0001104659-13-003673.txt : 20130122 0001104659-13-003673.hdr.sgml : 20130121 20130122110607 ACCESSION NUMBER: 0001104659-13-003673 CONFORMED SUBMISSION TYPE: 497 PUBLIC DOCUMENT COUNT: 7 FILED AS OF DATE: 20130122 DATE AS OF CHANGE: 20130122 EFFECTIVENESS DATE: 20130122 FILER: COMPANY DATA: COMPANY CONFORMED NAME: MORGAN STANLEY INSTITUTIONAL FUND INC CENTRAL INDEX KEY: 0000836487 IRS NUMBER: 000000000 STATE OF INCORPORATION: MD FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 497 SEC ACT: 1933 Act SEC FILE NUMBER: 033-23166 FILM NUMBER: 13539390 BUSINESS ADDRESS: STREET 1: 522 FIFTH AVENUE CITY: NEW YORK STATE: NY ZIP: 10036 BUSINESS PHONE: 6175578742 MAIL ADDRESS: STREET 1: 522 FIFTH AVENUE CITY: NEW YORK STATE: NY ZIP: 10036 FORMER COMPANY: FORMER CONFORMED NAME: MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND INC DATE OF NAME CHANGE: 19990329 FORMER COMPANY: FORMER CONFORMED NAME: MORGAN STANLEY INSTITUTIONAL FUND INC DATE OF NAME CHANGE: 19920703

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497 1 a13-2188_25497.htm 497

MORGAN STANLEY INSTITUTIONAL FUND, INC.

522 Fifth Avenue

New York, New York 10036

VIA EDGAR

January 22, 2013

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re: Morgan Stanley Institutional Fund, Inc.

File Nos. 33-23166; 811-05624

Ladies and Gentlemen:

On behalf of Morgan Stanley Institutional Fund, Inc. (“Registrant”), we hereby submit for filing pursuant to Rule 497(e) under the Securities Act of 1933, as amended, exhibits containing interactive data format risk/return summary information for the Registrant. These exhibits contain the risk/return summary information in the prospectuses for the Registrant dated April 30, 2012. The purpose of this filing is to submit the XBRL information from the 497(e) filing dated January 14, 2013 for the Registrant.

If you have any questions, please feel free to contact me at 212.296.6983 (tel.) or 646.452.4799 (fax).

		Very truly yours,

		/s/ Tara Farrelly
		Tara Farrelly
		Assistant Secretary

Enclosures

cc: Stefanie V. Chang Yu, Esq.

