Company’s Chief Executive Officer on behalf of EntreMed China. As of September 30, 2012, the Company has recorded $55,685 as a payable to related party in the accompanying consolidated balance sheet, representing amounts owed to the Company’s Chief Executive Officer as reimbursement for expenses paid.

 

4.Stockholders’ Equity

 

In connection with the Strategic Financing (see Note 2), and upon stockholder approval of the Strategic Financing at the 2012 annual meeting on April 30, 2012, Celgene converted all of its preferred stock to an aggregate of 1,522,727 shares of common stock, pursuant to the terms and conditions of the Series A Preferred Stock. As of May 1, 2012, there is no Series A Preferred Stock or any class of preferred stock outstanding. In connection with the stockholder approval of the Strategic Financing, Celgene has waived all accrued dividends on the Series A Preferred Stock, and Celgene is no longer entitled to any liquidation preference on its shares.

 

9
 

 

5.Share-Based Compensation

 

The Company has adopted incentive and nonqualified stock option plans for executive, scientific and administrative personnel of the Company as well as outside directors and consultants. In April 2012, the Company’s shareholders approved an amendment to the 2011 Long-Term Incentive Plan, increasing the number of shares reserved for issuance from 835,341 to 1,730,000 shares of common stock to be available for grants and awards. In April 2012, 150,000 options were granted to the Company’s Chief Executive Officer outside of the Company’s 2011 Long-Term Incentive Plan, as an inducement award material to his employment, in accordance NASDAQ Listing Rule 5635(c)(4). As of September 30, 2012, there are 1,647,253 shares issuable under options previously granted and currently outstanding, with exercise prices ranging from $1.75 to $60.39. During the three months ended September 30, 2012, the Company awarded options to two officers, a portion of which is subject to certain performance conditions and market conditions. Options granted under the plans generally vest over periods varying from immediately to three years, are not transferable and generally expire ten years from the date of grant. As of September 30, 2012, 637,000 shares remained available for grant under the Company’s 2011 Long-Term Incentive Plan.

 

The Company records compensation expense associated with service, performance, market condition based stock options and other equity-based compensation in accordance with provisions of authoritative guidance. The fair value of awards whose fair values are calculated using the Black-Scholes option pricing model is generally being amortized on a straight-line basis over the requisite service period and is recognized based on the proportionate amount of the requisite service period that has been rendered during each reporting period. The fair value of awards with market conditions is being amortized based upon the estimated derived service period. Share based awards granted to employees with a performance condition are measured based on the probable outcome of that performance condition during the requisite service period. Such an award with a performance condition will be expensed if it is probable that a performance condition will be achieved. As of September 30, 2012, no expense has been recorded for share awards with performance conditions.

 

The Company’s net loss for the nine months ended September 30, 2012 and 2011 includes compensation expense of $746,104 and $565,948, respectively, related to the Company’s share-based compensation awards. The compensation expense related to the Company’s share-based compensation arrangements is recorded as components of general and administrative expense and research and development expense, as follows:

 

   NINE MONTH PERIOD ENDED
SEPTEMBER 30,
 
   2012   2011 
Research and development  $186,003   $114,257 
General and administrative   560,101    451,691 
Share-based compensation expense  $746,104   $565,948 
Net share-based compensation expense, per common share:          
Basic and diluted  $0.04   $0.05 

 

The Company uses the Black-Scholes-Merton valuation model to estimate the fair value of service based and performance based stock options granted to employees. For market condition based options, the Company uses a binomial model to estimate fair value. These option valuation models require the input of highly subjective assumptions, and changes in the assumptions used can materially affect the grant date fair value of an award.

 

10
 

 

Following are the weighted-average assumptions used in valuing the stock options granted to employees during the six-month periods ended September 30, 2012 and 2011:

 

   NINE MONTH PERIOD ENDED
SEPTEMBER 30,
 
   2012   2011 
Expected volatility   101.67%   94.09%
Risk-free interest rate   0.94%   2.04%
Expected term of option   5.74 years    5.49 years 
Forfeiture rate*   5.00%   5.00%
Expected dividend yield   0.00%   0.00%

 

* - Authoritative guidance requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates. During the nine-month periods ended September 30, 2012 and 2011, forfeitures were estimated at 5%.

 

The weighted average fair value of stock options granted during the nine-month periods ended September 30, 2012 and 2011 was $2.04 and $4.63, respectively.

 

A summary of the Company’s stock option plans and of changes in options outstanding under the plans for the nine months ended September 30, 2012, is as follows:

 

   Number of
Options
   Weighted
Average
Exercise
Price
 
Outstanding at January 1, 2012   621,889   $16.23 
Granted   1,249,000   $2.04 
Exercised   (1,136)  $1.76 
Expired   (194,250)  $21.46 
Forfeited   (28,250)  $5.27 
Outstanding at September 30, 2012   1,647,253   $5.05 
Vested and expected to vest at September 30, 2012   1,600,823   $5.13 
Exercisable at September 30, 2012   718,645   $8.77 

 

Cash received from option exercises under all share-based payment arrangements for the three and nine months ended September 30, 2012 was $0 and $1,999, respectively. Cash received from option exercises for the three and nine months ended September 30, 2011 was $0 and $23,338, respectively.

 

6.Income Taxes

 

At December 31, 2011, the Company has a $3.1 million unrecognized tax benefit. The Company has recorded a full valuation allowance on the net deferred tax asset recognized in the consolidated financial statements as of December 31, 2011.

 

11
 

 

During the nine months ended September 30, 2012 there were no material changes to the measurement of unrecognized tax benefits in various taxing jurisdictions. The Company recognizes interest and penalties related to uncertain tax positions as a component of income tax expense.

 

The tax returns for all years in the Company’s major tax jurisdictions are not settled as of January 1, 2012; no changes in settled tax years have occurred through September 30, 2012. Due to the existence of tax attribute carryforwards (which are currently offset by a full valuation allowance), the Company treats all years’ tax positions as unsettled due to the taxing authorities’ ability to modify these attributes.

 

ITEM 2.  MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS.

 

OVERVIEW

 

We are a clinical-stage pharmaceutical company employing a drug development strategy primarily in the United States and China to develop targeted therapeutics for the global market. Our current lead drug candidate is ENMD-2076, an Aurora A and angiogenic kinase inhibitor for the treatment of cancer. ENMD-2076 has completed Phase 1 studies in patients with advanced solid tumors, multiple myeloma and leukemia and is currently completing data for a multi-center Phase 2 study in patients with platinum resistant ovarian cancer. Additionally, in July 2012, we initiated a Phase 2 study of ENMD-2076 in triple-negative breast cancer. We intend to pursue additional trials and are in various assessment and planning stages.

 

ENMD-2076 is a novel orally-active, Aurora A/angiogenic kinase inhibitor with potent activity against Aurora A and multiple tyrosine kinases linked to cancer and inflammatory diseases. ENMD-2076 is relatively selective for the Aurora A isoform in comparison to Aurora B. Aurora kinases are key regulators of the process of mitosis, or cell division, and are often over-expressed in human cancers. ENMD-2076 exerts its effects through multiple mechanisms of action, including anti-proliferative activity and the inhibition of angiogenesis. ENMD-2076 has demonstrated significant, dose-dependent preclinical activity as a single agent, including tumor regression, in multiple xenograft models (e.g. breast, colon, leukemia), as well as activity towards ex vivo-treated human leukemia patient cells.

 

Clinical Phase 1 results were published (Clin Cancer Res 2011;17:849-860) and data from the leukemia and myeloma studies were presented during the American Society of Hematology meeting in December 2010. Anti-cancer activity was demonstrated with ENMD-2076 treatment in a variety of solid and hematological cancer patients. Also, as previously reported, at the American Society of Clinical Oncology (ASCO) Annual Meeting in June 2011, Phase 2 data in ovarian cancer patients was presented by the principal investigator conducting the Phase 2 ENMD-2076 study. The data demonstrated ENMD-2076 activity in a population of difficult to treat platinum resistant patients. In October 2011, we announced that the final data for the primary endpoint of progression free survival rate at 6 months was 22 percent.  Phase 2 data in ovarian cancer were also published in the European Journal of Cancer in September 2012 in an article entitled “ENMD-2076, an Oral Inhibitor of Angiogenic and Proliferation Kinases, Has Activity in Recurrent, Platinum Resistant Ovarian Cancer.” We believe that the data, together with the Phase 1 results, provide support for additional clinical studies in ovarian cancer and other forms of cancer. We continue to monitor patients who are receiving ENMD-2076, and are focused on collecting additional data on overall survival and other endpoints. We intend to advance our clinical development of ENMD-2076 and are currently assessing strategies with our clinical trial investigators and consultants and intend to pursue opportunities and leverage our resources in both the United States and China.

