EXHIBIT 21.1

SUBSIDIARIES OF THE REGISTRANT

THE SPECTRANETICS CORPORATION

SUBSIDIARIES

SPECTRANETICS INTERNATIONAL B.V.

Established January 1993, Incorporated June 1993

Jurisdiction: The Netherlands

SPECTRANETICS II B.V.

Incorporated December 2011

Jurisdiction: The Netherlands

Subsidiary of Spectranetics International B.V.

SPECTRANETICS DEUTSCHLAND GMBH

Acquired May 2008

Jurisdiction: Germany

Subsidiary of Spectranetics International B.V.

SPECTRANETICS AUSTRIA GMBH

Incorporated December 2011

Jurisdiction: Austria

Subsidiary of Spectranetics International B.V.

SPECTRANETICS UK

Registered January 2012

Jurisdiction: United Kingdom

Subsidiary of Spectranetics International B.V.