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ck0000836487:S000002820Member ck0000836487:C000007737Member 2013-01-14 2013-01-14 0000836487 ck0000836487:P0001-S000002820Member ck0000836487:S000002820Member 2013-01-14 2013-01-14 Other 2013-01-14 MORGAN STANLEY INSTITUTIONAL FUND INC 0000836487 false 2013-01-14 2013-01-14 2012-04-30 Active International Allocation Portfolio <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'> </font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Active International Allocation Portfolio<br /> Asian Equity Portfolio<br /> Emerging Markets Portfolio<br /> Global Franchise Portfolio<br /> International Equity Portfolio<br /> International Small Cap Portfolio<br /> Select Global Infrastructure Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 52 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Active International Allocation, Asian Equity, Emerging Markets, International Equity and International Small Cap Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Active International Allocation Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MSIBX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002820Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002820Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002820Member ~</div> </div> Class P 636 871 1125 1849 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002820Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002820Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002820Member ~</div> </div> Class P Return before Taxes -0.1922 -0.0493 0.0401 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002820Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002820Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002820Member ~</div> </div> U.S. Real Estate Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Real Estate Portfolio<br /> International Real Estate Portfolio<br /> U.S. Real Estate Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 22 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Real Estate and U.S. Real Estate Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the U.S. Real Estate Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MUSDX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002821Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002821Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002821Member ~</div> </div> 647 904 1180 1968 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002821Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002821Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002821Member ~</div> </div> Class P Return before Taxes -0.0027 -0.0302 0.1011 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002821Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002821Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002821Member ~</div> </div> International Small Cap Portfolio <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'> </font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Active International Allocation Portfolio<br /> Asian Equity Portfolio<br /> Emerging Markets Portfolio<br /> Global Franchise Portfolio<br /> International Equity Portfolio<br /> International Small Cap Portfolio<br /> Select Global Infrastructure Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 52 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Active International Allocation, Asian Equity, Emerging Markets, International Equity and International Small Cap Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the International Small Cap Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MSCPX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002822Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002822Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002822Member ~</div> </div> Class P 660 945 1251 2117 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002822Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002822Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002822Member ~</div> </div> Class P (commenced operations on 10/21/08) Return before Taxes -0.2283 0.0000 0.0000 0.0448 2008-10-21 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002822Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002822Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002822Member ~</div> </div> Small Company Growth Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Discovery Portfolio<br /> Growth Portfolio<br /> Small Company Growth Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 32 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Small Company Growth Portfolio, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"     The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Small Company Growth Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MSSMX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002825Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002825Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002825Member ~</div> </div> 650 915 1200 2010 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002825Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002825Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002825Member ~</div> </div> Class P Return before Taxes -0.1407 -0.0083 0.0485 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002825Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002825Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002825Member ~</div> </div> Emerging Markets Portfolio <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'> </font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Active International Allocation Portfolio<br /> Asian Equity Portfolio<br /> Emerging Markets Portfolio<br /> Global Franchise Portfolio<br /> International Equity Portfolio<br /> International Small Cap Portfolio<br /> Select Global Infrastructure Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 52 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Active International Allocation, Asian Equity, Emerging Markets, International Equity and International Small Cap Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Emerging Markets Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MMKBX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002826Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002826Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002826Member ~</div> </div> Class P 670 974 1300 2222 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002826Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002826Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002826Member ~</div> </div> Class P Return before Taxes -0.2290 -0.0109 0.1208 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002826Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002826Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002826Member ~</div> </div> Emerging Markets Domestic Debt Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Emerging Markets Domestic Debt Portfolio<br /> (the "Portfolio")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> The first paragraph in the section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 13 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> The following replaces the "Shareholder Fees" table and related footnote thereto with respect to Class P and Class H shares only in the section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following replaces the "Annual Portfolio Operating Expenses" table and related footnotes thereto with respect to Class L shares only in the section of the Prospectus entitled "Portfolio Summary—Fees and Expenses—Annual Portfolio Operating Expenses:"   The following table replaces the "Example" table with respect to Class P, Class H and Class L shares only in the section of the Prospectus entitled "Portfolio Summary—Example:"   The following table replaces the "Average Annual Total Returns" table with respect to Class P and Class H shares only in the section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> IEDBX MSEHX 0.0425 0.0400 -0.0200 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002827Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002827Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002827Member ~</div> </div> 0.0075 0.0050 0.0044 0.0169 -0.0034 0.0135 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/OperatingExpensesData_P0001-S000002827Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002827Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002827Member ~</div> </div> 532 760 1005 1708 508 736 982 1687 137 428 739 1624 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002827Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002827Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002827Member ~</div> </div> Class P (commenced operations on 1/2/96) Return before Taxes -0.0801 0.0395 0.0899 0.0948 1996-01-02 Class H (commenced operations on 1/2/08) Return before Taxes -0.0771 0.0000 0.0000 0.0396 2008-01-02 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002827Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002827Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002827Member ~</div> </div> Growth Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Discovery Portfolio<br /> Growth Portfolio<br /> Small Company Growth Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 32 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Discovery and Growth Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Growth Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MSEGX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002828Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002828Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002828Member ~</div> </div> 618 815 1028 1641 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002828Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002828Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002828Member ~</div> </div> Class P Return before Taxes -0.0835 0.0198 0.0261 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002828Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002828Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002828Member ~</div> </div> Global Franchise Portfolio <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'> </font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Active International Allocation Portfolio<br /> Asian Equity Portfolio<br /> Emerging Markets Portfolio<br /> Global Franchise Portfolio<br /> International Equity Portfolio<br /> International Small Cap Portfolio<br /> Select Global Infrastructure Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 52 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Franchise and Select Global Infrastructure Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   With respect to the Global Franchise Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MSFBX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002830Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002830Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002830Member ~</div> </div> Class P 646 901 1175 1957 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002830Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002830Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002830Member ~</div> </div> Class P Return before Taxes 0.0324 0.0334 0.0956 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002830Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002830Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002830Member ~</div> </div> International Equity Portfolio <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'> </font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Active International Allocation Portfolio<br /> Asian Equity Portfolio<br /> Emerging Markets Portfolio<br /> Global Franchise Portfolio<br /> International Equity Portfolio<br /> International Small Cap Portfolio<br /> Select Global Infrastructure Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 52 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Active International Allocation, Asian Equity, Emerging Markets, International Equity and International Small Cap Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the International Equity Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MIQBX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002832Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002832Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002832Member ~</div> </div> Class P 641 886 1150 1903 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002832Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002832Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002832Member ~</div> </div> Class P Return before Taxes -0.1270 -0.0392 0.0490 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002832Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002832Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002832Member ~</div> </div> International Real Estate Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Real Estate Portfolio<br /> International Real Estate Portfolio<br /> U.S. Real Estate Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 22 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the International Real Estate Portfolio, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the International Real Estate Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> IERBX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000002835Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002835Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002835Member ~</div> </div> 646 901 1175 1957 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000002835Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002835Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002835Member ~</div> </div> Class P Return before Taxes -0.2434 -0.1309 0.0872 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000002835Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000002835Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000002835Member ~</div> </div> Global Real Estate Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Real Estate Portfolio<br /> International Real Estate Portfolio<br /> U.S. Real Estate Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 22 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Real Estate and U.S. Real Estate Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Global Real Estate Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MRLBX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000012825Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000012825Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000012825Member ~</div> </div> 649 913 1195 2000 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000012825Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000012825Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000012825Member ~</div> </div> Class P (commenced operations on 8/30/06) Return before Taxes -0.1460 -0.0622 -0.0301 2006-08-30 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000012825Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000012825Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000012825Member ~</div> </div> International Opportunity Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Opportunity Portfolio<br /> International Opportunity Portfolio<br /> Opportunity Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 25 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the International Opportunity Portfolio, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the