 

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ENMD-2076 has received orphan drug designation for the treatment of ovarian cancer, multiple myeloma and acute myeloid leukemia (“AML”).

 

ENMD-2076 is our only program currently under active clinical evaluation. This prioritization allows us to direct the majority of our limited resources to the clinical development of ENMD-2076. With the completion of our recent financing, as discussed above, we will continue to pursue the development of ENMD-2076 and will evaluate other therapeutic drug candidates available internally and externally. We are currently in the planning stages for the next ENMD-2076 trial. In developing drug candidates, we intend to use and leverage resources available to us in both the United States and China. In line with capitalizing on the drug development and capital resources available in China, we have established a wholly-owned subsidiary in China. We intend to pursue additional financing opportunities as well as opportunities to raise capital through forms of non- or less- dilutive arrangements, such as partnerships and collaborations with organizations that have capabilities and/or products that are complementary to our capabilities and products in order to continue the development of our product candidate that we intend to pursue to commercialization. However, there can be no assurance that adequate additional financing under such arrangements will be available to us on terms that we deem acceptable, if at all.

 

We have incurred significant losses from operations, due in large part to expenditures for our research and development activities. At September 30, 2012, we had an accumulated deficit of $393.0 million.  We expect to continue to incur operating losses, for the foreseeable future due to, among other factors, its continuing clinical activities. Based on current plans, due in large part to the $10 million proceeds from our Strategic Financing in February 2012, we expect our current available cash and cash equivalents to meet our cash requirements through at least December 31, 2013. The Company will continue to pursue opportunities, as required, to raise additional capital and will also actively pursue non- or less-dilutive arrangements in China to support the Company’s dual-country approach to drug development.

 

CRITICAL ACCOUNTING POLICIES AND THE USE OF ESTIMATES

 

The preparation of our financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the amounts reported in our consolidated financial statements and accompanying notes. Actual results could differ materially from those estimates. Our critical accounting policies, including the items in our financial statements requiring significant estimates and judgments, are as follows:

 

-Revenue Recognition - We recognize revenue in accordance with the provisions of authoritative guidance issued, whereby revenue is not recognized until it is realized or realizable and earned. Revenue is recognized when all of the following criteria are met: persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the price to the buyer is fixed and determinable and collectibility is reasonably assured.

 

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-Royalty Revenue – Royalties from licenses are based on third-party sales and recorded as earned in accordance with contract terms, when third-party results are reliably measured and collectibility is reasonably assured. We expect that the majority of our 2012 revenues will be primarily from royalties on the sale of Thalomid®. In 2004, certain provisions of a purchase agreement dated June 14, 2001 by and between Bioventure Investments kft (“Bioventure”) and the Company were satisfied and, as a result, beginning in 2005 we became entitled to share in the royalty payments received by Royalty Pharma Finance Trust, successor to Bioventure, on annual Thalomid® sales above a certain threshold. Based on the licensing agreement royalty formula, annual royalty sharing commences when net royalties received by Royalty Pharma exceeds $15,375,000.

 

-We are also eligible to receive royalties from Oxford Biomedica, PLC based on a portion of the net sales of products developed for the treatment of ophthalmic (eye) diseases based in part on the Endostatin gene. We did not receive any payment from Oxford Biomedica, PLC in 2011 and do not expect to receive additional payments from Oxford Biomedica, PLC in 2012.

 

-Royalty payments, if any, are recorded as revenue when received and/or when collectibility is reasonably assured.

 

-Research and Development - Research and development expenses consist primarily of compensation and other expenses related to research and development personnel, research collaborations, costs associated with preclinical testing and clinical trials of our product candidates, including the costs of manufacturing drug substance and drug product, regulatory maintenance costs, and facilities expenses. Research and development costs are expensed as incurred.

 

-Expenses for Clinical Trials – Expenses for clinical trials are incurred from planning through patient enrollment to reporting of the data. We estimate expenses incurred for clinical trials that are in process based on patient enrollment and based on clinical data collection and management. Costs that are associated with patient enrollment are recognized as each patient in the clinical trial completes the enrollment process. Estimated clinical trial costs related to enrollment can vary based on numerous factors, including expected number of patients in trials, the number of patients that do not complete participation in a trial, and when a patient drops out of a trial. Costs that are based on clinical data collection and management are recognized in the reporting period in which services are provided. In the event of early termination of a clinical trial, we would accrue an amount based on estimates of the remaining non-cancelable obligations associated with winding down the clinical trial.

 

-Stock-Based Compensation – All share-based payment transactions associated with service, performance, market condition based stock options and other equity-based compensation are recognized in the financial statements at their fair values. The fair value of awards whose fair values are calculated using the Black-Scholes option pricing model is generally being amortized on a straight-line basis over the requisite service period, which is generally the option vesting term of one to three years. The fair value of awards with market conditions is being amortized based upon the estimated derived service period. Share based awards granted to employees with a performance condition are measured based on the probable outcome of that performance condition during the requisite service period. Such an award with a performance condition will be expensed if it is probable that a performance condition will be achieved. Share-based compensation expense recognized for the nine months ended September 30, 2012 and 2011 totaled approximately $746,000 and $566,000, respectively.

 

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The determination of fair value of stock-based payment awards on the date of grant, using either the Black-Scholes or binomial option pricing model, is affected by our stock price, as well as the input of other subjective assumptions. These assumptions include, but are not limited to, the expected forfeiture rate and expected term of stock options and our expected stock price volatility over the term of the awards. Changes in the assumptions can materially affect the fair value estimates.

 

Any future changes to our share-based compensation strategy or programs would likely affect the amount of compensation expense recognized.

 

RESULTS OF OPERATIONS

 

For the Three and Nine Months Ended September 30, 2012 and 2011.

 

Revenues. Our 2012 revenues will likely result solely from Celgene’s sales of Thalomid®. We earn royalties once sales of Thalomid exceed approximately $225 million annually, pursuant to a 2001 agreement with Royalty Pharma. Thalomid® is distributed and sold by Celgene and/or its affiliates, and thus, we have no control over sales of Thalomid® or the amount, if any, of royalty payments we will receive. We recorded royalty revenue of $0 and $8,852 during the three and nine month periods ended September 30, 2011. This royalty related to certain sales by Celgene of Thalomid in 2010 that were not reported to Royalty Pharma until the second quarter of 2011, at which time we received our share of the applicable royalty payment. We do not expect to record royalty revenue in fiscal 2012 until the fourth quarter.

 

Research and Development Expenses. Our research and development expenses for the three and nine months ended September 30, 2012 totaled approximately $623,000 and $1,881,000, respectively. Research and development expenses for the corresponding 2011 periods were $703,000 and $3,051,000, respectively.

 

Reflected in our R&D expenses totaling $623,000 for the three-month period ended September 30, 2012 are direct project costs of $378,000 for ENMD-2076, $63,000 for Panzem® oncology, and $2,000 for ENMD-1198. The 2011 research and development expenses for the comparable period included $496,000 for ENMD-2076, $13,000 for Panzem® oncology, $5,000 for ENMD-1198 and $4,000 for MKC-1. Research and development expenses totaling $1,881,000 for the nine-month period ended September 30, 2012 include direct project costs of $1,008,000 related to ENMD-2076, $146,000 related to Panzem® oncology, $11,000 related to ENMD-1198 and $3,000 for MKC-1. The 2011 research and development expenses for the comparable period included $2,264,000 for ENMD-2076, $56,000 for Panzem®, $23,000 for ENMD-1198 and $29,000 for MKC-1. The overall decrease in research and development costs in the three and nine month periods ended September 30, 2012, as compared to same period in 2011, reflects a decrease in costs associated with the clinical development of ENMD-2076 as fewer patients were enrolled in and remained on clinical trials during 2012, as well as a decrease in the number of research and development personnel, offset by an increase in research and development costs incurred by EntreMed China, compared to the 2011 period when clinical development costs were increased as we were continuing to enroll patients.

