As filed with the Securities and Exchange Commission on October 15, 2012

Securities Act File No. 33-41694

Investment Company Act File No. 811-06352

U.S. SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-1A

Registration Statement Under The Securities Act Of 1933	x
Pre-Effective Amendment No.	¨
Post-Effective Amendment No. 159	x
and/or
Registration Statement Under The Investment Company Act Of 1940	x
Amendment No. 170 (Check appropriate box or boxes)	x

ING SERIES FUND, INC.

(Exact Name of Registrant Specified in Charter)

7337 East Doubletree Ranch Road, Suite 100

Scottsdale, Arizona 85258

(Address of Principal Executive Offices)

Registrant’s Telephone Number, Including Area Code: (800) 992-0180

Huey P. Falgout, Jr., Esq. ING Investments, LLC 7337 East Doubletree Ranch Road Scottsdale, Arizona 85258 (Name and Address of Agent for Service) With copies to: Philip H. Newman, Esq. Goodwin Procter LLP Exchange Place 53 State Street Boston, Massachusetts 02109

It is proposed that this filing will become effective (check appropriate box):

x	Immediately upon filing pursuant to paragraph (b)	¨	On (date) pursuant to paragraph (a)(1)
¨	On (date) pursuant to paragraph (b)	¨	75 days after filing pursuant to paragraph (a)(2)
¨	60 days after filing pursuant to paragraph (a)(1)	¨	On (date), pursuant to paragraph (a)(2) of Rule 485.

If appropriate, check the following box:

¨ This post-effective amendment designated a new effective date for a previously filed post-effective amendment.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended (the “1933 Act”), and the Investment Company Act of 1940, as amended, the Registrant certifies that it that it has duly caused this Post-Effective Amendment No. 159 to its Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Scottsdale and State of Arizona on the 15^th day of October, 2012.

	ING SERIES FUND, INC.
By:	/s/ Theresa K. Kelety
	Theresa K. Kelety   Secretary

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the date indicated.

SIGNATURE	TITLE	DATE
	President, Chief Executive	October 15, 2012
Shaun P. Mathews*	Officer and Interested Director
	Senior Vice President and	October 15, 2012
Todd Modic*	Chief/Principal Financial Officer
	Director	October 15, 2012
Albert E. DePrince Jr.*
	Director	October 15, 2012
Martin J. Gavin*
	Director	October 15, 2012
Russell H. Jones*
	Director	October 15, 2012
Sidney Koch*
	Director	October 15, 2012
Joseph E. Obermeyer*

*By:	/s/ Theresa K. Kelety
	Theresa K. Kelety
	Attorney-in-Fact**

** Powers of attorney for Todd Modic and each Director were attached to Post-Effective Amendment No. 155 to the Registrant’s Form N-1A Registration Statement on July 27, 2012 and incorporated herein by reference.

EXHIBIT INDEX

ING Series Fund, Inc.

Exhibit Number	Exhibit Description
EX-101.INS	XBRL Instance Document
EX-101.SCH	XBRL Taxonomy Extension Schema Document
EX-101.CAL	XBRL Taxonomy Extension Calculation Linkbase
EX-101.DEF	XBRL Taxonomy Extension Definition Linkbase
EX-101.LAB	XBRL Taxonomy Extension Labels Linkbase
EX-101.PRE	XBRL Taxonomy Extension Presentation Linkbase