EXHIBIT 21.1

SUBSIDIARIES OF THE REGISTRANT

THE SPECTRANETICS CORPORATION

SUBSIDIARIES

ANGIOSCORE INC.

Jurisdiction: Delaware

SPNC AUSTRALIA PTY LTD

Jurisdiction: Australia

SPECTRANETICS INTERNATIONAL B.V.

Jurisdiction: The Netherlands

SPECTRANETICS II B.V.

Jurisdiction: The Netherlands

Subsidiary of Spectranetics International B.V.

SPECTRANETICS DEUTSCHLAND GMBH

Jurisdiction: Germany

Subsidiary of Spectranetics International B.V.

SPECTRANETICS AUSTRIA GMBH

Jurisdiction: Austria

Subsidiary of Spectranetics International B.V.

SPECTRANETICS FRANCE SARL

Jurisdiction: France

Subsidiary of Spectranetics International B.V.

SPECTRANETICS SWITZERLAND GMBH

Jurisdiction: Switzerland

Subsidiary of Spectranetics International B.V.

SPECTRANETICS DENMARK APS

Jurisdiction: Denmark

Subsidiary of Spectranetics International B.V.

SPECTRANETICS UK

Jurisdiction: United Kingdom

Branch of Spectranetics International B.V.

SPECTRANETICS ITALY

Jurisdiction: Italy

Branch of Spectranetics International B.V.