 

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At September 30, 2012, accumulated direct project expenses for Panzem® oncology were $54,568,000; direct ENMD-1198 project expenses totaled $13,259,000; and, since acquired, accumulated direct project expenses for ENMD-2076 totaled $21,685,000 and for MKC-1, accumulated project expenses totaled $10,194,000. Our research and development expenses also include non-cash stock-based compensation totaling $94,000 and $186,000 for the three and nine months ended September 30, 2012 and $18,000 and $114,000 for the respective 2011 periods. The increase in stock-based compensation expense is related to stock options granted in August 2012. The balance of our research and development expenditures includes manufacturing costs in China, facility costs and other departmental overhead, and expenditures related to the non-clinical support of our programs.

 

We expect our research and development expenses in 2012 to be primarily for the ENMD-2076 program. We expect our ENMD-2076 expenses for the remainder of 2012 to increase, depending on the timing of our clinical development plan. Additional financial resources will enable us to accelerate and expand the breadth of our ENMD-2076 Phase 2 program. We will continue to conduct research on ENMD-2076 in order to comply with stipulations made by the FDA, as well as to increase understanding of the mechanism of action and toxicity parameters of ENMD-2076 and its metabolites.  Completion of clinical development may take several years or more, but the length of time generally varies substantially according to the type, complexity, novelty and intended use of a product candidate.

 

We estimate that clinical trials of the type we generally conduct are typically completed over the following timelines:

 

CLINICAL
PHASE
  ESTIMATED
COMPLETION
PERIOD
Phase 1   1-2 Years
Phase 2   2-3 Years
Phase 3   2-4 Years

 

The duration and the cost of clinical trials may vary significantly over the life of a project as a result of differences arising during the clinical trial protocol, including, among others, the following:

 

-the number of patients that ultimately participate in the trial;

 

-the duration of patient follow-up that seems appropriate in view of the results;

 

-the number of clinical sites included in the trials; and

 

-the length of time required to enroll suitable patient subjects.

 

We test our potential product candidates in numerous preclinical studies to identify indications for which they may be product candidates. We may conduct multiple clinical trials to cover a variety of indications for each product candidate. As we obtain results from trials, we may elect to discontinue clinical trials for certain indications in order to focus our resources on more promising indications.

 

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Our proprietary product candidates have also not yet achieved regulatory approval, which is required before we can market them as therapeutic products. In order to proceed to subsequent clinical trial stages and to ultimately achieve regulatory approval, regulatory agencies must conclude that our clinical data establish safety and efficacy. Historically, the results from preclinical testing and early clinical trials have often not been predictive of results obtained in later clinical trials. A number of new drugs and biologics have shown promising results in clinical trials, but subsequently failed to establish sufficient safety and efficacy data to obtain necessary regulatory approvals.

 

Our business strategy includes being opportunistic with collaborative arrangements with third parties to complete the development and commercialization of our product candidates. In the event that third parties take over the clinical trial process for one of our product candidates, the estimated completion date would largely be under the control of that third party rather than us. We cannot forecast with any degree of certainty which proprietary products or indications, if any, will be subject to future collaborative arrangements, in whole or in part, and how such arrangements would affect our capital requirements.

 

As a result of the uncertainties discussed above, among others, we are unable to estimate the duration and completion costs of our research and development projects. Our inability to complete our research and development projects in a timely manner or our failure to enter into collaborative agreements, when appropriate, could significantly increase our capital requirements and could adversely impact our liquidity. These uncertainties could force us to seek additional, external sources of financing from time to time in order to continue with our business strategy. There can be no assurance that we will be able to successfully access external sources of financing in the future. Our inability to raise additional capital, or to do so on terms reasonably acceptable to us, would jeopardize the future success of our business.

 

Research and development expenses consist primarily of compensation and other expenses related to research and development personnel, research collaborations, costs associated with internal and contract preclinical testing and clinical trials of our product candidates, including the costs of manufacturing drug substance and drug product, regulatory maintenance costs, and facilities expenses. Research and development expenses decreased to $623,000 during the three months ended September 30, 2012 from $703,000 for the corresponding period in 2011. Research and development expenses decreased to $1,881,000 during the nine months ended September 30, 2012 from $3,051,000 for the corresponding period in 2011. Expenditures during the three and nine months ended September 30, 2012 were specifically impacted by the following:

 

-Outside Services – In the three-month period ended September 30, 2012, we expended $14,000 on outside service activities versus $4,000 in the same 2011 period. For the nine-month period ended September 30, 2012 outside services are $36,000 compared to $51,000 for the same 2011 period. The increase in 2012 as compared to 2011 for the three month period reflects costs associated with the translation of documents to Chinese for regulatory purposes in China. The decrease in the nine month period primarily reflects increased costs in 2011 associated with clinical trials for the development of the ENMD-2076.

 

-Clinical Trial Costs – Clinical trial costs, which include clinical site fees, monitoring costs and data management costs, decreased to $58,000 in the three months ended September 30, 2012 from $159,000 in the three-month period ended September 30, 2011. The decrease during this period relates to fewer patients on trial during the 2012 period compared to the 2011 period and increased costs associated with data analysis during the 2011 period. Clinical trial costs for the nine-month period ended September 30, 2012 decreased to $186,000 from $934,000 for the comparable 2011 period. This decrease relates to fewer patients on clinical trials during the 2012 period and increased costs during the 2011 period due to continued new patient enrollment in the Phase 2 trials in early 2011.

 

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-Contract Manufacturing Costs - The costs of manufacturing the material used in clinical trials for our product candidates is reflected in contract manufacturing. These costs include bulk manufacturing, encapsulation and fill and finish services, product release costs and storage fees. Contract manufacturing costs for the three months ended September 30, 2012 increased to $114,000 compared to $9,000 during the same period in 2011. The 2012 increase relates to contract manufacturing costs associated with our operations in China. For the nine-month period ended September 30, 2012, manufacturing costs decreased to $156,000 from $226,000 for the comparable 2011 period. The 2012 decrease reflects a net reduction in encapsulation costs for ENMD-2076 as there was a large production of material in early 2011.

 

-Personnel Costs — Personnel costs decreased to $200,000 in the three-month period ended September 30, 2012 from $304,000 in the corresponding 2011 period. For the nine-month period, personnel costs decreased in 2012 to $858,000 from $1,018,000 for the corresponding 2011 period. This decrease is attributed to the impact of the elimination of seven positions during 2011 and 2012, offset by both the severance expense of $290,000 in 2012 and the increase in non-cash stock-based compensation of $72,000 related to stock options granted in 2012.
   
-Also reflected in our 2012 research and development expenses for the three-month period ended September 30, 2012 are patent costs of $136,000 and facility and related expenses of $24,000. In the corresponding 2011 period, these expenses totaled $134,000 and $43,000, respectively. For the nine-month period ended September 30, 2012, patent costs were $389,000 and facility and related expenses were $47,000. In the corresponding 2011 period, these expenses totaled $440,000 and $145,000, respectively. Patent costs during the nine months ended September 30, 2012 decreased primarily due to higher costs in 2011 associated with the execution of our intellectual property strategy, including maintaining our patent portfolio and expanding our patent protection internationally. The reduction in expenses in facilities and related expenses in 2012 resulted from an overall decrease in leased office space.

 

General and Administrative Expenses. General and administrative expenses include compensation and other expenses related to finance, business development and administrative personnel, professional services and facilities.

 

General and administrative expenses were $565,000 in the three-month period ended September 30, 2012 which was consistent with $557,000 in the corresponding 2011 period. For the nine-month period, general and administrative expenses decreased in 2012 to $2,263,000 from $2,530,000 for the corresponding 2011 period. This decrease is primarily related to the reduction in salary and facility costs, as well as professional fees compared to the 2011 period, in addition to the continuation of cost savings initiatives during 2012.

 

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Interest Expense. Interest expense for the nine month period ended September 30, 2012 was $10,041,000. All of the interest expense was non-cash interest (including $684,000, related to amortization of deferred financing costs; $2,156,000, related to amortization of debt discount; and $145,000, related to accrued interest on our Notes payable which was converted to shares of common stock on May 1, 2012). Also included as non-cash interest expense for nine month period ended September 30, 2012 was $7,057,000, representing the value of the beneficial conversion feature associated with the Notes. There was no interest expense for the three month periods ended September 30, 2012 and 2011 or for the nine-months ended September 30, 2011.

