101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Condensed Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Condensed Consolidated Statements of Operations link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Condensed Consolidated Statements of Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 107 - Statement - Condensed Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - The Company link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Summary of Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Marketable Securities link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Inventories link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Property and Equipment link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Accounts Payable and Accrued Expenses link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Long-Term Debt link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Convertible Notes and Warrant Modification link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Stock-Based Compensation link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Stockholders' Equity link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Research Collaboration Agreements link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Summary of Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Summary of Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Marketable Securities (Tables) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Inventories (Tables) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Property and Equipment (Tables) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Accounts Payable and Accrued Expenses (Tables) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Long-Term Debt (Tables) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Stock-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Commitments and Contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Research Collaboration Agreements (Tables) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - The Company - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Financial Assets Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Customers Representing Greater than Ten Percent of Accounts Receivable (Detail) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Customers Representing Greater than Ten Percent of Revenues (Detail) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Depreciation Periods for Property and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Computation of Basic and Diluted Net Loss Per Common Share (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Potentially Dilutive, Common Share Equivalents Excluded from Calculation of Diluted Net Loss Per Common Share (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Available for Sale Securities (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Summary of Amortized Cost and Fair Value of Marketable Securities, Classified by Stated Maturity (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Inventories (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Property and Equipment Summary (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Accounts Payable and Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Long-Term Debt Summary (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Long-Term Debt - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 147 - Disclosure - Aggregated Maturities of Debt (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Convertible Notes and Warrant Modification - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Fair Value of Employee Stock Options Estimated Using Weighted Average Assumptions (Detail) link:calculationLink link:presentationLink link:definitionLink 151 - Disclosure - Stock-Based Compensation Costs Included in Operating Expenses and Total Intrinsic Value of Options Exercised (Detail) link:calculationLink link:presentationLink link:definitionLink 152 - Disclosure - Summary of Stock Option Transactions under Option Plans (Detail) link:calculationLink link:presentationLink link:definitionLink 153 - Disclosure - Summary of Information about Stock Options Outstanding and Exercisable (Detail) link:calculationLink link:presentationLink link:definitionLink 154 - Disclosure - Summary of Restricted Stock Transactions under Option Plans (Detail) link:calculationLink link:presentationLink link:definitionLink 155 - Disclosure - Stockholders' Equity - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 156 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 157 - Disclosure - Future Minimum Payments under Noncancelable Operating Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 158 - Disclosure - Research Collaboration Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 159 - Disclosure - Future Minimum Payments under Company's Research Collaboration (Detail) link:calculationLink link:presentationLink link:definitionLink