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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 Bb/PDcQ3hbgMLiIjOH9Nqg==

<SEC-DOCUMENT>0001181431-10-058293.txt : 20101201
<SEC-HEADER>0001181431-10-058293.hdr.sgml : 20101201
<ACCEPTANCE-DATETIME>20101201130837
ACCESSION NUMBER:		0001181431-10-058293
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101129
FILED AS OF DATE:		20101201
DATE AS OF CHANGE:		20101201

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SAMANT VIJAY B
		CENTRAL INDEX KEY:			0001198238
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21088
		FILM NUMBER:		101224207

	MAIL ADDRESS:	
		STREET 1:		9373 TOWNE CENTRE DRIVE SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-3088

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VICAL INC
		CENTRAL INDEX KEY:			0000819050
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				930948554
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		10390 PACIFIC CENTER COURT
		STREET 2:		.
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-4340
		BUSINESS PHONE:		858-646-1100

	MAIL ADDRESS:	
		STREET 1:		10390 PACIFIC CENTER COURT
		STREET 2:		.
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-4340
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd292631.xml
<DESCRIPTION>NOVEMBER 2010 OPEN MARKET PURCHASE
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-11-29</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000819050</issuerCik>
        <issuerName>VICAL INC</issuerName>
        <issuerTradingSymbol>VICL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001198238</rptOwnerCik>
            <rptOwnerName>SAMANT VIJAY B</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>10390 PACIFIC CENTER COURT</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; CEO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock $.01 par value</value>
            </securityTitle>
            <transactionDate>
                <value>2010-11-29</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.98</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>383442</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Purchase was made pursuant to a 10b5-1 trading plan dated November 16, 2010.</footnote>
        <footnote id="F2">This balance includes 174,687 of unvested retricted stock units.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Sandy R. Medina (via Power of Attorney)</signatureName>
        <signatureDate>2010-12-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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