 

Dividends on Series A Convertible Preferred Stock. The Consolidated Statements of Operations for the nine months ended September 30, 2012 and 2011 reflect accrued, but unpaid, dividends of $335,000 and $753,750, respectively relating to Series A Convertible Preferred Stock held by Celgene pursuant to a Securities Purchase Agreement dated December 31, 2002. Celgene, the holder of Series A Preferred Stock accumulated dividends at a rate of 6% and participated in dividends declared and paid on the common stock, if any. In connection with the stockholder approval of the Strategic Financing on April 30, 2012, Celgene has waived all accrued dividends on the Series A Preferred Stock, and is no longer entitled to any liquidation preference on its shares. There are no outstanding shares of Series A Convertible Preferred Stock.

 

LIQUIDITY AND CAPITAL RESOURCES

 

To date, we have been engaged primarily in research and development activities. As a result, we have incurred and expect to continue to incur operating losses in 2012 and the foreseeable future before we commercialize any products. Based on our current plans and following the consummation of the Strategic Financing in February 2012, we expect our current available cash and cash equivalents to meet our cash requirements through at least December 31, 2013.

 

We will require significant additional funding to fund operations until such time, if ever, we become profitable. We intend to augment our cash balances by pursuing other forms of capital infusion, including strategic alliances or collaborative development opportunities with organizations that have capabilities and/or products that are complementary to our capabilities and products in order to continue the development of our potential product candidates that we intend to pursue to commercialization. If we seek strategic alliances, licenses, or other alternative arrangements, such as arrangements with collaborative partners or others, to raise further financing, we may need to relinquish rights to certain of our existing product candidates, or products we would otherwise seek to develop or commercialize on our own, or to license the rights to our product candidates on terms that are not favorable to us.

 

We will continue to seek to raise additional capital to fund our research and development and advance the clinical development of ENMD-2076. We intend to explore one or more of the following alternatives to raise additional capital:

 

·selling additional equity securities;
·out-licensing product candidates to one or more corporate partners;
·completing an outright sale of non-priority assets; and/or
·engaging in one or more strategic transactions.

 

We also will consider additional actions to reduce our expenses.

 

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There can be no assurance that adequate additional financing under such arrangements will be available to us on terms that we deem acceptable, if at all. If additional funds are raised by issuing equity securities, dilution to existing shareholders may result, or the equity securities may have rights, preferences, or privileges senior to those of the holders of our common stock. If we fail to obtain additional capital when needed, we may be required to delay or scale back our Phase 2 plans for ENMD-2076.

 

At September 30, 2012, we had cash of $8,812,133, with working capital of $8,324,784.

 

We expect that the majority of our 2012 revenues will continue to be from royalties on the sales of Thalomid®. Thalomid® is sold by a third-party and is subject to competition from other products and generic drugs, and we have no control over such party’s sales efforts or the resources devoted to Thalomid® sales. In 2011 and 2010, we earned royalty-sharing revenue in the amount of $1,941,000 and $3,449,000, respectively. There can be no assurance on the future trends of Thalomid® sales and the amount of revenue we will receive and record in 2012. Based on the trend, we expect annual sales of Thalomid® in 2012 to continue to decrease, which will result in a reduction in our revenues in 2012.

 

In addition, under our licensing agreement with Oxford Biomedica, PLC and Oxford Biomedica (UK) Limited Oxford, we are entitled to receive payments upon the achievement of certain milestones with respect to the development of gene therapies for ophthalmic (eye) diseases. In connection with the announced collaboration between Oxford Biomedica and Sanofi Aventis which included certain compounds that are governed by our licensing agreement, we are also eligible to receive milestone payments. No payments were received in 2011 or 2012 to date from this licensing agreement. We do not control the drug development efforts of Oxford and have no information or control over when or whether any milestones will be reached that would result in additional payments to us.

 

INFLATION AND INTEREST RATE CHANGES

 

Management does not believe that our working capital needs are sensitive to inflation and changes in interest rates.

 

ITEM 3.    QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

 

The primary objective of our investment activities is to preserve our capital until it is required to fund operations while at the same time maximizing the income we receive from our investments without incurring investment market volatility risk. Our investment income is sensitive to the general level of U.S. interest rates. In this regard, changes in the U.S. interest rates affect the interest earned on our cash and cash equivalents. Due to the short-term nature of our cash and cash equivalent holdings, a 10% movement in market interest rates would not materially impact on the total fair market value of our portfolio as of September 30, 2012.

 

ITEM 4.    CONTROLS AND PROCEDURES

 

Evaluation of Disclosure Controls and Procedures

 

Based on an evaluation under the supervision and with the participation of the Company’s management, the Company’s Chief Executive Officer and Principal Accounting Officer have concluded that the Company’s disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”) were effective as of September 30, 2012 to ensure that information required to be disclosed by the Company in reports that it files or submits under the Exchange Act is (i) recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission rules and forms and (ii) accumulated and communicated to the Company’s management, including its Chief Executive Officer and Principal Accounting Officer, as appropriate to allow timely decisions regarding required disclosure.

 

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Management’s assessment of the effectiveness of internal control over financial reporting is expressed at the level of reasonable assurance because a control system, no matter how well designed and operated, can provide only reasonable, but not absolute, assurance that the control system’s objectives will be met.

 

Changes in Internal Control Over Financial Reporting

 

There were no changes in the Company’s internal control over financial reporting that occurred during the quarter ended September 30, 2012 that have materially affected or are reasonably likely to materially affect the Company’s internal control over financial reporting.

 

PART II.        OTHER INFORMATION

 

ITEM 1.  LEGAL PROCEEDINGS

 

We are subject in the normal course of business to various legal proceedings in which claims for monetary or other damages may be asserted. Management does not believe such legal proceedings, except as otherwise disclosed herein, are material.

 

ITEM 1A.  RISK FACTORS

 

For information regarding factors that could affect the Company’s results of operations, financial condition and liquidity, see the risk factors discussion set forth in Item 1A of EntreMed’s Annual Report on Form 10-K for the fiscal year ended December 31, 2011 and the information under “Special Note Regarding Forward-Looking Statements” included in this report. There have been no material changes to our risk factors from those disclosed in our Annual Report on Form 10-K for the fiscal year ended December 31, 2011.

 

ITEM 2.  UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

 

None.

 

ITEM 3.  DEFAULTS UPON SENIOR SECURITIES

 

Not applicable.

 

ITEM 4.  REMOVED AND RESERVED

 

ITEM 5.  OTHER INFORMATION

 

Not applicable.

 

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ITEM 6.  EXHIBITS

 

3.1   Certificate of Elimination of Series A Convertible Preferred Stock (incorporated by reference from the Registrant’s Current Report on Form 8-K filed on September 20, 2012)
31.1   Rule 13a-14(a) Certification of Chief Executive Officer
31.2   Rule 13a-14(a) Certification of Principal Accounting Officer
32.1   Section 1350 Certification of Chief Executive Officer
32.2   Section 1350 Certification of Principal Accounting Officer
101   The following financial information from the Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, formatted in eXtensible Business Reporting Language (XBRL):  (i) Unaudited Consolidated Balance Sheets at September 30, 2012 and December 31, 2011, (ii) Unaudited Consolidated Statements of Operations for the Three and Nine months ended September 30, 2012 and 2011, (iii) Unaudited Consolidated Statements of Cash Flows for the Nine months ended September 30, 2012 and 2011 and (iv) Notes to Unaudited Consolidated Financial Statements.*

 

* This exhibit is furnished and will not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (15 U.S.C. 78r), or otherwise subject to the liability of that section. Such exhibit will not be deemed to be incorporated by reference into any filing under the Securities Act or Securities Exchange Act, except to the extent that the Registrant specifically incorporates it by reference.

