Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1) Registration Statement (Form S-3 No. 333-227805) of Progenics Pharmaceuticals, Inc.,

(2) Registration Statement (Form S-8 No. 333-225951) pertaining to the 2018 Performance Incentive Plan of Progenics Pharmaceuticals, Inc., and

(3) Registration Statements (Form S-8 Nos. 333-197071, 333-183511, 333-176204, 333-160389, 333-143670, and 333-124910) pertaining to the 2005 Stock Incentive Plan of Progenics Pharmaceuticals, Inc.

of our reports dated March 13, 2020, with respect to the consolidated financial statements of Progenics Pharmaceuticals, Inc. and the effectiveness of internal control over financial reporting of Progenics Pharmaceuticals, Inc. included in this Annual Report (Form 10-K) of Progenics Pharmaceuticals, Inc. for the year ended December 31, 2019.

/s/ Ernst & Young LLP

Stamford, Connecticut

March 13, 2020