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  <element name="FinancingTextualsAbstract" id="esrx_FinancingTextualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="MarginOverLIBORMinimum" id="esrx_MarginOverLIBORMinimum" type="us-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="MarginOverLIBORMaximum" id="esrx_MarginOverLIBORMaximum" type="us-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="InstrumentUnusedBorrowingCapacityFeeMinimum" id="esrx_InstrumentUnusedBorrowingCapacityFeeMinimum" type="us-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="InstrumentUnusedBorrowingCapacityFeeMaximum" id="esrx_InstrumentUnusedBorrowingCapacityFeeMaximum" type="us-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="CommonStockDetailsAbstract" id="esrx_CommonStockDetailsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="StockBasedCompensationPlansTablesAbstract" id="esrx_StockBasedCompensationPlansTablesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="StockBasedCompensationPlansDetailsAbstract" id="esrx_StockBasedCompensationPlansDetailsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="CommonStockTextualsAbstract" id="esrx_CommonStockTextualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="CommonStockSharesSoldAsResultOfUnderwritersExerciseOfOverallotmentOption" id="esrx_CommonStockSharesSoldAsResultOfUnderwritersExerciseOfOverallotmentOption" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="UnderwritersExerciseOfCommonStockOverallotmentOptionInFullAtClosing" id="esrx_UnderwritersExerciseOfCommonStockOverallotmentOptionInFullAtClosing" type="us-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="MinimumMember" id="esrx_MinimumMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="MaximumMember" id="esrx_MaximumMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="WeightedAverageAssumptionsTextBlock" id="esrx_WeightedAverageAssumptionsTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="StockBasedCompensationPlansTextualsAbstract" id="esrx_StockBasedCompensationPlansTextualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="SegmentInformationTablesAbstract" id="esrx_SegmentInformationTablesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="BalanceSheetInformationAboutReportableSegmentsTextBlock" id="esrx_BalanceSheetInformationAboutReportableSegmentsTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_SegmentInformationDetailsAbstract" name="SegmentInformationDetailsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="EmMember" id="esrx_EmMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="PbmMember" id="esrx_PbmMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="UnamortizedStockBasedCompensationForRestrictedStockAndPerformanceShares" id="esrx_UnamortizedStockBasedCompensationForRestrictedStockAndPerformanceShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="DocumentAndEntityInformationAbstract" id="esrx_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="MaximumContractualTermOfStockOptionsAndSsrsInYears" id="esrx_MaximumContractualTermOfStockOptionsAndSsrsInYears" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="ReportableSegmentsInformationAbstract" id="esrx_ReportableSegmentsInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="NetworkRevenuesBySegment" id="esrx_NetworkRevenuesBySegment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="HomeDeliveryAndSpecialtyRevenuesBySegment" id="esrx_HomeDeliveryAndSpecialtyRevenuesBySegment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="OtherRevenuesBySegment" id="esrx_OtherRevenuesBySegment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="ServiceRevenuesBySegment" id="esrx_ServiceRevenuesBySegment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="CapitalExpendituresBySegment" id="esrx_CapitalExpendituresBySegment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="TotalAmountsReportedInFinancialStatementsAbstract" id="esrx_TotalAmountsReportedInFinancialStatementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="SegmentInformationTextualsAbstract" id="esrx_SegmentInformationTextualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="RetailPharmacyCoPaymentsIncludedInNetworkRevenues" id="esrx_RetailPharmacyCoPaymentsIncludedInNetworkRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="ServiceRevenues" id="esrx_ServiceRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="NetworkRevenues" id="esrx_NetworkRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="HomeDeliveryAndSpecialtyRevenues" id="esrx_HomeDeliveryAndSpecialtyRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="OtherRevenues" id="esrx_OtherRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="CondensedConsolidatingFinancialInformationDetailsAbstract" id="esrx_CondensedConsolidatingFinancialInformationDetailsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="Intercompany" id="esrx_Intercompany" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="EquityInEarningsOfSubsidiaries" id="esrx_EquityInEarningsOfSubsidiaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="NetTransactionsWithParent" id="esrx_NetTransactionsWithParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="OwnershipInDomesticSubsidiaries" id="esrx_OwnershipInDomesticSubsidiaries" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="InvestmentsInSubsidiaries" id="esrx_InvestmentsInSubsidiaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="InterestExpenseNet" id="esrx_InterestExpenseNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="CondensedConsolidatingFinancialInformationTablesAbstract" id="esrx_CondensedConsolidatingFinancialInformationTablesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="BalanceSheetTextBlock" id="esrx_BalanceSheetTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="StatementOfOperationsTextBlock" id="esrx_StatementOfOperationsTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="StatementOfCashFlowsTextBlock" id="esrx_StatementOfCashFlowsTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="EstimatedValueOfSection338H10ElectionMinimum" id="esrx_EstimatedValueOfSection338H10ElectionMinimum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="EstimatedValueOfSection338H10ElectionMaximum" id="esrx_EstimatedValueOfSection338H10ElectionMaximum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="CompletedSharePurchaseOfAcquisitionInPercent" id="esrx_CompletedSharePurchaseOfAcquisitionInPercent" type="us-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element