 

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SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 

  ENTREMED, INC.
    (Registrant)
   
Date: November 14, 2012 /s/ Ken Keyong Ren
  Ken Keyong Ren
  Chief Executive Officer
   
Date: November 14, 2012 /s/ Sara B. Capitelli
  Sara B. Capitelli
  Principal Accounting Officer

 

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EXHIBIT INDEX

 

3.1   Certificate of Elimination of Series A Convertible Preferred Stock (incorporated by reference from the Registrant’s Current Report on Form 8-K filed on September 20, 2012)
31.1   Rule 13a-14(a) Certification of Chief Executive Officer
31.2   Rule 13a-14(a) Certification of Principal Accounting Officer
32.1   Section 1350 Certification of Chief Executive Officer
32.2   Section 1350 Certification of Principal Accounting Officer
101   The following financial information from the Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2012, formatted in eXtensible Business Reporting Language (XBRL):  (i) Unaudited Consolidated Balance Sheets at September 30, 2012 and December 31, 2011, (ii) Unaudited Consolidated Statements of Operations for the Three and Nine months ended September 30, 2012 and 2011, (iii) Unaudited Consolidated Statements of Cash Flows for the Nine months ended September 30, 2012 and 2011 and (iv) Notes to Unaudited Consolidated Financial Statements.*

 

* This exhibit is furnished and will not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (15 U.S.C. 78r), or otherwise subject to the liability of that section. Such exhibit will not be deemed to be incorporated by reference into any filing under the Securities Act or Securities Exchange Act, except to the extent that the Registrant specifically incorporates it by reference.

 

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EX-31.1 2 v326286_ex31-1.htm EXHIBIT 31.1

 

Exhibit 31.1

 

CERTIFICATION OF CHIEF EXECUTIVE OFFICER

 

I, Ken Keyong Ren, certify that:

 

1. I have reviewed this quarterly report on Form 10-Q of EntreMed, Inc.;

 

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3. Based on my knowledge, the consolidated financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of consolidated financial statements for external purposes in accordance with generally accepted accounting principles;

 

c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures as of the end of the period covered by this report based on such evaluation; and

 

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 

5. The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

 

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

 

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

 

Date: November 14, 2012

 

/s/ Ken Keyong Ren  
Ken Keyong Ren  
Chief Executive Officer  

 

 

EX-31.2 3 v326286_ex31-2.htm EXHIBIT 31.2

 

Exhibit 31.2

 

CERTIFICATION OF PRINCIPAL ACCOUNTING OFFICER

 

I, Sara B. Capitelli, certify that:

 

1. I have reviewed this quarterly report on Form 10-Q of EntreMed, Inc.;

 

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

3. Based on my knowledge, the consolidated financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

 

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of consolidated financial statements for external purposes in accordance with generally accepted accounting principles;

 

c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures as of the end of the period covered by this report based on such evaluation; and

 

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 

5. The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

 

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

 

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

 

Date: November 14, 2012

 

/s/ Sara B. Capitelli  
Sara B. Capitelli  
Principal Accounting Officer  

 

 

EX-32.1 4 v326286_ex32-1.htm EXHIBIT 32.1

 

Exhibit 32.1

 

CERTIFICATION BY CHIEF EXECUTIVE OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

 

In connection with the Quarterly Report of EntreMed, Inc. (the “Company”) on Form 10-Q for the period ending September 30, 2012 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Ken Keyong Ren, as Chief Executive Officer of the Company, hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to the best of my knowledge, that:

 

(1)The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

 

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the dates and periods covered by the Report.

 

The foregoing certification is being furnished solely pursuant to 18 U.S.C. Section 1350 and is not being filed as part of the Report or as a separate disclosure document.

 

Date:   November 14, 2012   /s/ Ken Keyong Ren  
    Ken Keyong Ren  
    Chief Executive Officer  

 

 

EX-32.2 5 v326286_ex32-2.htm EXHIBIT 32.2

 

Exhibit 32.2

 

CERTIFICATION BY PRINCIPAL ACCOUNTING OFFICER
PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

 

In connection with the Quarterly Report of EntreMed, Inc. (the “Company”) on Form 10-Q for the period ending September 30, 2012 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Sara B. Capitelli, as Principal Accounting Officer of the Company, hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to the best of my knowledge, that:

 

(1)The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

 

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the dates and periods covered by the Report.

 

The foregoing certification is being furnished solely pursuant to 18 U.S.C. Section 1350 and is not being filed as part of the Report or as a separate disclosure document.

 

Date:  November 14, 2012   /s/ Sara B. Capitelli  
    Sara B. Capitelli  
    Principal Accounting Officer  

 

 

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Stockholders' Equity
9 Months Ended
Sep. 30, 2012
Stockholders Equity Note [Abstract]  
Stockholders' Equity Note Disclosure [Text Block]
4. Stockholders’ Equity

 

In connection with the Strategic Financing (see Note 2), and upon stockholder approval of the Strategic Financing at the 2012 annual meeting on April 30, 2012, Celgene converted all of its preferred stock to an aggregate of 1,522,727 shares of common stock, pursuant to the terms and conditions of the Series A Preferred Stock. As of May 1, 2012, there is no Series A Preferred Stock or any class of preferred stock outstanding. In connection with the stockholder approval of the Strategic Financing, Celgene has waived all accrued dividends on the Series A Preferred Stock, and Celgene is no longer entitled to any liquidation preference on its shares.

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IDEA: XBRL DOCUMENT v2.4.0.6
Related Party Transactions
9 Months Ended
Sep. 30, 2012
Related Party Transactions [Abstract]  
Related Party Transactions Disclosure [Text Block]
3. Related Party Transactions

 

On October 31, 2012, EntreMed China obtained the necessary approvals to establish a bank account in Beijing. The Board of Directors has approved a transfer of $3,000,000 to EntreMed China from the EntreMed, Inc. to capitalize its wholly-owned subsidiary, of which $500,000 was advanced on October 31, 2012. Prior to establishing a bank account, EntreMed China incurred certain startup and initial operating expenses, which have been advanced by the Company’s Chief Executive Officer on behalf of EntreMed China. As of September 30, 2012, the Company has recorded $55,685 as a payable to related party in the accompanying consolidated balance sheet, representing amounts owed to the Company’s Chief Executive Officer as reimbursement for expenses paid.

XML 16 R2.htm IDEA: XBRL DOCUMENT v2.4.0.6
Consolidated Balance Sheets (USD $)
Sep. 30, 2012
Dec. 31, 2011
ASSETS    
Cash and cash equivalents $ 8,812,133 $ 1,080,630
Accounts receivable, net of allowance for doubtful accounts of $12,536 and $13,036 at September 30, 2012 and December 31, 2011, respectively 0 1,932,742
Prepaid expenses and other 238,797 193,657
Total current assets 9,050,930 3,207,029
Property and equipment, net 21,322 24,621
Other assets 17,427 4,184
Total assets 9,089,679 3,235,834
LIABILITIES AND STOCKHOLDERS' EQUITY    
Accounts payable 484,526 453,329
Payable to related party 55,685 0
Accrued liabilities 185,935 250,762
Total current liabilities 726,146 704,091
Commitments and contingencies 0 0
Stockholders' equity :    
Convertible preferred stock, $1.00 par value; 5,000,000 shares authorized and 0 and 3,350,000 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively (liquidation value - $0 and $33,500,000 at September 30, 2012 and December 31, 2011, respectively) 0 3,350,000
Common stock, $.01 par value: 170,000,000 shares authorized at September 30, 2012 and December 31, 2011: 22,582,938 and 12,237,644 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively 225,829 122,376
Additional paid-in capital 409,142,766 385,879,634
Treasury stock, at cost: 79,545 shares held at September 30, 2012 and December 31, 2011 (8,034,244) (8,034,244)
Accumulated deficit (392,970,818) (378,786,023)
Total stockholders' equity 8,363,533 2,531,743
Total liabilities and stockholders' equity $ 9,089,679 $ 3,235,834
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Basis of Presentation
9 Months Ended
Sep. 30, 2012
Organization, Consolidation and Presentation Of Financial Statements [Abstract]  
Basis of Accounting [Text Block]
1. Basis of Presentation

 

The accompanying consolidated financial statements include the accounts of EntreMed, Inc. (the Company or EntreMed) and its subsidiaries, Miikana Therapeutics, Inc. (Miikana) and EntreMed (Beijing) Co., Ltd. (EntreMed China). EntreMed China is a non-stock Chinese entity with 100% of its interest owned by EntreMed. EntreMed China received approval for a business license from the Beijing Industry and Commercial Administration in August 2012 and has entered into a lease for operating facilities in Beijing. All inter-company balances and transactions have been eliminated in consolidation. The Company refers to EntreMed and its consolidated subsidiaries.