International Opportunity Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns":   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MIOPX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000027992Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027992Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027992Member ~</div> </div> 660 945 1251 2117 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000027992Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027992Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027992Member ~</div> </div> Class P (commenced operations on 3/31/10) Return before Taxes -0.1505 0.0133 2010-03-31 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000027992Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027992Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027992Member ~</div> </div> Advantage Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Advantage Portfolio<br /> Global Advantage Portfolio<br /> International Advantage Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 25 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Advantage and Global Advantage Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Advantage Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MAPPX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000027993Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027993Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027993Member ~</div> </div> 650 915 1200 2010 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000027993Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027993Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027993Member ~</div> </div> Class P (commenced operations on 5/21/10) Return before Taxes -0.0043 0.1223 2010-05-21 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000027993Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027993Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027993Member ~</div> </div> Opportunity Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Opportunity Portfolio<br /> International Opportunity Portfolio<br /> Opportunity Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 25 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Opportunity and Opportunity Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Opportunity Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns":   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MEGPX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000027994Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027994Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027994Member ~</div> </div> 634 865 1115 1827 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000027994Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027994Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027994Member ~</div> </div> Class P (commenced operations on 5/21/10) Return before Taxes -0.0593 0.0000 0.0000 0.1069 2010-05-21 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000027994Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027994Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027994Member ~</div> </div> Global Opportunity Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Opportunity Portfolio<br /> International Opportunity Portfolio<br /> Opportunity Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 25 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Opportunity and Opportunity Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Global Opportunity Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns":   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MGGPX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000027995Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027995Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027995Member ~</div> </div> 670 974 1300 2222 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000027995Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027995Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027995Member ~</div> </div> Class P (commenced operations on 5/21/10) Return before Taxes -0.1014 0.1223 2010-05-21 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000027995Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000027995Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000027995Member ~</div> </div> Select Global Infrastructure Portfolio <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'> </font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Active International Allocation Portfolio<br /> Asian Equity Portfolio<br /> Emerging Markets Portfolio<br /> Global Franchise Portfolio<br /> International Equity Portfolio<br /> International Small Cap Portfolio<br /> Select Global Infrastructure Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 52 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Franchise and Select Global Infrastructure Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Select Global Infrastructure Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MTIPX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000029874Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000029874Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000029874Member ~</div> </div> Class P 660 945 1251 2117 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000029874Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000029874Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000029874Member ~</div> </div> Class P (commenced operations on 9/20/10) Return before Taxes 0.0957 0.1153 2010-09-20 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000029874Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000029874Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000029874Member ~</div> </div> Global Advantage Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Advantage Portfolio<br /> Global Advantage Portfolio<br /> International Advantage Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 25 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Advantage and Global Advantage Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Global Advantage Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MIGPX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000030616Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030616Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030616Member ~</div> </div> 674 989 1325 2274 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000030616Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030616Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030616Member ~</div> </div> Class P (commenced operations on 12/28/10) Return before Taxes -0.0514 -0.0501 2010-12-28 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000030616Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030616Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030616Member ~</div> </div> Global Discovery Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Global Discovery Portfolio<br /> Growth Portfolio<br /> Small Company Growth Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 32 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Global Discovery and Growth Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Global Discovery Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MGDPX 0.0525 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000030617Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030617Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030617Member ~</div> </div> 679 1003 1350 2325 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000030617Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030617Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030617Member ~</div> </div> Class P (commenced operations on 12/28/10) Return before Taxes -0.1279 -0.1294 2010-12-28 