name="GoodwillAndOtherIntangibleAssetsAbstract" id="esrx_GoodwillAndOtherIntangibleAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="GoodwillAndOtherIntangibleAssetsTablesAbstract" id="esrx_GoodwillAndOtherIntangibleAssetsTablesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="SummaryOfGoodwillAndOtherIntangibleAssetsTextBlock" id="esrx_SummaryOfGoodwillAndOtherIntangibleAssetsTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="GoodwillAndOtherIntangibleAssetsDetailsAbstract" id="esrx_GoodwillAndOtherIntangibleAssetsDetailsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="OtherIntangibleAssetsMember" id="esrx_OtherIntangibleAssetsMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="GrossCarryingAmountOfGoodwill" id="esrx_GrossCarryingAmountOfGoodwill" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="AccumulatedAmortization" id="esrx_AccumulatedAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <element name="PeriodOfContract" id="esrx_PeriodOfContract" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="IntangibleAssetsGross" id="esrx_IntangibleAssetsGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="PublicOfferingOfSeniorNotesGross" id="esrx_PublicOfferingOfSeniorNotesGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <element name="AcquisitionTablesAbstract" id="esrx_AcquisitionTablesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="PurchasePriceAllocationTextBlock" id="esrx_PurchasePriceAllocationTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="MeasurementPeriod" id="esrx_MeasurementPeriod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="PurchasePriceAdjustmentForWorkingCapital" id="esrx_PurchasePriceAdjustmentForWorkingCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="PerformanceShareGrantsMultiplier" id="esrx_PerformanceShareGrantsMultiplier" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="DiscontinuedOperationsAbstract" id="esrx_DiscontinuedOperationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="DiscontinuedOperationsTextualsAbstract" id="esrx_DiscontinuedOperationsTextualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="DiscontinuedOperationsDetailsAbstract" id="esrx_DiscontinuedOperationsDetailsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="DiscontinuedOperationsTablesAbstract" id="esrx_DiscontinuedOperationsTablesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="DiscOpMember" id="esrx_DiscOpMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="ContingenciesDetailsAbstract" id="esrx_ContingenciesDetailsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="ContingenciesTextualsAbstract" id="esrx_ContingenciesTextualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="ImpairmentChargeOnClassificationDiscontinuedOperationMajorityIncludingGoodwillAndOtherIntangibleAssets" id="esrx_ImpairmentChargeOnClassificationDiscontinuedOperationMajorityIncludingGoodwillAndOtherIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element name="TaxBenefitRealizedPeriod" id="esrx_TaxBenefitRealizedPeriod" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="ConsolidatingFinancialInformationTextualsAbstract" id="esrx_ConsolidatingFinancialInformationTextualsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element name="ActivityRelatedToDiscontinuedLineOfBusinessTextBlock" id="esrx_ActivityRelatedToDiscontinuedLineOfBusinessTextBlock" type="us-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="BenefitsRelatedToAmendmentOfClientContract" id="esrx_BenefitsRelatedToAmendmentOfClientContract" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="StockIssuedDuringPeriodSharesIncludesEsppShareBasedCompensationRestrictedStockForfeituresAndStockRedeemedForTaxes" id="esrx_StockIssuedDuringPeriodSharesIncludesEsppShareBasedCompensationRestrictedStockForfeituresAndStockRedeemedForTaxes" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="StockIssuedDuringPeriodValueIncludesEsppShareBasedCompensationRestrictedStockForfeituresAndStockRedeemedForTaxes" id="esrx_StockIssuedDuringPeriodValueIncludesEsppShareBasedCompensationRestrictedStockForfeituresAndStockRedeemedForTaxes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <element name="NoneOfClientRepresentedConsolidatedRevenue" id="esrx_NoneOfClientRepresentedConsolidatedRevenue" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="ClientOneMember" id="esrx_ClientOneMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element name="ClientTwoMember" id="esrx_ClientTwoMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_PerformanceSharesGrantedToCertainOfficersExceedingCertainPerformanceMeasures" name="PerformanceSharesGrantedToCertainOfficersExceedingCertainPerformanceMeasures" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_GoodwillAndOtherIntangibleAssetsTextualsAbstract" name="GoodwillAndOtherIntangibleAssetsTextualsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_AmortizationForCustomerContractsRelatedToPBMAgreementRecordedAsOffsetToRevenue" name="AmortizationForCustomerContractsRelatedToPBMAgreementRecordedAsOffsetToRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="esrx_PbmSegmentMember" name="PbmSegmentMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_EmSegmentMember" name="EmSegmentMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_DiscOpSegmentMember" name="DiscOpSegmentMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_LineOfCreditFacilityTwoMember" name="LineOfCreditFacilityTwoMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_LineOfCreditFacilityOneMember" name="LineOfCreditFacilityOneMember" type="us-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_LineOfCreditFacilityDuration" name="LineOfCreditFacilityDuration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_IntercompanyLiabilities" name="IntercompanyLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="esrx_RevenuePercentageRepresentedByFiveTopClients" name="RevenuePercentageRepresentedByFiveTopClients" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_RevenuePercentageRepresentedByLargestClients" name="RevenuePercentageRepresentedByLargestClients" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="esrx_RepaymentOfTermLoans" name="RepaymentOfTermLoans" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
</schema>