 

The accompanying unaudited consolidated financial statements have been prepared in accordance with U. S. generally accepted accounting principles for interim financial information and in accordance with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, such consolidated financial statements do not include all of the information and disclosures required by U. S. generally accepted accounting principles for complete consolidated financial statements. In the opinion of management, all adjustments (consisting of normal recurring accruals) considered necessary for a fair presentation have been included. Operating results for the three and nine-month periods ended September 30, 2012 are not necessarily indicative of the results that may be expected for the year ending December 31, 2012. For further information, refer to our audited consolidated financial statements and footnotes thereto included in our Form 10-K for the year ended December 31, 2011.

 

Material subsequent events have been considered for disclosure and recognition through the filing date of these consolidated financial statements.

 

Liquidity Risks and Management’s Plans

 

The accompanying consolidated financial statements have been prepared on a going-concern basis, which contemplates the realization of assets and satisfaction of liabilities in the normal course of business. Since inception, the Company has incurred significant losses from operations and has incurred an accumulated deficit of $393.0 million.  The Company expects to continue to incur operating losses, for the foreseeable future due to, among other factors, its continuing clinical activities. The proceeds from the issuance of the Company’s $10 million convertible notes, and warrants to purchase 1,739,132 shares of the Company’s common stock (the “Strategic Financing”) in February 2012 allow the Company to have sufficient cash to meet its cash requirements for at least the next 12 months. At the Company’s 2012 annual stockholders’ meeting held on April 30, 2012, the stockholders approved the Strategic Financing transaction, and the convertible notes automatically converted into common stock on May 1, 2012 (See Note 2). The Company will continue to exercise tight controls over operating expenditures. The Company will continue to pursue opportunities, as required, to raise additional capital and will also actively pursue non- or less-dilutive arrangements in China to support the Company’s dual-country approach to drug development.

 

The Company previously reported that on November 22, 2011, the Company received a letter from the Listing Qualifications Staff (the “Staff”) of the Nasdaq Stock Market (“Nasdaq”), notifying the Company that it did not comply with Nasdaq Listing Rule 5550(b)(1) (the “Rule”), which requires the Company to maintain a minimum of $2.5 million in stockholders’ equity for continued listing on the Nasdaq Capital Market if it does not otherwise meet the other requirements under the Nasdaq Capital Market continued listing rules. On May 4, 2012, the Company received a letter from the Staff stating that the Company regained compliance with the Rule.

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XML 20 R7.htm IDEA: XBRL DOCUMENT v2.4.0.6
Strategic Financing
9 Months Ended
Sep. 30, 2012
Strategic Financing [Abstract]  
Strategic Financing [Text Block]
2. Strategic Financing

 

As described in Note 1 and in connection with the Strategic Financing, on January 20, 2012, the Company entered into a Convertible Note and Warrant Purchase Agreement (the “Purchase Agreement”) with certain strategic accredited investors (the “Investors”), pursuant to which the Company issued and sold to the Investors, in a private placement, subordinated mandatorily convertible promissory notes (collectively, the “Notes”) with an aggregate principal amount of $10 million. The Company also issued warrants (the “2012 Warrants”) to the Investors to purchase an aggregate of 1,739,132 shares of the Company's common stock, par value $0.01 per share (“Common Stock”). The 2012 Warrants cover a number of shares of common stock equal to 20% of the principal amount of the Notes purchased by each Investor, divided by $1.15.  The 2012 Warrants have an exercise price of $1.40 per share and shall be exercisable on or after July 29, 2012 and expire five years after the exercisable date. The relative fair value of the 2012 Warrants issued is $2,155,527, calculated using the Black-Scholes-Merton valuation model value of $1.58 with an expected and contractual life of 5.5 years, an assumed volatility of 103%, and a risk-free interest rate of 0.71%. In February 2012, the 2012 Warrants were recorded as additional paid-in-capital and a discount on the Notes. For the nine-month period ended September 30, 2012, the debt discount of $2,155,527 has been fully amortized as non-cash interest expense as a result of the conversion of the Notes.

 

The Strategic Financing was completed on February 2, 2012 (the “Closing”). The Company received net proceeds of approximately $9.3 million. The Company paid one of the investors a fee in the amount of 6% of the aggregate amount invested in the Strategic Financing, for the investor’s due diligence, role in structuring and negotiating the transaction and as reimbursement for the investor’s fees incurred in connection with the Strategic Financing. Through September 30, 2012 and December 31, 2011, the Company incurred $683,955 and $19,733 of debt issuance costs that were deferred and recorded as other current assets. All debt issuance costs have been fully amortized and recorded as interest expense upon conversion of the Notes in the second quarter of 2012. Non-cash interest expense related to the amortization of debt issuance costs, which includes the fee paid to the investor, was $683,955 for the nine-month period ended September 30, 2012.

 

The Company received approval of the Strategic Financing from the Company's stockholders at the 2012 annual stockholders meeting held on April 30, 2012. On May 1, 2012, the Notes, including accrued interest of $144,658, automatically and immediately converted into 8,821,431 shares of common stock and the 2012 Warrants became exercisable on or after July 29, 2012.  The Notes bore an interest rate of 6% and converted at a conversion price of $1.15 per share.  The conversion price reflects the 10-day average closing sale price of the Company’s Common Stock ending on January 20, 2012.

 

The Notes were not convertible, and the Warrants were not exercisable, prior to receiving stockholder approval. The Notes contain a contingent beneficial conversion feature as the conversion price of the shares was less than the share price on the date of the Notes issuance. The beneficial conversion feature is valued at $7,057,153 and was recorded as non-cash interest expense and additional paid-in-capital in the second quarter of 2012, upon removal of the contingency and conversion of the Notes on May 1, 2012.

 

Pursuant to the terms of the Purchase Agreement, the Company has granted registration rights to the Investors. The Company filed a resale registration statement, which became effective on August 8, 2012, covering the shares of Common Stock underlying the Notes and upon exercise of the Warrants.

 

The Company granted representatives of the Investors, the right to designate up to two members of the Company’s Board of Directors (each, an “Investor Designee”) or to designate a board observer in lieu of an Investor Designee. In the event either representative declines to designate an Investor Designee, the other shall have the right to designate a second Investor Designee. Pursuant to the terms of the Purchase Agreement, the Investors’ board representation rights shall decrease ratably in proportion to their ownership of Common Stock, such that the percentage of the Board of Directors represented by the Investors Designees shall not exceed the Investors’ proportionate percentage equity ownership in the Company at any time.

XML 21 R3.htm IDEA: XBRL DOCUMENT v2.4.0.6
Consolidated Balance Sheets [Parenthetical] (USD $)
Sep. 30, 2012
Dec. 31, 2011
Allowance for doubtful accounts (in dollars) $ 12,536 $ 13,036
Convertible preferred stock, par value (in dollars per share) $ 1.00 $ 1.00
Convertible preferred stock, shares authorized 5,000,000 5,000,000
Convertible preferred stock, shares issued 0 3,350,000
Convertible preferred stock, shares outstanding 0 3,350,000
Convertible preferred stock, liquidation value (in dollars) $ 0 $ 33,500,000
Common stock, par value (in dollars per share) $ 0.01 $ 0.01
Common stock, shares authorized 170,000,000 170,000,000
Common stock, shares issued 22,582,938 12,237,644
Common stock, shares outstanding 22,582,938 12,237,644
Treasury stock, shares held 79,545 79,545
XML 22 R17.htm IDEA: XBRL DOCUMENT v2.4.0.6
Share-Based Compensation (Details) (USD $)
3 Months Ended 9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Sep. 30, 2011
Research and development $ 623,092 $ 703,456 $ 1,880,629 $ 3,051,437
General and administrative 564,626 556,601 2,262,874 2,529,604
Share-based compensation expense     746,104 565,948
Net share-based compensation expense, per common share:        
Basic and diluted     $ 0.04 $ 0.05
Research and Development Expense [Member]
       
Share-based compensation expense     186,003 114,257
General and Administrative Expense [Member]
       
