EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

CytRx Corporation

Los Angeles, California

We hereby consent to the incorporation by reference in the Registration Statements on Form S­3 (Nos. 333-100947, 333-109708, 333-106629, 333-109708, 333-133269, 333-142591 and 333-147605) and Form S­8 (Nos. 333-84657, 333-68200, 333-91068, 333-93305, 333-123339 and 333-163212) of CytRx Corporation of our reports dated March 12, 2010, relating to the consolidated financial statements, the effectiveness of CytRx Corporation’s internal control over financial reporting, and schedules of CytRx Corporation, which appear in this Form 10-K.

Los Angeles, California

March 12, 2010