<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created by RR Donnelley IM Processor 7.0.0.0 using Fujitsu Interstage XWand-->
<xbrl xmlns:wf11="http://www.wilmingtonfunds.com/20130222" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dei="http://xbrl.sec.gov/dei/2012-01-31" xmlns:rr="http://xbrl.sec.gov/rr/2012-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.xbrl.org/2003/instance">
  <link:schemaRef xlink:type="simple" xlink:href="wf11-20130222.xsd" />
  <context id="Duration_01Sep2011_31Aug2012">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0000830744</identifier>
    </entity>
    <period>
      <startDate>2011-09-01</startDate>
      <endDate>2012-08-31</endDate>
    </period>
  </context>
  <context id="Duration_01Sep2011_31Aug2012S000034850_Member">
    <entity>
      <identifier scheme="http://www.sec.gov/CIK">0000830744</identifier>
      <segment>
        <xbrldi:explicitMember dimension="dei:LegalEntityAxis">wf11:S000034850Member</xbrldi:explicitMember>
      </segment>
    </entity>
    <period>
      <startDate>2011-09-01</startDate>
      <endDate>2012-08-31</endDate>
    </period>
  </context>
  <dei:EntityRegistrantName contextRef="Duration_01Sep2011_31Aug2012">WILMINGTON FUNDS</dei:EntityRegistrantName>
  <dei:DocumentType contextRef="Duration_01Sep2011_31Aug2012">Other</dei:DocumentType>
  <dei:DocumentPeriodEndDate contextRef="Duration_01Sep2011_31Aug2012">2012-04-30</dei:DocumentPeriodEndDate>
  <dei:EntityCentralIndexKey contextRef="Duration_01Sep2011_31Aug2012">0000830744</dei:EntityCentralIndexKey>
  <dei:DocumentCreationDate contextRef="Duration_01Sep2011_31Aug2012">2013-02-22</dei:DocumentCreationDate>
  <dei:DocumentEffectiveDate contextRef="Duration_01Sep2011_31Aug2012">2013-02-22</dei:DocumentEffectiveDate>
  <dei:AmendmentFlag contextRef="Duration_01Sep2011_31Aug2012">false</dei:AmendmentFlag>
  <rr:ProspectusDate contextRef="Duration_01Sep2011_31Aug2012">2012-08-31</rr:ProspectusDate>
  <wf11:SupplementTextBlock contextRef="Duration_01Sep2011_31Aug2012">&lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px" align="center"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Supplement dated February 22, 2013, to the Wilmington Funds (the "Funds" or the "Trust") &lt;/b&gt;&lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px" align="center"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Prospectus dated August 31, 2012, as supplemented (the "Prospectus") &lt;/b&gt;&lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 12px"&gt;&amp;nbsp;&lt;/p&gt; &lt;table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%"&gt;  &lt;tr&gt; &lt;td width="3%"&gt;&lt;font size="1"&gt;&amp;nbsp;&lt;/font&gt;&lt;/td&gt; &lt;td valign="top" width="4%" align="left"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;&lt;i&gt;1.&lt;/i&gt;&lt;/b&gt;&lt;/font&gt;&lt;/td&gt; &lt;td valign="top" align="left"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;&lt;i&gt;Effective &lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;February 22&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;, 201&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;3&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;, the information in the Prospectus with respect to the Wilmingto&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;n Large-&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;Cap &lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;Strategy &lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;Fund&lt;/i&gt;&lt;/b&gt;&lt;b&gt; &lt;/b&gt;&lt;b&gt;&lt;i&gt;will be amended, supplemented or replaced as follows:&lt;/i&gt;&lt;/b&gt; &lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt; &lt;p style="MARGIN-TOP: 6px; TEXT-INDENT: 6%; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;i&gt;(a)&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;The following amends and replaces the entire existing text of the "Principal Investment Strategies of the Fund" sections on pages 1 and 83 of the Prospectus. &lt;/i&gt;&lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Fund invests at least 80% of its assets in a diversified portfolio of U.S. equity (or equity-related) securities of large-cap companies. Large-cap companies are companies that have a market capitalization at the time of purchase at least equal to that of the smallest company in the Russell 1000 Index ($671 billion as of June 30, 2012), or at least equal to that of the smallest company expected to be included in the Russell 1000 Index after its next scheduled reconstitution. The Fund expects to invest substantially all of its assets in common stocks of U.S. companies. &lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Fund's investment advisor determines the tactical allocation of the Fund's assets and uses returns-based and holdings-based style analysis tools to assess the tactical weightings. The tactical allocations may be based on one or more factors, such as investment style (e.g., growth or value), market capitalization (e.g., mega-cap or large/mid-cap), industry sector or security valuation measure (e.g., price/earnings ratio). Once the investment advisor determines the tactical allocations, the sub-advisor builds a portfolio in accordance with the investment advisor's allocation instructions. The sub-advisor uses quantitative models to construct a portfolio for the Fund. &lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The sub-advisor invests in a representative sample of securities which are included in the Fund's benchmark index (Russell 1000 Index) or another index of large-capitalization companies, weighted to reflect the investment advisor's tactical allocations. The return for each component of the portfolio is intended to correlate closely with the return for the corresponding component of the applicable benchmark index. The sub-advisor will use its proprietary quantitative models to rebalance the portfolio and to make buy and sell decisions on individual securities. There is no assurance that the sub-advisor's investment performance will equal or exceed that of the benchmark index.&amp;nbsp;&lt;/font&gt;&lt;/p&gt;</wf11:SupplementTextBlock>