Share-based compensation expense     $ 560,101 $ 451,691
XML 23 R1.htm IDEA: XBRL DOCUMENT v2.4.0.6
Document and Entity Information
9 Months Ended
Sep. 30, 2012
Nov. 08, 2012
Entity Registrant Name ENTREMED INC  
Entity Central Index Key 0000895051  
Current Fiscal Year End Date --12-31  
Entity Filer Category Smaller Reporting Company  
Trading Symbol enmd  
Entity Common Stock, Shares Outstanding   22,503,393
Document Type 10-Q  
Amendment Flag false  
Document Period End Date Sep. 30, 2012  
Document Fiscal Period Focus Q3  
Document Fiscal Year Focus 2012  
XML 24 R18.htm IDEA: XBRL DOCUMENT v2.4.0.6
Share-Based Compensation (Details 1)
9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Expected volatility 101.67% 94.09%
Risk-free interest rate 0.94% 2.04%
Expected term of option 5 years 8 months 27 days 5 years 5 months 26 days
Forfeiture rate 5.00% [1] 5.00% [1]
Expected dividend yield 0.00% 0.00%
[1] Authoritative guidance requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates. During the nine-month periods ended September 30, 2012 and 2011, forfeitures were estimated at 5%.
XML 25 R4.htm IDEA: XBRL DOCUMENT v2.4.0.6
Consolidated Statements of Operations (USD $)
3 Months Ended 9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Sep. 30, 2011
Revenues:        
Royalties $ 0 $ 0 $ 0 $ 8,852
Other 0 0 0 0
Revenues 0 0 0 8,852
Costs and expenses:        
Research and development 623,092 703,456 1,880,629 3,051,437
General and administrative 564,626 556,601 2,262,874 2,529,604
Costs and expenses 1,187,718 1,260,057 4,143,503 5,581,041
Interest expense 0 0 10,041,292 0
Other income (expense) 0 (48,320) 0 9,173
Net Loss (1,187,718) (1,308,377) (14,184,795) (5,563,016)
Dividends on Series A convertible preferred stock 0 (251,250) (335,000) (753,750)
Net loss attributable to common shareholders $ (1,187,718) $ (1,559,627) $ (14,519,795) $ (6,316,766)
Net loss per share (basic and diluted) (in dollars per share) $ (0.05) $ (0.13) $ (0.81) $ (0.54)
Weighted average number of common shares outstanding (basic and diluted) (in shares) 22,503,393 12,004,435 17,897,231 11,654,078
XML 26 R12.htm IDEA: XBRL DOCUMENT v2.4.0.6
Share-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2012
Disclosure Of Compensation Related Costs, Share-Based Payments [Abstract]  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
The compensation expense related to the Company’s share-based compensation arrangements is recorded as components of general and administrative expense and research and development expense, as follows:

 

    NINE MONTH PERIOD ENDED
SEPTEMBER 30,
 
    2012     2011  
Research and development   $ 186,003     $ 114,257  
General and administrative     560,101       451,691  
Share-based compensation expense   $ 746,104     $ 565,948  
Net share-based compensation expense, per common share:                
Basic and diluted   $ 0.04     $ 0.05  

 

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

Following are the weighted-average assumptions used in valuing the stock options granted to employees during the six-month periods ended September 30, 2012 and 2011:

 

    NINE MONTH PERIOD ENDED
SEPTEMBER 30,
 
    2012     2011  
Expected volatility     101.67 %     94.09 %
Risk-free interest rate     0.94 %     2.04 %
Expected term of option     5.74 years       5.49 years  
Forfeiture rate*     5.00 %     5.00 %
Expected dividend yield     0.00 %     0.00 %
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

A summary of the Company’s stock option plans and of changes in options outstanding under the plans for the nine months ended September 30, 2012, is as follows:

 

    Number of
Options
    Weighted
Average
Exercise
Price
 
Outstanding at January 1, 2012     621,889     $ 16.23  
Granted     1,249,000     $ 2.04  
Exercised     (1,136 )   $ 1.76  
Expired     (194,250 )   $ 21.46  
Forfeited     (28,250 )   $ 5.27  
Outstanding at September 30, 2012     1,647,253     $ 5.05  
Vested and expected to vest at September 30, 2012     1,600,823     $ 5.13  
Exercisable at September 30, 2012     718,645     $ 8.77  
XML 27 R11.htm IDEA: XBRL DOCUMENT v2.4.0.6
Income Taxes
9 Months Ended
Sep. 30, 2012
Income Tax Disclosure [Abstract]  
Income Tax Disclosure [Text Block]
6. Income Taxes

 

At December 31, 2011, the Company has a $3.1 million unrecognized tax benefit. The Company has recorded a full valuation allowance on the net deferred tax asset recognized in the consolidated financial statements as of December 31, 2011.

 

During the nine months ended September 30, 2012 there were no material changes to the measurement of unrecognized tax benefits in various taxing jurisdictions. The Company recognizes interest and penalties related to uncertain tax positions as a component of income tax expense.

 

The tax returns for all years in the Company’s major tax jurisdictions are not settled as of January 1, 2012; no changes in settled tax years have occurred through September 30, 2012. Due to the existence of tax attribute carryforwards (which are currently offset by a full valuation allowance), the Company treats all years’ tax positions as unsettled due to the taxing authorities’ ability to modify these attributes.

XML 28 R19.htm IDEA: XBRL DOCUMENT v2.4.0.6
Share-Based Compensation (Details 2) (USD $)
9 Months Ended
Sep. 30, 2012
Outstanding - Number of Options 621,889
Granted - Number of Options 1,249,000
Exercised - Number of Options (1,136)
Expired - Number of Options (194,250)
Forfeited - Number of Options (28,250)
Outstanding - Number of Options 1,647,253
Vested and expected to vest - Number of Options 1,600,823
Exercisable - Number of Options 718,645
Outstanding - Weighted Average Exercise Price $ 16.23
Granted - Weighted Average Exercise Price $ 2.04
Exercised - Weighted Average Exercise Price $ 1.76
Expired - Weighted Average Exercise Price $ 21.46
Forfeited - Weighted Average Exercise Price $ 5.27
Outstanding - Weighted Average Exercise Price $ 5.05
Vested and expected to vest - Weighted Average Exercise Price $ 5.13
Exercisable - Weighted Average Exercise Price $ 8.77
XML 29 R15.htm IDEA: XBRL DOCUMENT v2.4.0.6
Related Party Transactions (Details Textual) (USD $)
Oct. 31, 2012
Sep. 30, 2012
Amount Approved By Board For Capitalization Of Subsidiary   $ 3,000,000
Due to Related Parties   55,685
Investments In Subsidiary For Capitalization $ 500,000  
XML 30 R13.htm IDEA: XBRL DOCUMENT v2.4.0.6
Basis of Presentation (Details Textuals) (USD $)
9 Months Ended
Sep. 30, 2012
Dec. 31, 2011
Nov. 22, 2011
Accumulated deficit $ (392,970,818) $ (378,786,023)  
Proceeds from Convertible Debt 10,000,000    
Warrants Issued During The Period 1,739,132    
Minimum Continued Capital Required For Listing Requirement     $ 2,500,000
XML 31 R14.htm IDEA: XBRL DOCUMENT v2.4.0.6
Strategic Financing (Details Textuals) (USD $)
9 Months Ended
Sep. 30, 2012
Dec. 31, 2011
Proceeds from Convertible Debt $ 10,000,000  
Warrants Issued During The Period 1,739,132  
Common stock, par value (in dollars per share) $ 0.01 $ 0.01
Warrants Coverage Percentage On Principle Value Of Common Stock 20.00%  
Amortization of Debt Discount 2,155,527  
Net Proceeds Of Strategic Financing 9,300,000  
Professional Fees Percentage On Strategic Financing Proceeds 6.00%  
Debt Issuance Costs 683,955 19,733
Non Cash Interest Expense Related To Amortization Of Debt Issuance Costs 683,955  
Accrued interest 144,658  
Convertible Debt Instrument Shares Issued On Conversion 8,821,431  
Debt Instrument, Interest Rate, Stated Percentage 6.00%  
Debt Instrument, Convertible, Conversion Price $ 1.15  
Future Debt Instrument Convertible Beneficial Conversion Feature 7,057,153  
Warrant [Member]
   
