As filed with the Securities and Exchange Commission on December 22, 2009

Registration No. 333-147147

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

POST-EFFECTIVE AMENDMENT NO. 1

TO

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

MTS Medication Technologies, Inc.

(Exact name of registrant as specified in its charter)

Delaware	59-2740462
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)
2003 Gandy Boulevard North, Suite 800 St. Petersburg, Florida	33702
(Address of Principal Executive Offices)	(Zip Code)

MTS MEDICATION TECHNOLOGIES, INC. 2007 STOCK INCENTIVE PLAN

(Full title of the plan)

Todd E. Siegel

MTS Medication Technologies, Inc.

2003 Gandy Boulevard North, Suite 800

St. Petersburg, Florida 33702

(Name and address of agent for service)

(727) 576-6311

(Telephone number, including area code, of agent for service)

Copies of all communications to:

Robert J. Grammig, Esq.

Holland & Knight LLP

100 North Tampa Street, Suite 4100

Tampa, Florida 33602

(813) 227-8500

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer	¨	Accelerated filer	¨
Non-accelerated filer	¨  (Do not check if a smaller reporting company)	Smaller reporting company	x

DEREGISTRATION OF SECURITIES

On November 5, 2007, MTS Medication Technologies, Inc. (“MTS”) filed with the Securities and Exchange Commission a registration statement on Form S-8 (Registration No. 333-147147) (the “Registration Statement”), registering 600,000 shares of MTS common stock for issuance under the MTS Medication Technologies, Inc. 2007 Stock Incentive Plan. MTS is filing this Post-Effective Amendment No. 1 to the Registration Statement, in accordance with the undertaking required by Item 512(a)(3) of Regulation S-K, to deregister any and all shares previously registered under the Registration Statement that remain unsold as of the date of this Post-Effective Amendment No. 1.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of St. Petersburg, State of Florida, on December 22, 2009.

MTS Medication Technologies, Inc. Registrant
By:	/s/    TODD E. SIEGEL
	Todd E. Siegel
	Chief Executive Officer and President

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

	Signatures	Title	Date
By:	/S/    TODD E. SIEGEL         Todd E. Siegel	Chief Executive Officer, President and Director (principal executive officer)	December 22, 2009
By:	/S/    MICHAEL P. CONROY         Michael P. Conroy	Chief Financial Officer, Vice President and Corporate Secretary (principal financial officer andprincipal accounting officer)	December 22, 2009
By:	/S/    MATTHEW C. HICKS         Matthew C. Hicks	Director	December 22, 2009
By:	/S/    DAVID L. KESSENICH         David L. Kessenich	Director	December 22, 2009
By:	/S/    ROBERT A. MARTIN         Robert A. Martin	Director	December 22, 2009