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000030617Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030617Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030617Member ~</div> </div> International Advantage Portfolio <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Advantage Portfolio<br /> Global Advantage Portfolio<br /> International Advantage Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 25 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the International Advantage Portfolio, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the International Advantage Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MFAPX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000030618Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030618Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030618Member ~</div> </div> 670 974 1300 2222 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000030618Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030618Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030618Member ~</div> </div> Class P (commenced operations on 12/28/10) Return before Taxes -0.0671 -0.0675 2010-12-28 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000030618Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030618Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030618Member ~</div> </div> Asian Equity Portfolio <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'> </font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;font-size:11.0pt;font-family:'calibri','sans-serif';margin-bottom:0in;margin-bottom:.0001pt;line-height: normal;text-autospace:none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>Prospectus Supplement</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:9.0pt;font-family:"Arial","sans-serif"'>January 14, 2013</font></b></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:21.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><font style='font-size:18.0pt;font-family:"Arial","sans-serif"'>Morgan Stanley Institutional Fund, Inc.</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Supplement dated January 14, 2013 to the Morgan Stanley Institutional Fund, Inc. Prospectus dated April 30, 2012 of:</font></p> <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:14.0pt;margin-right:0in;margin-bottom: 0in;margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace: none"><b><font style='font-size:8.0pt;font-family:"Arial","sans-serif"'>Active International Allocation Portfolio<br /> Asian Equity Portfolio<br /> Emerging Markets Portfolio<br /> Global Franchise Portfolio<br /> International Equity Portfolio<br /> International Small Cap Portfolio<br /> Select Global Infrastructure Portfolio<br /> (collectively, the "Portfolios")</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. 50000 The first paragraph in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses" is hereby deleted and replaced with the following:   <p class="MsoNormal" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in;margin-bottom:0in; margin-left:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><font style='font-size:10.0pt;font-family:"Times New Roman","serif"'>The table below describes the fees and expenses that you may pay if you buy and hold shares of the Portfolio. For shareholders of Class P and Class H shares, you may qualify for sales charge discounts if the cumulative net asset value ("NAV") of Class P or Class H shares of the Portfolio purchased in a single transaction, together with the NAV of all Class P or Class H shares of a portfolio of Morgan Stanley Institutional Fund, Inc. (the "Fund") or of a portfolio of Morgan Stanley Institutional Fund Trust held in related accounts, amounts to $25,000 or more with respect to Class P and $50,000 or more with respect to Class H. More information about these and other discounts is available from your financial adviser and in the "Shareholder Information—How To Purchase Class P and Class H Shares" section on page 52 of this Prospectus.</font></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> With respect to each of the Active International Allocation, Asian Equity, Emerging Markets, International Equity and International Small Cap Portfolios, the following table replaces the "Shareholder Fees" table with respect to Class P shares only in each such Portfolio's section of the Prospectus entitled "Portfolio Summary—Fees and Expenses:"   The following tables replace the "Example" tables with respect to Class P shares only in each Portfolio's section of the Prospectus entitled "Portfolio Summary—Example:"   With respect to the Asian Equity Portfolio, the following table replaces the "Average Annual Total Returns" table with respect to Class P shares only in such Portfolio's section of the Prospectus entitled "Portfolio Summary—Performance Information—Average Annual Total Returns:"   <p class="MsoNormal" align="center" style="font-size:11.0pt;font-family:'calibri','sans-serif';margin-top:8.0pt;margin-right:0in; margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-align:center; line-height:normal;text-autospace:none"><b><font style='font-size:10.0pt; font-family:"Arial","sans-serif"'>Please retain this supplement for future reference.</font></b></p> <p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-left:0in;margin-bottom:10.0pt;line-height:115%;font-size:11.0pt;font-family:'calibri','sans-serif';"> </p> MEQPX 0.0525 -0.0200 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ShareholderFeesData_P0001-S000030707Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030707Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030707Member ~</div> </div> Class P 689 1033 1400 2428 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/ExpenseExample_P0001-S000030707Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030707Member column rr_ProspectusShareClassAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030707Member ~</div> </div> Class P (commenced operations on 12/28/10) Return before Taxes -0.2140 -0.1976 2010-12-28 <div> <div style="display:none;" >~ http://www.morganstanley.com/20130114/role/PerformanceTableData_P0001-S000030707Member row primary compact * row dei_LegalEntityAxis compact ck0000836487_S000030707Member column rr_ProspectusShareClassAxis compact * column rr_PerformanceMeasureAxis compact * column dei_LegalEntityAxis compact ck0000836487_S000030707Member ~</div> </div> The historical performance of Class P shares has been restated to reflect the current maximum initial sales charge of 5.25%. The Board of Directors approved an amendment to the Distribution and Shareholder Services Plan reducing the distribution and shareholder services (12b-1) fee for the Portfolio's Class L shares from 0.75% to 0.50% of the average daily net assets of such Class, effective February 25, 2013. The Distribution and/or Service (12b-1) Fees shown in the table above have been restated to reflect such change. The Portfolio’s "Adviser," Morgan Stanley Investment Management Inc., has agreed to reduce its advisory fee and/or reimburse the Portfolio so that Total Annual Portfolio Operating Expenses, excluding certain investment related expenses, will not exceed 0.85% for Class I, 1.10% for Class P, 1.10% for Class H and 1.35% for Class L. The fee waivers and/or expense reimbursements will continue for at least one year or until such time as the Fund’s Board of Directors acts to discontinue all or a portion of such waivers and/or reimbursements when it deems such action is appropriate. The historical performance of Class P shares has been restated to reflect the current maximum initial sales charge of 4.25%. The historical performance of Class H shares has been restated to reflect the current maximum initial sales charge of 4.00%. 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