  <wf11:SupplementTextBlock contextRef="Duration_01Sep2011_31Aug2012S000034850_Member">&lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px" align="center"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Supplement dated February 22, 2013, to the Wilmington Funds (the "Funds" or the "Trust") &lt;/b&gt;&lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px" align="center"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Prospectus dated August 31, 2012, as supplemented (the "Prospectus") &lt;/b&gt;&lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 12px"&gt;&amp;nbsp;&lt;/p&gt; &lt;table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%"&gt;  &lt;tr&gt; &lt;td width="3%"&gt;&lt;font size="1"&gt;&amp;nbsp;&lt;/font&gt;&lt;/td&gt; &lt;td valign="top" width="4%" align="left"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;&lt;i&gt;1.&lt;/i&gt;&lt;/b&gt;&lt;/font&gt;&lt;/td&gt; &lt;td valign="top" align="left"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;&lt;i&gt;Effective &lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;February 22&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;, 201&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;3&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;, the information in the Prospectus with respect to the Wilmingto&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;n Large-&lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;Cap &lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;Strategy &lt;/i&gt;&lt;/b&gt;&lt;b&gt;&lt;i&gt;Fund&lt;/i&gt;&lt;/b&gt;&lt;b&gt; &lt;/b&gt;&lt;b&gt;&lt;i&gt;will be amended, supplemented or replaced as follows:&lt;/i&gt;&lt;/b&gt; &lt;/font&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt; &lt;p style="MARGIN-TOP: 6px; TEXT-INDENT: 6%; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;i&gt;(a)&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;The following amends and replaces the entire existing text of the "Principal Investment Strategies of the Fund" sections on pages 1 and 83 of the Prospectus. &lt;/i&gt;&lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Fund invests at least 80% of its assets in a diversified portfolio of U.S. equity (or equity-related) securities of large-cap companies. Large-cap companies are companies that have a market capitalization at the time of purchase at least equal to that of the smallest company in the Russell 1000 Index ($671 billion as of June 30, 2012), or at least equal to that of the smallest company expected to be included in the Russell 1000 Index after its next scheduled reconstitution. The Fund expects to invest substantially all of its assets in common stocks of U.S. companies. &lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Fund's investment advisor determines the tactical allocation of the Fund's assets and uses returns-based and holdings-based style analysis tools to assess the tactical weightings. The tactical allocations may be based on one or more factors, such as investment style (e.g., growth or value), market capitalization (e.g., mega-cap or large/mid-cap), industry sector or security valuation measure (e.g., price/earnings ratio). Once the investment advisor determines the tactical allocations, the sub-advisor builds a portfolio in accordance with the investment advisor's allocation instructions. The sub-advisor uses quantitative models to construct a portfolio for the Fund. &lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The sub-advisor invests in a representative sample of securities which are included in the Fund's benchmark index (Russell 1000 Index) or another index of large-capitalization companies, weighted to reflect the investment advisor's tactical allocations. The return for each component of the portfolio is intended to correlate closely with the return for the corresponding component of the applicable benchmark index. The sub-advisor will use its proprietary quantitative models to rebalance the portfolio and to make buy and sell decisions on individual securities. There is no assurance that the sub-advisor's investment performance will equal or exceed that of the benchmark index.&amp;nbsp;&lt;/font&gt;&lt;/p&gt;</wf11:SupplementTextBlock>
  <rr:StrategyNarrativeTextBlock contextRef="Duration_01Sep2011_31Aug2012S000034850_Member">&lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Fund invests at least 80% of its assets in a diversified portfolio of U.S. equity (or equity-related) securities of large-cap companies. Large-cap companies are companies that have a market capitalization at the time of purchase at least equal to that of the smallest company in the Russell 1000 Index ($671 billion as of June 30, 2012), or at least equal to that of the smallest company expected to be included in the Russell 1000 Index after its next scheduled reconstitution. The Fund expects to invest substantially all of its assets in common stocks of U.S. companies. &lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Fund's investment advisor determines the tactical allocation of the Fund's assets and uses returns-based and holdings-based style analysis tools to assess the tactical weightings. The tactical allocations may be based on one or more factors, such as investment style (e.g., growth or value), market capitalization (e.g., mega-cap or large/mid-cap), industry sector or security valuation measure (e.g., price/earnings ratio). Once the investment advisor determines the tactical allocations, the sub-advisor builds a portfolio in accordance with the investment advisor's allocation instructions. The sub-advisor uses quantitative models to construct a portfolio for the Fund. &lt;/font&gt;&lt;/p&gt; &lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The sub-advisor invests in a representative sample of securities which are included in the Fund's benchmark index (Russell 1000 Index) or another index of large-capitalization companies, weighted to reflect the investment advisor's tactical allocations. The return for each component of the portfolio is intended to correlate closely with the return for the corresponding component of the applicable benchmark index. The sub-advisor will use its proprietary quantitative models to rebalance the portfolio and to make buy and sell decisions on individual securities. There is no assurance that the sub-advisor's investment performance will equal or exceed that of the benchmark index.&amp;nbsp;&lt;/font&gt;&lt;/p&gt;</rr:StrategyNarrativeTextBlock>
</xbrl>