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 1.40  
Class of Warrant or Right, Date from which Warrants or Rights Exercisable Jul. 29, 2012  
Fair Value Warrants $ 2,155,527  
Fair Value Assumptions Exercise Price $ 1.58  
Fair Value Assumptions, Expected Term 5 years 6 months  
Fair Value Assumptions, Expected Volatility Rate 103.00%  
Fair Value Assumptions, Risk Free Interest Rate 0.71%  
XML 32 R16.htm IDEA: XBRL DOCUMENT v2.4.0.6
Stockholders' Equity (Details Textuals)
Sep. 30, 2012
Convertible Preferred Stock, Shares Issued upon Conversion 1,522,727
XML 33 R21.htm IDEA: XBRL DOCUMENT v2.4.0.6
Income Taxes (Details Textuals) (USD $)
Dec. 31, 2011
Unrecognized Tax Benefits $ 3,100,000
XML 34 R5.htm IDEA: XBRL DOCUMENT v2.4.0.6
Consolidated Statements of Cash Flows (USD $)
9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (14,184,795) $ (5,563,016)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 15,117 33,587
Stock-based compensation expense 746,104 565,948
Net gain on sale of assets 0 (8,180)
Realized gain on sale of short-term investment 0 (993)
Non-cash interest 10,041,292 0
Changes in operating assets and liabilities:    
Accounts receivable 1,932,742 2,750,447
Prepaid expenses and other (58,383) 41,515
Accounts payable 31,197 (859,065)
Payable to related party 55,685 0
Accrued liabilities (64,827) (326,986)
Net cash used in operating activities (1,485,868) (3,366,743)
CASH FLOWS FROM INVESTING ACTIVITIES    
Proceeds from sale of assets 0 56,500
Proceeds from sale of short-term investment 0 26,809
Purchases of furniture and equipment (11,818) (6,001)
Net cash provided by investing activities (11,818) 77,308
CASH FLOWS FROM FINANCING ACTIVITIES    
Proceeds from issuance of convertible notes and warrants 10,000,000 0
Debt issuance costs (683,955) 0
Stock issuance costs (88,855) (164,964)
Repayment of loan 0 (757,471)
Net proceeds from sale of common stock or exercise of options and warrants 1,999 1,312,063
Net cash provided by financing activities 9,229,189 389,628
Net increase (decrease) in cash and cash equivalents 7,731,503 (2,899,807)
Cash and cash equivalents at beginning of period 1,080,630 4,885,972
Cash and cash equivalents at end of period 8,812,133 1,986,165
Supplemental disclosure of cash flow information:    
Cash paid during the period for interest 0 7,145
Non-cash financing activity:    
Common stock issued in connection with conversion of convertible notes and accrued interest 10,144,658 0
Common stock issued in connection with conversion of preferred stock $ 3,500,000 $ 0
XML 35 R10.htm IDEA: XBRL DOCUMENT v2.4.0.6
Share-Based Compensation
9 Months Ended
Sep. 30, 2012
Disclosure Of Compensation Related Costs, Share-Based Payments [Abstract]  
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
5. Share-Based Compensation

 

The Company has adopted incentive and nonqualified stock option plans for executive, scientific and administrative personnel of the Company as well as outside directors and consultants. In April 2012, the Company’s shareholders approved an amendment to the 2011 Long-Term Incentive Plan, increasing the number of shares reserved for issuance from 835,341 to 1,730,000 shares of common stock to be available for grants and awards. In April 2012, 150,000 options were granted to the Company’s Chief Executive Officer outside of the Company’s 2011 Long-Term Incentive Plan, as an inducement award material to his employment, in accordance NASDAQ Listing Rule 5635(c)(4). As of September 30, 2012, there are 1,647,253 shares issuable under options previously granted and currently outstanding, with exercise prices ranging from $1.75 to $60.39. During the three months ended September 30, 2012, the Company awarded options to two officers, a portion of which is subject to certain performance conditions and market conditions. Options granted under the plans generally vest over periods varying from immediately to three years, are not transferable and generally expire ten years from the date of grant. As of September 30, 2012, 637,000 shares remained available for grant under the Company’s 2011 Long-Term Incentive Plan.

 

The Company records compensation expense associated with service, performance, market condition based stock options and other equity-based compensation in accordance with provisions of authoritative guidance. The fair value of awards whose fair values are calculated using the Black-Scholes option pricing model is generally being amortized on a straight-line basis over the requisite service period and is recognized based on the proportionate amount of the requisite service period that has been rendered during each reporting period. The fair value of awards with market conditions is being amortized based upon the estimated derived service period. Share based awards granted to employees with a performance condition are measured based on the probable outcome of that performance condition during the requisite service period. Such an award with a performance condition will be expensed if it is probable that a performance condition will be achieved. As of September 30, 2012, no expense has been recorded for share awards with performance conditions.

 

The Company’s net loss for the nine months ended September 30, 2012 and 2011 includes compensation expense of $746,104 and $565,948, respectively, related to the Company’s share-based compensation awards. The compensation expense related to the Company’s share-based compensation arrangements is recorded as components of general and administrative expense and research and development expense, as follows:

 

    NINE MONTH PERIOD ENDED
SEPTEMBER 30,
 
    2012     2011  
Research and development   $ 186,003     $ 114,257  
General and administrative     560,101       451,691  
Share-based compensation expense   $ 746,104     $ 565,948  
Net share-based compensation expense, per common share:                
Basic and diluted   $ 0.04     $ 0.05  

 

The Company uses the Black-Scholes-Merton valuation model to estimate the fair value of service based and performance based stock options granted to employees. For market condition based options, the Company uses a binomial model to estimate fair value. These option valuation models require the input of highly subjective assumptions, and changes in the assumptions used can materially affect the grant date fair value of an award.

 

Following are the weighted-average assumptions used in valuing the stock options granted to employees during the six-month periods ended September 30, 2012 and 2011:

 

    NINE MONTH PERIOD ENDED
SEPTEMBER 30,
 
    2012     2011  
Expected volatility     101.67 %     94.09 %
Risk-free interest rate     0.94 %     2.04 %
Expected term of option     5.74 years       5.49 years  
Forfeiture rate*     5.00 %     5.00 %
Expected dividend yield     0.00 %     0.00 %

 

* - Authoritative guidance requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates. During the nine-month periods ended September 30, 2012 and 2011, forfeitures were estimated at 5%.

 

The weighted average fair value of stock options granted during the nine-month periods ended September 30, 2012 and 2011 was $2.04 and $4.63, respectively.

 

A summary of the Company’s stock option plans and of changes in options outstanding under the plans for the nine months ended September 30, 2012, is as follows:

 

    Number of
Options
    Weighted
Average
Exercise
Price
 
Outstanding at January 1, 2012     621,889     $ 16.23  
Granted     1,249,000     $ 2.04  
Exercised     (1,136 )   $ 1.76  
Expired     (194,250 )   $ 21.46  
Forfeited     (28,250 )   $ 5.27  
Outstanding at September 30, 2012     1,647,253     $ 5.05  
Vested and expected to vest at September 30, 2012     1,600,823     $ 5.13  
Exercisable at September 30, 2012     718,645     $ 8.77  

 

Cash received from option exercises under all share-based payment arrangements for the three and nine months ended September 30, 2012 was $0 and $1,999, respectively. Cash received from option exercises for the three and nine months ended September 30, 2011 was $0 and $23,338, respectively.

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Share-Based Compensation (Details Textuals) (USD $)
3 Months Ended 9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Sep. 30, 2011
Common Stock Capital Shares Reserved For Future Issuance Before Amendment 835,341   835,341  
Common Stock Capital Shares Reserved For Future Issuance After Amendment 1,730,000   1,730,000  
Share Based Compensation Arrangement By Share Based Payment Award Options Grants Outstanding 1,647,253   1,647,253  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value     $ 2.04 $ 4.63
Proceeds from Stock Options Exercised $ 0 $ 0 $ 1,999 $ 23,338
Chief Executive Officer [Member]
       
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period     150,000  
Maximum [Member]
       
Share Based Compensation Arrangements By Share Based Payment Award Options Grants Exercise Price 60.39   60.39  
Minimum [Member]
       
Share Based Compensation Arrangements By Share Based Payment Award Options Grants Exercise Price 1.75   1.75  
Long Term Incentive Plan2011 [Member]
       
Share Based Compensation Arrangement By Share Based Payment Award Options Available For Grant 637,000   637,000